PharmaCoNets of Hexachlorophene (SPCN: 20.94 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Hexachlorophenehsa00190Oxidative phosphorylation7.13E-044Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Hexachlorophenehsa00220Arginine biosynthesis1.58E-022P05089, P49448ARG1, GLUD2More
Hexachlorophenehsa00280Valine, leucine and isoleucine degradation1.37E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Hexachlorophenehsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Hexachlorophenehsa00600Sphingolipid metabolism3.41E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Hexachlorophenehsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Hexachlorophenehsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Hexachlorophenehsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Hexachlorophenehsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Hexachlorophenehsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Hexachlorophenehsa03013RNA transport1.39E-0412O14980, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, Q06787, P51114XPO1, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, FMR1, FXR1More
Hexachlorophenehsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Hexachlorophenehsa03040Spliceosome6.42E-038Q14562, O43143, P08579, Q07955, Q01130, Q13243, P11142, O43447DHX8, DHX15, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8, PPIHMore
Hexachlorophenehsa04020Calcium signaling pathway9.34E-037P27987, P21796, P45880, Q13557, P19174, P0DP23, P05141ITPKB, VDAC1, VDAC2, CAMK2D, PLCG1, CALM1, SLC25A5More
Hexachlorophenehsa04022cGMP-PKG signaling pathway2.26E-038Q14814, Q99941, P18848, P05141, P21796, P45880, P0DP23, P01042MEF2D, CREBL1, ATF4, SLC25A5, VDAC1, VDAC2, CALM1, KNG1More
Hexachlorophenehsa04064NF-kappa B signaling pathway3.86E-025O00463, Q13077, P06239, P24522, P09341TRAF5, TRAF1, LCK, GADD45A, CXCL1More
Hexachlorophenehsa04070Phosphatidylinositol signaling system1.32E-025P19174, P0DP23, O14986, P23743, P27987PLCG1, CALM1, PIP5K1B, DGKA, ITPKBMore
Hexachlorophenehsa04141Protein processing in endoplasmic reticulum6.42E-038P18848, P30101, Q15437, Q15436, Q99941, P11142, P07900, P08238ATF4, PDIA3, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, HSP90AB1More
Hexachlorophenehsa04145Phagosome3.07E-026P60709, Q15075, Q15080, P14598, Q13488, O60603ACTB, EEA1, NCF4, NCF1, TCIRG1, TLR2More
Hexachlorophenehsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Hexachlorophenehsa04151PI3K-Akt signaling pathway1.24E-0212P62753, P27348, P07900, P08238, P62873, P63218, Q16363, P22105, P14784, Q99941, P18848, P30279RPS6, YWHAQ, HSP90AA1, HSP90AB1, GNB1, GNG5, LAMA4, TNXB, IL2RB, CREBL1, ATF4, CCND2More
Hexachlorophenehsa04217Necroptosis9.97E-038P42224, P07900, P08238, P15104, P05141, Q13557, P21796, P45880STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, CAMK2D, VDAC1, VDAC2More
Hexachlorophenehsa04621NOD-like receptor signaling pathway3.58E-028P42224, P25963, Q13489, Q9H1Y0, P10415, Q05823, P59665, P59666STAT1, NFKBIA, BIRC3, ATG5, BCL2, RNASEL, DEFA1; DEFA1B, DEFA3More
Hexachlorophenehsa04640Hematopoietic cell lineage6.39E-036P13612, P25063, P07766, P09693, P01730, P13765ITGA4, CD24, CD3E, CD3G, CD4, HLA-DOBMore
Hexachlorophenehsa04658Th1 and Th2 cell differentiation1.01E-047P07766, P20963, P09693, P01730, P06239, Q9UL17, P13765CD3E, CD247, CD3G, CD4, LCK, TBX21, HLA-DOBMore
Hexachlorophenehsa04659Th17 cell differentiation1.35E-0412P19174, P01730, P06239, P42224, P14784, P13765, Q9UL17, P07900, P08238, P07766, P09693, P20963PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, TBX21, HSP90AA1, HSP90AB1, CD3E, CD3G, CD247More
Hexachlorophenehsa04660T cell receptor signaling pathway1.18E-037O95267, Q08881, P07766, P20963, P09693, P01730, P06239RASGRP1, ITK, CD3E, CD247, CD3G, CD4, LCKMore
Hexachlorophenehsa04672Intestinal immune network for IgA production3.01E-022P13765, P13612HLA-DOB, ITGA4More
Hexachlorophenehsa04713Circadian entrainment4.76E-024P0DP23, Q13557, P62873, P63218CALM1, CAMK2D, GNB1, GNG5More
Hexachlorophenehsa04721Synaptic vesicle cycle4.83E-022Q13488, P31645TCIRG1, SLC6A4More
Hexachlorophenehsa04725Cholinergic synapse4.76E-024P62873, P63218, P18848, Q13557GNB1, GNG5, ATF4, CAMK2DMore
Hexachlorophenehsa04727GABAergic synapse4.02E-024P62873, P63218, P15104, P46459GNB1, GNG5, GLUL, NSFMore
Hexachlorophenehsa04728Dopaminergic synapse1.87E-026P62873, P63218, Q99941, P18848, Q13557, P0DP23GNB1, GNG5, CREBL1, ATF4, CAMK2D, CALM1More
Hexachlorophenehsa04740Olfactory transduction9.79E-033P62873, Q13557, P0DP23GNB1, CAMK2D, CALM1More
Hexachlorophenehsa04744Phototransduction1.42E-022P62873, P0DP23GNB1, CALM1More
Hexachlorophenehsa04750Inflammatory mediator regulation of TRP channels1.61E-025Q13557, P19174, P24723, P0DP23, P01042CAMK2D, PLCG1, PRKCH, CALM1, KNG1More
Hexachlorophenehsa04915Estrogen signaling pathway1.87E-026Q99941, P18848, P07900, P08238, P11142, P0DP23CREBL1, ATF4, HSP90AA1, HSP90AB1, HSPA8, CALM1More
Hexachlorophenehsa04925Aldosterone synthesis and secretion3.35E-024Q99941, P18848, P0DP23, Q13557CREBL1, ATF4, CALM1, CAMK2DMore
Hexachlorophenehsa05010Alzheimer disease4.56E-029P19404, P13073, P0DP23, P18848, Q71U36, Q13509, P05141, P21796, P45880NDUFV2, COX4I1, CALM1, ATF4, TUBA1A, TUBB3, SLC25A5, VDAC1, VDAC2More
Hexachlorophenehsa05012Parkinson disease6.70E-0411P19404, P13073, P05141, P21796, P45880, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509NDUFV2, COX4I1, SLC25A5, VDAC1, VDAC2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3More
Hexachlorophenehsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Hexachlorophenehsa05016Huntington disease9.64E-0310P19404, P13073, Q13547, P30876, P62487, P05141, P21796, P45880, Q71U36, Q13509NDUFV2, COX4I1, HDAC1, POLR2B, POLR2G, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3More
Hexachlorophenehsa05020Prion disease9.64E-0310P11142, P19404, P13073, P18848, P05141, P21796, P45880, Q71U36, Q13509, Q99941HSPA8, NDUFV2, COX4I1, ATF4, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3, CREBL1More
Hexachlorophenehsa05022Pathways of neurodegeneration - multiple diseases1.36E-0212Q71U36, Q13509, P19404, P13073, P21796, P18848, P19174, P05141, P45880, P20333, P0DP23, Q13557TUBA1A, TUBB3, NDUFV2, COX4I1, VDAC1, ATF4, PLCG1, SLC25A5, VDAC2, TNFRSF1B, CALM1, CAMK2DMore
Hexachlorophenehsa05031Amphetamine addiction6.57E-035P0DP23, Q13557, Q99941, P18848, Q13547CALM1, CAMK2D, CREBL1, ATF4, HDAC1More
Hexachlorophenehsa05034Alcoholism1.27E-027Q99941, P18848, Q13547, P0DP23, P62873, P63218, O60814CREBL1, ATF4, HDAC1, CALM1, GNB1, GNG5, H2BC12More
Hexachlorophenehsa05110Vibrio cholerae infection3.41E-023Q13488, P17252, P60709TCIRG1, PRKCA, ACTBMore
Hexachlorophenehsa05132Salmonella infection1.86E-029P25963, Q9UJU2, P60709, Q13489, P10415, P04406, O60603, Q13561, P49754NFKBIA, LEF1, ACTB, BIRC3, BCL2, GAPDH, TLR2, DCTN2, VPS41More
Hexachlorophenehsa05134Legionellosis3.35E-024P11215, P68104, P11142, P19875ITGAM, EEF1A1, HSPA8, CXCL2More
Hexachlorophenehsa05140Leishmaniasis8.90E-036P14598, P42224, O60603, P25963, P29350, Q15080NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4More
Hexachlorophenehsa05145Toxoplasmosis3.93E-026P25963, P10415, Q13489, P42224, P23229, O60603NFKBIA, BCL2, BIRC3, STAT1, ITGA6, TLR2More
Hexachlorophenehsa05146Amoebiasis3.24E-024P09341, P05089, P12814, P08311CXCL1, ARG1, ACTN1, CTSGMore
Hexachlorophenehsa05150Staphylococcus aureus infection4.02E-036P21462, O75015, Q14532, P59665, P59666, P12838FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4More
Hexachlorophenehsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-027P42224, P62873, P63218, P19875, P19174, P07948, P0DP23STAT1, GNB1, GNG5, CXCL2, PLCG1, LYN, CALM1More
Hexachlorophenehsa05169Epstein-Barr virus infection4.76E-0313P13765, Q13547, O00463, P07948, P30101, Q13761, P24522, O75293, P30279, P42224, P07766, P09693, P20963HLA-DOB, HDAC1, TRAF5, LYN, PDIA3, RUNX3, GADD45A, GADD45B, CCND2, STAT1, CD3E, CD3G, CD247More
Hexachlorophenehsa05170Human immunodeficiency virus 1 infection3.53E-026P50151, O00463, P01730, P07766, P09693, P20963GNG10, TRAF5, CD4, CD3E, CD3G, CD247More
Hexachlorophenehsa05200Pathways in cancer1.93E-0317Q16363, P07900, P08238, P42224, P19174, P43246, P20585, Q13547, P30279, P62873, P63218, P78417, O75293, P0DP23, Q13557, P14784, P01042LAMA4, HSP90AA1, HSP90AB1, STAT1, PLCG1, MSH2, MSH3, HDAC1, CCND2, GNB1, GNG5, GSTO1, GADD45B, CALM1, CAMK2D, IL2RB, KNG1More
Hexachlorophenehsa05203Viral carcinogenesis2.47E-0413Q12933, Q99941, P18848, P42229, P06746, P07948, P30279, P27348, P29083, Q7KZF4, Q13547, Q15283, O60814TRAF2, CREBL1, ATF4, STAT5A, POLB, LYN, CCND2, YWHAQ, GTF2E1, SND1, HDAC1, RASA2, H2BC12More
Hexachlorophenehsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Hexachlorophenehsa05206MicroRNAs in cancer1.92E-027P10415, P26358, Q9UM47, P35226, O95980, Q96EB6, P17252BCL2, DNMT1, NOTCH3, BMI1, RECK, SIRT1, PRKCAMore
Hexachlorophenehsa05214Glioma1.76E-024P0DP23, Q13557, P19174, O75293CALM1, CAMK2D, PLCG1, GADD45BMore
Hexachlorophenehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.92E-046O95267, P07766, P20963, P09693, P06239, P01730RASGRP1, CD3E, CD247, CD3G, LCK, CD4More
Hexachlorophenehsa05340Primary immunodeficiency3.29E-023P01730, P07766, P06239CD4, CD3E, LCKMore
Hexachlorophenehsa05415Diabetic cardiomyopathy3.07E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore

Community members of Hexachlorophene (SDC: 2.17)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O14521SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialReported00.04690.00670.56670.6035
P11142HSPA8Heat shock cognate 71 kDa proteinPredicted00.96820.07730.67291.3115
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P49448GLUD2Glutamate dehydrogenase 2, mitochondrialPredicted00.16410.01970.32420.4456
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)