PharmaCoNets of Hesperidin (SPCN: 64.84 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Hesperidinhsa00030Pentose phosphate pathway1.39E-023P51854, P11413, P37837TKTL1, G6PD, TALDO1More
Hesperidinhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Hesperidinhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Hesperidinhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Hesperidinhsa00220Arginine biosynthesis1.02E-052P15104, P49448GLUL, GLUD2More
Hesperidinhsa00250Alanine, aspartate and glutamate metabolism1.85E-042P49448, P15104GLUD2, GLULMore
Hesperidinhsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Hesperidinhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Hesperidinhsa00471D-Glutamine and D-glutamate metabolism3.94E-021P49448GLUD2More
Hesperidinhsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Hesperidinhsa00500Starch and sucrose metabolism1.91E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Hesperidinhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Hesperidinhsa00562Inositol phosphate metabolism4.55E-022P27987, P42338ITPKB, PIK3CBMore
Hesperidinhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Hesperidinhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Hesperidinhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Hesperidinhsa00910Nitrogen metabolism1.85E-042P15104, P49448GLUL, GLUD2More
Hesperidinhsa00983Drug metabolism - other enzymes2.83E-023P20839, P32320, P05164IMPDH1, CDA, MPOMore
Hesperidinhsa01100Metabolic pathways3.93E-0437Q9NR34, Q9Y259, P05089, P21953, P15104, P42338, P27987, P32320, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, P53004, P05186, P24666, P49619, O95954, Q9HCC0, P33121, Q02318, P09917, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737MAN1C1, CHKB, ARG1, BCKDHB, GLUL, PIK3CB, ITPKB, CDA, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, BLVRA, ALPL, ACP1, DGKG, FTCD, MCCC2, ACSL1, CYP27A1, ALOX5, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGLMore
Hesperidinhsa01200Carbon metabolism2.91E-021P11413G6PDMore
Hesperidinhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Hesperidinhsa03010Ribosome7.34E-036P62753, P62829, P62888, P61927, P61513, P36578RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4More
Hesperidinhsa03020RNA polymerase2.51E-022P24928, P62487POLR2A, POLR2GMore
Hesperidinhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Hesperidinhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Hesperidinhsa04020Calcium signaling pathway4.45E-023P0DP24, P51828, P23634CALM2, ADCY7, ATP2B4More
Hesperidinhsa04024cAMP signaling pathway3.79E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Hesperidinhsa04062Chemokine signaling pathway2.94E-024P07948, P42338, P50151, P49407LYN, PIK3CB, GNG10, ARRB1More
Hesperidinhsa04064NF-kappa B signaling pathway2.99E-027O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Hesperidinhsa04071Sphingolipid signaling pathway1.76E-037P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q9UQC2S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, GAB2More
Hesperidinhsa04080Neuroactive ligand-receptor interaction2.16E-027P08311, Q15722, P21453, Q9H228, P21462, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, FPR1, C5AR1, ADRB2More
Hesperidinhsa04110Cell cycle3.57E-023Q9UBD5, P06493, P33981ORC3, CDK1, TTKMore
Hesperidinhsa04114Oocyte meiosis3.15E-048P51812, Q02750, P0DP24, P16298, Q17RY0, P51828, P27348, Q13362RPS6KA3, MAP2K1, CALM2, PPP3CB, CPEB4, ADCY7, YWHAQ, PPP2R5CMore
Hesperidinhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Hesperidinhsa04145Phagosome2.24E-026O75015, Q15080, P05164, P78380, P35443, P13765FCGR3B, NCF4, MPO, OLR1, THBS4, HLA-DOBMore
Hesperidinhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Hesperidinhsa04151PI3K-Akt signaling pathway3.96E-028P43657, P09603, Q9GZP0, P63218, P50151, P13612, O15335, Q13751P2RY5, CSF1, PDGFD, GNG5, GNG10, ITGA4, CHAD, LAMB3More
Hesperidinhsa04217Necroptosis1.26E-049P01375, P48023, Q9NQC7, Q14765, P07900, P15104, P01584, Q99878, Q9H444TNF, FASLG, CYLD, STAT4, HSP90AA1, GLUL, IL1B, H2AC14, CHMP4BMore
Hesperidinhsa04261Adrenergic signaling in cardiomyocytes1.06E-024P51828, Q13362, P0DP24, P23634ADCY7, PPP2R5C, CALM2, ATP2B4More
Hesperidinhsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Hesperidinhsa04340Hedgehog signaling pathway3.91E-021P17612PRKACAMore
Hesperidinhsa04360Axon guidance2.19E-023P42338, O14639, P24844PIK3CB, ABLIM1, MYL9More
Hesperidinhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Hesperidinhsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Hesperidinhsa04512ECM-receptor interaction4.41E-023Q13751, P13612, O15335LAMB3, ITGA4, CHADMore
Hesperidinhsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Hesperidinhsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Hesperidinhsa04612Antigen processing and presentation5.33E-037P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Hesperidinhsa04613Neutrophil extracellular trap formation2.25E-0315P05164, P08246, Q9UM07, P04908, Q93077, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539MPO, ELA2, PADI4, H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Hesperidinhsa04621NOD-like receptor signaling pathway2.92E-023P01584, P07900, P43490IL1B, HSP90AA1, PBEF1More
Hesperidinhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Hesperidinhsa04650Natural killer cell mediated cytotoxicity2.29E-0411P16298, P50591, P01375, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, P26715PPP3CB, TNFSF10, TNF, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Hesperidinhsa04657IL-17 signaling pathway1.95E-059P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Hesperidinhsa04658Th1 and Th2 cell differentiation1.26E-026Q04759, P20963, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, STAT4, GATA3, TBX21, HLA-DOBMore
Hesperidinhsa04660T cell receptor signaling pathway5.84E-038P01375, Q04759, P10747, O95267, Q08881, P20963, P01732, Q13191TNF, PRKCQ, CD28, RASGRP1, ITK, CD247, CD8A, CBLBMore
Hesperidinhsa04662B cell receptor signaling pathway1.21E-023P42338, P60033, P07948PIK3CB, CD81, LYNMore
Hesperidinhsa04664Fc epsilon RI signaling pathway6.27E-046P01375, Q16539, P42338, Q9UQC2, P07948, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, ALOX5More
Hesperidinhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Hesperidinhsa04710Circadian rhythm4.40E-021O15516CLOCKMore
Hesperidinhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Hesperidinhsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Hesperidinhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Hesperidinhsa04724Glutamatergic synapse9.51E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Hesperidinhsa04727GABAergic synapse2.03E-033P63218, P50151, P15104GNG5, GNG10, GLULMore
Hesperidinhsa04730Long-term depression3.72E-022Q14344, P07948GNA13, LYNMore
Hesperidinhsa04742Taste transduction3.91E-021P17612PRKACAMore
Hesperidinhsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Hesperidinhsa04924Renin secretion1.55E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Hesperidinhsa04925Aldosterone synthesis and secretion1.32E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Hesperidinhsa04926Relaxin signaling pathway2.59E-023P42338, P50151, P49407PIK3CB, GNG10, ARRB1More
Hesperidinhsa04929GnRH secretion1.40E-022P42338, P49407PIK3CB, ARRB1More
Hesperidinhsa04932Non-alcoholic fatty liver disease2.43E-048P01375, P49841, P48023, P01584, P12074, O15239, Q16718, O14521TNF, GSK3B, FASLG, IL1B, COX6A1, NDUFA1, NDUFA5, SDHDMore
Hesperidinhsa04940Type I diabetes mellitus7.38E-044P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Hesperidinhsa04960Aldosterone-regulated sodium reabsorption4.40E-021O00141SGKMore
Hesperidinhsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Hesperidinhsa04970Salivary secretion2.33E-047P07550, P51828, P22694, Q14643, P23634, P0DP24, P49913ADRB2, ADCY7, PRKACB, ITPR1, ATP2B4, CALM2, CAMPMore
Hesperidinhsa04972Pancreatic secretion4.94E-033P23634, P51828, P62491ATP2B4, ADCY7, RAB11AMore
Hesperidinhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Hesperidinhsa05010Alzheimer disease4.39E-026O15399, Q9NZJ5, Q13564, Q71U36, P09603, P21796GRIN2D, EIF2AK3, APPBP1, TUBA1A, CSF1, VDAC1More
Hesperidinhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Hesperidinhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Hesperidinhsa05032Morphine addiction1.34E-024P63218, P50151, Q07343, P43250GNG5, GNG10, PDE4B, GRK6More
Hesperidinhsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Hesperidinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Hesperidinhsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Hesperidinhsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Hesperidinhsa05143African trypanosomiasis3.01E-034P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Hesperidinhsa05146Amoebiasis5.82E-038P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Hesperidinhsa05150Staphylococcus aureus infection2.66E-036P21730, P21462, O75015, P13765, P12838, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, DEFA4, CAMPMore
Hesperidinhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Hesperidinhsa05163Human cytomegalovirus infection3.04E-038P01375, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463TNF, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Hesperidinhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Hesperidinhsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Hesperidinhsa05171Coronavirus disease - COVID-193.18E-037P01584, P62753, P36578, P62888, P61927, P61513, P62829IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23More
Hesperidinhsa05202Transcriptional misregulation in cancer3.18E-0311Q12778, Q13315, P41732, P14780, Q15744, Q16548, P35226, P05164, P12838, P08246, Q9C0K0FOXO1, ATM, TSPAN7, MMP9, CEBPE, BCL2A1, BMI1, MPO, DEFA4, ELA2, BCL11BMore
Hesperidinhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Hesperidinhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Hesperidinhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Hesperidinhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Hesperidinhsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Hesperidinhsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore
Hesperidinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Hesperidinhsa05310Asthma6.83E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Hesperidinhsa05321Inflammatory bowel disease2.27E-035P01375, P13765, Q14765, Q9UL17, P23771TNF, HLA-DOB, STAT4, TBX21, GATA3More
Hesperidinhsa05322Systemic lupus erythematosus4.51E-026O75015, P08246, P08311, P01375, P10747, P13765FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOBMore
Hesperidinhsa05323Rheumatoid arthritis2.62E-024P01375, P13765, P10747, P09341TNF, HLA-DOB, CD28, CXCL1More
Hesperidinhsa05330Allograft rejection2.02E-034P13765, P48023, P10747, P01375HLA-DOB, FASLG, CD28, TNFMore
Hesperidinhsa05332Graft-versus-host disease5.75E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Hesperidinhsa05415Diabetic cardiomyopathy4.92E-035Q16718, O14521, Q16539, P49841, P11413NDUFA5, SDHD, MAPK14, GSK3B, G6PDMore
Hesperidinhsa05418Fluid shear stress and atherosclerosis1.26E-048Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Hesperidin (SDC: 4.97)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P11511CYP19A1AromatasePredicted00.815610.15882.5666
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)