PharmaCoNets of Halothane (SPCN: 18.49 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Halothanehsa00071Fatty acid degradation2.52E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Halothanehsa00220Arginine biosynthesis3.52E-022P15104, P49448GLUL, GLUD2More
Halothanehsa00230Purine metabolism3.71E-024Q13370, P36959, Q13956, P27707PDE3B, GMPR, PDE6H, DCKMore
Halothanehsa00250Alanine, aspartate and glutamate metabolism3.52E-022P49448, P15104GLUD2, GLULMore
Halothanehsa00310Lysine degradation3.52E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Halothanehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Halothanehsa00500Starch and sucrose metabolism1.07E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Halothanehsa00562Inositol phosphate metabolism1.44E-024P27987, Q13572, P19174, P42338ITPKB, ITPK1, PLCG1, PIK3CBMore
Halothanehsa00630Glyoxylate and dicarboxylate metabolism8.71E-072P40925, P15104MDH1, GLULMore
Halothanehsa00730Thiamine metabolism8.96E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Halothanehsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Halothanehsa00770Pantothenate and CoA biosynthesis2.27E-022O95498, O95497VNN2, VNN1More
Halothanehsa00910Nitrogen metabolism3.52E-022P15104, P49448GLUL, GLUD2More
Halothanehsa00970Aminoacyl-tRNA biosynthesis2.77E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Halothanehsa01100Metabolic pathways3.52E-0223P05089, O95455, P21953, P32320, P11766, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, Q08477, P15907, Q9UNP4, P37837, P32321, Q9BPW9, Q9UHY7, P43490, P46976, P06737ARG1, TGDS, BCKDHB, CDA, ADH5, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, CYP4F3, ST6GAL1, ST3GAL5, TALDO1, DCTD, DHRS9, ENOPH1, PBEF1, GYG1, PYGLMore
Halothanehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Halothanehsa03013RNA transport1.13E-028P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, TACC3More
Halothanehsa03022Basal transcription factors2.17E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Halothanehsa03040Spliceosome3.11E-027O60508, P08579, Q13595, P84103, P11142, O43447, O75643CDC40, SNRPB2, TRA2A, SFRS3, HSPA8, PPIH, ASCC3L1More
Halothanehsa03050Proteasome1.40E-021P55036PSMD4More
Halothanehsa03430Mismatch repair3.21E-022P43246, P15927MSH2, RPA2More
Halothanehsa04012ErbB signaling pathway1.44E-024P16333, Q13191, P19174, P42338NCK1, CBLB, PLCG1, PIK3CBMore
Halothanehsa04020Calcium signaling pathway6.05E-048P27987, P21796, P30679, O15399, P19174, P0DP23, P23634, P49767ITPKB, VDAC1, GNA15, GRIN2D, PLCG1, CALM1, ATP2B4, VEGFCMore
Halothanehsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Halothanehsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Halothanehsa04062Chemokine signaling pathway2.21E-028P25024, P19875, P07948, P42338, P19174, P63218, P50151, P43250CXCR1, CXCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6More
Halothanehsa04070Phosphatidylinositol signaling system2.82E-023P0DP23, Q16760, Q96PE3CALM1, DGKD, INPP4AMore
Halothanehsa04072Phospholipase D signaling pathway7.71E-045Q92529, P61586, O14986, Q14344, P63092SHC3, RHOA, PIP5K1B, GNA13, GNASMore
Halothanehsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Halothanehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Halothanehsa04144Endocytosis4.40E-026Q13191, P11142, P25024, P43250, P14784, Q9Y5X3CBLB, HSPA8, CXCR1, GRK6, IL2RB, SNX5More
Halothanehsa04150mTOR signaling pathway2.23E-023P42338, Q13322, P49841PIK3CB, GRB10, GSK3BMore
Halothanehsa04151PI3K-Akt signaling pathway2.09E-0311P42338, P43657, P49767, P08238, P63218, P50151, P13612, O15335, Q13751, P14784, P30279PIK3CB, P2RY5, VEGFC, HSP90AB1, GNG5, GNG10, ITGA4, CHAD, LAMB3, IL2RB, CCND2More
Halothanehsa04213Longevity regulating pathway - multiple species4.29E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Halothanehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Halothanehsa04380Osteoclast differentiation4.80E-024P06239, P42338, P14778, Q8N149LCK, PIK3CB, IL1R1, LILRA2More
Halothanehsa04510Focal adhesion6.16E-0310P13612, P42338, O14986, P12814, P61586, O15335, Q16363, Q13751, P30279, P49767ITGA4, PIK3CB, PIP5K1B, ACTN1, RHOA, CHAD, LAMA4, LAMB3, CCND2, VEGFCMore
Halothanehsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Halothanehsa04621NOD-like receptor signaling pathway2.70E-0310Q16539, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P59665, P59666, P12838MAPK14, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA1; DEFA1B, DEFA3, DEFA4More
Halothanehsa04657IL-17 signaling pathway1.03E-026O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Halothanehsa04658Th1 and Th2 cell differentiation1.86E-037P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Halothanehsa04659Th17 cell differentiation4.57E-059P19174, P06239, P14784, P14778, Q9UL17, Q13485, P08238, P07766, P20963PLCG1, LCK, IL2RB, IL1R1, TBX21, SMAD4, HSP90AB1, CD3E, CD247More
Halothanehsa04660T cell receptor signaling pathway4.18E-038P42338, P19174, P16333, P07766, P20963, Q13191, P06239, O43318PIK3CB, PLCG1, NCK1, CD3E, CD247, CBLB, LCK, MAP3K7More
Halothanehsa04662B cell receptor signaling pathway1.26E-036P49841, P42338, P60033, P07948, P21854, Q8N149GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Halothanehsa04664Fc epsilon RI signaling pathway1.44E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Halothanehsa04670Leukocyte transendothelial migration2.88E-026P13612, P11215, P42338, P19174, Q15669, P12814ITGA4, ITGAM, PIK3CB, PLCG1, RHOH, ACTN1More
Halothanehsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Halothanehsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Halothanehsa04724Glutamatergic synapse2.48E-046O15399, P63092, P62873, P63218, P50151, P15104GRIN2D, GNAS, GNB1, GNG5, GNG10, GLULMore
Halothanehsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Halothanehsa04730Long-term depression3.52E-021Q14344GNA13More
Halothanehsa04750Inflammatory mediator regulation of TRP channels4.24E-034P14778, P19174, P42338, P24723IL1R1, PLCG1, PIK3CB, PRKCHMore
Halothanehsa04926Relaxin signaling pathway3.63E-036P42338, P63218, P50151, P49767, P30679, P49407PIK3CB, GNG5, GNG10, VEGFC, GNA15, ARRB1More
Halothanehsa04929GnRH secretion3.63E-022P42338, P49407PIK3CB, ARRB1More
Halothanehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Halothanehsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Halothanehsa04964Proximal tubule bicarbonate reclamation3.52E-022P49448, P40925GLUD2, MDH1More
Halothanehsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Halothanehsa04973Carbohydrate digestion and absorption4.12E-032O43451, P42338MGAM, PIK3CBMore
Halothanehsa05017Spinocerebellar ataxia2.09E-034Q92915, O15399, P42338, P21796FGF14, GRIN2D, PIK3CB, VDAC1More
Halothanehsa05032Morphine addiction4.42E-059P62873, P63218, P50151, P48169, P78334, P63092, P32298, P43250, P49407GNB1, GNG5, GNG10, GABRA4, GABRE, GNAS, GRK4, GRK6, ARRB1More
Halothanehsa05120Epithelial cell signaling in Helicobacter pylori infection1.22E-037Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Halothanehsa05135Yersinia infection3.13E-025P13612, P06239, P19174, O43318, P42338ITGA4, LCK, PLCG1, MAP3K7, PIK3CBMore
Halothanehsa05140Leishmaniasis1.32E-039P13612, O75015, P14598, O60603, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, TLR2, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Halothanehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Halothanehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Halothanehsa05146Amoebiasis3.18E-0511Q13751, P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P12814LAMB3, CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, ACTN1More
Halothanehsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Halothanehsa05162Measles2.06E-027P14784, P07766, P42338, P11142, Q13191, P30279, O43318IL2RB, CD3E, PIK3CB, HSPA8, CBLB, CCND2, MAP3K7More
Halothanehsa05163Human cytomegalovirus infection3.51E-0416P42338, P01375, P62873, P63218, P50151, Q14344, P61586, P49841, P14778, Q13651, P25025, Q16539, P63092, O00463, P30101, P61769PIK3CB, TNF, GNB1, GNG5, GNG10, GNA13, RHOA, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, GNAS, TRAF5, PDIA3, B2MMore
Halothanehsa05166Human T-cell leukemia virus 1 infection4.02E-0210P14784, P30279, P21796, Q13485, Q13042, P14778, P07766, P42338, P06239, P06746IL2RB, CCND2, VDAC1, SMAD4, CDC16, IL1R1, CD3E, PIK3CB, LCK, POLBMore
Halothanehsa05169Epstein-Barr virus infection1.57E-029Q13547, O43318, P42338, P07948, P30101, Q13761, P30279, P07766, P20963HDAC1, MAP3K7, PIK3CB, LYN, PDIA3, RUNX3, CCND2, CD3E, CD247More
Halothanehsa05170Human immunodeficiency virus 1 infection3.76E-028P42338, P63218, P50151, P30101, O43318, P19174, P07766, P20963PIK3CB, GNG5, GNG10, PDIA3, MAP3K7, PLCG1, CD3E, CD247More
Halothanehsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Halothanehsa05200Pathways in cancer1.51E-0215Q13751, P42338, P08238, P19174, P43246, Q13485, Q13547, P30279, P49767, P43657, P63218, P50151, Q14344, P78417, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD4, HDAC1, CCND2, VEGFC, P2RY5, GNG5, GNG10, GNA13, GSTO1, IL2RBMore
Halothanehsa05225Hepatocellular carcinoma1.85E-022Q92529, P51531SHC3, SMARCA2More
Halothanehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.03E-025P42338, P19174, P07766, P20963, P06239PIK3CB, PLCG1, CD3E, CD247, LCKMore
Halothanehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Halothanehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Halothanehsa05418Fluid shear stress and atherosclerosis2.43E-037Q16539, P42338, P10599, P14780, P01375, P14778, P27930MAPK14, PIK3CB, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Halothane (SDC: 1.89)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P20020ATP2B1Plasma membrane calciumNonetransporting ATPase 1Reported00.1480.01330.25720.3578
P23634ATP2B4Plasma membrane calciumNonetransporting ATPase 4Reported00.52210.01330.25720.5449
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
P78508KCNJ10ATPNonesensitive inward rectifier potassium channel 10Predicted00.07310.08780.20670.4189
Q99712KCNJ15ATPNonesensitive inward rectifier potassium channel 15Predicted00.15870.07790.12670.3619
P63218GNG5Guanine nucleotideNonebinding protein G(I)/G(S)/G(O) subunit gammaNone5Predicted00.02320.00320.7750.7931
P50151GNG10Guanine nucleotideNonebinding protein G(I)/G(S)/G(O) subunit gammaNone10Predicted00.09040.00370.7750.8275
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)