PharmaCoNets of Haloperidol (SPCN: 48.56 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Haloperidolhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Haloperidolhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Haloperidolhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Haloperidolhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Haloperidolhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Haloperidolhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Haloperidolhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Haloperidolhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Haloperidolhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Haloperidolhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Haloperidolhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Haloperidolhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Haloperidolhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Haloperidolhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Haloperidolhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Haloperidolhsa03013RNA transport2.99E-024P38919, P37198, P35658, P55884EIF4A3, NUP62, NUP214, EIF3BMore
Haloperidolhsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Haloperidolhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Haloperidolhsa03030DNA replication5.00E-021P27694RPA1More
Haloperidolhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Haloperidolhsa04061Viral protein interaction with cytokine and cytokine receptor2.43E-024P09341, P02775, P47992, Q9UBD3CXCL1, PPBP, XCL1, XCL2More
Haloperidolhsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Haloperidolhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Haloperidolhsa04120Ubiquitin mediated proteolysis4.81E-034Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Haloperidolhsa04145Phagosome2.94E-024P05164, P78380, P35443, P13765MPO, OLR1, THBS4, HLA-DOBMore
Haloperidolhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Haloperidolhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Haloperidolhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Haloperidolhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Haloperidolhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Haloperidolhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Haloperidolhsa04514Cell adhesion molecules1.22E-022P23229, P30511ITGA6, HLA-FMore
Haloperidolhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Haloperidolhsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Haloperidolhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Haloperidolhsa04613Neutrophil extracellular trap formation2.15E-0511P11215, Q13547, P04908, Q93077, P58876, P62807, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Haloperidolhsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Haloperidolhsa04657IL-17 signaling pathway2.10E-035P49841, P19875, P14780, P80188, P01375GSK3B, CXCL2, MMP9, LCN2, TNFMore
Haloperidolhsa04658Th1 and Th2 cell differentiation1.99E-024Q04759, P06239, P23771, P13765PRKCQ, LCK, GATA3, HLA-DOBMore
Haloperidolhsa04659Th17 cell differentiation4.12E-024Q04759, P06239, P13765, P23771PRKCQ, LCK, HLA-DOB, GATA3More
Haloperidolhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Haloperidolhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Haloperidolhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Haloperidolhsa04730Long-term depression5.00E-021Q14344GNA13More
Haloperidolhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Haloperidolhsa04742Taste transduction1.01E-021P30939HTR1FMore
Haloperidolhsa04810Regulation of actin cytoskeleton2.68E-022P23229, Q14344ITGA6, GNA13More
Haloperidolhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Haloperidolhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Haloperidolhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Haloperidolhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Haloperidolhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Haloperidolhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Haloperidolhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Haloperidolhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Haloperidolhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Haloperidolhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Haloperidolhsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Haloperidolhsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Haloperidolhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Haloperidolhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Haloperidolhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Haloperidolhsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Haloperidolhsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Haloperidolhsa05133Pertussis4.94E-021P0C0L4C4AMore
Haloperidolhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Haloperidolhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Haloperidolhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Haloperidolhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Haloperidolhsa05163Human cytomegalovirus infection4.31E-022P30511, Q14344HLA-F, GNA13More
Haloperidolhsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Haloperidolhsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Haloperidolhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Haloperidolhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Haloperidolhsa05310Asthma2.27E-022P13765, P12724HLA-DOB, RNASE3More
Haloperidolhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Haloperidolhsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Haloperidolhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Haloperidolhsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Haloperidolhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Haloperidol (SDC: 5.17)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07305H1None0Histone H1.0Predicted10.0540.080100.1872
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P04156PRNPMajor prion proteinPredicted00.59090.173700.6429
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
O14786NRP1NeuropilinNone1Predicted10.38340.20260.51531.1123
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P27694RPA1Replication protein A 70 kDa DNANonebinding subunitPredicted00.22730.17560.27460.7395
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416IC500.16
DRD2P14416IC500.7
DRD2P14416IC504
DRD2P14416Ki0.12
DRD2P14416Ki0.16
DRD2P14416Ki0.16