PharmaCoNets of Guanfacine (SPCN: 3.44 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Guanfacinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Guanfacinehsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Guanfacinehsa03015mRNA surveillance pathway1.83E-023Q13362, Q14738, Q9UBU9PPP2R5C, PPP2R5D, NXF1More
Guanfacinehsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Guanfacinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Guanfacinehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Guanfacinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Guanfacinehsa04261Adrenergic signaling in cardiomyocytes4.22E-023Q13362, Q14738, P0DP23PPP2R5C, PPP2R5D, CALM1More
Guanfacinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Guanfacinehsa04728Dopaminergic synapse2.66E-023Q13362, Q14738, P0DP23PPP2R5C, PPP2R5D, CALM1More
Guanfacinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Guanfacinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Guanfacinehsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Guanfacinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Guanfacinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Guanfacinehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Guanfacinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Guanfacinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Guanfacinehsa05167Kaposi sarcoma-associated herpesvirus infection4.82E-023P23458, Q13469, P0DP23JAK1, NFATC2, CALM1More
Guanfacinehsa05212Pancreatic cancer4.16E-022Q15311, P23458RALBP1, JAK1More
Guanfacinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Guanfacinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore

Community members of Guanfacine (SDC: 1.25)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)