PharmaCoNets of Granisetron (SPCN: 292.59 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Granisetronhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Granisetronhsa00030Pentose phosphate pathway9.38E-073P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Granisetronhsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Granisetronhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Granisetronhsa00190Oxidative phosphorylation6.31E-094Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Granisetronhsa00220Arginine biosynthesis7.10E-063P15104, P05089, P49448GLUL, ARG1, GLUD2More
Granisetronhsa00230Purine metabolism4.02E-022P31350, P21589RRM2, NT5EMore
Granisetronhsa00240Pyrimidine metabolism2.54E-043P31350, P21589, P04818RRM2, NT5E, TYMSMore
Granisetronhsa00250Alanine, aspartate and glutamate metabolism1.34E-042P49448, P15104GLUD2, GLULMore
Granisetronhsa00270Cysteine and methionine metabolism1.92E-022Q96RQ9, P40926IL4I1, MDH2More
Granisetronhsa00310Lysine degradation4.14E-021Q02809PLOD1More
Granisetronhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Granisetronhsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Granisetronhsa00471D-Glutamine and D-glutamate metabolism1.65E-021P49448GLUD2More
Granisetronhsa00500Starch and sucrose metabolism9.19E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Granisetronhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Granisetronhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Granisetronhsa00520Amino sugar and nucleotide sugar metabolism2.11E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Granisetronhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Granisetronhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Granisetronhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Granisetronhsa00600Sphingolipid metabolism2.44E-022Q9BX95, Q06136SGPP1, FVT1More
Granisetronhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Granisetronhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Granisetronhsa00630Glyoxylate and dicarboxylate metabolism1.15E-044P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Granisetronhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Granisetronhsa00670One carbon pool by folate7.39E-043O95954, P04818, Q99707FTCD, TYMS, MTRMore
Granisetronhsa00730Thiamine metabolism2.39E-052P05186, P24666ALPL, ACP1More
Granisetronhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Granisetronhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Granisetronhsa00830Retinol metabolism2.27E-035P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Granisetronhsa00860Porphyrin and chlorophyll metabolism3.15E-022P36551, P30043CPOX, BLVRBMore
Granisetronhsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Granisetronhsa00910Nitrogen metabolism1.34E-042P15104, P49448GLUL, GLUD2More
Granisetronhsa00970Aminoacyl-tRNA biosynthesis2.24E-033O95363, P14868, Q15046FARS2, DARS, KARSMore
Granisetronhsa00980Metabolism of xenobiotics by cytochrome P4508.40E-043P78417, P28332, P11712GSTO1, ADH6, CYP2C9More
Granisetronhsa00982Drug metabolism - cytochrome P4508.40E-043P11712, P78417, P28332CYP2C9, GSTO1, ADH6More
Granisetronhsa00983Drug metabolism - other enzymes2.30E-033P04183, P32320, P05164TK1, CDA, MPOMore
Granisetronhsa01100Metabolic pathways6.99E-0330Q9NR34, Q9Y259, P05089, P32320, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, P49619, O95954, Q9HCC0, P33121, Q02318, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737MAN1C1, CHKB, ARG1, CDA, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, DGKG, FTCD, MCCC2, ACSL1, CYP27A1, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGLMore
Granisetronhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Granisetronhsa012102-Oxocarboxylic acid metabolism1.40E-021P50213IDH3AMore
Granisetronhsa01230Biosynthesis of amino acids2.24E-057P51854, P60891, Q99707, P50213, P05089, P15104, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, GLUL, TALDO1More
Granisetronhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Granisetronhsa01521EGFR tyrosine kinase inhibitor resistance3.30E-033P49841, P04049, Q9NRA1GSK3B, RAF1, PDGFCMore
Granisetronhsa01522Endocrine resistance3.41E-026P14780, P22694, P04049, Q9UM47, P10415, Q13323MMP9, PRKACB, RAF1, NOTCH3, BCL2, BIKMore
Granisetronhsa01523Antifolate resistance4.04E-054P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Granisetronhsa01524Platinum drug resistance4.78E-021P31751AKT2More
Granisetronhsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Granisetronhsa03013RNA transport2.06E-1226P62826, O14980, P52298, Q09161, O14893, P61326, P38919, Q15287, Q9UBU9, Q9H307, P37198, Q7Z3B4, P35658, P63279, P68104, P47813, Q14152, P55884, O75822, Q9H777, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, RNPS1, NXF1, PNN, NUP62, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF3A, EIF3B, EIF3J, ELAC1, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1More
Granisetronhsa03020RNA polymerase6.63E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Granisetronhsa03022Basal transcription factors2.97E-033P20226, O00268, Q15544TBP, TAF4, TAF11More
Granisetronhsa03040Spliceosome3.35E-0714Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Granisetronhsa03050Proteasome4.83E-021P55036PSMD4More
Granisetronhsa03060Protein export4.02E-053Q15070, P37108, Q15005OXA1L, SRP14, SPCS2More
Granisetronhsa03320PPAR signaling pathway2.42E-034Q6PCB7, Q9UNU6, Q13133, Q02318SLC27A1, CYP8B1, NR1H3, CYP27A1More
Granisetronhsa03410Base excision repair1.11E-033P27695, P49005, P29372APEX1, POLD2, MPGMore
Granisetronhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Granisetronhsa04010MAPK signaling pathway1.61E-026P04049, Q15283, P21860, Q12933, P01584, O14944RAF1, RASA2, ERBB3, TRAF2, IL1B, EREGMore
Granisetronhsa04012ErbB signaling pathway6.63E-034P16333, P19174, P01106, P04049NCK1, PLCG1, MYC, RAF1More
Granisetronhsa04014Ras signaling pathway1.71E-0311P04049, P31751, P42338, P20827, P49767, Q13009, Q7LDG7, P0DP23, P63218, P50151, P19174RAF1, AKT2, PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, CALM1, GNG5, GNG10, PLCG1More
Granisetronhsa04015Rap1 signaling pathway7.70E-0411P04049, P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P31751, P0DP23, P19174RAF1, EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, AKT2, CALM1, PLCG1More
Granisetronhsa04020Calcium signaling pathway1.80E-048Q96DU7, Q08828, Q13557, P21860, P0DP23, P0DP24, P05141, P51828ITPKC, ADCY1, CAMK2D, ERBB3, CALM1, CALM2, SLC25A5, ADCY7More
Granisetronhsa04022cGMP-PKG signaling pathway1.73E-0510Q02153, P04049, Q99941, P18848, P31751, Q08828, P51828, P05141, P0DP23, P0DP24GUCY1B3, RAF1, CREBL1, ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1, CALM2More
Granisetronhsa04024cAMP signaling pathway8.43E-058Q08828, P51828, P42338, P31751, P0DP23, P04049, Q13370, Q13009ADCY1, ADCY7, PIK3CB, AKT2, CALM1, RAF1, PDE3B, TIAM1More
Granisetronhsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Granisetronhsa04061Viral protein interaction with cytokine and cytokine receptor1.83E-049Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Granisetronhsa04062Chemokine signaling pathway7.01E-0618P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P04049, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, RAF1, PIK3R5More
Granisetronhsa04064NF-kappa B signaling pathway5.45E-1424P10415, Q13489, P51617, O00463, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Granisetronhsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Granisetronhsa04070Phosphatidylinositol signaling system1.25E-0511P0DP23, Q14643, P42338, O14986, P23743, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252CALM1, ITPR1, PIK3CB, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Granisetronhsa04071Sphingolipid signaling pathway9.46E-0810P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Granisetronhsa04072Phospholipase D signaling pathway2.43E-0412P04049, P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Granisetronhsa04080Neuroactive ligand-receptor interaction3.82E-0310P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2More
Granisetronhsa04110Cell cycle3.68E-078Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, CDKN2C, MYCMore
Granisetronhsa04114Oocyte meiosis8.04E-0710Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Granisetronhsa04115p53 signaling pathway3.34E-022P31350, P06493RRM2, CDK1More
Granisetronhsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Granisetronhsa04140Autophagy - animal1.20E-0311P31751, P04049, Q7L523, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9AKT2, RAF1, RRAGA, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Granisetronhsa04141Protein processing in endoplasmic reticulum3.96E-027P18848, Q15436, Q99941, P11142, Q9H3Z4, P07900, Q9NR31ATF4, SEC23A, CREBL1, HSPA8, DNAJC5, HSP90AA1, SAR1AMore
Granisetronhsa04142Lysosome2.45E-039Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Granisetronhsa04144Endocytosis2.89E-038P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Granisetronhsa04145Phagosome1.71E-0513O75015, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Granisetronhsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Granisetronhsa04150mTOR signaling pathway7.74E-034P04049, Q02750, Q9NQL2, P51812RAF1, MAP2K1, RRAGD, RPS6KA3More
Granisetronhsa04151PI3K-Akt signaling pathway6.37E-0532P62753, P42338, P21860, P43657, P25116, P27348, P09603, P20827, P49767, Q9GZP0, Q13362, P07900, P08238, Q8WYR1, P62873, P63218, P50151, P61952, P13612, P16144, O15335, Q16363, Q13751, P22105, O60603, P14784, P01568, Q99941, P18848, P10415, P17252, P30281RPS6, PIK3CB, ERBB3, P2RY5, F2R, YWHAQ, CSF1, EFNA1, VEGFC, PDGFD, PPP2R5C, HSP90AA1, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, GNG11, ITGA4, ITGB4, CHAD, LAMA4, LAMB3, TNXB, TLR2, IL2RB, IFNA21, CREBL1, ATF4, BCL2, PRKCA, CCND3More
Granisetronhsa04152AMPK signaling pathway2.34E-022Q96EB6, P36956SIRT1, SREBF1More
Granisetronhsa04210Apoptosis3.64E-035O76075, P01375, Q9NR28, Q16548, P04049DFFB, TNF, DIABLO, BCL2A1, RAF1More
Granisetronhsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Granisetronhsa04213Longevity regulating pathway - multiple species3.34E-048P31751, P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Granisetronhsa04217Necroptosis5.63E-0923P01375, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q13557, O43633, O75351, Q08752TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CAMK2D, CHMP2A, VPS4B, PPIDMore
Granisetronhsa04218Cellular senescence1.43E-043P31751, P04049, P0DP23AKT2, RAF1, CALM1More
Granisetronhsa04261Adrenergic signaling in cardiomyocytes8.93E-0712P09493, P07550, Q08828, P51828, P22694, P31751, P18848, Q13362, Q14738, P0DP23, P17252, P10415TPM1, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1, PRKCA, BCL2More
Granisetronhsa04270Vascular smooth muscle contraction2.27E-037P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Granisetronhsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Granisetronhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Granisetronhsa04340Hedgehog signaling pathway2.94E-045P49841, P17612, P22694, Q13635, P10415GSK3B, PRKACA, PRKACB, PTCH1, BCL2More
Granisetronhsa04360Axon guidance9.70E-048P16333, P20827, O95631, P42338, P07332, P23528, P04049, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, RAF1, PLCG1More
Granisetronhsa04370VEGF signaling pathway1.43E-085P16298, P31751, Q05397, Q02750, P04049PPP3CB, AKT2, PTK2, MAP2K1, RAF1More
Granisetronhsa04371Apelin signaling pathway6.36E-0616P62873, P63218, P50151, P61952, Q8WYR1, P31751, P04049, Q08828, P51828, Q14814, Q14344, Q13485, P84022, P62753, P0DP23, P0DP24GNB1, GNG5, GNG10, GNG11, PIK3R5, AKT2, RAF1, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, RPS6, CALM1, CALM2More
Granisetronhsa04380Osteoclast differentiation3.07E-0714Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Granisetronhsa04390Hippo signaling pathway5.79E-034P04628, Q9UJU2, O43623, Q13489WNT1, LEF1, SNAI2, BIRC3More
Granisetronhsa04510Focal adhesion3.48E-021P04049RAF1More
Granisetronhsa04512ECM-receptor interaction4.41E-023Q13751, P13612, O15335LAMB3, ITGA4, CHADMore
Granisetronhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Granisetronhsa04540Gap junction2.79E-035P17252, Q13509, P68371, P04049, Q14643PRKCA, TUBB3, TUBB2C, RAF1, ITPR1More
Granisetronhsa04550Signaling pathways regulating pluripotency of stem cells1.58E-033P04628, P40189, P04049WNT1, IL6ST, RAF1More
Granisetronhsa04610Complement and coagulation cascades5.18E-061P0C0L4C4AMore
Granisetronhsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Granisetronhsa04612Antigen processing and presentation2.05E-0710P13765, P48382, P01730, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Granisetronhsa04613Neutrophil extracellular trap formation2.68E-0825P17252, P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Granisetronhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Granisetronhsa04620Toll-like receptor signaling pathway4.91E-043P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Granisetronhsa04621NOD-like receptor signaling pathway2.80E-0312Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, P29728, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, OAS2, RNASEL, TNF, CXCL1, DEFA4More
Granisetronhsa04622RIG-I-like receptor signaling pathway1.81E-021Q9NQC7CYLDMore
Granisetronhsa04623Cytosolic DNA-sensing pathway6.79E-096P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Granisetronhsa04625C-type lectin receptor signaling pathway1.30E-0712Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Granisetronhsa04630JAK-STAT signaling pathway3.48E-047P31751, O75925, P23458, P40189, Q13651, Q06124, P04049AKT2, PIAS1, JAK1, IL6ST, IL10RA, PTPN11, RAF1More
Granisetronhsa04640Hematopoietic cell lineage3.10E-0816P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Granisetronhsa04650Natural killer cell mediated cytotoxicity3.32E-1418P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Granisetronhsa04657IL-17 signaling pathway3.47E-079O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1BMore
Granisetronhsa04658Th1 and Th2 cell differentiation2.79E-1615Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Granisetronhsa04659Th17 cell differentiation6.96E-1421Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Granisetronhsa04660T cell receptor signaling pathway4.17E-1417P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Granisetronhsa04662B cell receptor signaling pathway4.90E-047P31751, P42338, P60033, P07948, P21854, Q8N149, P04049AKT2, PIK3CB, CD81, LYN, CD72, LILRA2, RAF1More
Granisetronhsa04664Fc epsilon RI signaling pathway1.64E-049P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5More
Granisetronhsa04666Fc gamma R-mediated phagocytosis3.18E-038O75015, P42338, P04049, P23528, P06396, O14494, P14598, P17252FCGR3B, PIK3CB, RAF1, CFL1, GSN, PLPP1, NCF1, PRKCAMore
Granisetronhsa04668TNF signaling pathway4.50E-0612P01375, Q12933, O00463, Q16539, Q99941, P18848, P19875, P01584, P20749, P14780, P20333, O95429TNF, TRAF2, TRAF5, MAPK14, CREBL1, ATF4, CXCL2, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Granisetronhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Granisetronhsa04713Circadian entrainment8.49E-0710P0DP23, P0DP24, Q13557, Q02153, P17252, P62873, P61952, Q14643, Q08828, P51828CALM1, CALM2, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG11, ITPR1, ADCY1, ADCY7More
Granisetronhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Granisetronhsa04720Long-term potentiation5.67E-0711P17252, Q13557, P16298, P0DP23, P0DP24, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Granisetronhsa04721Synaptic vesicle cycle9.45E-042Q13488, P31645TCIRG1, SLC6A4More
Granisetronhsa04722Neurotrophin signaling pathway7.07E-068Q05655, P31751, P04049, P49841, O43524, P48023, P52566, P0DP23PRKCD, AKT2, RAF1, GSK3B, FOXO3, FASLG, ARHGDIB, CALM1More
Granisetronhsa04723Retrograde endocannabinoid signaling1.69E-037Q14643, P17252, P62873, P61952, Q08828, O15239, Q16718ITPR1, PRKCA, GNB1, GNG11, ADCY1, NDUFA1, NDUFA5More
Granisetronhsa04724Glutamatergic synapse2.59E-058O15399, Q08828, P51828, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLULMore
Granisetronhsa04725Cholinergic synapse2.06E-0510Q08828, P51828, Q14643, P17252, P62873, P61952, P18848, Q13557, P31751, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, GNG11, ATF4, CAMK2D, AKT2, BCL2More
Granisetronhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Granisetronhsa04727GABAergic synapse6.94E-058Q08828, P51828, P62873, P63218, P50151, P61952, P15104, Q15111ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, PLCL1More
Granisetronhsa04728Dopaminergic synapse5.42E-0713Q14643, P17252, P62873, P61952, P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23, P0DP24, O15516ITPR1, PRKCA, GNB1, GNG11, AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1, CALM2, CLOCKMore
Granisetronhsa04730Long-term depression1.34E-023Q14344, P04049, P07948GNA13, RAF1, LYNMore
Granisetronhsa04740Olfactory transduction1.25E-045P62873, Q9H255, Q13557, P0DP24, P0DP23GNB1, OR51E2, CAMK2D, CALM2, CALM1More
Granisetronhsa04742Taste transduction7.70E-042P30939, P17612HTR1F, PRKACAMore
Granisetronhsa04744Phototransduction1.33E-043P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Granisetronhsa04750Inflammatory mediator regulation of TRP channels2.36E-0814P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Granisetronhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Granisetronhsa04910Insulin signaling pathway2.43E-056P0DP23, P22694, P06737, P04049, P31751, P49841CALM1, PRKACB, PYGL, RAF1, AKT2, GSK3BMore
Granisetronhsa04911Insulin secretion3.69E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Granisetronhsa04912GnRH signaling pathway2.16E-0411P17252, Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049PRKCA, ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1More
Granisetronhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Granisetronhsa04914Progesterone-mediated oocyte maturation2.40E-068Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750, P04049CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Granisetronhsa04915Estrogen signaling pathway8.84E-0612P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1More
Granisetronhsa04916Melanogenesis4.08E-056P0DP23, Q08828, P51828, P49841, Q01726, P04049CALM1, ADCY1, ADCY7, GSK3B, MC1R, RAF1More
Granisetronhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Granisetronhsa04918Thyroid hormone synthesis3.71E-024Q08828, Q99941, P18848, P02768ADCY1, CREBL1, ATF4, ALBMore
Granisetronhsa04919Thyroid hormone signaling pathway6.83E-045P49841, P04049, P22694, O60244, Q9NVC6GSK3B, RAF1, PRKACB, MED14, MED17More
Granisetronhsa04920Adipocytokine signaling pathway3.82E-043Q06124, Q9Y478, P31751PTPN11, PRKAB1, AKT2More
Granisetronhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Granisetronhsa04922Glucagon signaling pathway2.33E-035Q12778, P31751, Q13370, P0DP23, Q14643FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Granisetronhsa04923Regulation of lipolysis in adipocytes5.39E-056Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Granisetronhsa04924Renin secretion1.39E-055P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Granisetronhsa04925Aldosterone synthesis and secretion1.78E-047Q99941, P18848, Q08828, P51828, P0DP23, P0DP24, Q13557CREBL1, ATF4, ADCY1, ADCY7, CALM1, CALM2, CAMK2DMore
Granisetronhsa04926Relaxin signaling pathway4.15E-0511P31751, P62873, P61952, Q99941, P18848, P22694, P14780, Q08828, P51828, P04049, P30679AKT2, GNB1, GNG11, CREBL1, ATF4, PRKACB, MMP9, ADCY1, ADCY7, RAF1, GNA15More
Granisetronhsa04927Cortisol synthesis and secretion8.16E-055Q99941, P18848, Q08828, P51828, P22694CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Granisetronhsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Granisetronhsa04929GnRH secretion1.87E-042P31751, P04049AKT2, RAF1More
Granisetronhsa04930Type II diabetes mellitus2.68E-021Q05655PRKCDMore
Granisetronhsa04931Insulin resistance9.16E-045P01375, P49841, Q06124, P06737, Q9Y478TNF, GSK3B, PTPN11, PYGL, PRKAB1More
Granisetronhsa04932Non-alcoholic fatty liver disease5.62E-0815P31751, P01375, P49841, O43521, P18848, P48023, O75460, Q12933, P01584, P13073, P12074, O15239, Q16718, O95298, O14521AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, TRAF2, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Granisetronhsa04933AGE-RAGE signaling pathway in diabetic complications1.19E-039P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Granisetronhsa04934Cushing syndrome6.11E-056Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Granisetronhsa04935Growth hormone synthesis, secretion and action5.00E-035Q08828, P51828, P04049, P18848, P31751ADCY1, ADCY7, RAF1, ATF4, AKT2More
Granisetronhsa04940Type I diabetes mellitus2.61E-034P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Granisetronhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Granisetronhsa04964Proximal tubule bicarbonate reclamation4.03E-032P00918, P49448CA2, GLUD2More
Granisetronhsa04966Collecting duct acid secretion1.95E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Granisetronhsa04970Salivary secretion3.31E-068P07550, Q08828, P51828, P22694, P0DP23, P0DP24, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CALM2, GUCY1B3, CAMPMore
Granisetronhsa04971Gastric acid secretion4.91E-044Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Granisetronhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Granisetronhsa04976Bile secretion7.42E-066O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Granisetronhsa05010Alzheimer disease8.93E-0728Q92542, O15239, Q16718, O95298, O14521, P05496, P12074, Q14643, O15399, Q00535, Q9NZJ5, O75460, P0DP23, Q13564, P01584, Q12933, P18848, Q71U36, Q13509, P68371, O15169, P09603, P31751, P05141, P21796, Q08752, P28070, P43686NCSTN, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX6A1, ITPR1, GRIN2D, CDK5, EIF2AK3, ERN1, CALM1, APPBP1, IL1B, TRAF2, ATF4, TUBA1A, TUBB3, TUBB2C, AXIN1, CSF1, AKT2, SLC25A5, VDAC1, PPID, PSMB4, PSMC4More
Granisetronhsa05012Parkinson disease3.50E-0416P62987, O15239, Q16718, O14521, P13073, P12074, P05496, P05141, P18848, P43686, Q14643, P0DP23, P0DP24, Q13557, Q13509, P68371UBA52, NDUFA1, NDUFA5, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, ATF4, PSMC4, ITPR1, CALM1, CALM2, CAMK2D, TUBB3, TUBB2CMore
Granisetronhsa05014Amyotrophic lateral sclerosis3.57E-0316P01375, O15239, Q16718, O14521, P12074, P36542, P05496, Q12933, P43686, P09651, P37198, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA1, NDUFA5, SDHD, COX6A1, ATP5C1, ATP5G1, TRAF2, PSMC4, HNRNPA1, NUP62, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Granisetronhsa05016Huntington disease1.76E-0310O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Granisetronhsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Granisetronhsa05020Prion disease3.50E-0722P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P13073, P12074, Q92736, Q14643, P18848, P05141, P43686, O60282, Q13509, P68371, P49841, Q99941, P14598, Q15080, Q16539IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, RYR2, ITPR1, ATF4, SLC25A5, PSMC4, KIF5C, TUBB3, TUBB2C, GSK3B, CREBL1, NCF1, NCF4, MAPK14More
Granisetronhsa05022Pathways of neurodegeneration - multiple diseases2.20E-0728Q14643, Q13509, P68371, P49841, P10415, O15239, Q16718, O95298, O14521, P12074, P05496, Q8TEV9, O75460, P18848, Q12933, Q13561, P05141, P17252, Q16539, Q00535, O15169, P01584, Q08752, P0DP23, Q13557, P62987, P28070, P43686ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA1, NDUFA5, NDUFC2, SDHD, COX6A1, ATP5G1, SMCR8, ERN1, ATF4, TRAF2, DCTN2, SLC25A5, PRKCA, MAPK14, CDK5, AXIN1, IL1B, PPID, CALM1, CAMK2D, UBA52, PSMB4, PSMC4More
Granisetronhsa05030Cocaine addiction4.19E-021Q00535CDK5More
Granisetronhsa05031Amphetamine addiction3.12E-047P0DP24, P0DP23, Q13557, P22694, Q99941, P18848, Q13547CALM2, CALM1, CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Granisetronhsa05032Morphine addiction1.34E-024P63218, P50151, Q07343, P43250GNG5, GNG10, PDE4B, GRK6More
Granisetronhsa05034Alcoholism3.77E-0511Q99941, P18848, P0DP24, P62873, P61952, P04049, P0C0S5, Q93077, P62807, O60814, P68431CREBL1, ATF4, CALM2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Granisetronhsa05110Vibrio cholerae infection1.86E-042Q99437, P17612ATP6V0B, PRKACAMore
Granisetronhsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Granisetronhsa05131Shigellosis3.99E-0310P68431, Q05655, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, P07737H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1More
Granisetronhsa05132Salmonella infection3.66E-0614P04049, Q9UJU2, P84095, O00471, Q13546, Q13489, P10415, P07737, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371RAF1, LEF1, RHOG, EXOC5, RIPK1, BIRC3, BCL2, PFN1, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Granisetronhsa05133Pertussis3.60E-031P0C0L4C4AMore
Granisetronhsa05134Legionellosis6.26E-058P01584, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Granisetronhsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Granisetronhsa05140Leishmaniasis1.29E-1115P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Granisetronhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Granisetronhsa05144Malaria6.46E-056P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Granisetronhsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Granisetronhsa05146Amoebiasis1.64E-1114P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Granisetronhsa05150Staphylococcus aureus infection2.10E-0612P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, Q14532, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Granisetronhsa05152Tuberculosis1.53E-0517P04049, Q13488, Q99437, P0DP23, O75015, P42224, P48382, O60603, P01375, P31751, P10415, P13765, P25774, P01568, P49913, Q9UDY8, P51617RAF1, TCIRG1, ATP6V0B, CALM1, FCGR3B, STAT1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CTSS, IFNA21, CAMP, MALT1, IRAK1More
Granisetronhsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Granisetronhsa05161Hepatitis B1.99E-021P04049RAF1More
Granisetronhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Granisetronhsa05163Human cytomegalovirus infection1.82E-0823P31751, P04049, P01375, P62873, P61952, Q14643, P0DP23, P0DP24, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P61769AKT2, RAF1, TNF, GNB1, GNG11, ITPR1, CALM1, CALM2, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, B2MMore
Granisetronhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Granisetronhsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Granisetronhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Granisetronhsa05167Kaposi sarcoma-associated herpesvirus infection1.04E-0512P01568, P31751, P42224, P62873, P62879, P16298, Q14643, P04049, Q02750, P0DP23, P0CG47, Q9UJU2IFNA21, AKT2, STAT1, GNB1, GNB2, PPP3CB, ITPR1, RAF1, MAP2K1, CALM1, UBB, LEF1More
Granisetronhsa05168Herpes simplex virus 1 infection2.73E-0518P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P42338, Q9Y2A4, Q13398, P51522, Q9HCX3, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF304, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Granisetronhsa05169Epstein-Barr virus infection5.59E-0412P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P01375, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, TNF, OAS2, CD3E, CD3G, CD247More
Granisetronhsa05170Human immunodeficiency virus 1 infection1.25E-0616P31751, P04049, Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5, P20333AKT2, RAF1, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2, TNFRSF1BMore
Granisetronhsa05200Pathways in cancer4.29E-0530Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P31751, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784, P40189LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, AKT2, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Granisetronhsa05202Transcriptional misregulation in cancer6.79E-0721Q12778, Q15532, Q13315, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Granisetronhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Granisetronhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Granisetronhsa05205Proteoglycans in cancer1.09E-026P04049, P14780, P01375, P23588, Q13635, P22694RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Granisetronhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Granisetronhsa05210Colorectal cancer1.66E-021P04049RAF1More
Granisetronhsa05211Renal cell carcinoma1.29E-032P31751, P04049AKT2, RAF1More
Granisetronhsa05212Pancreatic cancer7.58E-069P42338, P31751, P04049, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RAF1, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Granisetronhsa05213Endometrial cancer4.41E-044O15169, P31751, Q02750, P04049AXIN1, AKT2, MAP2K1, RAF1More
Granisetronhsa05214Glioma1.88E-055P0DP23, P04049, P42338, P31751, O75293CALM1, RAF1, PIK3CB, AKT2, GADD45BMore
Granisetronhsa05215Prostate cancer1.33E-021P04049RAF1More
Granisetronhsa05217Basal cell carcinoma7.91E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Granisetronhsa05218Melanoma4.47E-042P31751, P04049AKT2, RAF1More
Granisetronhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Granisetronhsa05220Chronic myeloid leukemia4.90E-047Q13547, Q13485, P84022, P31751, P42338, P04049, O75293HDAC1, SMAD4, SMAD3, AKT2, PIK3CB, RAF1, GADD45BMore
Granisetronhsa05221Acute myeloid leukemia8.16E-042P31751, P04049AKT2, RAF1More
Granisetronhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Granisetronhsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Granisetronhsa05224Breast cancer1.24E-025P04049, P49841, Q92837, P04637, P24522RAF1, GSK3B, FRAT1, TP53, GADD45AMore
Granisetronhsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Granisetronhsa05226Gastric cancer5.51E-056P04049, Q02750, P31751, O15169, P04628, P10826RAF1, MAP2K1, AKT2, AXIN1, WNT1, RARBMore
Granisetronhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Granisetronhsa05231Choline metabolism in cancer2.66E-057P04049, P31751, Q9Y259, P19174, P49619, Q16760, O14986RAF1, AKT2, CHKB, PLCG1, DGKG, DGKD, PIP5K1BMore
Granisetronhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.15E-0713P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, PRKCQ, MAPK14, CD4More
Granisetronhsa05310Asthma5.91E-073P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Granisetronhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Granisetronhsa05321Inflammatory bowel disease7.35E-138O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Granisetronhsa05322Systemic lupus erythematosus1.86E-0614O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Granisetronhsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Granisetronhsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Granisetronhsa05332Graft-versus-host disease1.33E-096P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Granisetronhsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Granisetronhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Granisetronhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Granisetronhsa05415Diabetic cardiomyopathy5.60E-058P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Granisetronhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Granisetronhsa05418Fluid shear stress and atherosclerosis1.58E-0613Q16539, P31751, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, AKT2, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Granisetron (SDC: 11.15)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9HB89NMUR1NeuromedinNoneU receptor 1Predicted00.00240.30300.6072
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
O60502MGEA5Protein ONoneGlcNAcasePredicted00.51010.04550.10570.4517
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q9Y478PRKAB15'NoneAMPNoneactivated protein kinase subunit betaNone1Predicted10.14780.10880.55640.8479
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q6V1X1DPP8Dipeptidyl peptidase 8Predicted00.28410.125900.3939
Q6PCB7SLC27A1LongNonechain fatty acid transport protein 1Predicted00.29150.07680.09920.3985
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)