PharmaCoNets of Glutethimide (SPCN: 37.50 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Aminoglutethimidehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Aminoglutethimidehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Aminoglutethimidehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Aminoglutethimidehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Aminoglutethimidehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Aminoglutethimidehsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Aminoglutethimidehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Aminoglutethimidehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Aminoglutethimidehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Aminoglutethimidehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Aminoglutethimidehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Aminoglutethimidehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Glutethimidehsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Glutethimidehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Glutethimidehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Glutethimidehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Glutethimidehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Glutethimidehsa03013RNA transport4.09E-029P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Glutethimidehsa03050Proteasome1.40E-021P55036PSMD4More
Glutethimidehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Glutethimidehsa04020Calcium signaling pathway4.45E-023P0DP24, P51828, P23634CALM2, ADCY7, ATP2B4More
Glutethimidehsa04024cAMP signaling pathway2.98E-036P63092, P51828, P26678, P0DP24, P23634, P61586GNAS, ADCY7, PLN, CALM2, ATP2B4, RHOAMore
Glutethimidehsa04064NF-kappa B signaling pathway1.91E-0412P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45AMore
Glutethimidehsa04071Sphingolipid signaling pathway7.60E-049P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, BCL2, GAB2More
Glutethimidehsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Glutethimidehsa04080Neuroactive ligand-receptor interaction1.18E-027P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1More
Glutethimidehsa04114Oocyte meiosis3.15E-048P51812, Q02750, P0DP24, P16298, Q17RY0, P51828, P27348, Q13362RPS6KA3, MAP2K1, CALM2, PPP3CB, CPEB4, ADCY7, YWHAQ, PPP2R5CMore
Glutethimidehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Glutethimidehsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Glutethimidehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Glutethimidehsa04145Phagosome1.98E-028Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Glutethimidehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Glutethimidehsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Glutethimidehsa04261Adrenergic signaling in cardiomyocytes1.06E-024P51828, Q13362, P0DP24, P23634ADCY7, PPP2R5C, CALM2, ATP2B4More
Glutethimidehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Glutethimidehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Glutethimidehsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Glutethimidehsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Glutethimidehsa04613Neutrophil extracellular trap formation1.30E-0313P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, P21730, P21462PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1More
Glutethimidehsa04621NOD-like receptor signaling pathway5.46E-0413Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P59665, P59666, P12838ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Glutethimidehsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Glutethimidehsa04660T cell receptor signaling pathway4.20E-027P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITKMore
Glutethimidehsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Glutethimidehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Glutethimidehsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Glutethimidehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Glutethimidehsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Glutethimidehsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Glutethimidehsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Glutethimidehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Glutethimidehsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Glutethimidehsa04925Aldosterone synthesis and secretion1.32E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Glutethimidehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Glutethimidehsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Glutethimidehsa04970Salivary secretion1.06E-037P51828, P22694, Q14643, P23634, P17252, P0DP24, P49913ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM2, CAMPMore
Glutethimidehsa04972Pancreatic secretion3.95E-045P23634, P63092, P51828, P62491, P61586ATP2B4, GNAS, ADCY7, RAB11A, RHOAMore
Glutethimidehsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Glutethimidehsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Glutethimidehsa05132Salmonella infection2.98E-0211P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3More
Glutethimidehsa05140Leishmaniasis1.18E-027P14598, P13765, O60603, P25963, P01375, P51617, Q15080NCF1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4More
Glutethimidehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Glutethimidehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Glutethimidehsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Glutethimidehsa05150Staphylococcus aureus infection9.80E-045Q14532, P59665, P59666, P12838, P49913KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Glutethimidehsa05152Tuberculosis2.07E-029Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Glutethimidehsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Glutethimidehsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Glutethimidehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Glutethimidehsa05168Herpes simplex virus 1 infection4.79E-028P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189More
Glutethimidehsa05170Human immunodeficiency virus 1 infection2.58E-0518Q02750, P62879, P16298, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333MAP2K1, GNB2, PPP3CB, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Glutethimidehsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Glutethimidehsa05202Transcriptional misregulation in cancer1.51E-0414Q12778, Q15532, Q13315, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Glutethimidehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Glutethimidehsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Glutethimidehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Glutethimidehsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Glutethimidehsa05321Inflammatory bowel disease1.28E-025O60603, P01375, P13765, Q14765, P23771TLR2, TNF, HLA-DOB, STAT4, GATA3More
Glutethimidehsa05322Systemic lupus erythematosus4.20E-027P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Glutethimidehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Glutethimidehsa05332Graft-versus-host disease8.44E-046P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More

Community members of Glutethimide (SDC: 4.17)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
CYP19A1P11511IC505.2
CYP19A1P11511IC50250
CYP19A1P11511IC50270
CYP19A1P11511Ki470
CYP19A1P11511Ki600
CYP19A1P11511Ki680