PharmaCoNets of Glutamic-acid (SPCN: 26.55 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Glutamic-acidhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Glutamic-acidhsa00100Steroid biosynthesis4.70E-021P35610SOAT1More
Glutamic-acidhsa00220Arginine biosynthesis1.58E-022P05089, P49448ARG1, GLUD2More
Glutamic-acidhsa00230Purine metabolism1.82E-021P49915GMPSMore
Glutamic-acidhsa00250Alanine, aspartate and glutamate metabolism3.58E-022Q96RQ9, P15104IL4I1, GLULMore
Glutamic-acidhsa00280Valine, leucine and isoleucine degradation4.31E-022P26440, Q02252IVD, ALDH6A1More
Glutamic-acidhsa00310Lysine degradation1.53E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Glutamic-acidhsa00330Arginine and proline metabolism3.77E-021P54886ALDH18A1More
Glutamic-acidhsa00410beta-Alanine metabolism4.50E-021Q6ZQY3GADL1More
Glutamic-acidhsa00471D-Glutamine and D-glutamate metabolism2.28E-021Q7Z3D6C14orf159More
Glutamic-acidhsa00480Glutathione metabolism3.02E-021P48506GCLCMore
Glutamic-acidhsa00500Starch and sucrose metabolism1.13E-033O43451, P46976, P35557MGAM, GYG1, GCKMore
Glutamic-acidhsa00512Mucin type O-glycan biosynthesis1.22E-022O95395, Q8N4A0GCNT3, GALNT4More
Glutamic-acidhsa00524Neomycin, kanamycin and gentamicin biosynthesis4.70E-021P35557GCKMore
Glutamic-acidhsa00562Inositol phosphate metabolism2.54E-034P27987, Q13572, Q96PE3, P42338ITPKB, ITPK1, INPP4A, PIK3CBMore
Glutamic-acidhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis4.50E-021Q14442PIGHMore
Glutamic-acidhsa00564Glycerophospholipid metabolism1.97E-023P48651, Q9Y6K0, P35790PTDSS1, CEPT1, CHKAMore
Glutamic-acidhsa00565Ether lipid metabolism3.21E-031Q8N661TMEM86BMore
Glutamic-acidhsa00670One carbon pool by folate1.14E-022O95954, Q99707FTCD, MTRMore
Glutamic-acidhsa00730Thiamine metabolism1.75E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Glutamic-acidhsa00770Pantothenate and CoA biosynthesis6.41E-043O95498, O95497, Q6ZQY3VNN2, VNN1, GADL1More
Glutamic-acidhsa00860Porphyrin and chlorophyll metabolism1.05E-043P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Glutamic-acidhsa00970Aminoacyl-tRNA biosynthesis3.58E-022O95363, Q15046FARS2, KARSMore
Glutamic-acidhsa00983Drug metabolism - other enzymes6.63E-031P49915GMPSMore
Glutamic-acidhsa01240Biosynthesis of cofactors3.34E-023P05186, Q9Y6K8, O75911ALPL, AK5, DHRS3More
Glutamic-acidhsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Glutamic-acidhsa02010ABC transporters7.05E-032Q8IZY2, Q99758ABCA7, ABCA3More
Glutamic-acidhsa03010Ribosome1.22E-022P46777, P50914RPL5, RPL14More
Glutamic-acidhsa03018RNA degradation3.02E-021Q13901C1DMore
Glutamic-acidhsa03040Spliceosome2.10E-0717Q14562, O43143, O60508, O14776, P08579, P26368, P09651, Q15365, O75494, Q13595, Q01130, Q13243, Q16629, P11142, Q9Y2W2, O43447, P61326DHX8, DHX15, CDC40, TCERG1, SNRPB2, U2AF2, HNRNPA1, PCBP1, FUSIP1, TRA2A, SFRS2, SFRS5, SFRS7, HSPA8, WBP11, PPIH, MAGOHMore
Glutamic-acidhsa03060Protein export4.36E-021Q15005SPCS2More
Glutamic-acidhsa03430Mismatch repair3.12E-023P43246, Q15054, Q04837MSH2, POLD3, SSBP1More
Glutamic-acidhsa03450Non-homologous end-joining3.27E-032Q9NP87, P13010POLM, XRCC5More
Glutamic-acidhsa04014Ras signaling pathway3.62E-025P42338, P49767, P0DP23, P63218, P50151PIK3CB, VEGFC, CALM1, GNG5, GNG10More
Glutamic-acidhsa04020Calcium signaling pathway5.15E-058P27987, P21796, Q16566, P30679, O15399, P0DP23, P23634, P49767ITPKB, VDAC1, CAMK4, GNA15, GRIN2D, CALM1, ATP2B4, VEGFCMore
Glutamic-acidhsa04024cAMP signaling pathway2.46E-036P42338, P0DP23, P23634, Q16566, Q09472, O15399PIK3CB, CALM1, ATP2B4, CAMK4, EP300, GRIN2DMore
Glutamic-acidhsa04062Chemokine signaling pathway1.81E-023P10145, P09769, Q13009IL8, FGR, TIAM1More
Glutamic-acidhsa04064NF-kappa B signaling pathway3.86E-025O00463, Q13077, P06239, P24522, P09341TRAF5, TRAF1, LCK, GADD45A, CXCL1More
Glutamic-acidhsa04070Phosphatidylinositol signaling system1.49E-035P0DP23, P42338, Q96PE3, Q13572, P27987CALM1, PIK3CB, INPP4A, ITPK1, ITPKBMore
Glutamic-acidhsa04071Sphingolipid signaling pathway1.94E-026Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Glutamic-acidhsa04080Neuroactive ligand-receptor interaction2.60E-022P00734, Q96G91F2, P2RY11More
Glutamic-acidhsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Glutamic-acidhsa04145Phagosome4.44E-023P60709, P63261, P30511ACTB, ACTG1, HLA-FMore
Glutamic-acidhsa04151PI3K-Akt signaling pathway6.25E-0317P42338, P21860, P43657, P07900, P08238, P63218, P50151, P61952, P23229, O15335, Q13751, P48551, P14784, P16871, P15336, Q16513, O00141PIK3CB, ERBB3, P2RY5, HSP90AA1, HSP90AB1, GNG5, GNG10, GNG11, ITGA6, CHAD, LAMB3, IFNAR2, IL2RB, IL7R, ATF2, PKN2, SGKMore
Glutamic-acidhsa04216Ferroptosis4.50E-021P48506GCLCMore
Glutamic-acidhsa04217Necroptosis1.93E-024P48551, P52630, P07384, Q99878IFNAR2, STAT2, CAPN1, H2AC14More
Glutamic-acidhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Glutamic-acidhsa04340Hedgehog signaling pathway8.25E-046P49841, P22694, Q13635, O43791, P30279, P10415GSK3B, PRKACB, PTCH1, SPOP, CCND2, BCL2More
Glutamic-acidhsa04371Apelin signaling pathway7.45E-035P63218, P50151, Q13485, Q16566, P0DP23GNG5, GNG10, SMAD4, CAMK4, CALM1More
Glutamic-acidhsa04390Hippo signaling pathway2.00E-022P30279, P41134CCND2, ID1More
Glutamic-acidhsa04530Tight junction3.85E-023P60709, P63261, P60660ACTB, ACTG1, MYL6More
Glutamic-acidhsa04610Complement and coagulation cascades4.11E-083P00734, P0C0L4, P05107F2, C4A, ITGB2More
Glutamic-acidhsa04621NOD-like receptor signaling pathway7.28E-035P52630, P48551, P59665, P59666, Q16513STAT2, IFNAR2, DEFA1; DEFA1B, DEFA3, PKN2More
Glutamic-acidhsa04622RIG-I-like receptor signaling pathway1.36E-022Q12933, P10145TRAF2, IL8More
Glutamic-acidhsa04630JAK-STAT signaling pathway1.44E-024P52630, P48551, P16871, Q06124STAT2, IFNAR2, IL7R, PTPN11More
Glutamic-acidhsa04640Hematopoietic cell lineage9.13E-0510P13612, P08514, P21926, P14778, P25063, P07766, P09693, P01730, P09564, P13765ITGA4, ITGA2B, CD9, IL1R1, CD24, CD3E, CD3G, CD4, CD7, HLA-DOBMore
Glutamic-acidhsa04658Th1 and Th2 cell differentiation1.01E-047P07766, P20963, P09693, P01730, P06239, Q9UL17, P13765CD3E, CD247, CD3G, CD4, LCK, TBX21, HLA-DOBMore
Glutamic-acidhsa04659Th17 cell differentiation4.70E-059Q16539, P01730, P06239, P13765, P14778, Q9UL17, P07766, P09693, P20963MAPK14, CD4, LCK, HLA-DOB, IL1R1, TBX21, CD3E, CD3G, CD247More
Glutamic-acidhsa04660T cell receptor signaling pathway1.18E-037O95267, Q08881, P07766, P20963, P09693, P01730, P06239RASGRP1, ITK, CD3E, CD247, CD3G, CD4, LCKMore
Glutamic-acidhsa04662B cell receptor signaling pathway2.37E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Glutamic-acidhsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Glutamic-acidhsa04666Fc gamma R-mediated phagocytosis4.10E-023P07948, P42338, P23528LYN, PIK3CB, CFL1More
Glutamic-acidhsa04672Intestinal immune network for IgA production3.01E-022P13765, P13612HLA-DOB, ITGA4More
Glutamic-acidhsa04713Circadian entrainment5.49E-047O15399, P0DP23, Q13557, Q02153, P63218, P50151, P61952GRIN2D, CALM1, CAMK2D, GUCY1B3, GNG5, GNG10, GNG11More
Glutamic-acidhsa04714Thermogenesis2.84E-034P15336, P60709, P63261, P36542ATF2, ACTB, ACTG1, ATP5C1More
Glutamic-acidhsa04720Long-term potentiation1.63E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Glutamic-acidhsa04724Glutamatergic synapse1.65E-036O15399, P43003, P63218, P50151, P61952, P15104GRIN2D, SLC1A3, GNG5, GNG10, GNG11, GLULMore
Glutamic-acidhsa04725Cholinergic synapse4.23E-046P63218, P50151, P61952, Q16566, Q13557, P42338GNG5, GNG10, GNG11, CAMK4, CAMK2D, PIK3CBMore
Glutamic-acidhsa04726Serotonergic synapse1.52E-024P63218, P50151, P33260, P09917GNG5, GNG10, CYP2C18, ALOX5More
Glutamic-acidhsa04727GABAergic synapse1.54E-025P63218, P50151, P61952, P15104, Q15111GNG5, GNG10, GNG11, GLUL, PLCL1More
Glutamic-acidhsa04728Dopaminergic synapse5.26E-037P14416, P63218, P50151, P15336, P07101, P0DP23, O00327DRD2, GNG5, GNG10, ATF2, TH, CALM1, ARNTLMore
Glutamic-acidhsa04921Oxytocin signaling pathway2.81E-023P60660, P60709, P63261MYL6, ACTB, ACTG1More
Glutamic-acidhsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Glutamic-acidhsa04925Aldosterone synthesis and secretion3.14E-023P0DP23, Q16566, P23634CALM1, CAMK4, ATP2B4More
Glutamic-acidhsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P30679PIK3CB, GNG5, GNG10, VEGFC, GNA15More
Glutamic-acidhsa04950Maturity onset diabetes of the young4.70E-021P35557GCKMore
Glutamic-acidhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Glutamic-acidhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Glutamic-acidhsa05017Spinocerebellar ataxia5.94E-034Q8TB72, O15399, P42338, P21796PUM2, GRIN2D, PIK3CB, VDAC1More
Glutamic-acidhsa05030Cocaine addiction1.35E-033P14416, P07101, P15336DRD2, TH, ATF2More
Glutamic-acidhsa05034Alcoholism2.44E-039O15399, P07101, P15336, Q16566, P0DP23, P14416, P63218, P50151, Q99878GRIN2D, TH, ATF2, CAMK4, CALM1, DRD2, GNG5, GNG10, H2AC14More
Glutamic-acidhsa05100Bacterial invasion of epithelial cells2.44E-022P60709, P63261ACTB, ACTG1More
Glutamic-acidhsa05110Vibrio cholerae infection2.44E-022P60709, P63261ACTB, ACTG1More
Glutamic-acidhsa05120Epithelial cell signaling in Helicobacter pylori infection6.89E-032Q99437, P10145ATP6V0B, IL8More
Glutamic-acidhsa05130Pathogenic Escherichia coli infection2.21E-024P60709, P63261, Q06124, O95487ACTB, ACTG1, PTPN11, SEC24BMore
Glutamic-acidhsa05133Pertussis8.35E-053P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Glutamic-acidhsa05134Legionellosis4.99E-032P11142, P19875HSPA8, CXCL2More
Glutamic-acidhsa05135Yersinia infection2.81E-023P60709, P63261, Q16513ACTB, ACTG1, PKN2More
Glutamic-acidhsa05143African trypanosomiasis4.21E-052P69905, P68871HBA2, HBBMore
Glutamic-acidhsa05144Malaria3.30E-058P69905, P68871, O60603, P01375, P05107, P35443, P10145, P26718HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1More
Glutamic-acidhsa05146Amoebiasis3.24E-024P09341, P05089, P12814, P08311CXCL1, ARG1, ACTN1, CTSGMore
Glutamic-acidhsa05150Staphylococcus aureus infection3.50E-022P0C0L4, P05107C4A, ITGB2More
Glutamic-acidhsa05162Measles3.73E-022P11142, P30279HSPA8, CCND2More
Glutamic-acidhsa05163Human cytomegalovirus infection4.19E-025P42338, P63218, P50151, P0DP23, P30101PIK3CB, GNG5, GNG10, CALM1, PDIA3More
Glutamic-acidhsa05164Influenza A8.62E-034P48551, P52630, P60709, P63261IFNAR2, STAT2, ACTB, ACTG1More
Glutamic-acidhsa05167Kaposi sarcoma-associated herpesvirus infection4.19E-025P42338, P63218, P50151, P07948, P0DP23PIK3CB, GNG5, GNG10, LYN, CALM1More
Glutamic-acidhsa05169Epstein-Barr virus infection4.01E-026P13765, O00463, P24522, P07766, P09693, P20963HLA-DOB, TRAF5, GADD45A, CD3E, CD3G, CD247More
Glutamic-acidhsa05170Human immunodeficiency virus 1 infection3.30E-0311P42338, P63218, P50151, P0DP23, O00463, P30101, P01730, P23528, P07766, P09693, P20963PIK3CB, GNG5, GNG10, CALM1, TRAF5, PDIA3, CD4, CFL1, CD3E, CD3G, CD247More
Glutamic-acidhsa05204Chemical carcinogenesis4.62E-022P78417, P33260GSTO1, CYP2C18More
Glutamic-acidhsa05214Glioma2.32E-023P0DP23, Q16566, P42338CALM1, CAMK4, PIK3CBMore
Glutamic-acidhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Glutamic-acidhsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Glutamic-acidhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.98E-057O95267, P07766, P20963, P09693, P06239, Q9HC35, P01730RASGRP1, CD3E, CD247, CD3G, LCK, EML4, CD4More
Glutamic-acidhsa05321Inflammatory bowel disease4.92E-024O60603, P01375, Q14765, Q9UL17TLR2, TNF, STAT4, TBX21More
Glutamic-acidhsa05323Rheumatoid arthritis4.28E-022Q99437, P10145ATP6V0B, IL8More
Glutamic-acidhsa05332Graft-versus-host disease1.80E-024P10747, P01375, P26715, Q13241CD28, TNF, KLRC1, KLRD1More
Glutamic-acidhsa05340Primary immunodeficiency6.61E-065P01730, P11912, Q8WV28, P07766, P06239CD4, CD79A, BLNK, CD3E, LCKMore
Glutamic-acidhsa05410Hypertrophic cardiomyopathy1.58E-035P23229, P26012, P09493, P60709, P63261ITGA6, ITGB8, TPM1, ACTB, ACTG1More
Glutamic-acidhsa05412Arrhythmogenic right ventricular cardiomyopathy2.01E-034P54284, P23229, P60709, P63261CACNB3, ITGA6, ACTB, ACTG1More
Glutamic-acidhsa05414Dilated cardiomyopathy1.57E-023P23229, P60709, P63261ITGA6, ACTB, ACTG1More
Glutamic-acidhsa05416Viral myocarditis2.29E-033P30511, P60709, P63261HLA-F, ACTB, ACTG1More

Community members of Glutamic-acid (SDC: 2.13)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
SLC1A3P43003IC5011000
SLC1A3P43003IC5011482
SLC1A3P43003Ki35000
SLC1A1P43005IC5032000
SLC1A1P43005IC5032359
SLC1A1P43005Ki51
GRIA4P48058Ki868