PharmaCoNets of Gluconolactone (SPCN: 4.55 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Gluconolactonehsa00220Arginine biosynthesis2.21E-022P15104, P49448GLUL, GLUD2More
Gluconolactonehsa00230Purine metabolism4.02E-022P31350, P21589RRM2, NT5EMore
Gluconolactonehsa00240Pyrimidine metabolism2.54E-043P31350, P21589, P04818RRM2, NT5E, TYMSMore
Gluconolactonehsa00250Alanine, aspartate and glutamate metabolism2.21E-022P49448, P15104GLUD2, GLULMore
Gluconolactonehsa00500Starch and sucrose metabolism3.88E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Gluconolactonehsa00640Propanoate metabolism1.63E-022Q02252, P21953ALDH6A1, BCKDHBMore
Gluconolactonehsa00730Thiamine metabolism3.79E-022P05186, P24666ALPL, ACP1More
Gluconolactonehsa00910Nitrogen metabolism2.21E-022P15104, P49448GLUL, GLUD2More
Gluconolactonehsa00970Aminoacyl-tRNA biosynthesis4.16E-022O95363, Q15046FARS2, KARSMore
Gluconolactonehsa01523Antifolate resistance6.06E-032Q92820, P04818GGH, TYMSMore
Gluconolactonehsa03010Ribosome4.16E-022P46777, P50914RPL5, RPL14More
Gluconolactonehsa04064NF-kappa B signaling pathway2.69E-029P10415, O00463, P01375, Q04759, Q13077, Q16548, Q8WV28, P24522, P09341BCL2, TRAF5, TNF, PRKCQ, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Gluconolactonehsa04071Sphingolipid signaling pathway2.06E-027Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Gluconolactonehsa04080Neuroactive ligand-receptor interaction2.54E-027P08311, Q15722, Q9H228, P21462, P21730, Q16581, P35318CTSG, LTB4R, EDG8, FPR1, C5AR1, C3AR1, ADMMore
Gluconolactonehsa04110Cell cycle2.34E-023P06493, O60566, P33981CDK1, BUB1B, TTKMore
Gluconolactonehsa04115p53 signaling pathway3.34E-022P31350, P06493RRM2, CDK1More
Gluconolactonehsa04218Cellular senescence2.19E-026P01106, Q9H422, P42338, Q16539, P24522, P30304MYC, HIPK3, PIK3CB, MAPK14, GADD45A, CDC25AMore
Gluconolactonehsa04340Hedgehog signaling pathway1.43E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Gluconolactonehsa04370VEGF signaling pathway4.16E-022P42338, Q16539PIK3CB, MAPK14More
Gluconolactonehsa04613Neutrophil extracellular trap formation1.37E-0212O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Gluconolactonehsa04621NOD-like receptor signaling pathway2.64E-0210Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, DEFA4More
Gluconolactonehsa04657IL-17 signaling pathway1.28E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Gluconolactonehsa04658Th1 and Th2 cell differentiation3.21E-039Q04759, P20963, P09693, Q16539, Q14765, P42226, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, STAT6, GATA3, TBX21, HLA-DOBMore
Gluconolactonehsa04659Th17 cell differentiation3.33E-0312Q04759, Q16539, P01730, P06239, P42226, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, CD4, LCK, STAT6, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Gluconolactonehsa04660T cell receptor signaling pathway1.07E-029P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, MAPK14, GSK3BMore
Gluconolactonehsa04724Glutamatergic synapse1.17E-024P48058, P43003, P50151, P15104GRIA4, SLC1A3, GNG10, GLULMore
Gluconolactonehsa04973Carbohydrate digestion and absorption7.81E-032O43451, P42338MGAM, PIK3CBMore
Gluconolactonehsa05012Parkinson disease3.20E-024P60604, O60282, Q13509, P68371UBE2G2, KIF5C, TUBB3, TUBB2CMore
Gluconolactonehsa05020Prion disease4.79E-024O60282, Q13509, P68371, P14598KIF5C, TUBB3, TUBB2C, NCF1More
Gluconolactonehsa05135Yersinia infection4.60E-024P06239, Q16539, P42338, P01730LCK, MAPK14, PIK3CB, CD4More
Gluconolactonehsa05145Toxoplasmosis3.96E-022P28068, Q16787HLA-DMB, LAMA3More
Gluconolactonehsa05150Staphylococcus aureus infection4.37E-026P21730, P21462, O75015, P13765, Q16581, P12838C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA4More
Gluconolactonehsa05163Human cytomegalovirus infection2.62E-026P42338, P50151, P01106, P14778, Q13651, Q16539PIK3CB, GNG10, MYC, IL1R1, IL10RA, MAPK14More
Gluconolactonehsa05165Human papillomavirus infection2.01E-023Q16787, Q02930, Q13315LAMA3, CREB5, ATMMore
Gluconolactonehsa05166Human T-cell leukemia virus 1 infection2.41E-0312P01106, Q02930, O60566, P14778, P27930, P07766, P42338, P28068, P42773, P06239, Q13315, P01730MYC, CREB5, BUB1B, IL1R1, IL1R2, CD3E, PIK3CB, HLA-DMB, CDKN2C, LCK, ATM, CD4More
Gluconolactonehsa05169Epstein-Barr virus infection4.32E-0211P13765, O00463, P16070, P10415, Q16539, P24522, Q8WV28, P01375, O60603, P09693, P20963HLA-DOB, TRAF5, CD44, BCL2, MAPK14, GADD45A, BLNK, TNF, TLR2, CD3G, CD247More
Gluconolactonehsa05202Transcriptional misregulation in cancer8.07E-0414Q15532, P14780, P27930, Q16548, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522SS18, MMP9, IL1R2, BCL2A1, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45AMore
Gluconolactonehsa05213Endometrial cancer3.83E-023P01106, P42338, P24522MYC, PIK3CB, GADD45AMore
Gluconolactonehsa05217Basal cell carcinoma1.43E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Gluconolactonehsa05224Breast cancer1.64E-024P42338, P01106, Q92837, P24522PIK3CB, MYC, FRAT1, GADD45AMore
Gluconolactonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.28E-025P42338, P07766, P06239, Q16539, P01730PIK3CB, CD3E, LCK, MAPK14, CD4More
Gluconolactonehsa05321Inflammatory bowel disease7.62E-047O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3More
Gluconolactonehsa05418Fluid shear stress and atherosclerosis2.60E-025Q16539, P42338, P10599, P14778, P27930MAPK14, PIK3CB, TXN, IL1R1, IL1R2More

Community members of Gluconolactone (SDC: 0.95)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
P06737PYGLGlycogen phosphorylase, liver formPredicted00.37330.22110.31690.9457
P05162LGALS2GalectinNone2Predicted00.00380.018900.0396
P13866SLC5A1Sodium/glucose cotransporter 1Predicted00.37190.11050.1050.512
Q9UEF7KLKlothoPredicted00.09680.00250.30590.3593
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)