PharmaCoNets of Gestrinone (SPCN: 83.54 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Gestrinonehsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Gestrinonehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Gestrinonehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Gestrinonehsa00190Oxidative phosphorylation4.36E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Gestrinonehsa00220Arginine biosynthesis4.88E-021P49448GLUD2More
Gestrinonehsa00250Alanine, aspartate and glutamate metabolism4.88E-021P49448GLUD2More
Gestrinonehsa00471D-Glutamine and D-glutamate metabolism1.65E-021P49448GLUD2More
Gestrinonehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Gestrinonehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Gestrinonehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Gestrinonehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Gestrinonehsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Gestrinonehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Gestrinonehsa00910Nitrogen metabolism4.88E-021P49448GLUD2More
Gestrinonehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Gestrinonehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Gestrinonehsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Gestrinonehsa01230Biosynthesis of amino acids3.91E-023P51854, Q99707, P50213TKTL1, MTR, IDH3AMore
Gestrinonehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Gestrinonehsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Gestrinonehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Gestrinonehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Gestrinonehsa03040Spliceosome6.28E-036Q14562, O43143, O60508, Q07955, Q01130, Q13243DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5More
Gestrinonehsa03060Protein export3.28E-021Q15070OXA1LMore
Gestrinonehsa03430Mismatch repair4.38E-021P20585MSH3More
Gestrinonehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Gestrinonehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Gestrinonehsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Gestrinonehsa04015Rap1 signaling pathway5.18E-043P08069, P06213, O00522IGF1R, INSR, KRIT1More
Gestrinonehsa04024cAMP signaling pathway4.25E-037P63092, P42338, P26678, P0DP23, P61586, Q13370, Q13009GNAS, PIK3CB, PLN, CALM1, RHOA, PDE3B, TIAM1More
Gestrinonehsa04064NF-kappa B signaling pathway4.58E-034Q13489, Q13546, Q9UDY8, Q9UNE0BIRC3, RIPK1, MALT1, EDARMore
Gestrinonehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Gestrinonehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Gestrinonehsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Gestrinonehsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Gestrinonehsa04114Oocyte meiosis3.19E-035P51812, Q02750, P16298, Q17RY0, P08069RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Gestrinonehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Gestrinonehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Gestrinonehsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Gestrinonehsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Gestrinonehsa04150mTOR signaling pathway7.74E-034P08069, Q02750, Q9NQL2, P51812IGF1R, MAP2K1, RRAGD, RPS6KA3More
Gestrinonehsa04152AMPK signaling pathway2.07E-033P08069, Q96EB6, P36956IGF1R, SIRT1, SREBF1More
Gestrinonehsa04211Longevity regulating pathway1.34E-034Q12778, P08069, Q9UEF7, Q96KQ7FOXO1, IGF1R, KL, EHMT2More
Gestrinonehsa04213Longevity regulating pathway - multiple species1.66E-021P08069IGF1RMore
Gestrinonehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Gestrinonehsa04217Necroptosis1.85E-037P01375, P01568, P48023, Q13489, Q13546, Q14765, Q99878TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, H2AC14More
Gestrinonehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Gestrinonehsa04360Axon guidance7.48E-045P20827, O95631, P42338, P23528, Q06124EFNA1, NTN1, PIK3CB, CFL1, PTPN11More
Gestrinonehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Gestrinonehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Gestrinonehsa04510Focal adhesion8.84E-034O14986, P61586, Q16363, P08069PIP5K1B, RHOA, LAMA4, IGF1RMore
Gestrinonehsa04520Adherens junction1.65E-054P08069, P19784, P67870, P61586IGF1R, CSNK2A2, CSNK2B, RHOAMore
Gestrinonehsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Gestrinonehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Gestrinonehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Gestrinonehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Gestrinonehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Gestrinonehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Gestrinonehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Gestrinonehsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Gestrinonehsa04659Th17 cell differentiation3.99E-037P25963, P42224, P14784, P40189, P84022, Q13485, P08238NFKBIA, STAT1, IL2RB, IL6ST, SMAD3, SMAD4, HSP90AB1More
Gestrinonehsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Gestrinonehsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Gestrinonehsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Gestrinonehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Gestrinonehsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Gestrinonehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Gestrinonehsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Gestrinonehsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Gestrinonehsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Gestrinonehsa04730Long-term depression1.16E-021P08069IGF1RMore
Gestrinonehsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Gestrinonehsa04914Progesterone-mediated oocyte maturation9.67E-047P08069, Q17RY0, P42338, Q13370, P08238, P51812, Q02750IGF1R, CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1More
Gestrinonehsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Gestrinonehsa04923Regulation of lipolysis in adipocytes3.76E-021P06213INSRMore
Gestrinonehsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Gestrinonehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Gestrinonehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Gestrinonehsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Gestrinonehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Gestrinonehsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Gestrinonehsa04964Proximal tubule bicarbonate reclamation4.53E-032P00918, P49448CA2, GLUD2More
Gestrinonehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Gestrinonehsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Gestrinonehsa04975Fat digestion and absorption9.50E-041O14494PLPP1More
Gestrinonehsa05032Morphine addiction2.47E-033P62873, P48169, P63092GNB1, GABRA4, GNASMore
Gestrinonehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Gestrinonehsa05132Salmonella infection5.76E-047P25963, Q13546, Q13489, P10415, Q9BQS8, O60282, P68371NFKBIA, RIPK1, BIRC3, BCL2, FYCO1, KIF5C, TUBB2CMore
Gestrinonehsa05133Pertussis4.20E-021P0C0L4C4AMore
Gestrinonehsa05140Leishmaniasis4.50E-035P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Gestrinonehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Gestrinonehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Gestrinonehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Gestrinonehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Gestrinonehsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Gestrinonehsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Gestrinonehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Gestrinonehsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Gestrinonehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Gestrinonehsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Gestrinonehsa05202Transcriptional misregulation in cancer2.82E-021P08069IGF1RMore
Gestrinonehsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Gestrinonehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Gestrinonehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Gestrinonehsa05212Pancreatic cancer1.44E-035P42338, P42224, P84022, Q13485, O75293PIK3CB, STAT1, SMAD3, SMAD4, GADD45BMore
Gestrinonehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Gestrinonehsa05214Glioma1.88E-034P08069, P0DP23, P42338, O75293IGF1R, CALM1, PIK3CB, GADD45BMore
Gestrinonehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Gestrinonehsa05218Melanoma6.63E-031P08069IGF1RMore
Gestrinonehsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Gestrinonehsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Gestrinonehsa05224Breast cancer1.49E-021P08069IGF1RMore
Gestrinonehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Gestrinonehsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Gestrinonehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Gestrinonehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Gestrinonehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Gestrinonehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Gestrinonehsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore
Gestrinonehsa05418Fluid shear stress and atherosclerosis3.73E-024P42338, P14598, P0DP23, P08238PIK3CB, NCF1, CALM1, HSP90AB1More

Community members of Gestrinone (SDC: 6.27)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Predicted00.32530.5650.15791.4506
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q9HB89NMUR1NeuromedinNoneU receptor 1Predicted00.00240.30300.6072
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)