PharmaCoNets
.
Gentamicin
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PharmaCoNets of Gentamicin (S
PCN
: 0.33 )
Gentamicin regulated-network (S
DN
: 0.61)
Drug Name
Pathway ID
Pathway name
P-value
No. of gene members
UniProt AC
Gene name
Detail of Coexpression
Gentamicin
hsa00670
One carbon pool by folate
3.62E-02
1
P00374
DHFR
More
Genes in community(ComG)
Gene name of ComG
Protein name of ComG
Co-expressed genes in pathway (PathG)
Gene name of PathG
Protein name of PathG
Coexpression
P00374
DHFR
Dihydrofolate reductase
P00374
DHFR
Dihydrofolate reductase
1
Gentamicin
hsa00790
Folate biosynthesis
3.62E-02
1
P00374
DHFR
More
Genes in community(ComG)
Gene name of ComG
Protein name of ComG
Co-expressed genes in pathway (PathG)
Gene name of PathG
Protein name of PathG
Coexpression
P00374
DHFR
Dihydrofolate reductase
P00374
DHFR
Dihydrofolate reductase
1
Gentamicin
hsa04919
Thyroid hormone signaling pathway
4.77E-02
1
O60244
MED14
More
Genes in community(ComG)
Gene name of ComG
Protein name of ComG
Co-expressed genes in pathway (PathG)
Gene name of PathG
Protein name of PathG
Coexpression
Q14114
LRP8
Low-density lipoprotein receptor-related protein 8
O60244
MED14
Mediator of RNA polymerase II transcription subunit 14
0.728
Gentamicin
hsa05034
Alcoholism
2.79E-02
2
P62879, Q9BTM1
GNB2, H2AFJ
More
Genes in community(ComG)
Gene name of ComG
Protein name of ComG
Co-expressed genes in pathway (PathG)
Gene name of PathG
Protein name of PathG
Coexpression
P00374
DHFR
Dihydrofolate reductase
P62879
GNB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
0.721
P00374
DHFR
Dihydrofolate reductase
Q9BTM1
H2AFJ
Histone H2A.J
-0.728
Gentamicin
hsa05200
Pathways in cancer
4.70E-02
3
P17301, P20585, P62879
ITGA2, MSH3, GNB2
More
Genes in community(ComG)
Gene name of ComG
Protein name of ComG
Co-expressed genes in pathway (PathG)
Gene name of PathG
Protein name of PathG
Coexpression
P00374
DHFR
Dihydrofolate reductase
P17301
ITGA2
Integrin alpha-2
0.784
P00374
DHFR
Dihydrofolate reductase
P20585
MSH3
DNA mismatch repair protein Msh3
1
P00374
DHFR
Dihydrofolate reductase
P62879
GNB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
0.721
Community members of Gentamicin (S
DC
: 0.55)
UniProtAC
Gene Name
Protein Name
Reported/
Predicted
DisGeNET
S
PV
S
drugability
S
HiSBiN
S
DisG
P00374
DHFR
Dihydrofolate reductase
Reported
0
0.338
0.1868
0.2263
0.7688
BDBM ID
C.S.
Homologus UniProt ID
Gene Name
I.S.
Text mining Similar drug DB ID
C.S.
None
None
None
None
None
None
None
Q14114
LRP8
LowNonedensity lipoprotein receptorNonerelated protein 8
Predicted
0
0.0526
0.0057
0
0.0377
BDBM ID
C.S.
Homologus UniProt ID
Gene Name
I.S.
Text mining Similar drug DB ID
C.S.
None
None
Q14114
LRP8
0.373
None
None
This pair is Reported in Drugbank.
Gene name
UniProt_ID
Bioactivity
Value (nM)
