PharmaCoNets of Gemcitabine (SPCN: 3.97 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Gemcitabinehsa00190Oxidative phosphorylation3.20E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Gemcitabinehsa00230Purine metabolism4.02E-022P31350, P21589RRM2, NT5EMore
Gemcitabinehsa00240Pyrimidine metabolism2.54E-043P31350, P21589, P04818RRM2, NT5E, TYMSMore
Gemcitabinehsa01523Antifolate resistance6.06E-032Q92820, P04818GGH, TYMSMore
Gemcitabinehsa03040Spliceosome1.64E-0311Q14562, O43143, O14776, O75940, P52298, P09651, O75494, Q07955, Q13243, O95777, P61326DHX8, DHX15, TCERG1, SMNDC1, NCBP2, HNRNPA1, FUSIP1, SFRS1, SFRS5, LSM8, MAGOHMore
Gemcitabinehsa04061Viral protein interaction with cytokine and cytokine receptor4.28E-027P51684, P09341, P25024, P25025, P47992, Q9UBD3, P01375CCR6, CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNFMore
Gemcitabinehsa04064NF-kappa B signaling pathway1.75E-0210P10415, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522, P09341BCL2, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A, CXCL1More
Gemcitabinehsa04071Sphingolipid signaling pathway9.29E-037P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Gemcitabinehsa04110Cell cycle2.34E-023P06493, O60566, P33981CDK1, BUB1B, TTKMore
Gemcitabinehsa04115p53 signaling pathway3.34E-022P31350, P06493RRM2, CDK1More
Gemcitabinehsa04613Neutrophil extracellular trap formation1.02E-0214O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Gemcitabinehsa04621NOD-like receptor signaling pathway4.83E-0210Q16539, Q14643, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P49913, P12838MAPK14, ITPR1, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, CAMP, DEFA4More
Gemcitabinehsa04658Th1 and Th2 cell differentiation8.47E-038Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Gemcitabinehsa04660T cell receptor signaling pathway2.57E-0311P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14More
Gemcitabinehsa04744Phototransduction2.59E-022P62873, P0DP23GNB1, CALM1More
Gemcitabinehsa05132Salmonella infection2.35E-0312P25963, P08238, Q13489, P10415, P04406, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P49754NFKBIA, HSP90AB1, BIRC3, BCL2, GAPDH, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, VPS41More
Gemcitabinehsa05140Leishmaniasis2.25E-026P14598, P42224, O60603, P25963, P29350, Q15080NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4More
Gemcitabinehsa05146Amoebiasis3.11E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Gemcitabinehsa05150Staphylococcus aureus infection2.53E-026P21730, P21462, O75015, P13765, P12838, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, DEFA4, CAMPMore
Gemcitabinehsa05152Tuberculosis2.26E-0415Q13488, Q15075, P0DP23, O75015, P42224, P48382, P25208, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, Q16539TCIRG1, EEA1, CALM1, FCGR3B, STAT1, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, MAPK14More
Gemcitabinehsa05168Herpes simplex virus 1 infection7.93E-0417O60603, P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, P51522, Q9NR11, Q9HCX3, P17097, Q03923, P52738, O75820, P10415TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF85, ZNF140, ZNF189, BCL2More
Gemcitabinehsa05170Human immunodeficiency virus 1 infection4.82E-0211P01375, O00463, Q14643, Q16539, O60603, Q13315, P09693, P20963, P10415, Q93034, Q9Y6Q5TNF, TRAF5, ITPR1, MAPK14, TLR2, ATM, CD3G, CD247, BCL2, CUL5, AP1M2More
Gemcitabinehsa05202Transcriptional misregulation in cancer8.28E-0314Q15532, Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Gemcitabinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.11E-027O95267, P20963, P09693, O60603, P10747, Q04759, Q16539RASGRP1, CD247, CD3G, TLR2, CD28, PRKCQ, MAPK14More
Gemcitabinehsa05310Asthma2.48E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Gemcitabinehsa05321Inflammatory bowel disease2.47E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Gemcitabinehsa05322Systemic lupus erythematosus4.61E-028O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Gemcitabinehsa05323Rheumatoid arthritis2.84E-025P01375, P13765, P10747, P09341, O60603TNF, HLA-DOB, CD28, CXCL1, TLR2More
Gemcitabinehsa05332Graft-versus-host disease3.93E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More

Community members of Gemcitabine (SDC: 0.85)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P04818TYMSThymidylate synthaseReported10.45530.27060.18930.9582
P27707DCKDeoxycytidine kinasePredicted00.05740.06140.16530.3169
P32320CDACytidine deaminasePredicted00.05160.05690.16530.3049
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)