PharmaCoNets of Ganirelix (SPCN: 24.83 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ganirelixhsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Ganirelixhsa00280Valine, leucine and isoleucine degradation4.31E-022P26440, Q02252IVD, ALDH6A1More
Ganirelixhsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Ganirelixhsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Ganirelixhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Ganirelixhsa00860Porphyrin and chlorophyll metabolism5.29E-032P53004, P30043BLVRA, BLVRBMore
Ganirelixhsa00900Terpenoid backbone biosynthesis1.40E-021Q01581HMGCS1More
Ganirelixhsa01200Carbon metabolism4.06E-025P37837, O14521, P50213, P60891, Q02252TALDO1, SDHD, IDH3A, PRPS1, ALDH6A1More
Ganirelixhsa01521EGFR tyrosine kinase inhibitor resistance2.18E-022P49841, Q9NRA1GSK3B, PDGFCMore
Ganirelixhsa01522Endocrine resistance4.51E-022P04637, P42773TP53, CDKN2CMore
Ganirelixhsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Ganirelixhsa03010Ribosome1.53E-058P62753, P62906, P46776, Q07020, P61513, P27635, P62249, P23396RPS6, RPL10A, RPL27A, RPL18, RPL37A, RPL10, RPS16, RPS3More
Ganirelixhsa03013RNA transport7.24E-0311P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, O14602, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF1AY, EIF3A, EIF3J, RPP38, TACC3More
Ganirelixhsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Ganirelixhsa03430Mismatch repair4.38E-021P20585MSH3More
Ganirelixhsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Ganirelixhsa04015Rap1 signaling pathway9.14E-032P06213, O00522INSR, KRIT1More
Ganirelixhsa04064NF-kappa B signaling pathway2.44E-024P10415, Q13546, Q9UDY8, Q13315BCL2, RIPK1, MALT1, ATMMore
Ganirelixhsa04080Neuroactive ligand-receptor interaction4.15E-022Q01726, P41968MC1R, MC3RMore
Ganirelixhsa04110Cell cycle2.75E-049P30260, P06493, O75293, P04637, P49918, P30304, P33981, P42773, P01106CDC27, CDK1, GADD45B, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYCMore
Ganirelixhsa04115p53 signaling pathway2.54E-023O15151, Q13315, P10415MDM4, ATM, BCL2More
Ganirelixhsa04141Protein processing in endoplasmic reticulum2.82E-048P18848, Q15437, Q15436, Q99941, P11142, P07900, Q9NR31, P14625ATF4, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, SAR1A, HSP90B1More
Ganirelixhsa04145Phagosome4.79E-023P14598, Q13509, P68371NCF1, TUBB3, TUBB2CMore
Ganirelixhsa04151PI3K-Akt signaling pathway5.85E-0512P62753, P04637, P27348, P07900, P14625, Q16363, P22105, Q99941, P18848, Q96BR1, O00141, P56279RPS6, TP53, YWHAQ, HSP90AA1, HSP90B1, LAMA4, TNXB, CREBL1, ATF4, SGK3, SGK, TCL1AMore
Ganirelixhsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Ganirelixhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Ganirelixhsa04261Adrenergic signaling in cardiomyocytes1.46E-024P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Ganirelixhsa04540Gap junction7.81E-033Q13509, P68371, Q9NRA1TUBB3, TUBB2C, PDGFCMore
Ganirelixhsa04613Neutrophil extracellular trap formation9.53E-0313P17252, O60603, P08246, Q9UM07, Q92769, Q6FI13, P14598, Q15080, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, ELA2, PADI4, HDAC2, H2AC18; H2AC19, NCF1, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Ganirelixhsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Ganirelixhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Ganirelixhsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Ganirelixhsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Ganirelixhsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Ganirelixhsa04912GnRH signaling pathway5.80E-037P17252, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643PRKCA, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1More
Ganirelixhsa04913Ovarian steroidogenesis2.52E-021P06213INSRMore
Ganirelixhsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Ganirelixhsa04916Melanogenesis2.18E-022P49841, Q01726GSK3B, MC1RMore
Ganirelixhsa04918Thyroid hormone synthesis1.98E-045P51828, Q99941, P18848, P14625, P02768ADCY7, CREBL1, ATF4, HSP90B1, ALBMore
Ganirelixhsa04923Regulation of lipolysis in adipocytes3.76E-021P06213INSRMore
Ganirelixhsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Ganirelixhsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Ganirelixhsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Ganirelixhsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Ganirelixhsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Ganirelixhsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Ganirelixhsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Ganirelixhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Ganirelixhsa04972Pancreatic secretion3.86E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Ganirelixhsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Ganirelixhsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Ganirelixhsa05131Shigellosis1.80E-025Q13546, Q9UDY8, Q12778, Q13315, P10415RIPK1, MALT1, FOXO1, ATM, BCL2More
Ganirelixhsa05132Salmonella infection4.85E-024Q13546, P10415, Q13509, P68371RIPK1, BCL2, TUBB3, TUBB2CMore
Ganirelixhsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Ganirelixhsa05171Coronavirus disease - COVID-194.36E-058P23396, P62753, P62249, P62906, P27635, Q07020, P46776, P61513RPS3, RPS6, RPS16, RPL10A, RPL10, RPL18, RPL27A, RPL37AMore
Ganirelixhsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Ganirelixhsa05215Prostate cancer3.06E-035P10415, Q12778, P18848, Q9NRA1, P14625BCL2, FOXO1, ATF4, PDGFC, HSP90B1More
Ganirelixhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Ganirelixhsa05222Small cell lung cancer4.26E-026P10826, Q13489, P10415, Q13077, O00463, P24522RARB, BIRC3, BCL2, TRAF1, TRAF5, GADD45AMore
Ganirelixhsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Ganirelixhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Ganirelixhsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Ganirelixhsa05415Diabetic cardiomyopathy3.19E-027P17252, P14598, Q15080, Q16718, O14521, Q16539, P14780PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, MMP9More

Community members of Ganirelix (SDC: 3.06)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
O15151MDM4Protein Mdm4Predicted00.10140.08980.24890.4791
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
O60603TLR2TollNonelike receptor 2Predicted10.21260.080511.2673
P14625HSP90B1EndoplasminPredicted00.23360.14970.53840.9546
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)