PharmaCoNets of Galantamine (SPCN: 28.44 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Galantaminehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Galantaminehsa00190Oxidative phosphorylation1.00E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Galantaminehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Galantaminehsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.01E-021Q14442PIGHMore
Galantaminehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Galantaminehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Galantaminehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Galantaminehsa00830Retinol metabolism3.49E-021P00325ADH1BMore
Galantaminehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Galantaminehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Galantaminehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Galantaminehsa02010ABC transporters3.01E-021P45844ABCG1More
Galantaminehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Galantaminehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Galantaminehsa04014Ras signaling pathway4.65E-023Q15311, P0DP23, P17612RALBP1, CALM1, PRKACAMore
Galantaminehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Galantaminehsa04114Oocyte meiosis2.15E-023P0DP23, P17612, Q13362CALM1, PRKACA, PPP2R5CMore
Galantaminehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Galantaminehsa04144Endocytosis4.07E-035Q9H444, O75351, P42566, Q15438, Q14161CHMP4B, VPS4B, EPS15, PSCD1, GIT2More
Galantaminehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Galantaminehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Galantaminehsa04217Necroptosis1.57E-0718P01568, P23458, Q13489, Q9NQC7, P42224, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q93077, Q13557, Q9H444, O43633, O75351, Q08752IFNA21, JAK1, BIRC3, CYLD, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, HIST1H2AC, CAMK2D, CHMP4B, CHMP2A, VPS4B, PPIDMore
Galantaminehsa04261Adrenergic signaling in cardiomyocytes2.50E-023P17612, Q13362, P0DP23PRKACA, PPP2R5C, CALM1More
Galantaminehsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Galantaminehsa04340Hedgehog signaling pathway1.39E-044P49841, P17612, P22694, Q9Y496GSK3B, PRKACA, PRKACB, KIF3AMore
Galantaminehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Galantaminehsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Galantaminehsa04613Neutrophil extracellular trap formation1.02E-048P11215, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Galantaminehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Galantaminehsa04657IL-17 signaling pathway4.48E-035P07900, P49841, P14780, P01375, P01584HSP90AA1, GSK3B, MMP9, TNF, IL1BMore
Galantaminehsa04713Circadian entrainment4.42E-022P0DP23, P17612CALM1, PRKACAMore
Galantaminehsa04720Long-term potentiation4.42E-022P0DP23, P17612CALM1, PRKACAMore
Galantaminehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Galantaminehsa04728Dopaminergic synapse1.55E-023P17612, Q13362, P0DP23PRKACA, PPP2R5C, CALM1More
Galantaminehsa04740Olfactory transduction6.71E-032P0DP23, P17612CALM1, PRKACAMore
Galantaminehsa04742Taste transduction3.91E-021P17612PRKACAMore
Galantaminehsa04910Insulin signaling pathway1.91E-035P0DP23, P17612, P22694, P06737, P49841CALM1, PRKACA, PRKACB, PYGL, GSK3BMore
Galantaminehsa04916Melanogenesis2.87E-022P17612, P0DP23PRKACA, CALM1More
Galantaminehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Galantaminehsa04921Oxytocin signaling pathway1.84E-023P0DP23, P17612, Q96RR4CALM1, PRKACA, CAMKK2More
Galantaminehsa04924Renin secretion1.09E-022P17612, P0DP23PRKACA, CALM1More
Galantaminehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Galantaminehsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Galantaminehsa04970Salivary secretion2.20E-022P17612, P0DP23PRKACA, CALM1More
Galantaminehsa04971Gastric acid secretion2.87E-022P17612, P0DP23PRKACA, CALM1More
Galantaminehsa04976Bile secretion1.19E-034P17612, P22694, P08183, Q14032PRKACA, PRKACB, ABCB1, BAATMore
Galantaminehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Galantaminehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Galantaminehsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Galantaminehsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Galantaminehsa05031Amphetamine addiction2.87E-022P0DP23, P17612CALM1, PRKACAMore
Galantaminehsa05034Alcoholism8.54E-0710P17612, Q13547, P0DP23, Q96RR4, Q93077, P58876, P62807, Q16778, O60814, P68431PRKACA, HDAC1, CALM1, CAMKK2, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Galantaminehsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Galantaminehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Galantaminehsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Galantaminehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Galantaminehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Galantaminehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Galantaminehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Galantaminehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Galantaminehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Galantaminehsa05212Pancreatic cancer2.87E-022Q15311, P23458RALBP1, JAK1More
Galantaminehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Galantaminehsa05415Diabetic cardiomyopathy1.49E-0310P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q13557, P04406PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, CAMK2D, GAPDHMore

Community members of Galantamine (SDC: 4.29)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P00441SOD1Superoxide dismutase [CuNoneZn]Predicted10.53850.07130.48710.8991
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
Q8NFZ4NLGN2NeuroliginNone2Predicted00.5660.06920.16270.5841
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)