PharmaCoNets of Gabapentin (SPCN: 43.54 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Gabapentinhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Gabapentinhsa00230Purine metabolism4.48E-022Q08828, P51828ADCY1, ADCY7More
Gabapentinhsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Gabapentinhsa00531Glycosaminoglycan degradation8.18E-042P15586, P34059GNS, GALNSMore
Gabapentinhsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate2.92E-021Q9Y2C2USTMore
Gabapentinhsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Gabapentinhsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Gabapentinhsa00830Retinol metabolism3.19E-021P00325ADH1BMore
Gabapentinhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Gabapentinhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Gabapentinhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Gabapentinhsa01522Endocrine resistance6.51E-033Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Gabapentinhsa03008Ribosome biogenesis in eukaryotes2.06E-022Q9NYH9, Q9BVP2UTP6, GNL3More
Gabapentinhsa03020RNA polymerase9.80E-052Q9GZM3, P52435POLR2J2, POLR2JMore
Gabapentinhsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Gabapentinhsa03050Proteasome1.20E-022P55036, P40306PSMD4, PSMB10More
Gabapentinhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Gabapentinhsa04015Rap1 signaling pathway3.69E-045P15498, Q08828, P51828, P31751, P0DP23VAV1, ADCY1, ADCY7, AKT2, CALM1More
Gabapentinhsa04020Calcium signaling pathway1.42E-023Q08828, P0DP23, P51828ADCY1, CALM1, ADCY7More
Gabapentinhsa04022cGMP-PKG signaling pathway2.66E-034P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Gabapentinhsa04024cAMP signaling pathway6.94E-055Q08828, P51828, P31751, P0DP23, P15498ADCY1, ADCY7, AKT2, CALM1, VAV1More
Gabapentinhsa04062Chemokine signaling pathway7.23E-034P15498, Q08828, P51828, P31751VAV1, ADCY1, ADCY7, AKT2More
Gabapentinhsa04071Sphingolipid signaling pathway8.46E-047P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Gabapentinhsa04072Phospholipase D signaling pathway1.67E-023P31751, Q08828, P51828AKT2, ADCY1, ADCY7More
Gabapentinhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Gabapentinhsa04114Oocyte meiosis1.67E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Gabapentinhsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Gabapentinhsa04142Lysosome1.14E-023P43234, P15586, P34059CTSO, GNS, GALNSMore
Gabapentinhsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Gabapentinhsa04210Apoptosis9.18E-034P04637, P24522, P43234, P63261TP53, GADD45A, CTSO, ACTG1More
Gabapentinhsa04211Longevity regulating pathway5.35E-045P31751, Q08828, P51828, Q99941, P18848AKT2, ADCY1, ADCY7, CREBL1, ATF4More
Gabapentinhsa04213Longevity regulating pathway - multiple species2.91E-033P31751, Q08828, P51828AKT2, ADCY1, ADCY7More
Gabapentinhsa04261Adrenergic signaling in cardiomyocytes1.82E-0510P07550, Q08828, P51828, P22694, P31751, Q99941, P18848, Q13362, P0DP23, Q13557ADRB2, ADCY1, ADCY7, PRKACB, AKT2, CREBL1, ATF4, PPP2R5C, CALM1, CAMK2DMore
Gabapentinhsa04270Vascular smooth muscle contraction9.93E-033P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Gabapentinhsa04340Hedgehog signaling pathway1.80E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Gabapentinhsa04371Apelin signaling pathway1.09E-034P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Gabapentinhsa04380Osteoclast differentiation6.51E-033Q9NQC7, P23458, P31751CYLD, JAK1, AKT2More
Gabapentinhsa04512ECM-receptor interaction4.78E-021Q16787LAMA3More
Gabapentinhsa04540Gap junction3.73E-022Q08828, P51828ADCY1, ADCY7More
Gabapentinhsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Gabapentinhsa04611Platelet activation5.11E-033P31751, Q08828, P51828AKT2, ADCY1, ADCY7More
Gabapentinhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Gabapentinhsa04625C-type lectin receptor signaling pathway3.91E-033Q9NQC7, P31751, P0DP23CYLD, AKT2, CALM1More
Gabapentinhsa04630JAK-STAT signaling pathway2.91E-033P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Gabapentinhsa04650Natural killer cell mediated cytotoxicity1.64E-0411P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Gabapentinhsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Gabapentinhsa04658Th1 and Th2 cell differentiation9.73E-036P20963, P09693, Q16539, P06239, Q9UL17, P13765CD247, CD3G, MAPK14, LCK, TBX21, HLA-DOBMore
Gabapentinhsa04659Th17 cell differentiation7.42E-037Q16539, P06239, P13765, P14778, Q9UL17, P09693, P20963MAPK14, LCK, HLA-DOB, IL1R1, TBX21, CD3G, CD247More
Gabapentinhsa04662B cell receptor signaling pathway2.41E-022P31751, P15498AKT2, VAV1More
Gabapentinhsa04664Fc epsilon RI signaling pathway2.41E-022P31751, P15498AKT2, VAV1More
Gabapentinhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Gabapentinhsa04713Circadian entrainment2.91E-033P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Gabapentinhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Gabapentinhsa04720Long-term potentiation3.73E-022P0DP23, Q08828CALM1, ADCY1More
Gabapentinhsa04723Retrograde endocannabinoid signaling4.48E-022Q08828, P51828ADCY1, ADCY7More
Gabapentinhsa04724Glutamatergic synapse3.73E-022Q08828, P51828ADCY1, ADCY7More
Gabapentinhsa04725Cholinergic synapse3.34E-045Q08828, P51828, P18848, Q13557, P31751ADCY1, ADCY7, ATF4, CAMK2D, AKT2More
Gabapentinhsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Gabapentinhsa04750Inflammatory mediator regulation of TRP channels3.91E-033Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Gabapentinhsa04910Insulin signaling pathway3.04E-022P0DP23, P31751CALM1, AKT2More
Gabapentinhsa04911Insulin secretion2.59E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Gabapentinhsa04912GnRH signaling pathway3.34E-045Q08828, P51828, P18848, Q13557, P0DP23ADCY1, ADCY7, ATF4, CAMK2D, CALM1More
Gabapentinhsa04913Ovarian steroidogenesis1.67E-034P42330, Q08828, P51828, P22694AKR1C3, ADCY1, ADCY7, PRKACBMore
Gabapentinhsa04914Progesterone-mediated oocyte maturation6.51E-033Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Gabapentinhsa04915Estrogen signaling pathway2.31E-058Q99941, P18848, Q08828, P51828, P31751, P07900, P11142, P0DP23CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA8, CALM1More
Gabapentinhsa04916Melanogenesis1.41E-033P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Gabapentinhsa04918Thyroid hormone synthesis1.98E-045Q08828, P51828, Q99941, P18848, P02768ADCY1, ADCY7, CREBL1, ATF4, ALBMore
Gabapentinhsa04921Oxytocin signaling pathway1.42E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Gabapentinhsa04923Regulation of lipolysis in adipocytes2.69E-043Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Gabapentinhsa04924Renin secretion3.43E-033P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Gabapentinhsa04925Aldosterone synthesis and secretion1.78E-056Q99941, P18848, Q08828, P51828, P0DP23, Q13557CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2DMore
Gabapentinhsa04926Relaxin signaling pathway6.87E-058P31751, Q99941, P18848, P22694, P14780, Q08828, P51828, P30679AKT2, CREBL1, ATF4, PRKACB, MMP9, ADCY1, ADCY7, GNA15More
Gabapentinhsa04927Cortisol synthesis and secretion1.74E-055Q99941, P18848, Q08828, P51828, P22694CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Gabapentinhsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Gabapentinhsa04934Cushing syndrome1.10E-045Q99941, P18848, Q08828, P51828, Q13557CREBL1, ATF4, ADCY1, ADCY7, CAMK2DMore
Gabapentinhsa04935Growth hormone synthesis, secretion and action5.35E-045Q08828, P51828, Q99941, P18848, P31751ADCY1, ADCY7, CREBL1, ATF4, AKT2More
Gabapentinhsa04970Salivary secretion8.44E-056P07550, Q08828, P51828, P22694, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMPMore
Gabapentinhsa04971Gastric acid secretion1.41E-033Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Gabapentinhsa04972Pancreatic secretion2.41E-022Q08828, P51828ADCY1, ADCY7More
Gabapentinhsa04973Carbohydrate digestion and absorption2.41E-021P13866SLC5A1More
Gabapentinhsa04976Bile secretion1.91E-033Q08828, P51828, P13866ADCY1, ADCY7, SLC5A1More
Gabapentinhsa05016Huntington disease1.07E-023Q9GZM3, P52435, P55036POLR2J2, POLR2J, PSMD4More
Gabapentinhsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Gabapentinhsa05031Amphetamine addiction8.84E-045Q13557, P22694, Q99941, P18848, Q13547CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Gabapentinhsa05032Morphine addiction2.41E-022Q08828, P51828ADCY1, ADCY7More
Gabapentinhsa05120Epithelial cell signaling in Helicobacter pylori infection6.89E-032Q99437, P41240ATP6V0B, CSKMore
Gabapentinhsa05133Pertussis4.94E-021P0C0L4C4AMore
Gabapentinhsa05135Yersinia infection2.24E-023Q14161, P15498, P31751GIT2, VAV1, AKT2More
Gabapentinhsa05142Chagas disease4.48E-022Q08828, P31751ADCY1, AKT2More
Gabapentinhsa05144Malaria1.22E-045P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Gabapentinhsa05145Toxoplasmosis1.67E-023P23458, P31751, Q13651JAK1, AKT2, IL10RAMore
Gabapentinhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Gabapentinhsa05152Tuberculosis9.49E-034P0DP23, P23458, P31751, Q13651CALM1, JAK1, AKT2, IL10RAMore
Gabapentinhsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Gabapentinhsa05163Human cytomegalovirus infection2.17E-046P31751, P0DP23, Q08828, P51828, P23458, Q13651AKT2, CALM1, ADCY1, ADCY7, JAK1, IL10RAMore
Gabapentinhsa05164Influenza A3.67E-023P31751, P23458, Q9UBU9AKT2, JAK1, NXF1More
Gabapentinhsa05166Human T-cell leukemia virus 1 infection3.02E-024P23458, Q08828, P51828, P31751JAK1, ADCY1, ADCY7, AKT2More
Gabapentinhsa05167Kaposi sarcoma-associated herpesvirus infection2.24E-023P31751, P23458, P0DP23AKT2, JAK1, CALM1More
Gabapentinhsa05168Herpes simplex virus 1 infection2.09E-024Q9UBU9, P23458, P31751, Q6NUN9NXF1, JAK1, AKT2, ZNF746More
Gabapentinhsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Gabapentinhsa05200Pathways in cancer1.65E-025P23458, P31751, Q08828, P51828, P0DP23JAK1, AKT2, ADCY1, ADCY7, CALM1More
Gabapentinhsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Gabapentinhsa05205Proteoglycans in cancer4.79E-038P63261, P04637, P14780, P01375, P23588, Q06124, Q13635, P22694ACTG1, TP53, MMP9, TNF, EIF4B, PTPN11, PTCH1, PRKACBMore
Gabapentinhsa05211Renal cell carcinoma7.75E-032Q06124, Q99814PTPN11, EPAS1More
Gabapentinhsa05212Pancreatic cancer1.33E-034P31751, P23458, P04637, P24522AKT2, JAK1, TP53, GADD45AMore
Gabapentinhsa05213Endometrial cancer2.60E-022P04637, P24522TP53, GADD45AMore
Gabapentinhsa05214Glioma1.04E-034P0DP23, P31751, P04637, P24522CALM1, AKT2, TP53, GADD45AMore
Gabapentinhsa05216Thyroid cancer1.14E-022P04637, P24522TP53, GADD45AMore
Gabapentinhsa05217Basal cell carcinoma2.06E-022P04637, P24522TP53, GADD45AMore
Gabapentinhsa05218Melanoma1.14E-022P04637, P24522TP53, GADD45AMore
Gabapentinhsa05220Chronic myeloid leukemia7.90E-033Q06124, P04637, P24522PTPN11, TP53, GADD45AMore
Gabapentinhsa05222Small cell lung cancer4.78E-021Q16787LAMA3More
Gabapentinhsa05223Non-small cell lung cancer3.19E-022P04637, P24522TP53, GADD45AMore
Gabapentinhsa05224Breast cancer4.51E-022P04637, P24522TP53, GADD45AMore
Gabapentinhsa05225Hepatocellular carcinoma3.30E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Gabapentinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.63E-037P31751, P20963, P09693, P06239, P23458, O60603, Q16539AKT2, CD247, CD3G, LCK, JAK1, TLR2, MAPK14More
Gabapentinhsa05321Inflammatory bowel disease3.02E-034O60603, P01375, Q14765, Q9UL17TLR2, TNF, STAT4, TBX21More
Gabapentinhsa05332Graft-versus-host disease4.96E-044P10747, P01375, P26715, Q13241CD28, TNF, KLRC1, KLRD1More
Gabapentinhsa05414Dilated cardiomyopathy4.48E-022Q08828, P51828ADCY1, ADCY7More

Community members of Gabapentin (SDC: 2.55)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P98170BIRC4E3 ubiquitinNoneprotein ligase XIAPPredicted00.29740.22980.791.3984
Q9Y4K0LOXL2Lysyl oxidase homolog 2Predicted00.02690.119800.253
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P12955PEPDXaaNonePro dipeptidasePredicted00.33850.018800.2068
P40306PSMB10Proteasome subunit beta typeNone10Predicted00.26880.0510.01830.2548
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)