PharmaCoNets of Furosemide (SPCN: 18.31 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Furosemidehsa00030Pentose phosphate pathway6.21E-043P52209, P11413, P37837PGD, G6PD, TALDO1More
Furosemidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Furosemidehsa00220Arginine biosynthesis2.86E-022P15104, P05089GLUL, ARG1More
Furosemidehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Furosemidehsa00520Amino sugar and nucleotide sugar metabolism3.76E-021Q13231CHIT1More
Furosemidehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Furosemidehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Furosemidehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Furosemidehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Furosemidehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Furosemidehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Furosemidehsa04060Cytokine-cytokine receptor interaction1.71E-029P27930, P14778, P26842, Q13651, P25024, P09341, P18510, P09603, P01730IL1R2, IL1R1, CD27, IL10RA, CXCR1, CXCL1, IL1RN, CSF1, CD4More
Furosemidehsa04071Sphingolipid signaling pathway1.87E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Furosemidehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Furosemidehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Furosemidehsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Furosemidehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Furosemidehsa04613Neutrophil extracellular trap formation7.32E-0313O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Furosemidehsa04614Renin-angiotensin system2.52E-021P50052AGTR2More
Furosemidehsa04640Hematopoietic cell lineage7.16E-037P13612, P14778, P27930, P07766, P01730, P09564, P09603ITGA4, IL1R1, IL1R2, CD3E, CD4, CD7, CSF1More
Furosemidehsa04657IL-17 signaling pathway3.87E-038P07900, O00463, Q16539, P14780, Q9UJX4, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Furosemidehsa04658Th1 and Th2 cell differentiation4.54E-036P07766, P20963, P01730, P06239, Q9UL17, Q13761CD3E, CD247, CD4, LCK, TBX21, RUNX3More
Furosemidehsa04659Th17 cell differentiation1.43E-026P01730, P06239, P14778, Q9UL17, P07766, P20963CD4, LCK, IL1R1, TBX21, CD3E, CD247More
Furosemidehsa04664Fc epsilon RI signaling pathway2.18E-022P09917, P20292ALOX5, ALOX5APMore
Furosemidehsa04724Glutamatergic synapse2.72E-035P48058, P43003, P63218, P50151, P15104GRIA4, SLC1A3, GNG5, GNG10, GLULMore
Furosemidehsa04727GABAergic synapse3.89E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Furosemidehsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Furosemidehsa04962Vasopressin-regulated water reabsorption2.18E-022P52566, P62491ARHGDIB, RAB11AMore
Furosemidehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Furosemidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Furosemidehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Furosemidehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Furosemidehsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Furosemidehsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Furosemidehsa05133Pertussis4.20E-021P0C0L4C4AMore
Furosemidehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Furosemidehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Furosemidehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Furosemidehsa05146Amoebiasis4.54E-036Q13751, P09341, P14778, P27930, P05089, P12814LAMB3, CXCL1, IL1R1, IL1R2, ARG1, ACTN1More
Furosemidehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Furosemidehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Furosemidehsa05202Transcriptional misregulation in cancer1.45E-0212Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, GADD45AMore
Furosemidehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Furosemidehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Furosemidehsa05415Diabetic cardiomyopathy7.11E-035P05141, O15239, P13073, Q13557, P11413SLC25A5, NDUFA1, COX4I1, CAMK2D, G6PDMore

Community members of Furosemide (SDC: 2.92)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Reported10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P52209PGD6Nonephosphogluconate dehydrogenase, decarboxylatingPredicted00.1950.14540.26420.6525
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
O75493CA11Carbonic anhydraseNonerelated protein 11Predicted00.07450.061200.1597
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P43657P2RY5Lysophosphatidic acid receptor 6Predicted00.75390.04480.37080.8373
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
CA2P00918Ki65
CA2P00918Ki6.50E+04