PharmaCoNets of Fostamatinib (SPCN: 224.15 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Fostamatinibhsa00010Glycolysis / Gluconeogenesis3.64E-022P11766, P07195ADH5, LDHBMore
Fostamatinibhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Fostamatinibhsa00030Pentose phosphate pathway8.94E-114P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Fostamatinibhsa00040Pentose and glucuronate interconversions1.97E-032O60701, P14550UGDH, AKR1A1More
Fostamatinibhsa00051Fructose and mannose metabolism3.48E-045P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Fostamatinibhsa00052Galactose metabolism3.77E-045P06280, P08237, O43451, P15121, P19367GLA, PFKM, MGAM, AKR1B1, HK1More
Fostamatinibhsa00053Ascorbate and aldarate metabolism1.99E-021P14550AKR1A1More
Fostamatinibhsa00071Fatty acid degradation2.38E-023P11310, O75521, P33121ACADM, ECI2, ACSL1More
Fostamatinibhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Fostamatinibhsa00190Oxidative phosphorylation7.86E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Fostamatinibhsa00220Arginine biosynthesis7.40E-113P15104, P05089, P49448GLUL, ARG1, GLUD2More
Fostamatinibhsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Fostamatinibhsa00250Alanine, aspartate and glutamate metabolism2.86E-073Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Fostamatinibhsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Fostamatinibhsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Fostamatinibhsa00280Valine, leucine and isoleucine degradation1.93E-046P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Fostamatinibhsa00310Lysine degradation2.16E-067Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Fostamatinibhsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Fostamatinibhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Fostamatinibhsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Fostamatinibhsa00500Starch and sucrose metabolism3.15E-084O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Fostamatinibhsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Fostamatinibhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Fostamatinibhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Fostamatinibhsa00514Other types of O-glycan biosynthesis3.20E-022O15294, Q9NY28OGT, GALNT8More
Fostamatinibhsa00520Amino sugar and nucleotide sugar metabolism2.98E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Fostamatinibhsa00524Neomycin, kanamycin and gentamicin biosynthesis4.25E-021P19367HK1More
Fostamatinibhsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Fostamatinibhsa00562Inositol phosphate metabolism4.54E-045Q9NRR6, P27987, O14732, P19174, P42338INPP5E, ITPKB, IMPA2, PLCG1, PIK3CBMore
Fostamatinibhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Fostamatinibhsa00564Glycerophospholipid metabolism1.25E-046P48651, Q9Y6K0, P35790, P23743, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, DGKA, PLPP1, ADPRMMore
Fostamatinibhsa00565Ether lipid metabolism3.94E-021Q8N661TMEM86BMore
Fostamatinibhsa00590Arachidonic acid metabolism2.97E-021P09917ALOX5More
Fostamatinibhsa00600Sphingolipid metabolism2.90E-043Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Fostamatinibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Fostamatinibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Fostamatinibhsa00620Pyruvate metabolism2.51E-022P07195, P11766LDHB, ADH5More
Fostamatinibhsa00630Glyoxylate and dicarboxylate metabolism5.29E-084P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Fostamatinibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Fostamatinibhsa00670One carbon pool by folate1.72E-053O95954, P04818, Q99707FTCD, TYMS, MTRMore
Fostamatinibhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Fostamatinibhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Fostamatinibhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Fostamatinibhsa00770Pantothenate and CoA biosynthesis3.98E-021Q6ZQY3GADL1More
Fostamatinibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Fostamatinibhsa00790Folate biosynthesis3.23E-033P05186, P07101, P42330ALPL, TH, AKR1C3More
Fostamatinibhsa00830Retinol metabolism3.35E-045P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Fostamatinibhsa00860Porphyrin and chlorophyll metabolism2.26E-033P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Fostamatinibhsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Fostamatinibhsa00910Nitrogen metabolism4.93E-062P15104, P49448GLUL, GLUD2More
Fostamatinibhsa00920Sulfur metabolism3.18E-021Q16762TSTMore
Fostamatinibhsa00970Aminoacyl-tRNA biosynthesis2.65E-034O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Fostamatinibhsa00980Metabolism of xenobiotics by cytochrome P4503.20E-022P78417, P11712GSTO1, CYP2C9More
Fostamatinibhsa00982Drug metabolism - cytochrome P4503.20E-022P11712, P78417CYP2C9, GSTO1More
Fostamatinibhsa00983Drug metabolism - other enzymes9.78E-065P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Fostamatinibhsa01100Metabolic pathways8.01E-0769Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, Q9UJ14, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, Q86XP1, O95861, Q96RQ9, Q9HCC0, P33121, Q9UHK6, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P57054, Q14442, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, GGTL3, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKH, BPNT1, IL4I1, MCCC2, ACSL1, AMACR, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, PIGP, PIGH, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHEMore
Fostamatinibhsa01200Carbon metabolism1.47E-025P04406, P52209, P37837, Q9P2R7, P11766GAPDH, PGD, TALDO1, SUCLA2, ADH5More
Fostamatinibhsa012102-Oxocarboxylic acid metabolism1.40E-021P50213IDH3AMore
Fostamatinibhsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Fostamatinibhsa01230Biosynthesis of amino acids2.13E-057P51854, P60891, Q99707, P50213, P05089, P15104, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, GLUL, TALDO1More
Fostamatinibhsa01240Biosynthesis of cofactors1.53E-058Q969G6, P13716, P36551, P22557, O60701, P14550, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, AKR1A1, PKM2, LIPT1More
Fostamatinibhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Fostamatinibhsa01522Endocrine resistance1.02E-047P04049, Q9UM47, P04637, P42773, P08069, P10415, Q13323RAF1, NOTCH3, TP53, CDKN2C, IGF1R, BCL2, BIKMore
Fostamatinibhsa01523Antifolate resistance1.88E-034P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Fostamatinibhsa01524Platinum drug resistance1.28E-048P10415, Q13489, P98170, Q14790, P48023, P78417, P43246, P31751BCL2, BIRC3, BIRC4, CASP8, FASLG, GSTO1, MSH2, AKT2More
Fostamatinibhsa02010ABC transporters4.48E-021Q8IZY2ABCA7More
Fostamatinibhsa03010Ribosome4.35E-1124P26373, P62753, P42677, P25398, P32969, P62917, P62829, P46776, P46777, Q9H0U6, Q07020, P62888, P62899, P62910, P18077, P61927, P61513, Q02878, P36578, P27635, P50914, P05386, P62249, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL8, RPL23, RPL27A, RPL5, MRPL18, RPL18, RPL30, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPL6, RPL4, RPL10, RPL14, RPLP1, RPS16, RPS3More
Fostamatinibhsa03013RNA transport1.48E-2029P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1More
Fostamatinibhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Fostamatinibhsa03020RNA polymerase5.44E-094P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Fostamatinibhsa03040Spliceosome1.09E-1623Q14562, O43143, O60508, P17844, O14776, P08579, P26368, O75940, P52298, P09651, Q15365, O75494, Q13595, Q07955, Q01130, P84103, Q13243, Q16629, P11142, Q9Y2W2, O43447, O75643, P61326DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, U2AF2, SMNDC1, NCBP2, HNRNPA1, PCBP1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, SFRS7, HSPA8, WBP11, PPIH, ASCC3L1, MAGOHMore
Fostamatinibhsa03060Protein export3.67E-094Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Fostamatinibhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Fostamatinibhsa03430Mismatch repair4.38E-021P20585MSH3More
Fostamatinibhsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Fostamatinibhsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Fostamatinibhsa04010MAPK signaling pathway8.69E-054P04049, P08069, Q9H2K8, Q12933RAF1, IGF1R, TAOK3, TRAF2More
Fostamatinibhsa04012ErbB signaling pathway3.61E-057Q13153, P16333, Q13191, P19174, P42338, P01106, P04049PAK1, NCK1, CBLB, PLCG1, PIK3CB, MYC, RAF1More
Fostamatinibhsa04014Ras signaling pathway1.95E-0616P04049, P31751, P42338, P20827, P49767, P08069, Q13009, P17252, Q15311, Q7LDG7, Q14644, P0DP23, P62873, P63218, P50151, P19174RAF1, AKT2, PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, PRKCA, RALBP1, RASGRP2, RASA3, CALM1, GNB1, GNG5, GNG10, PLCG1More
Fostamatinibhsa04015Rap1 signaling pathway2.24E-0720P04049, P20827, P49767, P08069, P06213, Q96FS4, P11215, P25116, Q8TEU7, Q13009, O00522, Q7LDG7, Q08828, P51828, P42338, P31751, P0DP23, P08514, P17252, P19174RAF1, EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, KRIT1, RASGRP2, ADCY1, ADCY7, PIK3CB, AKT2, CALM1, ITGA2B, PRKCA, PLCG1More
Fostamatinibhsa04020Calcium signaling pathway2.19E-1016P27987, Q96DU7, Q08828, P45880, Q13557, P17252, P21860, O15399, P19174, P61073, P0DP24, P0DP23, P05141, P51828, P23634, P49767ITPKB, ITPKC, ADCY1, VDAC2, CAMK2D, PRKCA, ERBB3, GRIN2D, PLCG1, CXCR4, CALM2, CALM1, SLC25A5, ADCY7, ATP2B4, VEGFCMore
Fostamatinibhsa04022cGMP-PKG signaling pathway1.32E-0712Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Fostamatinibhsa04024cAMP signaling pathway8.25E-0611Q08828, P51828, P31751, P0DP23, P23634, P04049, Q13557, Q13370, O15399, Q13009, Q13153ADCY1, ADCY7, AKT2, CALM1, ATP2B4, RAF1, CAMK2D, PDE3B, GRIN2D, TIAM1, PAK1More
Fostamatinibhsa04060Cytokine-cytokine receptor interaction5.78E-1025P14784, P27930, P14778, P37173, P08476, P26842, Q06643, Q9UHF4, Q13651, P16871, Q9HBE5, P78552, P25024, P25025, Q9UBD3, P47992, P02775, P01375, P09341, P19875, P32248, P80075, P18510, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, INHBA, CD27, LTB, IL20RA, IL10RA, IL7R, IL21R, IL13RA1, CXCR1, CXCR2, XCL2, XCL1, PPBP, TNF, CXCL1, CXCL2, CCR7, CCL8, IL1RN, CD4, TNFRSF25More
Fostamatinibhsa04061Viral protein interaction with cytokine and cytokine receptor3.47E-1012Q8NHW4, P32248, P09341, P25024, P02775, P25025, P47992, Q9UBD3, Q13651, P14784, Q9UHF4, P01375CCL4L2, CCR7, CXCL1, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL10RA, IL2RB, IL20RA, TNFMore
Fostamatinibhsa04062Chemokine signaling pathway4.10E-0926P51684, P25024, P09341, Q8NHW4, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q08828, P51828, Q7LDG7, Q13009, P14598, P42224, P31751, P04049, P25963, Q8WYR1CCR6, CXCR1, CXCL1, CCL4L2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, ADCY1, ADCY7, RASGRP2, TIAM1, NCF1, STAT1, AKT2, RAF1, NFKBIA, PIK3R5More
Fostamatinibhsa04064NF-kappa B signaling pathway2.93E-1926P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, O75293, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, GADD45B, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Fostamatinibhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Fostamatinibhsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Fostamatinibhsa04070Phosphatidylinositol signaling system2.52E-0812P19174, P0DP23, Q14643, O14986, P23743, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIP5K1B, DGKA, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Fostamatinibhsa04071Sphingolipid signaling pathway5.57E-0715P04049, P17252, P21453, Q9H228, P01375, Q96G23, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2, Q12933, Q02156, P01042RAF1, PRKCA, S1PR1, EDG8, TNF, LASS2, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2, TRAF2, PRKCE, KNG1More
Fostamatinibhsa04072Phospholipase D signaling pathway7.01E-0612P04049, P31751, Q9UQC2, P19174, P17252, O14986, Q15438, Q08828, P51828, P23743, Q16760, P00734RAF1, AKT2, GAB2, PLCG1, PRKCA, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKA, DGKD, F2More
Fostamatinibhsa04080Neuroactive ligand-receptor interaction1.67E-039P08311, Q15722, P21453, Q9H228, P43657, P21462, P21730, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY5, FPR1, C5AR1, ADRB2, ADMMore
Fostamatinibhsa04110Cell cycle5.36E-0914Q9UBD5, P30260, P06493, O60566, Q09472, Q14683, P24522, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, BUB1B, EP300, SMC1A, GADD45A, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Fostamatinibhsa04114Oocyte meiosis6.47E-1111Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Fostamatinibhsa04115p53 signaling pathway2.54E-023O15151, Q13315, P10415MDM4, ATM, BCL2More
Fostamatinibhsa04120Ubiquitin mediated proteolysis1.62E-034O00762, O95071, Q14139, P0CG47UBE2C, UBR5, UBE4A, UBBMore
Fostamatinibhsa04122Sulfur relay system3.18E-021Q16762TSTMore
Fostamatinibhsa04136Autophagy - other7.59E-032O94817, Q9H1Y0ATG12, ATG5More
Fostamatinibhsa04137Mitophagy - animal3.19E-055P67870, Q07817, P19532, P18848, P0CG47CSNK2B, BCL2L1, TFE3, ATF4, UBBMore
Fostamatinibhsa04140Autophagy - animal3.73E-0616P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, Q96RR4, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, CAMKK2, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Fostamatinibhsa04141Protein processing in endoplasmic reticulum1.13E-0412P18848, Q12933, P30101, Q15436, P60604, Q99941, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9UNL2ATF4, TRAF2, PDIA3, SEC23A, UBE2G2, CREBL1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SSR3More
Fostamatinibhsa04142Lysosome1.89E-0613Q99437, P25774, O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900ATP6V0B, CTSS, TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Fostamatinibhsa04144Endocytosis3.76E-0822Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, Q9NZZ3, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, Q96QK1, O75154, Q9UMY4, Q9Y5X3, Q9UNH7CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, VPS35, RAB11FIP3, SNX12, SNX5, SNX6More
Fostamatinibhsa04145Phagosome3.59E-0613O75015, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Fostamatinibhsa04146Peroxisome1.43E-024O00623, P56589, Q9UKG9, P33121PEX12, PEX3, CROT, ACSL1More
Fostamatinibhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Fostamatinibhsa04151PI3K-Akt signaling pathway5.18E-0938P62753, P42338, P21860, P43657, P25116, O43521, P04637, P27348, P20827, P49767, Q13362, P07900, P08238, Q8WYR1, P62873, P63218, P50151, P61952, P16144, O15335, P02452, P24821, Q16363, Q13751, P22105, O60603, P14784, P23458, P01568, Q99941, P18848, P10415, P17252, Q96BR1, O00141, Q6ZUJ8, P30281, P56279RPS6, PIK3CB, ERBB3, P2RY5, F2R, BCL2L11, TP53, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, GNG11, ITGB4, CHAD, COL1A1, TNC, LAMA4, LAMB3, TNXB, TLR2, IL2RB, JAK1, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK3, SGK, PIK3AP1, CCND3, TCL1AMore
Fostamatinibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Fostamatinibhsa04210Apoptosis1.18E-0513Q07817, P04637, O76075, Q14790, P48023, P24522, Q16548, P43234, Q14643, P42575, P63261, Q71U36, P04049BCL2L1, TP53, DFFB, CASP8, FASLG, GADD45A, BCL2A1, CTSO, ITPR1, CASP2, ACTG1, TUBA1A, RAF1More
Fostamatinibhsa04211Longevity regulating pathway2.60E-046P31751, P08069, Q08828, P51828, P18848, Q96RR4AKT2, IGF1R, ADCY1, ADCY7, ATF4, CAMKK2More
Fostamatinibhsa04213Longevity regulating pathway - multiple species2.13E-0813O43524, P31751, P42338, P08069, Q9Y4H2, P22694, Q08828, P51828, P0DMV8, P11142, Q9H1Y0, Q96EB6, Q13547FOXO3, AKT2, PIK3CB, IGF1R, IRS2, PRKACB, ADCY1, ADCY7, HSPA1A, HSPA8, ATG5, SIRT1, HDAC1More
Fostamatinibhsa04217Necroptosis3.97E-1922Q12933, P01568, P23458, Q13489, Q9NQC7, Q13546, P42224, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351, P45880, Q08752TRAF2, IFNA21, JAK1, BIRC3, CYLD, RIPK1, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4B, VDAC2, PPIDMore
Fostamatinibhsa04218Cellular senescence1.96E-047P31751, P04049, P30281, P0DP23, P01889, P10321, P12236AKT2, RAF1, CCND3, CALM1, HLA-B, HLA-C, SLC25A6More
Fostamatinibhsa04260Cardiac muscle contraction2.85E-034Q8IZS8, P67936, P13073, P12074CACNA2D3, TPM4, COX4I1, COX6A1More
Fostamatinibhsa04261Adrenergic signaling in cardiomyocytes5.10E-1415P09493, P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, P0DP24, Q13557, P17252, P10415, P23634TPM1, TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4More
Fostamatinibhsa04270Vascular smooth muscle contraction9.79E-0711P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Fostamatinibhsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Fostamatinibhsa04330Notch signaling pathway6.65E-033Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Fostamatinibhsa04340Hedgehog signaling pathway1.52E-045P49841, P17612, P22694, Q13635, P10415GSK3B, PRKACA, PRKACB, PTCH1, BCL2More
Fostamatinibhsa04360Axon guidance5.16E-0716P61073, P16298, Q05397, P16333, P20827, O95631, P17252, Q13873, Q13557, P42338, P07332, P23528, P04049, P19174, O14639, P24844CXCR4, PPP3CB, PTK2, NCK1, EFNA1, NTN1, PRKCA, BMPR2, CAMK2D, PIK3CB, FES, CFL1, RAF1, PLCG1, ABLIM1, MYL9More
Fostamatinibhsa04370VEGF signaling pathway6.18E-137P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Fostamatinibhsa04371Apelin signaling pathway4.93E-0918P62873, P63218, P50151, P61952, Q8WYR1, P31751, P04049, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P84022, P62753, Q16566, P0DP24, P0DP23GNB1, GNG5, GNG10, GNG11, PIK3R5, AKT2, RAF1, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, RPS6, CAMK4, CALM2, CALM1More
Fostamatinibhsa04380Osteoclast differentiation6.90E-0813Q9NQC7, Q9UQC2, Q16539, P23458, P42224, P31751, P01584, P14778, O75015, P01375, Q15080, P14598, Q8N149CYLD, GAB2, MAPK14, JAK1, STAT1, AKT2, IL1B, IL1R1, FCGR3B, TNF, NCF4, NCF1, LILRA2More
Fostamatinibhsa04390Hippo signaling pathway3.37E-055O95835, P04628, Q9UJU2, O43623, Q13489LATS1, WNT1, LEF1, SNAI2, BIRC3More
Fostamatinibhsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Fostamatinibhsa04510Focal adhesion5.54E-0411P16144, O75369, Q15942, P17252, P51636, Q13489, P10415, P30281, P04049, P08069, P49767ITGB4, FLNB, ZYX, PRKCA, CAV2, BIRC3, BCL2, CCND3, RAF1, IGF1R, VEGFCMore
Fostamatinibhsa04512ECM-receptor interaction3.06E-066P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Fostamatinibhsa04514Cell adhesion molecules8.19E-033P16109, P56750, O00501SELP, CLDN17, CLDN5More
Fostamatinibhsa04520Adherens junction8.29E-031P08069IGF1RMore
Fostamatinibhsa04530Tight junction1.38E-045Q8TEU7, P16989, P56750, O00501, Q14247RAPGEF6, CSDA, CLDN17, CLDN5, CTTNMore
Fostamatinibhsa04540Gap junction1.26E-0610P17252, Q13509, P68371, Q08828, P51828, Q71U36, Q02153, P04049, Q9NRA1, Q14643PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7, TUBA1A, GUCY1B3, RAF1, PDGFC, ITPR1More
Fostamatinibhsa04550Signaling pathways regulating pluripotency of stem cells1.06E-047P04628, P40189, Q13873, P04049, Q02750, P08069, Q86SE9WNT1, IL6ST, BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Fostamatinibhsa04610Complement and coagulation cascades4.70E-095P25116, P09871, P0C0L4, P20023, P05107F2R, C1S, C4A, CR2, ITGB2More
Fostamatinibhsa04611Platelet activation4.62E-097P25116, Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359F2R, TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Fostamatinibhsa04612Antigen processing and presentation1.92E-0912P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, PDIA3, HSPA8, TNFMore
Fostamatinibhsa04613Neutrophil extracellular trap formation2.42E-0828P19174, P17252, P04049, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q99878, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PLCG1, PRKCA, RAF1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, H2AC14, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Fostamatinibhsa04620Toll-like receptor signaling pathway3.57E-067P51617, Q13546, P01568, P01584, P31751, P42224, Q8NHW4IRAK1, RIPK1, IFNA21, IL1B, AKT2, STAT1, CCL4L2More
Fostamatinibhsa04621NOD-like receptor signaling pathway2.92E-0518P01584, P07900, P08238, Q14643, P23458, P42224, P01568, P45880, Q9H3M7, Q13489, P10599, P43490, O00463, P10415, P29728, P01375, P09341, P12838IL1B, HSP90AA1, HSP90AB1, ITPR1, JAK1, STAT1, IFNA21, VDAC2, TXNIP, BIRC3, TXN, PBEF1, TRAF5, BCL2, OAS2, TNF, CXCL1, DEFA4More
Fostamatinibhsa04622RIG-I-like receptor signaling pathway1.29E-075P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Fostamatinibhsa04623Cytosolic DNA-sensing pathway1.90E-105P01584, P01568, Q13546, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, POLR3H, CCL4L2More
Fostamatinibhsa04625C-type lectin receptor signaling pathway2.20E-0813Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, Q9UDY8, Q14643, P01375, Q13191, P31751, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, MALT1, ITPR1, TNF, CBLB, AKT2, CALM1, MAPK14More
Fostamatinibhsa04630JAK-STAT signaling pathway7.27E-0815P01106, P31751, P10415, Q09472, P42224, O75925, P23458, P14784, P40189, P16871, Q13651, Q9UHF4, Q06124, P04049, P01568MYC, AKT2, BCL2, EP300, STAT1, PIAS1, JAK1, IL2RB, IL6ST, IL7R, IL10RA, IL20RA, PTPN11, RAF1, IFNA21More
Fostamatinibhsa04640Hematopoietic cell lineage2.64E-1419P13612, P07359, P08514, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P16871, P13765, P01375ITGA4, GP1BA, ITGA2B, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, IL7R, HLA-DOB, TNFMore
Fostamatinibhsa04650Natural killer cell mediated cytotoxicity3.23E-1718P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Fostamatinibhsa04657IL-17 signaling pathway3.72E-0816P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P14780, Q9UJX4, P04141, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, CSF2, LCN2, TNF, S100A9, IL1BMore
Fostamatinibhsa04658Th1 and Th2 cell differentiation4.31E-3617P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, RUNX3More
Fostamatinibhsa04659Th17 cell differentiation4.96E-2819P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Fostamatinibhsa04660T cell receptor signaling pathway3.09E-2519P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Fostamatinibhsa04662B cell receptor signaling pathway1.45E-1614P25963, P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049NFKBIA, AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Fostamatinibhsa04664Fc epsilon RI signaling pathway2.22E-079P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5More
Fostamatinibhsa04666Fc gamma R-mediated phagocytosis1.94E-0310P08637, O75015, P08575, P19174, P04049, P23528, P06396, Q9UQC2, P14598, P17252FCGR3A, FCGR3B, PTPRC, PLCG1, RAF1, CFL1, GSN, GAB2, NCF1, PRKCAMore
Fostamatinibhsa04668TNF signaling pathway4.51E-0511P01375, Q12933, O00463, Q16539, Q99941, P18848, P01584, P20749, P14780, P20333, O95429TNF, TRAF2, TRAF5, MAPK14, CREBL1, ATF4, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Fostamatinibhsa04672Intestinal immune network for IgA production1.40E-044P29965, P10747, P13765, P13612CD40LG, CD28, HLA-DOB, ITGA4More
Fostamatinibhsa04710Circadian rhythm2.11E-031O15516CLOCKMore
Fostamatinibhsa04713Circadian entrainment3.96E-1211O15399, P0DP24, P0DP23, Q13557, Q02153, P17252, P62873, P61952, Q14643, Q08828, P51828GRIN2D, CALM2, CALM1, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG11, ITPR1, ADCY1, ADCY7More
Fostamatinibhsa04714Thermogenesis2.57E-0310P22694, Q16539, Q969G3, Q92618, P62753, P33121, P13073, Q7KZN9, Q16718, O14521PRKACB, MAPK14, SMARCE1, ZNF516, RPS6, ACSL1, COX4I1, COX15, NDUFA5, SDHDMore
Fostamatinibhsa04720Long-term potentiation1.62E-1213P17252, Q13557, P16298, P0DP24, P0DP23, Q15418, P51812, P18848, O15399, Q08828, Q02750, P04049, Q14643PRKCA, CAMK2D, PPP3CB, CALM2, CALM1, RPS6KA1, RPS6KA3, ATF4, GRIN2D, ADCY1, MAP2K1, RAF1, ITPR1More
Fostamatinibhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Fostamatinibhsa04722Neurotrophin signaling pathway9.79E-067Q05655, P31751, P04049, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, ARHGDIB, IRAK1, BCL2, CALM1More
Fostamatinibhsa04723Retrograde endocannabinoid signaling1.69E-037Q14643, P17252, P62873, P61952, Q08828, O15239, Q16718ITPR1, PRKCA, GNB1, GNG11, ADCY1, NDUFA1, NDUFA5More
Fostamatinibhsa04724Glutamatergic synapse5.51E-069O15399, Q08828, P51828, P17252, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, ADCY7, PRKCA, GNB1, GNG5, GNG10, GNG11, GLULMore
Fostamatinibhsa04725Cholinergic synapse7.90E-1113Q08828, P51828, Q14643, P17252, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Fostamatinibhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Fostamatinibhsa04727GABAergic synapse1.46E-0810Q08828, P51828, P62873, P63218, P50151, P61952, P15104, P46459, Q15111, P17252ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, NSF, PLCL1, PRKCAMore
Fostamatinibhsa04728Dopaminergic synapse1.29E-1018Q14643, P17252, P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP24, P0DP23, O15516, P48058ITPR1, PRKCA, GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM2, CALM1, CLOCK, GRIA4More
Fostamatinibhsa04730Long-term depression1.25E-042P08069, P04049IGF1R, RAF1More
Fostamatinibhsa04740Olfactory transduction7.78E-094P62873, Q13557, P0DP24, P0DP23GNB1, CAMK2D, CALM2, CALM1More
Fostamatinibhsa04742Taste transduction3.91E-021P17612PRKACAMore
Fostamatinibhsa04744Phototransduction1.11E-163P62873, P0DP24, P0DP23GNB1, CALM2, CALM1More
Fostamatinibhsa04750Inflammatory mediator regulation of TRP channels1.18E-1415P14778, P01584, Q08828, P51828, Q13557, Q16539, P19174, P42338, Q14643, P17252, P24723, Q04759, P0DP23, P0DP24, P01042IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCA, PRKCH, PRKCQ, CALM1, CALM2, KNG1More
Fostamatinibhsa04810Regulation of actin cytoskeleton1.41E-039Q15746, Q13009, P04049, P08514, P11215, P16144, P25116, P60709, P01042MYLK, TIAM1, RAF1, ITGA2B, ITGAM, ITGB4, F2R, ACTB, KNG1More
Fostamatinibhsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Fostamatinibhsa04911Insulin secretion1.80E-076Q08828, P51828, P17252, Q99941, P18848, Q13557ADCY1, ADCY7, PRKCA, CREBL1, ATF4, CAMK2DMore
Fostamatinibhsa04912GnRH signaling pathway8.90E-0812P17252, Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23, P22694, P04049, P45985PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1, PRKACB, RAF1, MAP2K4More
Fostamatinibhsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Fostamatinibhsa04914Progesterone-mediated oocyte maturation6.57E-0912P08069, Q17RY0, Q08828, P51828, P31751, Q13370, Q9UJX4, Q9Y6D9, P08238, P51812, Q02750, P04049IGF1R, CPEB4, ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Fostamatinibhsa04915Estrogen signaling pathway6.35E-1114P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P08238, P0DMV8, P11142, P0DP23, P0DP24, Q15788, P10415RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSP90AB1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1, BCL2More
Fostamatinibhsa04916Melanogenesis7.65E-054P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Fostamatinibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Fostamatinibhsa04918Thyroid hormone synthesis2.47E-045Q08828, Q99941, P18848, P02768, P05543ADCY1, CREBL1, ATF4, ALB, SERPINA7More
Fostamatinibhsa04919Thyroid hormone signaling pathway1.21E-047P19174, P04049, P42224, P60709, Q13547, Q9UM47, P01106PLCG1, RAF1, STAT1, ACTB, HDAC1, NOTCH3, MYCMore
Fostamatinibhsa04920Adipocytokine signaling pathway3.82E-043Q06124, Q9Y478, P31751PTPN11, PRKAB1, AKT2More
Fostamatinibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Fostamatinibhsa04922Glucagon signaling pathway3.24E-059P14618, P06737, Q09472, Q12778, P31751, Q13370, P0DP23, Q14643, P07195PKM2, PYGL, EP300, FOXO1, AKT2, PDE3B, CALM1, ITPR1, LDHBMore
Fostamatinibhsa04923Regulation of lipolysis in adipocytes6.66E-075Q08828, P51828, P06213, Q13370, P31751ADCY1, ADCY7, INSR, PDE3B, AKT2More
Fostamatinibhsa04924Renin secretion1.08E-055P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Fostamatinibhsa04925Aldosterone synthesis and secretion7.74E-119Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, P17252, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, PRKCA, CAMK2D, ATP2B4More
Fostamatinibhsa04926Relaxin signaling pathway9.79E-0713P31751, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P49407AKT2, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, ARRB1More
Fostamatinibhsa04927Cortisol synthesis and secretion2.32E-054Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Fostamatinibhsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Fostamatinibhsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Fostamatinibhsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Fostamatinibhsa04931Insulin resistance1.48E-022Q06124, Q9Y478PTPN11, PRKAB1More
Fostamatinibhsa04932Non-alcoholic fatty liver disease4.37E-1212P31751, Q14790, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, O95298, P19404AKT2, CASP8, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2, NDUFV2More
Fostamatinibhsa04933AGE-RAGE signaling pathway in diabetic complications8.59E-1011P84022, Q13485, P01584, P42224, P10415, P31751, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, IL1B, STAT1, BCL2, AKT2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Fostamatinibhsa04934Cushing syndrome2.02E-099Q14643, Q99941, P18848, Q08828, P51828, O15169, Q9UJU2, Q13557, P42773ITPR1, CREBL1, ATF4, ADCY1, ADCY7, AXIN1, LEF1, CAMK2D, CDKN2CMore
Fostamatinibhsa04935Growth hormone synthesis, secretion and action2.10E-049P19174, Q08828, P51828, P04049, P17252, P18848, P31751, P42224, P45985PLCG1, ADCY1, ADCY7, RAF1, PRKCA, ATF4, AKT2, STAT1, MAP2K4More
Fostamatinibhsa04940Type I diabetes mellitus1.55E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Fostamatinibhsa04960Aldosterone-regulated sodium reabsorption7.59E-032O00141, P06213SGK, INSRMore
Fostamatinibhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Fostamatinibhsa04966Collecting duct acid secretion1.95E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Fostamatinibhsa04970Salivary secretion1.88E-1211P07550, Q08828, P51828, P22694, Q14643, P23634, P17252, P0DP23, P0DP24, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM1, CALM2, GUCY1B3, CAMPMore
Fostamatinibhsa04971Gastric acid secretion4.22E-086Q08828, P51828, P15311, P0DP23, P0DP24, Q13557ADCY1, ADCY7, VIL2, CALM1, CALM2, CAMK2DMore
Fostamatinibhsa04972Pancreatic secretion1.92E-035P23634, P17252, Q08828, P51828, P62491ATP2B4, PRKCA, ADCY1, ADCY7, RAB11AMore
Fostamatinibhsa04973Carbohydrate digestion and absorption2.41E-021P31751AKT2More
Fostamatinibhsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Fostamatinibhsa04975Fat digestion and absorption4.83E-021O14494PLPP1More
Fostamatinibhsa04976Bile secretion2.70E-064Q08828, P51828, Q14032, Q9BY07ADCY1, ADCY7, BAAT, SLC4A5More
Fostamatinibhsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Fostamatinibhsa05010Alzheimer disease1.66E-0926P49768, Q92542, O15239, Q16718, O95298, P19404, O14521, P05496, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P01584, Q12933, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, Q08752, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, IL1B, TRAF2, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, PPID, PSMB4, PSMC4More
Fostamatinibhsa05012Parkinson disease7.54E-0520P0CG47, O15239, Q16718, O95298, O14521, P13073, P12074, P05496, P05141, O75460, P18848, P28070, Q14643, P0DP24, P0DP23, Q13557, Q71U36, Q13509, P68371, Q07817UBB, NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, ERN1, ATF4, PSMB4, ITPR1, CALM2, CALM1, CAMK2D, TUBA1A, TUBB3, TUBB2C, BCL2L1More
Fostamatinibhsa05014Amyotrophic lateral sclerosis4.18E-025P19404, P12074, O75460, P28070, Q8TEV9NDUFV2, COX6A1, ERN1, PSMB4, SMCR8More
Fostamatinibhsa05016Huntington disease1.51E-0612O95298, P19404, P13073, P12074, P24928, P30876, P62487, P05141, P45880, O75460, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC2, ERN1, PSMB4, PSMD12More
Fostamatinibhsa05017Spinocerebellar ataxia1.75E-0411P17252, Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, O00232, P05141, P21796PRKCA, FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, PSMD12, SLC25A5, VDAC1More
Fostamatinibhsa05020Prion disease8.82E-0621P01584, P46531, P0DMV8, P11142, O15239, Q16718, O95298, O14521, P05496, P13073, P12074, Q14643, P18848, P05141, P28070, Q13509, P68371, P67870, Q99941, P14598, Q15080IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, ATF4, SLC25A5, PSMB4, TUBB3, TUBB2C, CSNK2B, CREBL1, NCF1, NCF4More
Fostamatinibhsa05022Pathways of neurodegeneration - multiple diseases4.23E-1136Q14643, Q13509, P68371, P67870, P10415, O15239, Q16718, O95298, P19404, O14521, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, Q13561, P05141, P45880, P17252, P20333, Q15078, Q00535, O15169, P01584, P49768, Q08752, O15020, P0DP23, P0DP24, Q13557, P62987, P28070, P43686ITPR1, TUBB3, TUBB2C, CSNK2B, BCL2, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, DCTN2, SLC25A5, VDAC2, PRKCA, TNFRSF1B, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, PPID, SPTBN2, CALM1, CALM2, CAMK2D, UBA52, PSMB4, PSMC4More
Fostamatinibhsa05030Cocaine addiction5.99E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Fostamatinibhsa05031Amphetamine addiction8.12E-067O15399, P0DP24, P0DP23, Q13557, Q99941, P18848, P17252GRIN2D, CALM2, CALM1, CAMK2D, CREBL1, ATF4, PRKCAMore
Fostamatinibhsa05032Morphine addiction5.61E-035Q08828, P51828, P62873, Q13370, P17252ADCY1, ADCY7, GNB1, PDE3B, PRKCAMore
Fostamatinibhsa05034Alcoholism5.88E-0514Q99941, P18848, Q16566, Q13547, P0DP24, P0DP23, P62873, P61952, P04049, P0C0S5, P62807, Q16778, O60814, P68431CREBL1, ATF4, CAMK4, HDAC1, CALM2, CALM1, GNB1, GNG11, RAF1, H2AFZ, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Fostamatinibhsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Fostamatinibhsa05110Vibrio cholerae infection1.86E-042Q99437, P17612ATP6V0B, PRKACAMore
Fostamatinibhsa05120Epithelial cell signaling in Helicobacter pylori infection2.55E-1010Q16539, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240MAPK14, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSKMore
Fostamatinibhsa05130Pathogenic Escherichia coli infection8.48E-0513Q14247, P56750, O00501, P16333, Q13509, P60709, P25116, P25963, P04406, P29350, Q15438, P35579, P55061CTTN, CLDN17, CLDN5, NCK1, TUBB3, ACTB, F2R, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Fostamatinibhsa05131Shigellosis8.40E-0723Q12933, Q13546, P14778, Q16539, P68431, Q05655, Q02156, Q04759, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q14247, Q96JJ3, P63261, Q05397, Q14643, Q12778, P04637, Q13315, P10415, Q08752, P07737TRAF2, RIPK1, IL1R1, MAPK14, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, PRKCQ, MALT1, RRAGD, UBB, SEPT6, CTTN, ELMO2, ACTG1, PTK2, ITPR1, FOXO1, TP53, ATM, BCL2, PPID, PFN1More
Fostamatinibhsa05132Salmonella infection5.79E-1224P51617, P01584, P25963, P08238, P04049, Q9UJU2, P01106, P84095, P60709, Q96RF0, Q13546, Q13489, P10415, P04406, P08575, O75369, P07737, O60603, Q9BQS8, Q13561, Q13509, P68371, P49754, Q9NP90IRAK1, IL1B, NFKBIA, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, SNAG1, RIPK1, BIRC3, BCL2, GAPDH, PTPRC, FLNB, PFN1, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41, RAB9BMore
Fostamatinibhsa05133Pertussis2.33E-1010P11215, P05107, P0DP23, P01584, P10145, P23528, P09871, P0C0L4, P51617, Q02556ITGAM, ITGB2, CALM1, IL1B, IL8, CFL1, C1S, C4A, IRAK1, IRF8More
Fostamatinibhsa05134Legionellosis2.58E-089P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Fostamatinibhsa05135Yersinia infection1.86E-048Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8AMore
Fostamatinibhsa05140Leishmaniasis3.51E-0913P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Fostamatinibhsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Fostamatinibhsa05143African trypanosomiasis2.64E-045P01584, P69905, P68871, P17252, P01042IL1B, HBA2, HBB, PRKCA, KNG1More
Fostamatinibhsa05144Malaria4.06E-069P60033, P69905, P68871, O60603, P01375, P05107, P35443, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1More
Fostamatinibhsa05145Toxoplasmosis3.25E-0714P51617, P25963, P10415, Q13489, P23458, P42224, P13765, Q14790, P31751, Q13751, P11142, O60603, P29965, Q13651IRAK1, NFKBIA, BCL2, BIRC3, JAK1, STAT1, HLA-DOB, CASP8, AKT2, LAMB3, HSPA8, TLR2, CD40LG, IL10RAMore
Fostamatinibhsa05146Amoebiasis8.16E-1712P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Fostamatinibhsa05150Staphylococcus aureus infection5.41E-0815P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Fostamatinibhsa05152Tuberculosis1.89E-0617P04049, Q13488, Q99437, P0DP23, O75015, P42224, P48382, O60603, P01375, P31751, P10415, P13765, P25774, P01568, Q9UDY8, Q16539, P51617RAF1, TCIRG1, ATP6V0B, CALM1, FCGR3B, STAT1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CTSS, IFNA21, MALT1, MAPK14, IRAK1More
Fostamatinibhsa05160Hepatitis C2.32E-033Q13546, P01568, P04049RIPK1, IFNA21, RAF1More
Fostamatinibhsa05161Hepatitis B3.11E-0612P17252, P04049, Q99941, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617PRKCA, RAF1, CREBL1, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1More
Fostamatinibhsa05162Measles8.89E-0813P51617, P01568, P23458, P42224, P14784, P31751, P0DMV8, P11142, P01584, P19784, P67870, Q9NP90, P10415IRAK1, IFNA21, JAK1, STAT1, IL2RB, AKT2, HSPA1A, HSPA8, IL1B, CSNK2A2, CSNK2B, RAB9B, BCL2More
Fostamatinibhsa05163Human cytomegalovirus infection6.85E-1327P31751, P04049, P01375, P62873, P50151, P61952, Q14643, P0DP23, P0DP24, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, P17252, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P61769, P01568AKT2, RAF1, TNF, GNB1, GNG10, GNG11, ITPR1, CALM1, CALM2, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, PRKCA, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, B2M, IFNA21More
Fostamatinibhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Fostamatinibhsa05165Human papillomavirus infection7.06E-0517P16144, P02452, P24821, Q16363, Q05086, P30281, Q9UM47, P01568, P42224, P01889, P10321, Q13488, Q99437, Q13362, Q12778, P04628, Q13315ITGB4, COL1A1, TNC, LAMA4, UBE3A, CCND3, NOTCH3, IFNA21, STAT1, HLA-B, HLA-C, TCIRG1, ATP6V0B, PPP2R5C, FOXO1, WNT1, ATMMore
Fostamatinibhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Fostamatinibhsa05167Kaposi sarcoma-associated herpesvirus infection1.27E-0512P01568, P31751, P42224, P25963, P23458, P62873, P19174, Q14643, P04049, P01106, P0DP23, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, JAK1, GNB1, PLCG1, ITPR1, RAF1, MYC, CALM1, LEF1More
Fostamatinibhsa05168Herpes simplex virus 1 infection5.22E-0730O00463, O60603, P25963, P01568, P01584, Q05823, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q16629, Q13489, P51617, P61769, P31751, Q9Y2A4, Q13398, P51522, Q9NR11, Q6P280, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415, Q14232TRAF5, TLR2, NFKBIA, IFNA21, IL1B, RNASEL, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, SFRS7, BIRC3, IRAK1, B2M, AKT2, ZNF443, ZNF211, ZNF83, ZNF302, ZNF529, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2, EIF2B1More
Fostamatinibhsa05169Epstein-Barr virus infection1.20E-0818P20023, P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, O60603, P29728, P07766, P09693, P20963CR2, HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Fostamatinibhsa05170Human immunodeficiency virus 1 infection3.97E-1120P31751, P04049, Q02750, P62873, P62879, P16298, P0DP23, P61073, Q05397, P17252, P61769, Q14643, P01568, P51617, O60603, Q13315, P19174, P23528, P10415, Q9Y6Q5AKT2, RAF1, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, CXCR4, PTK2, PRKCA, B2M, ITPR1, IFNA21, IRAK1, TLR2, ATM, PLCG1, CFL1, BCL2, AP1M2More
Fostamatinibhsa05171Coronavirus disease - COVID-192.48E-0922P01584, P23396, P62753, P25398, P62249, P42677, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P62888, P46776, P62899, P62910, P18077, P61927, P61513, P05386, P62829IL1B, RPS3, RPS6, RPS12, RPS16, RPS27, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL30, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPLP1, RPL23More
Fostamatinibhsa05200Pathways in cancer3.41E-1749Q13751, P42338, P23458, P08238, P42224, P25963, Q13772, P19174, Q15311, P01106, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, Q13547, P14923, P30281, P10415, Q13489, P98170, Q13077, P49767, P14921, Q12778, P31751, P43657, P25116, Q08828, P51828, P62873, P63218, P50151, Q14344, Q7LDG7, P61073, Q9UM47, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042LAMB3, PIK3CB, JAK1, HSP90AB1, STAT1, NFKBIA, NCOA4, PLCG1, RALBP1, MYC, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, HDAC1, JUP, CCND3, BCL2, BIRC3, BIRC4, TRAF1, VEGFC, ETS1, FOXO1, AKT2, P2RY5, F2R, ADCY1, ADCY7, GNB1, GNG5, GNG10, GNA13, RASGRP2, CXCR4, NOTCH3, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1More
Fostamatinibhsa05202Transcriptional misregulation in cancer2.15E-0920Q12778, Q15532, Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, GADD45AMore
Fostamatinibhsa05203Viral carcinogenesis4.16E-0513Q12933, Q99941, P18848, P30281, P27348, Q13547, P06396, P12814, P01889, P10321, P06493, P62807, Q16778TRAF2, CREBL1, ATF4, CCND3, YWHAQ, HDAC1, GSN, ACTN1, HLA-B, HLA-C, CDK1, HIST1H2BC, HIST2H2BEMore
Fostamatinibhsa05204Chemical carcinogenesis3.70E-033P00325, P78417, P33260ADH1B, GSTO1, CYP2C18More
Fostamatinibhsa05205Proteoglycans in cancer6.79E-0510Q13009, Q12955, O75369, P60709, P04049, P01106, P08069, P19174, P29350, P08962TIAM1, ANK3, FLNB, ACTB, RAF1, MYC, IGF1R, PLCG1, PTPN6, CD63More
Fostamatinibhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Fostamatinibhsa05210Colorectal cancer1.03E-037Q9UKG1, P43246, P04049, P01106, P20585, P37173, O75293APPL1, MSH2, RAF1, MYC, MSH3, TGFBR2, GADD45BMore
Fostamatinibhsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Fostamatinibhsa05212Pancreatic cancer3.74E-079P42338, P31751, P04049, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RAF1, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Fostamatinibhsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Fostamatinibhsa05214Glioma3.10E-098P08069, P0DP23, Q13557, P17252, P04049, P31751, P19174, O75293IGF1R, CALM1, CAMK2D, PRKCA, RAF1, AKT2, PLCG1, GADD45BMore
Fostamatinibhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Fostamatinibhsa05216Thyroid cancer4.31E-022Q9UJU2, P24522LEF1, GADD45AMore
Fostamatinibhsa05217Basal cell carcinoma6.89E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Fostamatinibhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Fostamatinibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Fostamatinibhsa05220Chronic myeloid leukemia4.90E-047Q13547, Q13485, P84022, P31751, P42338, P04049, O75293HDAC1, SMAD4, SMAD3, AKT2, PIK3CB, RAF1, GADD45BMore
Fostamatinibhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Fostamatinibhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Fostamatinibhsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Fostamatinibhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Fostamatinibhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Fostamatinibhsa05226Gastric cancer6.88E-054P04049, P31751, P04628, P10826RAF1, AKT2, WNT1, RARBMore
Fostamatinibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Fostamatinibhsa05231Choline metabolism in cancer2.51E-069P04049, P31751, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494RAF1, AKT2, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1More
Fostamatinibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer9.48E-1817P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Fostamatinibhsa05310Asthma3.05E-093P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Fostamatinibhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Fostamatinibhsa05321Inflammatory bowel disease2.96E-167O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Fostamatinibhsa05322Systemic lupus erythematosus5.82E-0615P08637, O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, P62807, Q16778, P68431, P14678, P12814FCGR3A, FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2BC, HIST2H2BE, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SNRPB, ACTN1More
Fostamatinibhsa05323Rheumatoid arthritis7.52E-068P01375, Q06643, P13765, Q13488, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2More
Fostamatinibhsa05330Allograft rejection9.93E-044P13765, P29965, P10747, P01375HLA-DOB, CD40LG, CD28, TNFMore
Fostamatinibhsa05332Graft-versus-host disease2.87E-135P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Fostamatinibhsa05340Primary immunodeficiency3.46E-067P01730, P01732, P11912, Q8WV28, P16871, P07766, P06239CD4, CD8A, CD79A, BLNK, IL7R, CD3E, LCKMore
Fostamatinibhsa05410Hypertrophic cardiomyopathy3.63E-022P26012, P09493ITGB8, TPM1More
Fostamatinibhsa05412Arrhythmogenic right ventricular cardiomyopathy5.38E-034Q8IZS8, P54284, P60709, P35609CACNA2D3, CACNB3, ACTB, ACTN2More
Fostamatinibhsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Fostamatinibhsa05415Diabetic cardiomyopathy4.77E-049P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P14780, P37173PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, MMP9, TGFBR2More
Fostamatinibhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Fostamatinibhsa05418Fluid shear stress and atherosclerosis1.57E-0716Q16539, P31751, Q14145, P14598, P78417, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, P0DP23, P08238, Q92974MAPK14, AKT2, KEAP1, NCF1, GSTO1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, HSP90AB1, ARHGEF2More

Community members of Fostamatinib (SDC: 10.82)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenaseReported00.382210.27012.4612
P25774CTSSCathepsin SReported00.31850.49320.51681.6625
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialReported00.62760.245200.8043
P23458JAK1TyrosineNoneprotein kinase JAK1Reported10.55460.921113.1195
Q9P289STK26Serine/threonineNoneprotein kinase 26Reported10.02850.262800.5399
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaReported00.69370.525712.3982
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Reported00.54580.245200.7634
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinaseReported00.25730.245200.6191
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Reported00.06460.24520.14870.6715
Q02763TEKAngiopoietinNone1 receptorReported00.32060.62360.43041.8379
P37173TGFBR2TGFNonebeta receptor typeNone2Reported00.28670.3790.87421.7755
Q07912TNK2Activated CDC42 kinase 1Reported00.0090.347200.6988
P33981TTKDual specificity protein kinase TTKReported00.00390.58050.2591.422
P42681TXKTyrosineNoneprotein kinase TXKReported00.28040.30260.19130.9367
P07947YES1TyrosineNoneprotein kinase YesReported00.12120.43450.1651.0947
Q2M2I8AAK1AP2Noneassociated protein kinase 1Reported10.37690.328800.846
P30530AXLTyrosineNoneprotein kinase receptor UFOReported10.37970.53650.16371.4264
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Reported10.34760.24520.35481.019
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXReported00.05970.326300.6825
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaReported00.47780.3060.80951.6604
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Reported00.36280.34060.46511.3277
P06493CDK1CyclinNonedependent kinase 1Reported00.01310.6042.6105
P49759CLK1Dual specificity protein kinase CLK1Reported00.29680.45460.15871.2163
P49760CLK2Dual specificity protein kinase CLK2Reported00.03030.295100.6053
Q9HAZ1CLK4Dual specificity protein kinase CLK4Reported00.28830.31110.15870.9251
P41240CSKTyrosineNoneprotein kinase CSKReported00.69860.36260.10231.1768
P19784CSNK2A2Casein kinase II subunit alpha'Reported10.09660.32250.52971.2231
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1AReported00.0150.708201.4239
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Reported10.68060.29440.5571.4862
P07332FESTyrosineNoneprotein kinase Fes/FpsReported00.27220.26280.15130.8131
P09769FGRTyrosineNoneprotein kinase FgrReported00.06220.32440.2250.9049
O14976GAKCyclinNoneGNoneassociated kinaseReported10.57280.256200.7989
P49841GSK3BGlycogen synthase kinaseNone3 betaReported10.1678113.0839
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Reported00.3650.25080.2180.902
P06213INSRInsulin receptorReported00.27940.78130.72092.4232
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Reported00.02380.30.94441.5563
Q08881ITKTyrosineNoneprotein kinase ITK/TSKReported10.16350.55450.4221.6127
O95835LATS1Serine/threonineNoneprotein kinase LATS1Reported00.43320.24520.02170.7288
P06239LCKTyrosineNoneprotein kinase LckReported00.057610.72872.7575
P07948LYNTyrosineNoneprotein kinase LynReported00.0910.53190.6061.7154
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Reported00.45650.24520.14870.8674
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Reported00.35450.24520.43781.1055
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Reported00.35280.24520.1730.8399
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Reported00.38330.26730.14870.875
Q9Y4K4MAP4K5MitogenNoneactivated protein kinase kinase kinase kinase 5Reported00.12660.006700.0766
Q16539MAPK14MitogenNoneactivated protein kinase 14Reported10.0149113.0075
Q15746MYLKMyosin light chain kinase, smooth muscleReported00.04010.31160.42981.0731
P51955NEK2Serine/threonineNoneprotein kinase Nek2Reported00.65990.369201.0684
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Reported00.18390.245200.5825
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Reported10.46470.34710.78191.7084
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Reported00.4090.26690.50031.2386
Q00536PCTK1CyclinNonedependent kinase 16Reported00.27140.25600.6478
P09619PDGFRBPlateletNonederived growth factor receptor betaReported00.04960.94440.74082.6543
Q16513PKN2Serine/threonineNoneprotein kinase N2Reported00.04210.27780.33910.9157
Q9Y478PRKAB15'NoneAMPNoneactivated protein kinase subunit betaNone1Reported10.14780.10880.55640.8479
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaReported00.37370.298411.7836
Q05655PRKCDProtein kinase C delta typeReported00.08160.41940.65441.5339
Q02156PRKCEProtein kinase C epsilon typeReported00.11750.52870.53771.6539
Q04759PRKCQProtein kinase C theta typeReported00.04050.42440.61731.4864
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologReported00.13760.245200.5593
Q05397PTK2Focal adhesion kinase 1Reported00.21530.58640.97132.2518
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinaseReported10.5570.757212.7929
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Reported10.51990.41830.8431.9396
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Reported10.8320.32450.41461.4796
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Reported00.28650.39360.41461.345
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Reported00.0260.26840.31140.8612
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17AReported00.35040.337600.8504
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P48426PIP4K2APhosphatidylinositol 5Nonephosphate 4Nonekinase typeNone2 alphaPredicted00.22250.00520.28160.4033
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P18054ALOX12Polyunsaturated fatty acid lipoxygenase ALOX12Predicted00.00750.37030.24160.986
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
O75342ALOX12BArachidonate 12Nonelipoxygenase, 12RNonetypePredicted00.0750.03990.15890.2762
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
Q00013MPP155 kDa erythrocyte membrane proteinPredicted00.13140.003600.073
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
Q15131CDK10CyclinNonedependent kinase 10Predicted00.36120.032300.2453
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O14986PIP5K1BPhosphatidylinositol 4Nonephosphate 5Nonekinase typeNone1 betaPredicted00.84240.00210.48720.9127
P43234CTSOCathepsin OPredicted00.37710.00490.30080.4991
Q96RU8TRIB1Tribbles homolog 1Predicted00.06020.00200.0341
Q13239SLASrcNonelikeNoneadapterPredicted10.16050.009800.0999
Q9UBR2CTSZCathepsin ZPredicted00.23250.00220.30080.4215
O75832PSMD1026S proteasome nonNoneATPase regulatory subunit 10Predicted00.21030.018500.1422
P0DP23CALM1CalmodulinNone1Predicted00.45520.147911.5235
P0DP25CALM3CalmodulinNone3Predicted00.56610.147900.5789
P0DP24CALM2CalmodulinNone2Predicted00.43760.147900.5147
P42773CDKN2CCyclinNonedependent kinase 4 inhibitor CPredicted00.28520.00230.55780.705
O60880SH2D1ASH2 domainNonecontaining protein 1APredicted00.03520.01650.18070.2313
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)