PharmaCoNets of Fondaparinux (SPCN: 4.63 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Fondaparinuxhsa00220Arginine biosynthesis1.50E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Fondaparinuxhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Fondaparinuxhsa00670One carbon pool by folate3.91E-022O95954, Q99707FTCD, MTRMore
Fondaparinuxhsa01100Metabolic pathways3.37E-0236P05089, Q9UJ14, P15104, O14986, P48426, Q14642, Q96DU7, P07195, Q08828, Q02153, Q16875, O43286, O43451, Q86XP1, Q14739, Q9UHK6, P11511, Q86VZ5, Q08477, P15907, Q9UNP4, Q9H4F1, P32321, P60891, P49448, P15586, P00352, Q9BPW9, P43490, P46976, P05166, P13073, P05496, O15239, O15047, Q9NVH6ARG1, GGTL3, GLUL, PIP5K1B, PIP4K2A, INPP5A, ITPKC, LDHB, ADCY1, GUCY1B3, PFKFB3, B4GALT5, MGAM, DGKH, LBR, AMACR, CYP19A1, SGMS1, CYP4F3, ST6GAL1, ST3GAL5, ST6GALNAC4, DCTD, PRPS1, GLUD2, GNS, ALDH1A1, DHRS9, PBEF1, GYG1, PCCB, COX4I1, ATP5G1, NDUFA1, SETD1A, TMLHEMore
Fondaparinuxhsa03013RNA transport4.72E-027O14980, Q09161, P35658, P47813, Q14152, O75822, P51114XPO1, NCBP1, NUP214, EIF1AX, EIF3A, EIF3J, FXR1More
Fondaparinuxhsa03040Spliceosome1.26E-026P17844, P51991, P61978, Q15365, Q01130, P11142DDX5, HNRPA3, HNRPK, PCBP1, SFRS2, HSPA8More
Fondaparinuxhsa03060Protein export3.37E-022P37108, Q15005SRP14, SPCS2More
Fondaparinuxhsa04060Cytokine-cytokine receptor interaction4.33E-0211P27930, P14778, P01584, Q13651, Q9HBE5, Q9UBD3, P47992, P09341, P32248, P18510, P01730IL1R2, IL1R1, IL1B, IL10RA, IL21R, XCL2, XCL1, CXCL1, CCR7, IL1RN, CD4More
Fondaparinuxhsa04141Protein processing in endoplasmic reticulum6.04E-038P18848, Q15437, Q99941, O75460, P11142, Q9H3Z4, P07900, Q9NR31ATF4, SEC23B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, SAR1AMore
Fondaparinuxhsa04151PI3K-Akt signaling pathway1.16E-0321P21860, P43657, P01106, O43521, P27348, O14944, Q9GZP0, Q13362, P07900, P62873, P50151, P13612, P26012, P24821, Q16363, P22105, P23458, Q99941, P18848, O00141, Q6ZUJ8ERBB3, P2RY5, MYC, BCL2L11, YWHAQ, EREG, PDGFD, PPP2R5C, HSP90AA1, GNB1, GNG10, ITGA4, ITGB8, TNC, LAMA4, TNXB, JAK1, CREBL1, ATF4, SGK, PIK3AP1More
Fondaparinuxhsa04211Longevity regulating pathway4.57E-024P51828, Q99941, P18848, Q96RR4ADCY7, CREBL1, ATF4, CAMKK2More
Fondaparinuxhsa04217Necroptosis5.00E-037P23458, Q9NQC7, P07900, P05141, P01584, Q9H444, O75351JAK1, CYLD, HSP90AA1, SLC25A5, IL1B, CHMP4B, VPS4BMore
Fondaparinuxhsa04261Adrenergic signaling in cardiomyocytes1.26E-026P67936, P51828, Q99941, P18848, Q13362, P23634TPM4, ADCY7, CREBL1, ATF4, PPP2R5C, ATP2B4More
Fondaparinuxhsa04512ECM-receptor interaction4.68E-025Q16363, P24821, P22105, P13612, P26012LAMA4, TNC, TNXB, ITGA4, ITGB8More
Fondaparinuxhsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Fondaparinuxhsa04621NOD-like receptor signaling pathway2.39E-025P01584, P07900, P23458, Q9H3M7, P43490IL1B, HSP90AA1, JAK1, TXNIP, PBEF1More
Fondaparinuxhsa04640Hematopoietic cell lineage6.74E-0310P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P13765, P01584ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, HLA-DOB, IL1BMore
Fondaparinuxhsa04658Th1 and Th2 cell differentiation3.62E-0411Q04759, P07766, P20963, P09693, P01730, P06239, P23771, Q9UL17, P46531, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, GATA3, TBX21, NOTCH1, HLA-DOB, RUNX3More
Fondaparinuxhsa04659Th17 cell differentiation8.31E-0513Q04759, P01730, P06239, P13765, P14778, Q9HBE5, Q9UL17, P23771, P01584, P07900, P07766, P09693, P20963PRKCQ, CD4, LCK, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, IL1B, HSP90AA1, CD3E, CD3G, CD247More
Fondaparinuxhsa04660T cell receptor signaling pathway4.36E-0310Q04759, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Fondaparinuxhsa04750Inflammatory mediator regulation of TRP channels3.28E-026P14778, P01584, Q08828, Q13557, P24723, Q04759IL1R1, IL1B, ADCY1, CAMK2D, PRKCH, PRKCQMore
Fondaparinuxhsa04911Insulin secretion4.85E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Fondaparinuxhsa04915Estrogen signaling pathway1.65E-026Q99941, P18848, P51828, P07900, P11142, Q15788CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8, NCOA1More
Fondaparinuxhsa04918Thyroid hormone synthesis2.50E-024P51828, Q99941, P18848, P05543ADCY7, CREBL1, ATF4, SERPINA7More
Fondaparinuxhsa04925Aldosterone synthesis and secretion2.50E-024Q99941, P18848, P51828, P23634CREBL1, ATF4, ADCY7, ATP2B4More
Fondaparinuxhsa04927Cortisol synthesis and secretion3.29E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Fondaparinuxhsa04934Cushing syndrome2.63E-026Q99941, P18848, Q08828, O15169, Q13557, O00170CREBL1, ATF4, ADCY1, AXIN1, CAMK2D, AIPMore
Fondaparinuxhsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Fondaparinuxhsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Fondaparinuxhsa05146Amoebiasis7.62E-039P01584, Q16363, P09341, P14778, P27930, P05089, Q08828, P12814, P08311IL1B, LAMA4, CXCL1, IL1R1, IL1R2, ARG1, ADCY1, ACTN1, CTSGMore
Fondaparinuxhsa05163Human cytomegalovirus infection4.52E-027P51828, P23458, P01584, P61073, Q13651, Q99941, P18848ADCY7, JAK1, IL1B, CXCR4, IL10RA, CREBL1, ATF4More
Fondaparinuxhsa05203Viral carcinogenesis1.26E-026Q99941, P18848, P23458, P27348, Q7KZF4, P61978CREBL1, ATF4, JAK1, YWHAQ, SND1, HNRPKMore
Fondaparinuxhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.83E-027O95267, P07766, P20963, P09693, P06239, Q04759, P01730RASGRP1, CD3E, CD247, CD3G, LCK, PRKCQ, CD4More
Fondaparinuxhsa05321Inflammatory bowel disease4.68E-025P13765, Q9UL17, P23771, P01584, Q9HBE5HLA-DOB, TBX21, GATA3, IL1B, IL21RMore
Fondaparinuxhsa05340Primary immunodeficiency3.99E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore

Community members of Fondaparinux (SDC: 0.92)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P30740SERPINB1Leukocyte elastase inhibitorPredicted10.57720.013700.3159
P22891PROZVitamin KNonedependent protein ZPredicted00.79810.016800.4327
P01009SERPINA1AlphaNone1NoneantitrypsinPredicted10.03840.01330.0120.0577
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)