PharmaCoNets of Fluvastatin (SPCN: 38.68 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Fluvastatinhsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Fluvastatinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Fluvastatinhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Fluvastatinhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Fluvastatinhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Fluvastatinhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Fluvastatinhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Fluvastatinhsa01230Biosynthesis of amino acids2.22E-034P51854, P60891, Q99707, P37837TKTL1, PRPS1, MTR, TALDO1More
Fluvastatinhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Fluvastatinhsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Fluvastatinhsa03050Proteasome1.21E-021P28074PSMB5More
Fluvastatinhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Fluvastatinhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Fluvastatinhsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Fluvastatinhsa04071Sphingolipid signaling pathway9.82E-058P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Fluvastatinhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Fluvastatinhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Fluvastatinhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Fluvastatinhsa04145Phagosome1.81E-027O75015, Q15080, Q13488, P05164, O60603, P35443, P13765FCGR3B, NCF4, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Fluvastatinhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Fluvastatinhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Fluvastatinhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Fluvastatinhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Fluvastatinhsa04613Neutrophil extracellular trap formation9.10E-0416P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Fluvastatinhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Fluvastatinhsa04650Natural killer cell mediated cytotoxicity5.49E-0612P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1More
Fluvastatinhsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Fluvastatinhsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Fluvastatinhsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Fluvastatinhsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Fluvastatinhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Fluvastatinhsa04723Retrograde endocannabinoid signaling1.75E-025Q14643, P17252, P22694, Q16539, Q16718ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5More
Fluvastatinhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Fluvastatinhsa04912GnRH signaling pathway3.14E-035P17252, Q16539, Q9Y6R4, Q14643, P22694PRKCA, MAPK14, MAP3K4, ITPR1, PRKACBMore
Fluvastatinhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Fluvastatinhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Fluvastatinhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Fluvastatinhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Fluvastatinhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Fluvastatinhsa04928Parathyroid hormone synthesis, secretion and action3.75E-025Q14643, P22694, P23771, P17252, P10415ITPR1, PRKACB, GATA3, PRKCA, BCL2More
Fluvastatinhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Fluvastatinhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Fluvastatinhsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Fluvastatinhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Fluvastatinhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Fluvastatinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Fluvastatinhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Fluvastatinhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Fluvastatinhsa05146Amoebiasis2.05E-0511P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1More
Fluvastatinhsa05152Tuberculosis1.26E-028Q13488, O75015, P48382, O60603, P10415, P13765, Q9UDY8, Q16539TCIRG1, FCGR3B, RFX5, TLR2, BCL2, HLA-DOB, MALT1, MAPK14More
Fluvastatinhsa05202Transcriptional misregulation in cancer2.48E-0313Q12778, Q15532, P41732, P14780, P27930, Q16548, Q13489, O15550, P35226, P05164, P08246, Q9C0K0, P24522FOXO1, SS18, TSPAN7, MMP9, IL1R2, BCL2A1, BIRC3, UTX, BMI1, MPO, ELA2, BCL11B, GADD45AMore
Fluvastatinhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Fluvastatinhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Fluvastatinhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Fluvastatinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Fluvastatinhsa05321Inflammatory bowel disease2.11E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Fluvastatinhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Fluvastatinhsa05332Graft-versus-host disease3.37E-045P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More

Community members of Fluvastatin (SDC: 4.48)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q92769HDAC2Histone deacetylase 2Reported10.047310.9863.0097
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
Q15722LTB4RLeukotriene B4 receptor 1Predicted00.06770.219900.4736
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)