PharmaCoNets of Flutamide (SPCN: 11.55 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Flutamidehsa00220Arginine biosynthesis1.21E-021P15104GLULMore
Flutamidehsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Flutamidehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Flutamidehsa00670One carbon pool by folate3.62E-021P00374DHFRMore
Flutamidehsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Flutamidehsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Flutamidehsa01230Biosynthesis of amino acids5.53E-032P15104, P37837GLUL, TALDO1More
Flutamidehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Flutamidehsa04142Lysosome2.64E-022Q99437, P25774ATP6V0B, CTSSMore
Flutamidehsa04145Phagosome3.11E-022Q99437, P25774ATP6V0B, CTSSMore
Flutamidehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Flutamidehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Flutamidehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Flutamidehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Flutamidehsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Flutamidehsa04659Th17 cell differentiation3.17E-023P25963, P84022, Q13485NFKBIA, SMAD3, SMAD4More
Flutamidehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Flutamidehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Flutamidehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Flutamidehsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Flutamidehsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Flutamidehsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Flutamidehsa05034Alcoholism2.79E-022P62879, Q9BTM1GNB2, H2AFJMore
Flutamidehsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Flutamidehsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Flutamidehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Flutamidehsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore
Flutamidehsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Flutamidehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Flutamidehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Flutamidehsa05200Pathways in cancer4.70E-023P17301, P20585, P62879ITGA2, MSH3, GNB2More
Flutamidehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Flutamidehsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Flutamidehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Flutamidehsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Flutamidehsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Flutamidehsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More

Community members of Flutamide (SDC: 2.82)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Reported10.03150.949301.9143
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P00374DHFRDihydrofolate reductasePredicted00.3380.18680.22630.7688
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)