PharmaCoNets of Flurbiprofen (SPCN: 102.32 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Flurbiprofenhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Flurbiprofenhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Flurbiprofenhsa00190Oxidative phosphorylation2.35E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Flurbiprofenhsa00230Purine metabolism1.81E-022P20839, Q02153IMPDH1, GUCY1B3More
Flurbiprofenhsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Flurbiprofenhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Flurbiprofenhsa00500Starch and sucrose metabolism2.67E-021P35573AGLMore
Flurbiprofenhsa00510N-Glycan biosynthesis1.00E-022O94777, Q9BVK2DPM2, ALG8More
Flurbiprofenhsa00561Glycerolipid metabolism3.09E-022P14550, Q86XP1AKR1A1, DGKHMore
Flurbiprofenhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.47E-032O94777, Q14442DPM2, PIGHMore
Flurbiprofenhsa00565Ether lipid metabolism1.44E-052Q9Y6K0, Q8N661CEPT1, TMEM86BMore
Flurbiprofenhsa00600Sphingolipid metabolism4.47E-022Q96G23, Q86VZ5LASS2, SGMS1More
Flurbiprofenhsa00630Glyoxylate and dicarboxylate metabolism1.32E-022P40925, P15104MDH1, GLULMore
Flurbiprofenhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Flurbiprofenhsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Flurbiprofenhsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Flurbiprofenhsa00983Drug metabolism - other enzymes1.99E-035P04183, P32320, P05164, Q16772, P09211TK1, CDA, MPO, GSTA3, GSTP1More
Flurbiprofenhsa01100Metabolic pathways2.14E-0524Q9Y234, P35790, Q16772, P09211, Q9UJ14, P30041, Q6ZQY3, P20839, P40926, O94777, Q7KZN9, Q9Y6K0, P15121, Q86XP1, P14550, Q9UHK6, Q86VZ5, Q96G23, Q9BVK2, Q14442, Q9BQB6, Q06055, Q99437, Q9NVH6LIPT1, CHKA, GSTA3, GSTP1, GGTL3, PRDX6, GADL1, IMPDH1, MDH2, DPM2, COX15, CEPT1, AKR1B1, DGKH, AKR1A1, AMACR, SGMS1, LASS2, ALG8, PIGH, VKORC1, ATP5G2, ATP6V0B, TMLHEMore
Flurbiprofenhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Flurbiprofenhsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Flurbiprofenhsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Flurbiprofenhsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Flurbiprofenhsa03008Ribosome biogenesis in eukaryotes6.93E-046Q9NYH9, O14980, O60832, P78345, Q9BVP2, Q9GZY0UTP6, XPO1, DKC1, RPP38, GNL3, NXF2; NXF2BMore
Flurbiprofenhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Flurbiprofenhsa03013RNA transport4.39E-0718O14980, P52298, Q09161, O14893, P61326, P38919, Q9GZY0, P37198, Q7Z3B4, P35658, Q14152, P55884, O75822, P78345, Q14240, P23588, Q9Y6A5, Q53GS7XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, NXF2; NXF2B, NUP62, NUP54, NUP214, EIF3A, EIF3B, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, GLE1More
Flurbiprofenhsa03015mRNA surveillance pathway9.78E-036O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Flurbiprofenhsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Flurbiprofenhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Flurbiprofenhsa03040Spliceosome4.19E-0410Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, P11142, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8, PPIH, ASCC3L1More
Flurbiprofenhsa04012ErbB signaling pathway1.34E-024P16333, P19174, P42338, P01106NCK1, PLCG1, PIK3CB, MYCMore
Flurbiprofenhsa04014Ras signaling pathway2.92E-0410P42338, P20827, Q9NRA1, P49767, Q13009, P0DP23, P62873, P63218, P50151, P19174PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Flurbiprofenhsa04015Rap1 signaling pathway4.83E-038P20827, Q9NRA1, P49767, P11215, Q13009, P42338, P0DP23, P19174EFNA1, PDGFC, VEGFC, ITGAM, TIAM1, PIK3CB, CALM1, PLCG1More
Flurbiprofenhsa04020Calcium signaling pathway2.61E-026P27987, P21796, P19174, P0DP23, Q9NRA1, P49767ITPKB, VDAC1, PLCG1, CALM1, PDGFC, VEGFCMore
Flurbiprofenhsa04062Chemokine signaling pathway3.26E-0411P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q13009, P14598, P42224, P25963LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, TIAM1, NCF1, STAT1, NFKBIAMore
Flurbiprofenhsa04064NF-kappa B signaling pathway4.09E-038P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Flurbiprofenhsa04070Phosphatidylinositol signaling system1.12E-025P19174, P0DP23, P42338, P23743, P27987PLCG1, CALM1, PIK3CB, DGKA, ITPKBMore
Flurbiprofenhsa04071Sphingolipid signaling pathway1.05E-038P17252, P21453, Q9H228, Q13362, Q16537, Q9BX95, P04637, P10415PRKCA, S1PR1, EDG8, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2More
Flurbiprofenhsa04072Phospholipase D signaling pathway4.67E-025P42338, P19174, Q14344, P23743, Q9NRA1PIK3CB, PLCG1, GNA13, DGKA, PDGFCMore
Flurbiprofenhsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Flurbiprofenhsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Flurbiprofenhsa04120Ubiquitin mediated proteolysis2.89E-022O95071, P0CG47UBR5, UBBMore
Flurbiprofenhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Flurbiprofenhsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Flurbiprofenhsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Flurbiprofenhsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Flurbiprofenhsa04145Phagosome4.34E-0710P63261, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Flurbiprofenhsa04151PI3K-Akt signaling pathway5.62E-0312P42338, P01106, P20827, Q9NRA1, P49767, P08238, P62873, P63218, P50151, O15335, P14784, P01568PIK3CB, MYC, EFNA1, PDGFC, VEGFC, HSP90AB1, GNB1, GNG5, GNG10, CHAD, IL2RB, IFNA21More
Flurbiprofenhsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Flurbiprofenhsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Flurbiprofenhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Flurbiprofenhsa04330Notch signaling pathway1.68E-033Q92542, P49768, P78504NCSTN, PSEN1, JAG1More
Flurbiprofenhsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Flurbiprofenhsa04360Axon guidance2.87E-025P16333, P20827, O95631, P42338, P19174NCK1, EFNA1, NTN1, PIK3CB, PLCG1More
Flurbiprofenhsa04371Apelin signaling pathway2.41E-037P62873, P63218, P50151, Q13370, Q14814, Q14344, P0DP23GNB1, GNG5, GNG10, PDE3B, MEF2D, GNA13, CALM1More
Flurbiprofenhsa04540Gap junction3.53E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Flurbiprofenhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Flurbiprofenhsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Flurbiprofenhsa04613Neutrophil extracellular trap formation6.87E-0525P42338, P19174, P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P62807, Q93079, P68431, P21796, P14598, Q15080, P20160, P08311, P21730, P21462, P63261, O43315, Q16539PIK3CB, PLCG1, PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC9, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, AZU1, CTSG, C5AR1, FPR1, ACTG1, AQP9, MAPK14More
Flurbiprofenhsa04620Toll-like receptor signaling pathway4.00E-024P01568, P42224, P25963, P42338IFNA21, STAT1, NFKBIA, PIK3CBMore
Flurbiprofenhsa04623Cytosolic DNA-sensing pathway3.67E-022P01568, P25963IFNA21, NFKBIAMore
Flurbiprofenhsa04625C-type lectin receptor signaling pathway2.17E-025Q9ULY5, P42224, P25963, P42338, P0DP23CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1More
Flurbiprofenhsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Flurbiprofenhsa04650Natural killer cell mediated cytotoxicity2.96E-026O60880, P20963, Q13241, P26718, P26717, P26715SH2D1A, CD247, KLRD1, KLRK1, KLRC2, KLRC1More
Flurbiprofenhsa04657IL-17 signaling pathway4.87E-022P07900, P01584HSP90AA1, IL1BMore
Flurbiprofenhsa04658Th1 and Th2 cell differentiation3.11E-0513P25963, Q04759, P07766, P20963, P09693, P19174, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, PLCG1, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Flurbiprofenhsa04659Th17 cell differentiation1.42E-0312P25963, Q04759, P19174, P42224, P14784, P13765, Q9UL17, P23771, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, PLCG1, STAT1, IL2RB, HLA-DOB, TBX21, GATA3, HSP90AB1, CD3E, CD3G, CD247More
Flurbiprofenhsa04660T cell receptor signaling pathway1.00E-027Q9UDY8, Q04759, P10747, Q08881, P20963, P09693, P01732MALT1, PRKCQ, CD28, ITK, CD247, CD3G, CD8AMore
Flurbiprofenhsa04662B cell receptor signaling pathway1.12E-025P25963, P42338, P07948, P21854, Q8N149NFKBIA, PIK3CB, LYN, CD72, LILRA2More
Flurbiprofenhsa04664Fc epsilon RI signaling pathway1.34E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Flurbiprofenhsa04666Fc gamma R-mediated phagocytosis5.49E-059P07948, P42338, P19174, P23528, P49006, P06396, O14494, P14598, P17252LYN, PIK3CB, PLCG1, CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCAMore
Flurbiprofenhsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Flurbiprofenhsa04713Circadian entrainment4.00E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Flurbiprofenhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Flurbiprofenhsa04721Synaptic vesicle cycle3.09E-022Q99437, P43005ATP6V0B, SLC1A1More
Flurbiprofenhsa04724Glutamatergic synapse2.92E-024P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Flurbiprofenhsa04725Cholinergic synapse2.92E-024P62873, P63218, P50151, P42338GNB1, GNG5, GNG10, PIK3CBMore
Flurbiprofenhsa04727GABAergic synapse8.14E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Flurbiprofenhsa04744Phototransduction3.94E-042P62873, P0DP23GNB1, CALM1More
Flurbiprofenhsa04750Inflammatory mediator regulation of TRP channels4.00E-024P19174, P42338, P24723, P0DP23PLCG1, PIK3CB, PRKCH, CALM1More
Flurbiprofenhsa04810Regulation of actin cytoskeleton2.61E-026P12814, Q13009, P42338, P11215, Q14344, Q9NRA1ACTN1, TIAM1, PIK3CB, ITGAM, GNA13, PDGFCMore
Flurbiprofenhsa04914Progesterone-mediated oocyte maturation4.00E-024P42338, Q13370, P30304, P08238PIK3CB, PDE3B, CDC25A, HSP90AB1More
Flurbiprofenhsa04916Melanogenesis4.80E-024P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Flurbiprofenhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Flurbiprofenhsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Flurbiprofenhsa04926Relaxin signaling pathway8.74E-036P25963, P42338, P62873, P63218, P50151, P49767NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFCMore
Flurbiprofenhsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Flurbiprofenhsa04932Non-alcoholic fatty liver disease9.01E-047P49841, P18848, P01584, P13073, O15239, Q16718, O14521GSK3B, ATF4, IL1B, COX4I1, NDUFA1, NDUFA5, SDHDMore
Flurbiprofenhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Flurbiprofenhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Flurbiprofenhsa04972Pancreatic secretion1.99E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Flurbiprofenhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Flurbiprofenhsa05012Parkinson disease7.03E-0311O15239, P13073, P05141, P21796, P60604, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509NDUFA1, COX4I1, SLC25A5, VDAC1, UBE2G2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3More
Flurbiprofenhsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Flurbiprofenhsa05020Prion disease3.73E-0411P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14More
Flurbiprofenhsa05022Pathways of neurodegeneration - multiple diseases1.47E-0312P49841, O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, Q16539, P01584, Q08752, Q13557GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, MAPK14, IL1B, PPID, CAMK2DMore
Flurbiprofenhsa05032Morphine addiction7.60E-035P62873, P63218, P50151, Q13370, P43250GNB1, GNG5, GNG10, PDE3B, GRK6More
Flurbiprofenhsa05034Alcoholism6.32E-037Q13547, P0DP23, P62873, P63218, P50151, P62807, Q93079HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2BC, H2BC9More
Flurbiprofenhsa05120Epithelial cell signaling in Helicobacter pylori infection4.47E-022Q99437, P10145ATP6V0B, IL8More
Flurbiprofenhsa05132Salmonella infection1.62E-0417P51617, P25963, P08238, Q9UJU2, P01106, P63261, P42338, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, LEF1, MYC, ACTG1, PIK3CB, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41More
Flurbiprofenhsa05133Pertussis4.20E-021P0C0L4C4AMore
Flurbiprofenhsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Flurbiprofenhsa05140Leishmaniasis4.13E-025P14598, P13765, O60603, P49006, Q15080NCF1, HLA-DOB, TLR2, MARCKSL1, NCF4More
Flurbiprofenhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Flurbiprofenhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Flurbiprofenhsa05152Tuberculosis5.68E-039Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Flurbiprofenhsa05162Measles1.56E-039P01568, P25963, P42224, P14784, P07766, P42338, P11142, P01584, Q9NP90IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8, IL1B, RAB9BMore
Flurbiprofenhsa05163Human cytomegalovirus infection4.19E-0410P42338, P25963, P62873, P63218, P50151, P0DP23, Q14344, P01106, P30101, P01568PIK3CB, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, MYC, PDIA3, IFNA21More
Flurbiprofenhsa05167Kaposi sarcoma-associated herpesvirus infection7.49E-0511P01568, P42224, P25963, P42338, P62873, P63218, P50151, P19174, P07948, P01106, P0DP23IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, PLCG1, LYN, MYC, CALM1More
Flurbiprofenhsa05168Herpes simplex virus 1 infection4.57E-0210P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF189More
Flurbiprofenhsa05169Epstein-Barr virus infection1.08E-0311P01106, Q13547, P25963, P42338, P07948, P30101, Q13761, O75293, P42224, P01568, P07766MYC, HDAC1, NFKBIA, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, STAT1, IFNA21, CD3EMore
Flurbiprofenhsa05170Human immunodeficiency virus 1 infection7.42E-0519P42338, P62873, P63218, P50151, P0DP23, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, P19174, P23528, P07766, P10415, Q93034, Q9Y6Q5PIK3CB, GNB1, GNG5, GNG10, CALM1, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, PLCG1, CFL1, CD3E, BCL2, CUL5, AP1M2More
Flurbiprofenhsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Flurbiprofenhsa05200Pathways in cancer1.82E-0317P42338, P08238, P42224, P25963, P19174, P01106, P43246, Q13547, P49767, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, HDAC1, VEGFC, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Flurbiprofenhsa05202Transcriptional misregulation in cancer9.64E-0516Q12778, Q15532, Q13315, P41732, P14780, P14923, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, JUP, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, ELA2, BCL11B, GADD45AMore
Flurbiprofenhsa05203Viral carcinogenesis2.74E-0412Q12933, P42229, P42338, P06746, P07948, P29083, Q13547, Q15283, P12814, P25963, P62807, Q93079TRAF2, STAT5A, PIK3CB, POLB, LYN, GTF2E1, HDAC1, RASA2, ACTN1, NFKBIA, HIST1H2BC, H2BC9More
Flurbiprofenhsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Flurbiprofenhsa05205Proteoglycans in cancer9.14E-0412Q13009, Q12955, Q14643, O75369, P63261, P04637, P14780, P17252, O60603, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, ACTG1, TP53, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63More
Flurbiprofenhsa05206MicroRNAs in cancer2.79E-027P30304, P09493, P01106, P42338, Q13547, P20827, P19174CDC25A, TPM1, MYC, PIK3CB, HDAC1, EFNA1, PLCG1More
Flurbiprofenhsa05214Glioma1.34E-024P0DP23, P42338, P19174, O75293CALM1, PIK3CB, PLCG1, GADD45BMore
Flurbiprofenhsa05216Thyroid cancer3.35E-035P01106, Q9UJU2, P04637, P24522, O75293MYC, LEF1, TP53, GADD45A, GADD45BMore
Flurbiprofenhsa05217Basal cell carcinoma1.46E-024Q13635, Q9UJU2, P04637, P24522PTCH1, LEF1, TP53, GADD45AMore
Flurbiprofenhsa05218Melanoma2.31E-023Q9NRA1, P42338, O75293PDGFC, PIK3CB, GADD45BMore
Flurbiprofenhsa05220Chronic myeloid leukemia2.17E-025Q13547, P01106, P25963, P42338, O75293HDAC1, MYC, NFKBIA, PIK3CB, GADD45BMore
Flurbiprofenhsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Flurbiprofenhsa05231Choline metabolism in cancer2.92E-035P42338, Q9NRA1, Q9Y259, P19174, P23743PIK3CB, PDGFC, CHKB, PLCG1, DGKAMore
Flurbiprofenhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.32E-0413P25963, P42338, P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q9HC35, P01730NFKBIA, PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, EML4, CD4More
Flurbiprofenhsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Flurbiprofenhsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Flurbiprofenhsa05323Rheumatoid arthritis1.45E-034P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Flurbiprofenhsa05332Graft-versus-host disease3.45E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Flurbiprofenhsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Flurbiprofenhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Flurbiprofenhsa05415Diabetic cardiomyopathy1.02E-038P05141, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2DMore
Flurbiprofenhsa05418Fluid shear stress and atherosclerosis4.26E-026P14598, P14780, P63261, P04637, P10415, Q92974NCF1, MMP9, ACTG1, TP53, BCL2, ARHGEF2More

Community members of Flurbiprofen (SDC: 5.59)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P40925MDH1Malate dehydrogenase, cytoplasmicPredicted00.35660.27460.24260.97
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P10145IL8InterleukinNone8Predicted10.19670.130411.3591
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)