PharmaCoNets of Flurazepam (SPCN: 70.88 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Flurazepamhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Flurazepamhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Flurazepamhsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Flurazepamhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Flurazepamhsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Flurazepamhsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Flurazepamhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Flurazepamhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Flurazepamhsa00600Sphingolipid metabolism2.77E-023Q9BX95, Q8TCT0, P15289SGPP1, CERK, ARSAMore
Flurazepamhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Flurazepamhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Flurazepamhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Flurazepamhsa00983Drug metabolism - other enzymes1.64E-023P04183, P32320, P05164TK1, CDA, MPOMore
Flurazepamhsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Flurazepamhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Flurazepamhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Flurazepamhsa01522Endocrine resistance4.48E-024P22694, Q02750, Q9UM47, P46527PRKACB, MAP2K1, NOTCH3, CDKN1BMore
Flurazepamhsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Flurazepamhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Flurazepamhsa03008Ribosome biogenesis in eukaryotes6.92E-035Q9NYH9, P19784, P67870, P78345, Q9BVP2UTP6, CSNK2A2, CSNK2B, RPP38, GNL3More
Flurazepamhsa03013RNA transport7.94E-038P52298, O14893, P61326, Q7Z3B4, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, EIF3A, EIF3J, RPP38, TACC3More
Flurazepamhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Flurazepamhsa03050Proteasome1.40E-021P55036PSMD4More
Flurazepamhsa04014Ras signaling pathway4.04E-026Q02750, Q15389, P17252, P21359, P62879, P22694MAP2K1, ANGPT1, PRKCA, NF1, GNB2, PRKACBMore
Flurazepamhsa04015Rap1 signaling pathway3.07E-024P25116, Q8TEU7, P08514, P17252F2R, RAPGEF6, ITGA2B, PRKCAMore
Flurazepamhsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Flurazepamhsa04064NF-kappa B signaling pathway4.92E-026P10415, P51617, Q13546, Q9UDY8, Q13077, P24522BCL2, IRAK1, RIPK1, MALT1, TRAF1, GADD45AMore
Flurazepamhsa04066HIF-1 signaling pathway4.48E-024P17252, Q15389, Q02750, P46527PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Flurazepamhsa04070Phosphatidylinositol signaling system4.07E-024P0DP23, Q14643, O14732, P17252CALM1, ITPR1, IMPA2, PRKCAMore
Flurazepamhsa04071Sphingolipid signaling pathway3.85E-049P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2More
Flurazepamhsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Flurazepamhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Flurazepamhsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Flurazepamhsa04120Ubiquitin mediated proteolysis7.08E-046Q14145, Q13042, Q13191, P62837, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, UBE2D2, HERC1, HUWE1More
Flurazepamhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Flurazepamhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Flurazepamhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Flurazepamhsa04261Adrenergic signaling in cardiomyocytes2.85E-039P07550, P22694, P18848, Q13362, Q16537, P0DP23, P17252, P10415, P20020ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1More
Flurazepamhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Flurazepamhsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Flurazepamhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Flurazepamhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Flurazepamhsa04540Gap junction2.03E-024P17252, P22694, P68371, Q02750PRKCA, PRKACB, TUBB2C, MAP2K1More
Flurazepamhsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Flurazepamhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Flurazepamhsa04613Neutrophil extracellular trap formation1.57E-0416P17252, O60603, P08246, Q92769, P04908, Q6FI13, Q93077, P62807, P33778, O60814, P68431, P14598, Q15080, P21462, O43315, Q16539PRKCA, TLR2, ELA2, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14More
Flurazepamhsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Flurazepamhsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Flurazepamhsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Flurazepamhsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Flurazepamhsa04666Fc gamma R-mediated phagocytosis2.22E-024P49006, P06396, P14598, P17252MARCKSL1, GSN, NCF1, PRKCAMore
Flurazepamhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Flurazepamhsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Flurazepamhsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Flurazepamhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Flurazepamhsa04720Long-term potentiation1.43E-036P17252, P0DP23, P51812, P22694, Q02750, Q14643PRKCA, CALM1, RPS6KA3, PRKACB, MAP2K1, ITPR1More
Flurazepamhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Flurazepamhsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Flurazepamhsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Flurazepamhsa04725Cholinergic synapse2.43E-024P22694, P17252, P62879, Q02750PRKACB, PRKCA, GNB2, MAP2K1More
Flurazepamhsa04726Serotonergic synapse2.09E-036P63092, P22694, P17252, P62873, P62879, Q02750GNAS, PRKACB, PRKCA, GNB1, GNB2, MAP2K1More
Flurazepamhsa04727GABAergic synapse2.03E-024P62879, P22694, O60296, P17252GNB2, PRKACB, TRAK2, PRKCAMore
Flurazepamhsa04912GnRH signaling pathway4.42E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Flurazepamhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Flurazepamhsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Flurazepamhsa04919Thyroid hormone signaling pathway2.22E-025P17252, Q02750, P22694, Q12778, Q9UM47PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3More
Flurazepamhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Flurazepamhsa04925Aldosterone synthesis and secretion1.54E-024Q14643, P0DP23, P17252, P20020ITPR1, CALM1, PRKCA, ATP2B1More
Flurazepamhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Flurazepamhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Flurazepamhsa04928Parathyroid hormone synthesis, secretion and action4.48E-024P22694, Q02750, P17252, Q9Y5Q3PRKACB, MAP2K1, PRKCA, MAFBMore
Flurazepamhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Flurazepamhsa04940Type I diabetes mellitus6.87E-042P48023, P01375FASLG, TNFMore
Flurazepamhsa04966Collecting duct acid secretion3.15E-022P02730, Q9Y666SLC4A1, SLC12A7More
Flurazepamhsa04970Salivary secretion5.89E-057P07550, P22694, Q14643, P20020, P17252, P0DP23, P49913ADRB2, PRKACB, ITPR1, ATP2B1, PRKCA, CALM1, CAMPMore
Flurazepamhsa04972Pancreatic secretion1.42E-035Q14643, P20020, P17252, P63092, P61586ITPR1, ATP2B1, PRKCA, GNAS, RHOAMore
Flurazepamhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Flurazepamhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Flurazepamhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Flurazepamhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Flurazepamhsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Flurazepamhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Flurazepamhsa05132Salmonella infection1.02E-0310P51617, Q9UJU2, Q13546, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509IRAK1, LEF1, RIPK1, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3More
Flurazepamhsa05140Leishmaniasis1.56E-025P14598, O60603, P49006, P51617, Q15080NCF1, TLR2, MARCKSL1, IRAK1, NCF4More
Flurazepamhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Flurazepamhsa05143African trypanosomiasis1.51E-032P01375, P48023TNF, FASLGMore
Flurazepamhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Flurazepamhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Flurazepamhsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Flurazepamhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Flurazepamhsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Flurazepamhsa05165Human papillomavirus infection4.71E-0310P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATMMore
Flurazepamhsa05169Epstein-Barr virus infection2.54E-028Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P09693HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3GMore
Flurazepamhsa05170Human immunodeficiency virus 1 infection6.54E-039P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2More
Flurazepamhsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Flurazepamhsa05202Transcriptional misregulation in cancer3.76E-027Q12778, Q13315, Q15744, P46527, P05164, P08246, Q9C0K0FOXO1, ATM, CEBPE, CDKN1B, MPO, ELA2, BCL11BMore
Flurazepamhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Flurazepamhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Flurazepamhsa05205Proteoglycans in cancer4.46E-039Q12955, Q14247, P14780, P17252, P01375, P23588, Q13635, P22694, P08962ANK3, CTTN, MMP9, PRKCA, TNF, EIF4B, PTCH1, PRKACB, CD63More
Flurazepamhsa05206MicroRNAs in cancer3.66E-026P46527, Q9UM47, P16070, Q13315, P17252, Q02750CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1More
Flurazepamhsa05214Glioma1.00E-024P0DP23, P17252, P04637, P24522CALM1, PRKCA, TP53, GADD45AMore
Flurazepamhsa05216Thyroid cancer1.58E-035P01106, Q9UJU2, P04637, P24522, O75293MYC, LEF1, TP53, GADD45A, GADD45BMore
Flurazepamhsa05217Basal cell carcinoma4.42E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Flurazepamhsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Flurazepamhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Flurazepamhsa05310Asthma1.35E-022P13765, P29965HLA-DOB, CD40LGMore
Flurazepamhsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Flurazepamhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Flurazepamhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Flurazepamhsa05330Allograft rejection1.10E-044P13765, P29965, P48023, P01375HLA-DOB, CD40LG, FASLG, TNFMore
Flurazepamhsa05332Graft-versus-host disease6.49E-054P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Flurazepamhsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Flurazepamhsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-023P14923, P08514, Q9UJU2JUP, ITGA2B, LEF1More
Flurazepamhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Flurazepamhsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore

Community members of Flurazepam (SDC: 4.68)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)