PharmaCoNets of Fluoxymesterone (SPCN: 80.81 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Fluoxymesteronehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Fluoxymesteronehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Fluoxymesteronehsa00220Arginine biosynthesis1.94E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Fluoxymesteronehsa00250Alanine, aspartate and glutamate metabolism4.32E-022P49448, P15104GLUD2, GLULMore
Fluoxymesteronehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Fluoxymesteronehsa00500Starch and sucrose metabolism2.45E-053O43451, P46976, P06737MGAM, GYG1, PYGLMore
Fluoxymesteronehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Fluoxymesteronehsa00730Thiamine metabolism5.11E-052P05186, P24666ALPL, ACP1More
Fluoxymesteronehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Fluoxymesteronehsa00910Nitrogen metabolism4.32E-022P15104, P49448GLUL, GLUD2More
Fluoxymesteronehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Fluoxymesteronehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Fluoxymesteronehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Fluoxymesteronehsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Fluoxymesteronehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Fluoxymesteronehsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Fluoxymesteronehsa03430Mismatch repair4.38E-021P20585MSH3More
Fluoxymesteronehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Fluoxymesteronehsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Fluoxymesteronehsa04015Rap1 signaling pathway5.18E-043P08069, P06213, O00522IGF1R, INSR, KRIT1More
Fluoxymesteronehsa04062Chemokine signaling pathway3.13E-028P25024, P25025, P07948, P42338, P63218, P50151, P49407, P49841CXCR1, CXCR2, LYN, PIK3CB, GNG5, GNG10, ARRB1, GSK3BMore
Fluoxymesteronehsa04064NF-kappa B signaling pathway1.14E-0311Q13489, O00463, Q13546, P14778, Q9UDY8, Q13077, Q16548, Q8WV28, P24522, P09341, Q9UNE0BIRC3, TRAF5, RIPK1, IL1R1, MALT1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1, EDARMore
Fluoxymesteronehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Fluoxymesteronehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Fluoxymesteronehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Fluoxymesteronehsa04114Oocyte meiosis3.19E-035P51812, Q02750, P16298, Q17RY0, P08069RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Fluoxymesteronehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Fluoxymesteronehsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Fluoxymesteronehsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Fluoxymesteronehsa04150mTOR signaling pathway2.74E-037P08069, P42338, Q02750, Q9NQL2, P51812, Q13322, P49841IGF1R, PIK3CB, MAP2K1, RRAGD, RPS6KA3, GRB10, GSK3BMore
Fluoxymesteronehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Fluoxymesteronehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Fluoxymesteronehsa04211Longevity regulating pathway1.34E-034Q12778, P08069, Q9UEF7, Q96KQ7FOXO1, IGF1R, KL, EHMT2More
Fluoxymesteronehsa04213Longevity regulating pathway - multiple species2.83E-033P08069, Q9Y4H2, Q13547IGF1R, IRS2, HDAC1More
Fluoxymesteronehsa04217Necroptosis1.85E-037P01375, P01568, P48023, Q13489, Q13546, Q14765, Q99878TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, H2AC14More
Fluoxymesteronehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Fluoxymesteronehsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Fluoxymesteronehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Fluoxymesteronehsa04380Osteoclast differentiation4.71E-026Q16539, P06239, P42338, P14778, O75015, Q8N149MAPK14, LCK, PIK3CB, IL1R1, FCGR3B, LILRA2More
Fluoxymesteronehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Fluoxymesteronehsa04520Adherens junction8.29E-031P08069IGF1RMore
Fluoxymesteronehsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Fluoxymesteronehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Fluoxymesteronehsa04613Neutrophil extracellular trap formation1.23E-035P11215, Q13547, P58876, Q16778, O60814ITGAM, HDAC1, H2BC5, HIST2H2BE, H2BC12More
Fluoxymesteronehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Fluoxymesteronehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Fluoxymesteronehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Fluoxymesteronehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Fluoxymesteronehsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Fluoxymesteronehsa04657IL-17 signaling pathway5.03E-036O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Fluoxymesteronehsa04658Th1 and Th2 cell differentiation2.71E-037P07766, P20963, Q16539, P01730, P06239, Q9UL17, Q13761CD3E, CD247, MAPK14, CD4, LCK, TBX21, RUNX3More
Fluoxymesteronehsa04659Th17 cell differentiation1.05E-027Q16539, P01730, P06239, P14778, Q9UL17, P07766, P20963MAPK14, CD4, LCK, IL1R1, TBX21, CD3E, CD247More
Fluoxymesteronehsa04660T cell receptor signaling pathway2.27E-027P42338, P07766, P20963, P01730, P06239, Q16539, P49841PIK3CB, CD3E, CD247, CD4, LCK, MAPK14, GSK3BMore
Fluoxymesteronehsa04662B cell receptor signaling pathway2.80E-036P49841, P42338, P60033, P07948, P21854, Q8N149GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Fluoxymesteronehsa04664Fc epsilon RI signaling pathway1.80E-024Q16539, P42338, P07948, P09917MAPK14, PIK3CB, LYN, ALOX5More
Fluoxymesteronehsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Fluoxymesteronehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Fluoxymesteronehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Fluoxymesteronehsa04723Retrograde endocannabinoid signaling3.86E-024P63218, P50151, P48058, Q16539GNG5, GNG10, GRIA4, MAPK14More
Fluoxymesteronehsa04724Glutamatergic synapse7.09E-035P48058, P43003, P63218, P50151, P15104GRIA4, SLC1A3, GNG5, GNG10, GLULMore
Fluoxymesteronehsa04728Dopaminergic synapse2.35E-026P63218, P50151, P49841, Q16539, P49407, P48058GNG5, GNG10, GSK3B, MAPK14, ARRB1, GRIA4More
Fluoxymesteronehsa04730Long-term depression1.16E-021P08069IGF1RMore
Fluoxymesteronehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Fluoxymesteronehsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Fluoxymesteronehsa04914Progesterone-mediated oocyte maturation5.89E-034P08069, Q17RY0, P51812, Q02750IGF1R, CPEB4, RPS6KA3, MAP2K1More
Fluoxymesteronehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Fluoxymesteronehsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Fluoxymesteronehsa04923Regulation of lipolysis in adipocytes3.76E-021P06213INSRMore
Fluoxymesteronehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Fluoxymesteronehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Fluoxymesteronehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Fluoxymesteronehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Fluoxymesteronehsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Fluoxymesteronehsa04973Carbohydrate digestion and absorption1.57E-022O43451, P42338MGAM, PIK3CBMore
Fluoxymesteronehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Fluoxymesteronehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Fluoxymesteronehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Fluoxymesteronehsa05120Epithelial cell signaling in Helicobacter pylori infection1.61E-035Q16539, P09341, P25024, P25025, P07948MAPK14, CXCL1, CXCR1, CXCR2, LYNMore
Fluoxymesteronehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Fluoxymesteronehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Fluoxymesteronehsa05135Yersinia infection9.51E-036P13612, P06239, Q16539, P42338, P49841, P01730ITGA4, LCK, MAPK14, PIK3CB, GSK3B, CD4More
Fluoxymesteronehsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Fluoxymesteronehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Fluoxymesteronehsa05146Amoebiasis4.55E-025P09341, P14778, P27930, O60603, P05089CXCL1, IL1R1, IL1R2, TLR2, ARG1More
Fluoxymesteronehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Fluoxymesteronehsa05163Human cytomegalovirus infection4.78E-0411P42338, P63218, P50151, Q14643, P49841, P14778, Q13651, P25025, Q16539, P04637, O00463PIK3CB, GNG5, GNG10, ITPR1, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TP53, TRAF5More
Fluoxymesteronehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Fluoxymesteronehsa05169Epstein-Barr virus infection2.32E-029Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P07766, P20963HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, CD3E, CD247More
Fluoxymesteronehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Fluoxymesteronehsa05202Transcriptional misregulation in cancer8.55E-045P27930, P11215, P08069, Q13547, P12980IL1R2, ITGAM, IGF1R, HDAC1, LYL1More
Fluoxymesteronehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Fluoxymesteronehsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Fluoxymesteronehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Fluoxymesteronehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Fluoxymesteronehsa05214Glioma9.95E-031P08069IGF1RMore
Fluoxymesteronehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Fluoxymesteronehsa05218Melanoma6.63E-031P08069IGF1RMore
Fluoxymesteronehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Fluoxymesteronehsa05224Breast cancer1.24E-025P08069, P49841, Q92837, P04637, P24522IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Fluoxymesteronehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Fluoxymesteronehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Fluoxymesteronehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Fluoxymesteronehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.72E-039P42338, O95267, P07766, P20963, P09693, P06239, O60603, Q16539, P01730PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, MAPK14, CD4More
Fluoxymesteronehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Fluoxymesteronehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Fluoxymesteronehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Fluoxymesteronehsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore
Fluoxymesteronehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Fluoxymesterone (SDC: 5.97)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q9BPW9DHRS9Dehydrogenase/reductase SDR family member 9Predicted00.04540.04530.15430.2677
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)