PharmaCoNets of Fluorometholone (SPCN: 90.85 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Fluorometholonehsa00030Pentose phosphate pathway5.64E-033P60891, P11413, P37837PRPS1, G6PD, TALDO1More
Fluorometholonehsa00040Pentose and glucuronate interconversions9.59E-032P15121, P14550AKR1B1, AKR1A1More
Fluorometholonehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Fluorometholonehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Fluorometholonehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Fluorometholonehsa00500Starch and sucrose metabolism6.40E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Fluorometholonehsa00561Glycerolipid metabolism7.94E-033P15121, P14550, Q86XP1AKR1B1, AKR1A1, DGKHMore
Fluorometholonehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Fluorometholonehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Fluorometholonehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Fluorometholonehsa00630Glyoxylate and dicarboxylate metabolism1.32E-022P40925, P15104MDH1, GLULMore
Fluorometholonehsa00730Thiamine metabolism5.86E-042P05186, P24666ALPL, ACP1More
Fluorometholonehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Fluorometholonehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Fluorometholonehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Fluorometholonehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Fluorometholonehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Fluorometholonehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Fluorometholonehsa03010Ribosome1.60E-029P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3More
Fluorometholonehsa03030DNA replication1.48E-023P49005, P33993, P15927POLD2, MCM7, RPA2More
Fluorometholonehsa03040Spliceosome4.19E-0410Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, P11142, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8, PPIH, ASCC3L1More
Fluorometholonehsa04012ErbB signaling pathway1.34E-024P16333, P19174, P42338, P01106NCK1, PLCG1, PIK3CB, MYCMore
Fluorometholonehsa04014Ras signaling pathway2.92E-0410P42338, P20827, Q9NRA1, P49767, Q13009, P0DP23, P62873, P63218, P50151, P19174PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Fluorometholonehsa04015Rap1 signaling pathway4.83E-038P20827, Q9NRA1, P49767, P11215, Q13009, P42338, P0DP23, P19174EFNA1, PDGFC, VEGFC, ITGAM, TIAM1, PIK3CB, CALM1, PLCG1More
Fluorometholonehsa04020Calcium signaling pathway8.05E-0513P27987, Q96DU7, P21796, Q13557, P21860, P19174, P0DP23, P05141, P12236, P26678, P63092, Q9NRA1, P49767ITPKB, ITPKC, VDAC1, CAMK2D, ERBB3, PLCG1, CALM1, SLC25A5, SLC25A6, PLN, GNAS, PDGFC, VEGFCMore
Fluorometholonehsa04022cGMP-PKG signaling pathway9.36E-036P61586, P26678, Q99941, P18848, P05141, P12236RHOA, PLN, CREBL1, ATF4, SLC25A5, SLC25A6More
Fluorometholonehsa04062Chemokine signaling pathway3.26E-0411P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q13009, P14598, P42224, P25963LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, TIAM1, NCF1, STAT1, NFKBIAMore
Fluorometholonehsa04064NF-kappa B signaling pathway1.14E-0311Q13489, O00463, Q13546, P14778, Q9UDY8, Q13077, Q16548, Q8WV28, P24522, P09341, Q9UNE0BIRC3, TRAF5, RIPK1, IL1R1, MALT1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1, EDARMore
Fluorometholonehsa04070Phosphatidylinositol signaling system1.12E-025P19174, P0DP23, P42338, P23743, P27987PLCG1, CALM1, PIK3CB, DGKA, ITPKBMore
Fluorometholonehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Fluorometholonehsa04072Phospholipase D signaling pathway4.67E-025P42338, P19174, Q14344, P23743, Q9NRA1PIK3CB, PLCG1, GNA13, DGKA, PDGFCMore
Fluorometholonehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Fluorometholonehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Fluorometholonehsa04151PI3K-Akt signaling pathway2.62E-0421P42338, P21860, P01106, P27348, P20827, O14944, Q9NRA1, P49767, P07900, P08238, Q15831, P62873, P63218, P50151, O15335, P22105, P14784, P01568, Q99941, P18848, O95988PIK3CB, ERBB3, MYC, YWHAQ, EFNA1, EREG, PDGFC, VEGFC, HSP90AA1, HSP90AB1, STK11, GNB1, GNG5, GNG10, CHAD, TNXB, IL2RB, IFNA21, CREBL1, ATF4, TCL1BMore
Fluorometholonehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Fluorometholonehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Fluorometholonehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Fluorometholonehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Fluorometholonehsa04261Adrenergic signaling in cardiomyocytes3.12E-025P63092, Q99941, P18848, P26678, Q13557GNAS, CREBL1, ATF4, PLN, CAMK2DMore
Fluorometholonehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Fluorometholonehsa04360Axon guidance2.87E-025P16333, P20827, O95631, P42338, P19174NCK1, EFNA1, NTN1, PIK3CB, PLCG1More
Fluorometholonehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Fluorometholonehsa04371Apelin signaling pathway2.41E-037P62873, P63218, P50151, Q13370, Q14814, Q14344, P0DP23GNB1, GNG5, GNG10, PDE3B, MEF2D, GNA13, CALM1More
Fluorometholonehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Fluorometholonehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Fluorometholonehsa04612Antigen processing and presentation3.29E-038P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Fluorometholonehsa04613Neutrophil extracellular trap formation3.79E-0513P42338, P19174, P11215, Q13547, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431, P21796, P14598PIK3CB, PLCG1, ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1More
Fluorometholonehsa04620Toll-like receptor signaling pathway5.54E-035Q13546, P01568, P42224, P25963, P42338RIPK1, IFNA21, STAT1, NFKBIA, PIK3CBMore
Fluorometholonehsa04621NOD-like receptor signaling pathway4.48E-0312P01568, Q13489, Q9H1Y0, P43490, O00463, Q13546, Q05823, P01375, P49913, P59665, P59666, P12838IFNA21, BIRC3, ATG5, PBEF1, TRAF5, RIPK1, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Fluorometholonehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Fluorometholonehsa04623Cytosolic DNA-sensing pathway3.38E-043P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Fluorometholonehsa04625C-type lectin receptor signaling pathway2.17E-025Q9ULY5, P42224, P25963, P42338, P0DP23CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1More
Fluorometholonehsa04640Hematopoietic cell lineage1.58E-026P13612, P20023, P11836, P09693, P01732, P13765ITGA4, CR2, MS4A1, CD3G, CD8A, HLA-DOBMore
Fluorometholonehsa04650Natural killer cell mediated cytotoxicity3.23E-0512P16298, P50591, P01375, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, TNF, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Fluorometholonehsa04657IL-17 signaling pathway5.03E-036O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Fluorometholonehsa04658Th1 and Th2 cell differentiation3.42E-0411P25963, P07766, P20963, P09693, P19174, P42224, P23771, Q9UL17, P14784, P13765, Q13761NFKBIA, CD3E, CD247, CD3G, PLCG1, STAT1, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Fluorometholonehsa04659Th17 cell differentiation2.45E-0311P25963, P19174, P42224, P14784, P13765, Q9UL17, P23771, P08238, P07766, P09693, P20963NFKBIA, PLCG1, STAT1, IL2RB, HLA-DOB, TBX21, GATA3, HSP90AB1, CD3E, CD3G, CD247More
Fluorometholonehsa04660T cell receptor signaling pathway1.58E-026O95267, Q08881, P20963, P09693, P01732, Q13191RASGRP1, ITK, CD247, CD3G, CD8A, CBLBMore
Fluorometholonehsa04662B cell receptor signaling pathway1.12E-025P25963, P42338, P07948, P21854, Q8N149NFKBIA, PIK3CB, LYN, CD72, LILRA2More
Fluorometholonehsa04664Fc epsilon RI signaling pathway1.34E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Fluorometholonehsa04666Fc gamma R-mediated phagocytosis2.92E-024P07948, P42338, P19174, P14598LYN, PIK3CB, PLCG1, NCF1More
Fluorometholonehsa04672Intestinal immune network for IgA production4.27E-022P13765, P13612HLA-DOB, ITGA4More
Fluorometholonehsa04713Circadian entrainment4.00E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Fluorometholonehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Fluorometholonehsa04724Glutamatergic synapse2.92E-024P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Fluorometholonehsa04725Cholinergic synapse2.92E-024P62873, P63218, P50151, P42338GNB1, GNG5, GNG10, PIK3CBMore
Fluorometholonehsa04727GABAergic synapse8.14E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Fluorometholonehsa04744Phototransduction1.32E-022P62873, P0DP23GNB1, CALM1More
Fluorometholonehsa04750Inflammatory mediator regulation of TRP channels4.00E-024P19174, P42338, P24723, P0DP23PLCG1, PIK3CB, PRKCH, CALM1More
Fluorometholonehsa04810Regulation of actin cytoskeleton2.61E-026P12814, Q13009, P42338, P11215, Q14344, Q9NRA1ACTN1, TIAM1, PIK3CB, ITGAM, GNA13, PDGFCMore
Fluorometholonehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Fluorometholonehsa04911Insulin secretion4.47E-034P63092, Q99941, P18848, Q13557GNAS, CREBL1, ATF4, CAMK2DMore
Fluorometholonehsa04914Progesterone-mediated oocyte maturation4.29E-037Q17RY0, P42338, Q13370, P30304, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, CDC25A, HSP90AB1, RPS6KA3, MAP2K1More
Fluorometholonehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Fluorometholonehsa04925Aldosterone synthesis and secretion1.68E-024Q99941, P18848, P63092, Q13557CREBL1, ATF4, GNAS, CAMK2DMore
Fluorometholonehsa04926Relaxin signaling pathway8.74E-036P25963, P42338, P62873, P63218, P50151, P49767NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFCMore
Fluorometholonehsa04927Cortisol synthesis and secretion2.40E-023Q99941, P18848, P63092CREBL1, ATF4, GNASMore
Fluorometholonehsa04928Parathyroid hormone synthesis, secretion and action2.33E-024P63092, P61586, Q99941, P18848GNAS, RHOA, CREBL1, ATF4More
Fluorometholonehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Fluorometholonehsa04934Cushing syndrome1.37E-035Q99941, P18848, P63092, O15169, Q13557CREBL1, ATF4, GNAS, AXIN1, CAMK2DMore
Fluorometholonehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Fluorometholonehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Fluorometholonehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Fluorometholonehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Fluorometholonehsa05010Alzheimer disease1.36E-029Q92542, O15239, P05496, P18848, O15169, P05141, P12236, P43686, P62195NCSTN, NDUFA1, ATP5G1, ATF4, AXIN1, SLC25A5, SLC25A6, PSMC4, PSMC5More
Fluorometholonehsa05012Parkinson disease5.04E-0415O15239, P05496, P05141, P12236, P21796, P60604, P63092, P18848, P43686, P62195, P19174, P0DP23, Q13557, Q71U36, Q13509NDUFA1, ATP5G1, SLC25A5, SLC25A6, VDAC1, UBE2G2, GNAS, ATF4, PSMC4, PSMC5, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3More
Fluorometholonehsa05014Amyotrophic lateral sclerosis3.92E-028P20333, O15239, P05496, P18848, P43686, P62195, P51991, P35658TNFRSF1B, NDUFA1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, NUP214More
Fluorometholonehsa05020Prion disease1.15E-029P46531, O15239, P05496, P18848, P05141, P12236, P43686, P62195, Q99941NOTCH1, NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, PSMC4, PSMC5, CREBL1More
Fluorometholonehsa05022Pathways of neurodegeneration - multiple diseases1.57E-0210O15239, P05496, P18848, P05141, P12236, P20333, O15169, Q13557, P43686, P62195NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, TNFRSF1B, AXIN1, CAMK2D, PSMC4, PSMC5More
Fluorometholonehsa05030Cocaine addiction2.40E-023P63092, Q99941, P18848GNAS, CREBL1, ATF4More
Fluorometholonehsa05031Amphetamine addiction4.47E-034Q13557, P63092, Q99941, P18848CAMK2D, GNAS, CREBL1, ATF4More
Fluorometholonehsa05032Morphine addiction7.60E-035P62873, P63218, P50151, Q13370, P43250GNB1, GNG5, GNG10, PDE3B, GRK6More
Fluorometholonehsa05034Alcoholism1.63E-0612Q13547, P0DP23, P62873, P63218, P50151, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Fluorometholonehsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Fluorometholonehsa05132Salmonella infection1.41E-0312P25963, P08238, P01106, P42338, Q13546, Q13489, O75369, O60282, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, MYC, PIK3CB, RIPK1, BIRC3, FLNB, KIF5C, TUBA1A, TUBB3, TUBB2C, VPS41More
Fluorometholonehsa05133Pertussis4.20E-021P0C0L4C4AMore
Fluorometholonehsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Fluorometholonehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Fluorometholonehsa05144Malaria3.76E-036P60033, P69905, P68871, P01375, P35443, P26718CD81, HBA2, HBB, TNF, THBS4, KLRK1More
Fluorometholonehsa05146Amoebiasis4.55E-025P09341, P14778, P27930, O60603, P05089CXCL1, IL1R1, IL1R2, TLR2, ARG1More
Fluorometholonehsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Fluorometholonehsa05162Measles1.84E-027P01568, P25963, P42224, P14784, P07766, P42338, P11142IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8More
Fluorometholonehsa05163Human cytomegalovirus infection7.99E-0517P42338, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, P49841, P01106, P14778, P25025, Q16539, P04637, O00463, P30101, P01568PIK3CB, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, GSK3B, MYC, IL1R1, CXCR2, MAPK14, TP53, TRAF5, PDIA3, IFNA21More
Fluorometholonehsa05167Kaposi sarcoma-associated herpesvirus infection4.21E-0615P01568, P42224, P25963, P42338, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P01106, P0DP23, P0CG47IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, MYC, CALM1, UBBMore
Fluorometholonehsa05168Herpes simplex virus 1 infection4.57E-0210P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF189More
Fluorometholonehsa05169Epstein-Barr virus infection1.32E-0418P20023, P13765, P01106, Q13547, Q92769, O00463, P25963, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, P07766, P09693, P20963CR2, HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, NFKBIA, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, CD3E, CD3G, CD247More
Fluorometholonehsa05170Human immunodeficiency virus 1 infection5.72E-0515P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, P19174, P07766, P20333PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, PLCG1, CD3E, TNFRSF1BMore
Fluorometholonehsa05200Pathways in cancer1.82E-0317P42338, P08238, P42224, P25963, P19174, P01106, P43246, Q13547, P49767, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, HDAC1, VEGFC, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Fluorometholonehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Fluorometholonehsa05203Viral carcinogenesis1.68E-0618Q99941, P18848, P42338, P06746, P07948, P27348, P29083, Q13547, Q15283, P61586, P12814, P25963, P61978, P58876, P62807, Q93079, Q16778, O60814CREBL1, ATF4, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, HDAC1, RASA2, RHOA, ACTN1, NFKBIA, HNRPK, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12More
Fluorometholonehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Fluorometholonehsa05206MicroRNAs in cancer1.34E-0313P30304, P09493, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P61586, P20827, P19174CDC25A, TPM1, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, RHOA, EFNA1, PLCG1More
Fluorometholonehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Fluorometholonehsa05214Glioma1.34E-024P0DP23, P42338, P19174, O75293CALM1, PIK3CB, PLCG1, GADD45BMore
Fluorometholonehsa05217Basal cell carcinoma2.83E-023Q13635, Q9UJU2, P24522PTCH1, LEF1, GADD45AMore
Fluorometholonehsa05218Melanoma2.31E-023Q9NRA1, P42338, O75293PDGFC, PIK3CB, GADD45BMore
Fluorometholonehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Fluorometholonehsa05220Chronic myeloid leukemia2.17E-025Q13547, P01106, P25963, P42338, O75293HDAC1, MYC, NFKBIA, PIK3CB, GADD45BMore
Fluorometholonehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Fluorometholonehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Fluorometholonehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Fluorometholonehsa05231Choline metabolism in cancer2.92E-035P42338, Q9NRA1, Q9Y259, P19174, P23743PIK3CB, PDGFC, CHKB, PLCG1, DGKAMore
Fluorometholonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.44E-0310P25963, P42338, O95267, P19174, P07766, P09693, P42224, O60603, Q16539, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD3G, STAT1, TLR2, MAPK14, CD4More
Fluorometholonehsa05321Inflammatory bowel disease3.98E-023P13765, Q9UL17, P23771HLA-DOB, TBX21, GATA3More
Fluorometholonehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Fluorometholonehsa05332Graft-versus-host disease1.89E-023P13765, P26715, Q13241HLA-DOB, KLRC1, KLRD1More
Fluorometholonehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Fluorometholonehsa05415Diabetic cardiomyopathy6.56E-037P05141, P12236, O15239, P05496, Q13557, P11413, P26678SLC25A5, SLC25A6, NDUFA1, ATP5G1, CAMK2D, G6PD, PLNMore
Fluorometholonehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Fluorometholone (SDC: 5.57)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P07195LDHBLNonelactate dehydrogenase B chainPredicted00.01670.17490.2310.5892
P40925MDH1Malate dehydrogenase, cytoplasmicPredicted00.35660.27460.24260.97
P40926MDH2Malate dehydrogenase, mitochondrialPredicted00.47210.16110.24740.8055
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)