PharmaCoNets of Fluoroestradiol-f-18 (SPCN: 69.35 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Fluoroestradiol-F-18hsa00030Pentose phosphate pathway3.67E-033P60891, P11413, P37837PRPS1, G6PD, TALDO1More
Fluoroestradiol-F-18hsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Fluoroestradiol-F-18hsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Fluoroestradiol-F-18hsa00480Glutathione metabolism2.60E-055Q9UJ14, P11413, Q16772, P09211, P30041GGTL3, G6PD, GSTA3, GSTP1, PRDX6More
Fluoroestradiol-F-18hsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Fluoroestradiol-F-18hsa00591Linoleic acid metabolism1.29E-031P11712CYP2C9More
Fluoroestradiol-F-18hsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Fluoroestradiol-F-18hsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Fluoroestradiol-F-18hsa00980Metabolism of xenobiotics by cytochrome P4509.14E-054Q16772, P78417, P09211, P11712GSTA3, GSTO1, GSTP1, CYP2C9More
Fluoroestradiol-F-18hsa00982Drug metabolism - cytochrome P4501.77E-044P11712, Q16772, P09211, P78417CYP2C9, GSTA3, GSTP1, GSTO1More
Fluoroestradiol-F-18hsa00983Drug metabolism - other enzymes1.92E-035P04183, P32320, P05164, Q16772, P09211TK1, CDA, MPO, GSTA3, GSTP1More
Fluoroestradiol-F-18hsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Fluoroestradiol-F-18hsa01200Carbon metabolism2.91E-021P11413G6PDMore
Fluoroestradiol-F-18hsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Fluoroestradiol-F-18hsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Fluoroestradiol-F-18hsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Fluoroestradiol-F-18hsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Fluoroestradiol-F-18hsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Fluoroestradiol-F-18hsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Fluoroestradiol-F-18hsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Fluoroestradiol-F-18hsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Fluoroestradiol-F-18hsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Fluoroestradiol-F-18hsa04064NF-kappa B signaling pathway9.80E-0718P10415, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9NQC7BCL2, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, CYLDMore
Fluoroestradiol-F-18hsa04071Sphingolipid signaling pathway1.00E-035P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Fluoroestradiol-F-18hsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Fluoroestradiol-F-18hsa04080Neuroactive ligand-receptor interaction1.05E-038P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2More
Fluoroestradiol-F-18hsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Fluoroestradiol-F-18hsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Fluoroestradiol-F-18hsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Fluoroestradiol-F-18hsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Fluoroestradiol-F-18hsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Fluoroestradiol-F-18hsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Fluoroestradiol-F-18hsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Fluoroestradiol-F-18hsa04210Apoptosis3.83E-038Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Fluoroestradiol-F-18hsa04213Longevity regulating pathway - multiple species4.41E-034P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Fluoroestradiol-F-18hsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Fluoroestradiol-F-18hsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Fluoroestradiol-F-18hsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Fluoroestradiol-F-18hsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Fluoroestradiol-F-18hsa04530Tight junction1.74E-036P63261, P16989, P56750, Q9Y478, Q92974, Q14247ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTNMore
Fluoroestradiol-F-18hsa04612Antigen processing and presentation3.90E-036P13765, P48382, P26715, P26717, Q13241, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8AMore
Fluoroestradiol-F-18hsa04613Neutrophil extracellular trap formation1.31E-0623P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Fluoroestradiol-F-18hsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Fluoroestradiol-F-18hsa04625C-type lectin receptor signaling pathway8.11E-039Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Fluoroestradiol-F-18hsa04640Hematopoietic cell lineage2.62E-0314P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, IL1BMore
Fluoroestradiol-F-18hsa04650Natural killer cell mediated cytotoxicity4.09E-0616P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Fluoroestradiol-F-18hsa04657IL-17 signaling pathway1.56E-028O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Fluoroestradiol-F-18hsa04658Th1 and Th2 cell differentiation1.52E-0714Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Fluoroestradiol-F-18hsa04659Th17 cell differentiation7.74E-0614Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1More
Fluoroestradiol-F-18hsa04660T cell receptor signaling pathway8.13E-0616P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Fluoroestradiol-F-18hsa04714Thermogenesis1.73E-047Q16539, P15336, P63261, P33121, Q9Y478, Q16718, O14521MAPK14, ATF2, ACTG1, ACSL1, PRKAB1, NDUFA5, SDHDMore
Fluoroestradiol-F-18hsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Fluoroestradiol-F-18hsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Fluoroestradiol-F-18hsa04750Inflammatory mediator regulation of TRP channels3.14E-0411P14778, P01584, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2More
Fluoroestradiol-F-18hsa04912GnRH signaling pathway4.33E-026P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Fluoroestradiol-F-18hsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Fluoroestradiol-F-18hsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Fluoroestradiol-F-18hsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Fluoroestradiol-F-18hsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Fluoroestradiol-F-18hsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Fluoroestradiol-F-18hsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Fluoroestradiol-F-18hsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Fluoroestradiol-F-18hsa04927Cortisol synthesis and secretion8.60E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Fluoroestradiol-F-18hsa04928Parathyroid hormone synthesis, secretion and action2.33E-035Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Fluoroestradiol-F-18hsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Fluoroestradiol-F-18hsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Fluoroestradiol-F-18hsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Fluoroestradiol-F-18hsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Fluoroestradiol-F-18hsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Fluoroestradiol-F-18hsa05034Alcoholism3.52E-067Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Fluoroestradiol-F-18hsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Fluoroestradiol-F-18hsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Fluoroestradiol-F-18hsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Fluoroestradiol-F-18hsa05140Leishmaniasis2.29E-029P13612, O75015, P23458, P13765, O60603, P01375, P01584, Q16539, Q15080ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MAPK14, NCF4More
Fluoroestradiol-F-18hsa05144Malaria2.43E-026P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Fluoroestradiol-F-18hsa05146Amoebiasis1.54E-0413P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Fluoroestradiol-F-18hsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Fluoroestradiol-F-18hsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Fluoroestradiol-F-18hsa05202Transcriptional misregulation in cancer1.24E-0521Q12778, Q15532, Q13315, P17844, P14780, P27930, Q15744, Q16548, P11215, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Fluoroestradiol-F-18hsa05203Viral carcinogenesis1.46E-058Q12933, P42229, Q13547, Q15283, P58876, P62807, Q16778, O60814TRAF2, STAT5A, HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Fluoroestradiol-F-18hsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Fluoroestradiol-F-18hsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Fluoroestradiol-F-18hsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Fluoroestradiol-F-18hsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Fluoroestradiol-F-18hsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Fluoroestradiol-F-18hsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Fluoroestradiol-F-18hsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.51E-0412P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, P10747, Q04759, Q16539PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, CD28, PRKCQ, MAPK14More
Fluoroestradiol-F-18hsa05321Inflammatory bowel disease5.29E-068O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Fluoroestradiol-F-18hsa05322Systemic lupus erythematosus5.41E-077P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Fluoroestradiol-F-18hsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Fluoroestradiol-F-18hsa05332Graft-versus-host disease6.43E-054P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Fluoroestradiol-F-18hsa05415Diabetic cardiomyopathy4.92E-035Q16718, O14521, Q16539, P49841, P11413NDUFA5, SDHD, MAPK14, GSK3B, G6PDMore

Community members of Fluoroestradiol-f-18 (SDC: 6.13)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)