PharmaCoNets

PharmaCoNets of Flunarizine (S_PCN: 117.94 )

Flunarizine regulated-network (S_DN: 22.09)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Flunarizine

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Flunarizine

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Flunarizine

hsa00230

Purine metabolism

4.60E-02

Q13370, P36959, Q13956, P27707

PDE3B, GMPR, PDE6H, DCK

Flunarizine

hsa00240

Pyrimidine metabolism

4.01E-03

P21589, P32320, P27707, P04183

NT5E, CDA, DCK, TK1

Flunarizine

hsa00500

Starch and sucrose metabolism

1.47E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Flunarizine

hsa00513

Various types of N-glycan biosynthesis

4.96E-02

Q9NR34

MAN1C1

Flunarizine

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Flunarizine

hsa00534

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

4.77E-02

Q7LGA3

HS2ST1

Flunarizine

hsa00562

Inositol phosphate metabolism

1.28E-02

Q14642, P29218

INPP5A, IMPA1

Flunarizine

hsa00564

Glycerophospholipid metabolism

4.29E-02

Q6P1A2, P23743

MBOAT5, DGKA

Flunarizine

hsa00565

Ether lipid metabolism

3.52E-04

Q9Y6K0, Q8N661

CEPT1, TMEM86B

Flunarizine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Flunarizine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Flunarizine

hsa00670

One carbon pool by folate

3.99E-02

O95954, Q99707

FTCD, MTR

Flunarizine

hsa00730

Thiamine metabolism

4.07E-02

P05186, P24666

ALPL, ACP1

Flunarizine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Flunarizine

hsa00920

Sulfur metabolism

3.01E-02

O95571

ETHE1

Flunarizine

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Flunarizine

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Flunarizine

hsa00983

Drug metabolism - other enzymes

4.06E-02

P20839, Q16772

IMPDH1, GSTA3

Flunarizine

hsa01100

Metabolic pathways

1.51E-03

Q9NR34, Q9Y234, P05089, Q99707, Q14642, P29218, P11310, P27707, P32320, Q13370, P36959, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, P30043, Q14376, P05186, P24666, Q02252, O60701, O14772, P07101, O95954, Q9HCC0, P33121, Q02318, Q9UHK6, P04406, P57054, Q9UNP4, O15466, Q9BX95, P09960, P32321, Q9P2R7, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737, P12074, Q13488, Q16718, Q02809

MAN1C1, LIPT1, ARG1, MTR, INPP5A, IMPA1, ACADM, DCK, CDA, PDE3B, GMPR, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, BLVRB, GALE, ALPL, ACP1, ALDH6A1, UGDH, FPGT, TH, FTCD, MCCC2, ACSL1, CYP27A1, AMACR, GAPDH, PIGP, ST3GAL5, ST8SIA5, SGPP1, LTA4H, DCTD, SUCLA2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL, COX6A1, TCIRG1, NDUFA5, PLOD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
O15182	CETN3	Centrin-3	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.727
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
O15182	CETN3	Centrin-3	Q99707	MTR	Methionine synthase	0.924
Q09472	EP300	Histone acetyltransferase p300	Q14642	INPP5A	Inositol polyphosphate-5-phosphatase A	0.7
Q09472	EP300	Histone acetyltransferase p300	P29218	IMPA1	Inositol monophosphatase 1	0.772
O15182	CETN3	Centrin-3	P29218	IMPA1	Inositol monophosphatase 1	0.739
O15182	CETN3	Centrin-3	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	0.881
O15182	CETN3	Centrin-3	P27707	DCK	Deoxycytidine kinase	0.937
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
O15182	CETN3	Centrin-3	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.707
O15182	CETN3	Centrin-3	P36959	GMPR	GMP reductase 1	-0.724
O15182	CETN3	Centrin-3	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
O15182	CETN3	Centrin-3	P30043	BLVRB	Flavin reductase	-0.859
Q09472	EP300	Histone acetyltransferase p300	Q14376	GALE	UDP-glucose 4-epimerase	-0.905
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
O15182	CETN3	Centrin-3	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	0.801
O15182	CETN3	Centrin-3	O60701	UGDH	UDP-glucose 6-dehydrogenase	0.717
O15182	CETN3	Centrin-3	O14772	FPGT	Fucose-1-phosphate guanylyltransferase	0.862
Q09472	EP300	Histone acetyltransferase p300	P07101	TH	Tyrosine 3-monooxygenase	-0.739
O15182	CETN3	Centrin-3	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.706
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
O15182	CETN3	Centrin-3	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.805
Q09472	EP300	Histone acetyltransferase p300	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	0.848
O15182	CETN3	Centrin-3	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.765
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
O15182	CETN3	Centrin-3	O15466	ST8SIA5	Alpha-2,8-sialyltransferase 8E	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
O15182	CETN3	Centrin-3	P09960	LTA4H	Leukotriene A-4 hydrolase	-0.728
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
O15182	CETN3	Centrin-3	Q9P2R7	SUCLA2	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0.84
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
O15182	CETN3	Centrin-3	Q9UHY7	ENOPH1	Enolase-phosphatase E1	0.707
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
O15182	CETN3	Centrin-3	P35573	AGL	Glycogen debranching enzyme	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
Q09472	EP300	Histone acetyltransferase p300	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	-0.778
O15182	CETN3	Centrin-3	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.767
O15182	CETN3	Centrin-3	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.785
O15182	CETN3	Centrin-3	Q02809	PLOD1	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	-0.849

Flunarizine

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Flunarizine

hsa01522

Endocrine resistance

2.16E-02

P08069

IGF1R

Flunarizine

hsa01524

Platinum drug resistance

6.70E-03

P10415, Q13489, O15392, P78417, P11388, P43246

BCL2, BIRC3, BIRC5, GSTO1, TOP2A, MSH2

Flunarizine

hsa02010

ABC transporters

1.99E-04

P45844, P08183, Q8IZY2, Q99758

ABCG1, ABCB1, ABCA7, ABCA3

Flunarizine

hsa03013

RNA transport

4.79E-02

P62826, P63279

RAN, UBE2I

Flunarizine

hsa03015

mRNA surveillance pathway

3.62E-02

O43148, P61326, P52298

RNMT, MAGOH, NCBP2

Flunarizine

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Flunarizine

hsa03020

RNA polymerase

9.86E-07

Q9GZM3, P52435

POLR2J2, POLR2J

Flunarizine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Flunarizine

hsa03040

Spliceosome

1.11E-07

Q14562, O43143, O60508, P17844, O14776, P08579, O75940, P52298, P09651, Q15365, O75494, Q07955, Q01130, Q13243, P11142, O95777, O43447, P61326

DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, SMNDC1, NCBP2, HNRNPA1, PCBP1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, LSM8, PPIH, MAGOH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
P0DP25	CALM3	Calmodulin-3	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
P0DP24	CALM2	Calmodulin-2	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
P0DP23	CALM1	Calmodulin-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P0DP25	CALM3	Calmodulin-3	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P0DP24	CALM2	Calmodulin-2	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P0DP23	CALM1	Calmodulin-1	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P0DP25	CALM3	Calmodulin-3	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P0DP24	CALM2	Calmodulin-2	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P0DP24	CALM2	Calmodulin-2	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.734
O15182	CETN3	Centrin-3	O14776	TCERG1	Transcription elongation regulator 1	0.758
P0DP23	CALM1	Calmodulin-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
P0DP25	CALM3	Calmodulin-3	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
P0DP24	CALM2	Calmodulin-2	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
O15182	CETN3	Centrin-3	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	0.859
O15182	CETN3	Centrin-3	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.701
O15182	CETN3	Centrin-3	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	0.757
P0DP24	CALM2	Calmodulin-2	Q15365	PCBP1	Poly(rC)-binding protein 1	0.75
O15182	CETN3	Centrin-3	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	0.85
P0DP23	CALM1	Calmodulin-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP25	CALM3	Calmodulin-3	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP24	CALM2	Calmodulin-2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP23	CALM1	Calmodulin-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP25	CALM3	Calmodulin-3	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP24	CALM2	Calmodulin-2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP23	CALM1	Calmodulin-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP25	CALM3	Calmodulin-3	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP24	CALM2	Calmodulin-2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP23	CALM1	Calmodulin-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP25	CALM3	Calmodulin-3	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP24	CALM2	Calmodulin-2	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
O15182	CETN3	Centrin-3	O95777	LSM8	U6 snRNA-associated Sm-like protein LSm8	0.723
P0DP23	CALM1	Calmodulin-1	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748
P0DP25	CALM3	Calmodulin-3	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748
P0DP24	CALM2	Calmodulin-2	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748
O15182	CETN3	Centrin-3	P61326	MAGOH	Protein mago nashi homolog	0.811

Flunarizine

hsa03050

Proteasome

5.53E-03

P43686, P28070

PSMC4, PSMB4

Flunarizine

hsa03320

PPAR signaling pathway

2.18E-02

O00767, Q02318

SCD, CYP27A1

Flunarizine

hsa03460

Fanconi anemia pathway

3.70E-03

Q9NPI8, O60673, Q9UNA4

FANCF, REV3L, POLI

Flunarizine

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Flunarizine

hsa04014

Ras signaling pathway

1.42E-03

P31751, P20827, P49767, P08069, Q13009, P17252, Q15311, P0DP23, P62873, P19174

AKT2, EFNA1, VEGFC, IGF1R, TIAM1, PRKCA, RALBP1, CALM1, GNB1, PLCG1

Flunarizine

hsa04015

Rap1 signaling pathway

2.53E-04

P20827, P49767, P08069, P25116, Q8TEU7, Q13009, Q08828, P51828, P31751, P0DP23, P08514, P17252, P19174

EFNA1, VEGFC, IGF1R, F2R, RAPGEF6, TIAM1, ADCY1, ADCY7, AKT2, CALM1, ITGA2B, PRKCA, PLCG1

Flunarizine

hsa04020

Calcium signaling pathway

1.04E-06

P27987, Q08828, Q13557, P17252, O15399, P19174, P61073, P0DP23, P51828, P23634, P49767

ITPKB, ADCY1, CAMK2D, PRKCA, GRIN2D, PLCG1, CXCR4, CALM1, ADCY7, ATP2B4, VEGFC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P0DP25	CALM3	Calmodulin-3	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P0DP24	CALM2	Calmodulin-2	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP25	CALM3	Calmodulin-3	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP24	CALM2	Calmodulin-2	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP25	CALM3	Calmodulin-3	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP24	CALM2	Calmodulin-2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP24	CALM2	Calmodulin-2	P49767	VEGFC	Vascular endothelial growth factor C	-0.84

Flunarizine

hsa04024

cAMP signaling pathway

3.01E-03

Q08828, P51828, P31751, P0DP23, P23634, Q13557, Q13370, O15399, Q13009

ADCY1, ADCY7, AKT2, CALM1, ATP2B4, CAMK2D, PDE3B, GRIN2D, TIAM1

Flunarizine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Flunarizine

hsa04062

Chemokine signaling pathway

1.29E-03

P51684, P25024, P25025, P09341, P19875, Q8NHW4, P42338, P19174, P62873, P63218, P50151, Q08828, P51828, Q13009, P14598, P42224, P31751

CCR6, CXCR1, CXCR2, CXCL1, CXCL2, CCL4L2, PIK3CB, PLCG1, GNB1, GNG5, GNG10, ADCY1, ADCY7, TIAM1, NCF1, STAT1, AKT2

Flunarizine

hsa04064

NF-kappa B signaling pathway

1.24E-07

P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, P24522, O75293, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7

BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, GADD45A, GADD45B, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP23	CALM1	Calmodulin-1	P29965	CD40LG	CD40 ligand	-0.721
P0DP25	CALM3	Calmodulin-3	P29965	CD40LG	CD40 ligand	-0.721
P0DP24	CALM2	Calmodulin-2	P29965	CD40LG	CD40 ligand	-0.721
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P0DP23	CALM1	Calmodulin-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP25	CALM3	Calmodulin-3	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP24	CALM2	Calmodulin-2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P0DP23	CALM1	Calmodulin-1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.883
P0DP24	CALM2	Calmodulin-2	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.778

Flunarizine

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Flunarizine

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Flunarizine

hsa04070

Phosphatidylinositol signaling system

8.08E-05

P19174, P0DP23, P23743, P48426, P29218, Q14642, P27987, P17252

PLCG1, CALM1, DGKA, PIP4K2A, IMPA1, INPP5A, ITPKB, PRKCA

Flunarizine

hsa04071

Sphingolipid signaling pathway

3.36E-02

P17252, Q13510, Q13362, P10415, Q9UQC2, P01042

PRKCA, ASAH1, PPP2R5C, BCL2, GAB2, KNG1

Flunarizine

hsa04072

Phospholipase D signaling pathway

2.68E-03

P31751, P42338, P43657, P25024, P25025, P19174, P17252, Q15438, Q08828, P51828, P23743, P00734

AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PRKCA, PSCD1, ADCY1, ADCY7, DGKA, F2

Flunarizine

hsa04114

Oocyte meiosis

2.99E-02

P08069

IGF1R

Flunarizine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Flunarizine

hsa04140

Autophagy - animal

1.61E-02

P08069, P31751, Q7L523, Q96RR4, O75460, P10415, Q96GC9, Q8TEV9

IGF1R, AKT2, RRAGA, CAMKK2, ERN1, BCL2, TMEM49, SMCR8

Flunarizine

hsa04144

Endocytosis

8.99E-03

P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7

HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6

Flunarizine

hsa04145

Phagosome

5.56E-03

P60709, P63261, Q15075, Q15080, P14598, Q13509, Q13488, O60603

ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TCIRG1, TLR2

Flunarizine

hsa04150

mTOR signaling pathway

2.32E-02

P08069

IGF1R

Flunarizine

hsa04151

PI3K-Akt signaling pathway

4.68E-03

O43521, P27348, P20827, P49767, Q13362, P08238, P62873, P16144, P48551, P14784, P23458, P01568, P15336, P18848, P10415, P17252, Q16513, Q6ZUJ8

BCL2L11, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AB1, GNB1, ITGB4, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, ATF4, BCL2, PRKCA, PKN2, PIK3AP1

Flunarizine

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Flunarizine

hsa04210

Apoptosis

6.18E-03

P07384, P60709, P63261

CAPN1, ACTB, ACTG1

Flunarizine

hsa04211

Longevity regulating pathway

1.34E-03

Q12778, P08069, Q9UEF7, Q96KQ7

FOXO1, IGF1R, KL, EHMT2

Flunarizine

hsa04213

Longevity regulating pathway - multiple species

1.17E-02

P42338, P08069, Q9Y4H2, P11142, Q13547

PIK3CB, IGF1R, IRS2, HSPA8, HDAC1

Flunarizine

hsa04217

Necroptosis

3.44E-10

P01375, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P08238, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351

TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AB1, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.883
P0DP24	CALM2	Calmodulin-2	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.778
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P0DP23	CALM1	Calmodulin-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP24	CALM2	Calmodulin-2	P0C0S5	H2AFZ	Histone H2A.Z	0.749
P0DP23	CALM1	Calmodulin-1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
P0DP25	CALM3	Calmodulin-3	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
P0DP24	CALM2	Calmodulin-2	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP23	CALM1	Calmodulin-1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.73
P0DP24	CALM2	Calmodulin-2	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.713
P0DP23	CALM1	Calmodulin-1	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P0DP25	CALM3	Calmodulin-3	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P0DP24	CALM2	Calmodulin-2	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P0DP23	CALM1	Calmodulin-1	Q9NZZ3	CHMP5	Charged multivesicular body protein 5	0.713
P0DP24	CALM2	Calmodulin-2	Q9NZZ3	CHMP5	Charged multivesicular body protein 5	0.763
P0DP23	CALM1	Calmodulin-1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.784

Flunarizine

hsa04261

Adrenergic signaling in cardiomyocytes

4.43E-06

P09493, Q08828, P51828, P31751, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P23634

TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4

Flunarizine

hsa04360

Axon guidance

8.44E-04

P61073, P16333, P20827, O95631, P17252, Q13557, P23528, P19174

CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, CFL1, PLCG1

Flunarizine

hsa04371

Apelin signaling pathway

3.08E-02

P62873, P31751, Q08828, P51828, Q13370, Q13485, P0DP23

GNB1, AKT2, ADCY1, ADCY7, PDE3B, SMAD4, CALM1

Flunarizine

hsa04380

Osteoclast differentiation

4.18E-02

Q9NQC7, Q9UQC2, P23458, P42224, P01584, Q15080, P14598

CYLD, GAB2, JAK1, STAT1, IL1B, NCF4, NCF1

Flunarizine

hsa04390

Hippo signaling pathway

2.80E-02

P60709, P63261

ACTB, ACTG1

Flunarizine

hsa04510

Focal adhesion

1.26E-02

P16144, O75369, Q15942, P17252, Q13489, P10415, P08069, P49767

ITGB4, FLNB, ZYX, PRKCA, BIRC3, BCL2, IGF1R, VEGFC

Flunarizine

hsa04520

Adherens junction

6.59E-04

P08069, P60709, P63261

IGF1R, ACTB, ACTG1

Flunarizine

hsa04530

Tight junction

6.83E-04

P60709, P63261, P16989, P56750, Q14247, P60660

ACTB, ACTG1, CSDA, CLDN17, CTTN, MYL6

Flunarizine

hsa04540

Gap junction

4.08E-02

P17252, Q13509, P68371, Q08828, P51828

PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7

Flunarizine

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Flunarizine

hsa04610

Complement and coagulation cascades

1.29E-05

P00734, P0C0L4

F2, C4A

Flunarizine

hsa04611

Platelet activation

2.98E-03

P25116, P08514, P60709, P63261, P07359

F2R, ITGA2B, ACTB, ACTG1, GP1BA

Flunarizine

hsa04613

Neutrophil extracellular trap formation

2.18E-03

P04908, Q93077, P62807, O60814, P68431, O43315, Q16539

H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14

Flunarizine

hsa04620

Toll-like receptor signaling pathway

2.13E-03

P51617, Q13546, P01568, P31751, P42224, Q8NHW4

IRAK1, RIPK1, IFNA21, AKT2, STAT1, CCL4L2

Flunarizine

hsa04621

NOD-like receptor signaling pathway

7.87E-03

P01584, P08238, P23458, P42224, P01568, Q9H3M7, Q13489, P43490, P10415, Q13546

IL1B, HSP90AB1, JAK1, STAT1, IFNA21, TXNIP, BIRC3, PBEF1, BCL2, RIPK1

Flunarizine

hsa04622

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Flunarizine

hsa04623

Cytosolic DNA-sensing pathway

7.83E-04

P01568, Q13546, Q8NHW4

IFNA21, RIPK1, CCL4L2

Flunarizine

hsa04630

JAK-STAT signaling pathway

1.16E-02

P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P01568

AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, IFNA21

Flunarizine

hsa04640

Hematopoietic cell lineage

3.20E-04

P08514, P21926, P14778, P27930, P11215, P25063, P07766, P01732, P09564

ITGA2B, CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Flunarizine

hsa04650

Natural killer cell mediated cytotoxicity

2.48E-03

P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931

PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3

Flunarizine

hsa04657

IL-17 signaling pathway

4.55E-02

O00463, Q16539, P49841, P09341, P14780

TRAF5, MAPK14, GSK3B, CXCL1, MMP9

Flunarizine

hsa04658

Th1 and Th2 cell differentiation

2.21E-04

Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761

PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3

Flunarizine

hsa04659

Th17 cell differentiation

1.25E-03

Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963

PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247

Flunarizine

hsa04660

T cell receptor signaling pathway

3.37E-03

Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239

PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCK

Flunarizine

hsa04662

B cell receptor signaling pathway

3.68E-02

P25963, P20023

NFKBIA, CR2

Flunarizine

hsa04666

Fc gamma R-mediated phagocytosis

2.78E-02

P08575, P19174, P23528, Q9UQC2, P14598, P17252

PTPRC, PLCG1, CFL1, GAB2, NCF1, PRKCA

Flunarizine

hsa04670

Leukocyte transendothelial migration

4.07E-02

P60709, P63261

ACTB, ACTG1

Flunarizine

hsa04672

Intestinal immune network for IgA production

1.35E-02

P29965, P13765

CD40LG, HLA-DOB

Flunarizine

hsa04710

Circadian rhythm

3.74E-03

O00327, O15055

ARNTL, PER2

Flunarizine

hsa04713

Circadian entrainment

5.61E-05

O15399, P0DP23, Q13557, P17252, P62873, Q08828, P51828

GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, ADCY1, ADCY7

Flunarizine

hsa04714

Thermogenesis

3.66E-05

Q16539, P15336, P60709, P63261, P33121, Q16718, O14521, P36542

MAPK14, ATF2, ACTB, ACTG1, ACSL1, NDUFA5, SDHD, ATP5C1

Flunarizine

hsa04720

Long-term potentiation

3.26E-03

P17252, Q13557, P0DP23, P18848, O15399, Q08828

PRKCA, CAMK2D, CALM1, ATF4, GRIN2D, ADCY1

Flunarizine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Flunarizine

hsa04724

Glutamatergic synapse

5.91E-03

P48058, O15399, Q08828, P51828, P17252, P62873, P15104

GRIA4, GRIN2D, ADCY1, ADCY7, PRKCA, GNB1, GLUL

Flunarizine

hsa04725

Cholinergic synapse

4.42E-04

Q08828, P51828, P17252, P62873, P18848, Q13557, P31751, P10415

ADCY1, ADCY7, PRKCA, GNB1, ATF4, CAMK2D, AKT2, BCL2

Flunarizine

hsa04727

GABAergic synapse

4.08E-02

Q08828, P51828, P62873, P46459, P17252

ADCY1, ADCY7, GNB1, NSF, PRKCA

Flunarizine

hsa04730

Long-term depression

1.16E-02

P08069

IGF1R

Flunarizine

hsa04740

Olfactory transduction

2.61E-02

P62873, Q13557, P0DP23

GNB1, CAMK2D, CALM1

Flunarizine

hsa04744

Phototransduction

1.30E-05

P62873, P0DP23

GNB1, CALM1

Flunarizine

hsa04750

Inflammatory mediator regulation of TRP channels

1.34E-06

P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P17252, P24723, Q04759, P0DP23, P01042

IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCA, PRKCH, PRKCQ, CALM1, KNG1

Flunarizine

hsa04911

Insulin secretion

3.47E-02

Q08828, P17252, P18848, Q13557

ADCY1, PRKCA, ATF4, CAMK2D

Flunarizine

hsa04912

GnRH signaling pathway

2.85E-02

P17252, Q08828, P18848, Q13557, P0DP23

PRKCA, ADCY1, ATF4, CAMK2D, CALM1

Flunarizine

hsa04913

Ovarian steroidogenesis

1.16E-02

P08069

IGF1R

Flunarizine

hsa04914

Progesterone-mediated oocyte maturation

1.53E-02

P08069, Q08828, P51828, P31751, Q13370, Q9UJX4, P08238

IGF1R, ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, HSP90AB1

Flunarizine

hsa04915

Estrogen signaling pathway

3.28E-03

P18848, Q08828, P51828, P31751, P08238, P11142, P0DP23, Q15788, P10415

ATF4, ADCY1, ADCY7, AKT2, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2

Flunarizine

hsa04918

Thyroid hormone synthesis

3.16E-02

P17252, P27824

PRKCA, CANX

Flunarizine

hsa04919

Thyroid hormone signaling pathway

3.20E-02

P60709, P63261

ACTB, ACTG1

Flunarizine

hsa04921

Oxytocin signaling pathway

1.77E-03

P60660, P60709, P63261

MYL6, ACTB, ACTG1

Flunarizine

hsa04923

Regulation of lipolysis in adipocytes

1.20E-03

Q08828, P51828, P07550, Q13370, P42338, Q9Y4H2, P31751

ADCY1, ADCY7, ADRB2, PDE3B, PIK3CB, IRS2, AKT2

Flunarizine

hsa04925

Aldosterone synthesis and secretion

6.45E-04

P18848, Q08828, P51828, P0DP23, P17252, Q13557, P23634

ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, ATP2B4

Flunarizine

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Flunarizine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.04E-06

Q13485, P01584, P42224, P10415, P31751, P49767, P17252, P19174

SMAD4, IL1B, STAT1, BCL2, AKT2, VEGFC, PRKCA, PLCG1

Flunarizine

hsa04935

Growth hormone synthesis, secretion and action

3.93E-02

P19174, Q08828, P51828, P17252, P31751, P42224

PLCG1, ADCY1, ADCY7, PRKCA, AKT2, STAT1

Flunarizine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Flunarizine

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Flunarizine

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Flunarizine

hsa04970

Salivary secretion

1.35E-03

Q08828, P51828, P23634, P17252, P0DP23

ADCY1, ADCY7, ATP2B4, PRKCA, CALM1

Flunarizine

hsa04971

Gastric acid secretion

1.02E-02

P60709, P63261

ACTB, ACTG1

Flunarizine

hsa04972

Pancreatic secretion

1.92E-03

P23634, P17252, Q08828, P51828, P62491

ATP2B4, PRKCA, ADCY1, ADCY7, RAB11A

Flunarizine

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Flunarizine

hsa04975

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Flunarizine

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Flunarizine

hsa05014

Amyotrophic lateral sclerosis

2.98E-02

P36542, P60709, P63261

ATP5C1, ACTB, ACTG1

Flunarizine

hsa05016

Huntington disease

2.46E-05

Q9GZM3, P52435, Q9NYC9

POLR2J2, POLR2J, DNAH9

Flunarizine

hsa05017

Spinocerebellar ataxia

3.80E-03

P17252, O75460, Q8TB72, O15399, P31751, P28070, P43686, O00232

PRKCA, ERN1, PUM2, GRIN2D, AKT2, PSMB4, PSMC4, PSMD12

Flunarizine

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Flunarizine

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Flunarizine

hsa05031

Amphetamine addiction

2.85E-02

O15399, P0DP23, Q13557, P18848, P17252

GRIN2D, CALM1, CAMK2D, ATF4, PRKCA

Flunarizine

hsa05032

Morphine addiction

4.08E-02

Q08828, P51828, P62873, Q13370, P17252

ADCY1, ADCY7, GNB1, PDE3B, PRKCA

Flunarizine

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Flunarizine

hsa05100

Bacterial invasion of epithelial cells

8.79E-04

P60709, P63261, Q92529

ACTB, ACTG1, SHC3

Flunarizine

hsa05110

Vibrio cholerae infection

3.95E-03

P60709, P63261

ACTB, ACTG1

Flunarizine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.96E-04

Q16539, P09341, P19875, P19174, P25024, P25025

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Flunarizine

hsa05131

Shigellosis

1.91E-02

P60709, P63261, P07384

ACTB, ACTG1, CAPN1

Flunarizine

hsa05132

Salmonella infection

2.31E-05

P51617, P01584, P08238, Q96RF0, Q13546, Q13489, P10415, P08575, O75369, Q13561, O60282, Q13509, P68371, P49754, Q9NP90

IRAK1, IL1B, HSP90AB1, SNAG1, RIPK1, BIRC3, BCL2, PTPRC, FLNB, DCTN2, KIF5C, TUBB3, TUBB2C, VPS41, RAB9B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	Q96RF0	SNAG1	Sorting nexin-18	0.703
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P08575	PTPRC	Receptor-type tyrosine-protein phosphatase C	0.716
P0DP25	CALM3	Calmodulin-3	O75369	FLNB	Filamin-B	0.874
P0DP24	CALM2	Calmodulin-2	O75369	FLNB	Filamin-B	0.874
P0DP25	CALM3	Calmodulin-3	Q13561	DCTN2	Dynactin subunit 2	0.739
P0DP24	CALM2	Calmodulin-2	Q13561	DCTN2	Dynactin subunit 2	0.739
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P0DP25	CALM3	Calmodulin-3	Q13509	TUBB3	Tubulin beta-3 chain	0.892
P0DP24	CALM2	Calmodulin-2	Q13509	TUBB3	Tubulin beta-3 chain	0.892
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P0DP25	CALM3	Calmodulin-3	P68371	TUBB2C	Tubulin beta-4B chain	0.742
P0DP24	CALM2	Calmodulin-2	P68371	TUBB2C	Tubulin beta-4B chain	0.742
P0DP25	CALM3	Calmodulin-3	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.723
P0DP24	CALM2	Calmodulin-2	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.723
P0DP24	CALM2	Calmodulin-2	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.791

Flunarizine

hsa05133

Pertussis

3.90E-06

P0DP23, P01584, P23528, P09871, P0C0L4, P51617

CALM1, IL1B, CFL1, C1S, C4A, IRAK1

Flunarizine

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Flunarizine

hsa05135

Yersinia infection

3.88E-03

P60709, P63261, Q16513

ACTB, ACTG1, PKN2

Flunarizine

hsa05140

Leishmaniasis

1.84E-03

O75015, P14598, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080

FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4

Flunarizine

hsa05143

African trypanosomiasis

2.02E-06

P01375, P01584, P69905, P68871, P48023, P17252, P01042

TNF, IL1B, HBA2, HBB, FASLG, PRKCA, KNG1

Flunarizine

hsa05144

Malaria

3.09E-02

P69905, P68871

HBA2, HBB

Flunarizine

hsa05145

Toxoplasmosis

5.28E-05

P51617, P10415, Q13489, P23458, P42224, P31751, P11142, P29965, Q13651

IRAK1, BCL2, BIRC3, JAK1, STAT1, AKT2, HSPA8, CD40LG, IL10RA

Flunarizine

hsa05146

Amoebiasis

5.70E-05

P09341, P19875, P14778, P27930, O60603, P42338, P11215, P05089, P12814

CXCL1, CXCL2, IL1R1, IL1R2, TLR2, PIK3CB, ITGAM, ARG1, ACTN1

Flunarizine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Flunarizine

hsa05161

Hepatitis B

1.31E-04

P17252, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617

PRKCA, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1

Flunarizine

hsa05162

Measles

1.74E-04

P51617, P01568, P23458, P42224, P14784, P31751, P11142, P01584, Q9NP90, P10415

IRAK1, IFNA21, JAK1, STAT1, IL2RB, AKT2, HSPA8, IL1B, RAB9B, BCL2

Flunarizine

hsa05163

Human cytomegalovirus infection

3.61E-04

P31751, P62873, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, P17252, Q13651, P25025, Q16539, P18848, P04637, O00463, P61769, P01568

AKT2, GNB1, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, B2M, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P0DP24	CALM2	Calmodulin-2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.708
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P0DP24	CALM2	Calmodulin-2	P61769	B2M	Beta-2-microglobulin	0.787
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852

Flunarizine

hsa05164

Influenza A

7.10E-03

P48551, P60709, P63261

IFNAR2, ACTB, ACTG1

Flunarizine

hsa05168

Herpes simplex virus 1 infection

2.45E-05

P01568, P01584, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P61769, P31751, Q13398, Q6P280, Q03923, Q9UDV6, P10415, Q14232

IFNA21, IL1B, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, B2M, AKT2, ZNF211, ZNF529, ZNF85, ZNF212, BCL2, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP23	CALM1	Calmodulin-1	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.743
P0DP24	CALM2	Calmodulin-2	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.772
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP25	CALM3	Calmodulin-3	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP24	CALM2	Calmodulin-2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP23	CALM1	Calmodulin-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP25	CALM3	Calmodulin-3	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP24	CALM2	Calmodulin-2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP23	CALM1	Calmodulin-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP25	CALM3	Calmodulin-3	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP24	CALM2	Calmodulin-2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P61769	B2M	Beta-2-microglobulin	0.787
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	Q13398	ZNF211	Zinc finger protein 211	0.898
P0DP25	CALM3	Calmodulin-3	Q13398	ZNF211	Zinc finger protein 211	0.898
P0DP24	CALM2	Calmodulin-2	Q13398	ZNF211	Zinc finger protein 211	0.898
P0DP23	CALM1	Calmodulin-1	Q6P280	ZNF529	Zinc finger protein 529	0.767
P0DP23	CALM1	Calmodulin-1	Q03923	ZNF85	Zinc finger protein 85	-0.818
P0DP25	CALM3	Calmodulin-3	Q03923	ZNF85	Zinc finger protein 85	-0.818
P0DP24	CALM2	Calmodulin-2	Q03923	ZNF85	Zinc finger protein 85	-0.818
P0DP23	CALM1	Calmodulin-1	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P0DP25	CALM3	Calmodulin-3	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P0DP24	CALM2	Calmodulin-2	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.797

Flunarizine

hsa05170

Human immunodeficiency virus 1 infection

4.12E-05

P31751, P62873, P0DP23, P61073, P17252, P61769, P01568, P51617, P19174, P23528, P10415, Q9Y6Q5

AKT2, GNB1, CALM1, CXCR4, PRKCA, B2M, IFNA21, IRAK1, PLCG1, CFL1, BCL2, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP25	CALM3	Calmodulin-3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P61769	B2M	Beta-2-microglobulin	0.787
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	P23528	CFL1	Cofilin-1	-0.832
P0DP25	CALM3	Calmodulin-3	P23528	CFL1	Cofilin-1	-0.832
P0DP24	CALM2	Calmodulin-2	P23528	CFL1	Cofilin-1	-0.832
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742
P0DP25	CALM3	Calmodulin-3	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742
P0DP24	CALM2	Calmodulin-2	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742

Flunarizine

hsa05200

Pathways in cancer

4.30E-09

P23458, P08238, P42224, P19174, Q15311, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P31751, Q08828, P51828, P62873, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042

JAK1, HSP90AB1, STAT1, PLCG1, RALBP1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, AKT2, ADCY1, ADCY7, GNB1, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	Q15311	RALBP1	RalA-binding protein 1	0.858
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P0DP25	CALM3	Calmodulin-3	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P0DP24	CALM2	Calmodulin-2	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P0DP23	CALM1	Calmodulin-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP25	CALM3	Calmodulin-3	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP24	CALM2	Calmodulin-2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP23	CALM1	Calmodulin-1	P14923	JUP	Junction plakoglobin	-0.852
P0DP25	CALM3	Calmodulin-3	P14923	JUP	Junction plakoglobin	-0.852
P0DP24	CALM2	Calmodulin-2	P14923	JUP	Junction plakoglobin	-0.852
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP24	CALM2	Calmodulin-2	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP25	CALM3	Calmodulin-3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
P0DP25	CALM3	Calmodulin-3	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
P0DP24	CALM2	Calmodulin-2	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
P0DP23	CALM1	Calmodulin-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP25	CALM3	Calmodulin-3	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP24	CALM2	Calmodulin-2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP24	CALM2	Calmodulin-2	Q15788	NCOA1	Nuclear receptor coactivator 1	0.731
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP24	CALM2	Calmodulin-2	O43521	BCL2L11	Bcl-2-like protein 11	0.75
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP25	CALM3	Calmodulin-3	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP24	CALM2	Calmodulin-2	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP23	CALM1	Calmodulin-1	P16871	IL7R	Interleukin-7 receptor subunit alpha	0.718
P0DP23	CALM1	Calmodulin-1	P00734	F2	Prothrombin	-0.738
P0DP23	CALM1	Calmodulin-1	P01042	KNG1	Kininogen-1	-0.71
P0DP25	CALM3	Calmodulin-3	P01042	KNG1	Kininogen-1	-0.71
P0DP24	CALM2	Calmodulin-2	P01042	KNG1	Kininogen-1	-0.71

Flunarizine

hsa05202

Transcriptional misregulation in cancer

2.82E-02

P08069

IGF1R

Flunarizine

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Flunarizine

hsa05204

Chemical carcinogenesis

2.59E-04

P00325, P78417, P11712, P33260

ADH1B, GSTO1, CYP2C9, CYP2C18

Flunarizine

hsa05205

Proteoglycans in cancer

1.15E-02

Q12955, Q14247, P17252, P08069, P08962

ANK3, CTTN, PRKCA, IGF1R, CD63

Flunarizine

hsa05206

MicroRNAs in cancer

4.07E-02

P15311, P63279

VIL2, UBE2I

Flunarizine

hsa05212

Pancreatic cancer

5.55E-03

P31751, Q15311, P23458, P42224, Q13485, O75293

AKT2, RALBP1, JAK1, STAT1, SMAD4, GADD45B

Flunarizine

hsa05214

Glioma

3.96E-06

P08069, P0DP23, Q13557, P17252, P31751, P19174, O75293

IGF1R, CALM1, CAMK2D, PRKCA, AKT2, PLCG1, GADD45B

Flunarizine

hsa05215

Prostate cancer

1.33E-02

P08069

IGF1R

Flunarizine

hsa05218

Melanoma

6.63E-03

P08069

IGF1R

Flunarizine

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Flunarizine

hsa05224

Breast cancer

1.24E-02

P08069, P49841, Q92837, P04637, P24522

IGF1R, GSK3B, FRAT1, TP53, GADD45A

Flunarizine

hsa05225

Hepatocellular carcinoma

2.85E-03

P08069, P60709, P63261

IGF1R, ACTB, ACTG1

Flunarizine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.15E-03

P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4

Flunarizine

hsa05310

Asthma

1.35E-02

P13765, P29965

HLA-DOB, CD40LG

Flunarizine

hsa05320

Autoimmune thyroid disease

3.16E-02

P13765, P29965

HLA-DOB, CD40LG

Flunarizine

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Flunarizine

hsa05330

Allograft rejection

1.76E-03

P13765, P29965, P48023, P01375

HLA-DOB, CD40LG, FASLG, TNF

Flunarizine

hsa05332

Graft-versus-host disease

3.70E-02

P48023, P01375

FASLG, TNF

Flunarizine

hsa05340

Primary immunodeficiency

2.68E-02

P11912, P07766

CD79A, CD3E

Flunarizine

hsa05410

Hypertrophic cardiomyopathy

1.02E-02

P60709, P63261

ACTB, ACTG1

Flunarizine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

1.14E-04

P54284, P14923, P08514, P60709, P63261, Q9UJU2

CACNB3, JUP, ITGA2B, ACTB, ACTG1, LEF1

Flunarizine

hsa05414

Dilated cardiomyopathy

1.73E-02

P60709, P63261

ACTB, ACTG1

Flunarizine

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Flunarizine

hsa05416

Viral myocarditis

1.79E-03

P13765, P29965, P60709, P63261

HLA-DOB, CD40LG, ACTB, ACTG1

Flunarizine

hsa05418

Fluid shear stress and atherosclerosis

3.93E-04

Q16539, P14598, P78417, P10599, P14780, P60709, P63261, P04637, P10415, P14778, P27930, P0DP23, P08238, Q92974

MAPK14, NCF1, GSTO1, TXN, MMP9, ACTB, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, HSP90AB1, ARHGEF2

Community members of Flunarizine (S_DC: 5.34)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

CALM1

CalmodulinNone1

Reported

0.4552

0.1479

1.5235

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P22001

KCNA3

Potassium voltageNonegated channel subfamily A member 3

Predicted

0.1396

0.5055

1.0809

P08069

IGF1R

InsulinNonelike growth factor 1 receptor

Predicted

0.2082

0.9561

0.9883

3.0047

Q13133

NR1H3

Oxysterols receptor LXRNonealpha

Predicted

0.0162

0.439

0.2086

1.0947

Q09472

EP300

Histone acetyltransferase p300

Predicted

0.4182

0.0672

0.9307

1.2742

O15164

TRIM24

Transcription intermediary factor 1Nonealpha

Predicted

0.2807

0.1055

0.3514

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P25116

F2R

ProteinaseNoneactivated receptor 1

Predicted

0.2038

0.3196

0.5136

1.2547

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P08235

NR3C2

Mineralocorticoid receptor

Predicted

0.1855

0.0137

2.1064

P35790

CHKA

Choline kinase alpha

Predicted

0.583

0.0339

0.1639

0.5233

P0DP25

CALM3

CalmodulinNone3

Predicted

0.5661

0.1479

0.5789

P0DP24

CALM2

CalmodulinNone2

Predicted

0.4376

0.1479

0.5147

P60660

MYL6

Myosin light polypeptide 6

Predicted

0.5595

0.0687

0.2175

0.6346

P24844

MYL9

Myosin regulatory light polypeptide 9

Predicted

0.0064

0.063

0.6026

0.7318

P14649

MYL6B

Myosin light chain 6B

Predicted

0.0477

0.0653

0.2175

0.3719

P05976

MYL1

Myosin light chain 1/3, skeletal muscle isoform

Predicted

0.2581

0.0619

0.2528

O15182

CETN3

CentrinNone3

Predicted

0.1872

0.0594

0.2123

Q96A32

MYLPF

Myosin regulatory light chain 2, skeletal muscle isoform

Predicted

0.0135

0.0473

0.5412

0.6425

PharmaCoNets of Flunarizine (SPCN: 117.94 )

Flunarizine regulated-network (SDN: 22.09)

Community members of Flunarizine (SDC: 5.34)

PharmaCoNets of Flunarizine (S_PCN: 117.94 )

Flunarizine regulated-network (S_DN: 22.09)

Community members of Flunarizine (S_DC: 5.34)