PharmaCoNets

PharmaCoNets of Fludarabine (S_PCN: 158.06 )

Fludarabine regulated-network (S_DN: 23.88)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Fludarabine

hsa00010

Glycolysis / Gluconeogenesis

4.41E-02

P04075, P06733, P04406, P60174

ALDOA, ENO1, GAPDH, TPI1

Fludarabine

hsa00030

Pentose phosphate pathway

9.98E-04

P51854, P08237, P52209, P37837

TKTL1, PFKM, PGD, TALDO1

Fludarabine

hsa00051

Fructose and mannose metabolism

2.21E-02

O14772, P60174, P04075

FPGT, TPI1, ALDOA

Fludarabine

hsa00052

Galactose metabolism

6.10E-03

P06280, O43451, P35557

GLA, MGAM, GCK

Fludarabine

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Fludarabine

hsa00100

Steroid biosynthesis

4.70E-02

P35610

SOAT1

Fludarabine

hsa00190

Oxidative phosphorylation

3.20E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Fludarabine

hsa00220

Arginine biosynthesis

3.73E-03

P05089, P49448

ARG1, GLUD2

Fludarabine

hsa00230

Purine metabolism

2.11E-02

Q7LG56, P31350, P21589

RRM2B, RRM2, NT5E

Fludarabine

hsa00240

Pyrimidine metabolism

6.02E-09

Q7LG56, P31350, P21589, P32320, P04183, P04818

RRM2B, RRM2, NT5E, CDA, TK1, TYMS

Fludarabine

hsa00250

Alanine, aspartate and glutamate metabolism

4.88E-02

P49448

GLUD2

Fludarabine

hsa00310

Lysine degradation

3.15E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Fludarabine

hsa00340

Histidine metabolism

4.52E-02

O95954

FTCD

Fludarabine

hsa00410

beta-Alanine metabolism

3.98E-02

Q6ZQY3

GADL1

Fludarabine

hsa00471

D-Glutamine and D-glutamate metabolism

6.90E-04

Q7Z3D6, P49448

C14orf159, GLUD2

Fludarabine

hsa00480

Glutathione metabolism

3.36E-05

Q9UJ14, Q16772, P09211, Q7LG56, P31350, P30041

GGTL3, GSTA3, GSTP1, RRM2B, RRM2, PRDX6

Fludarabine

hsa00500

Starch and sucrose metabolism

3.92E-07

O43451, P46976, P35557, P06737

MGAM, GYG1, GCK, PYGL

Fludarabine

hsa00512

Mucin type O-glycan biosynthesis

1.31E-03

O95395, Q8N4A0

GCNT3, GALNT4

Fludarabine

hsa00524

Neomycin, kanamycin and gentamicin biosynthesis

8.73E-04

P35557

GCK

Fludarabine

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

1.91E-02

Q9NY97

B3GNT2

Fludarabine

hsa00564

Glycerophospholipid metabolism

3.84E-04

P48651, Q9Y6K0, P35790, Q9Y259, P49619

PTDSS1, CEPT1, CHKA, CHKB, DGKG

Fludarabine

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Fludarabine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Fludarabine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Fludarabine

hsa00600

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Fludarabine

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Fludarabine

hsa00630

Glyoxylate and dicarboxylate metabolism

2.86E-07

P40925, P15104

MDH1, GLUL

Fludarabine

hsa00730

Thiamine metabolism

2.27E-02

P05186, P24666

ALPL, ACP1

Fludarabine

hsa00770

Pantothenate and CoA biosynthesis

3.98E-02

Q6ZQY3

GADL1

Fludarabine

hsa00900

Terpenoid backbone biosynthesis

3.05E-02

Q01581

HMGCS1

Fludarabine

hsa00910

Nitrogen metabolism

4.88E-02

P49448

GLUD2

Fludarabine

hsa00970

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Fludarabine

hsa00980

Metabolism of xenobiotics by cytochrome P450

8.69E-06

Q16772, P78417, P11766, P09211, P11712

GSTA3, GSTO1, ADH5, GSTP1, CYP2C9

Fludarabine

hsa00982

Drug metabolism - cytochrome P450

1.66E-05

P11712, Q16772, P09211, P78417, P11766

CYP2C9, GSTA3, GSTP1, GSTO1, ADH5

Fludarabine

hsa00983

Drug metabolism - other enzymes

3.59E-09

P04183, P32320, Q7LG56, P31350, P05164, Q16772, P09211

TK1, CDA, RRM2B, RRM2, MPO, GSTA3, GSTP1

Fludarabine

hsa01040

Biosynthesis of unsaturated fatty acids

4.28E-02

P22307

SCP2

Fludarabine

hsa01100

Metabolic pathways

6.27E-05

Q9Y234, P35790, Q9Y259, Q16772, P09211, Q9UJ14, P15144, P30041, O14732, Q13956, Q02153, Q16774, P20839, P00918, P40926, P10768, P55809, P06280, Q7KZN9, Q9Y6K0, P15121, P08237, P49619, P21399, O95954, Q02318, Q9UHK6, P51854, Q86VZ5, Q9BVK2, P15907, Q9UBX8, O96024, P37837, P50213, P43490, P35573, Q9BQB6, Q969G6, Q13029, Q9NVH6

LIPT1, CHKA, CHKB, GSTA3, GSTP1, GGTL3, ANPEP, PRDX6, IMPA2, PDE6H, GUCY1B3, GUK1, IMPDH1, CA2, MDH2, ESD, OXCT1, GLA, COX15, CEPT1, AKR1B1, PFKM, DGKG, ACO1, FTCD, CYP27A1, AMACR, TKTL1, SGMS1, ALG8, ST6GAL1, B4GALT6, B3GALT4, TALDO1, IDH3A, PBEF1, AGL, VKORC1, RFK, PRDM2, TMLHE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.778
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P35790	CHKA	Choline kinase alpha	-0.856
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q16772	GSTA3	Glutathione S-transferase A3	-0.768
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P15144	ANPEP	Aminopeptidase N	0.846
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P30041	PRDX6	Peroxiredoxin-6	0.785
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	O14732	IMPA2	Inositol monophosphatase 2	0.738
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q02153	GUCY1B3	Guanylate cyclase soluble subunit beta-1	-0.774
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q16774	GUK1	Guanylate kinase	0.757
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	1
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P00918	CA2	Carbonic anhydrase 2	0.772
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P10768	ESD	S-formylglutathione hydrolase	-0.701
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.744
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P06280	GLA	Alpha-galactosidase A	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9Y6K0	CEPT1	Choline/ethanolaminephosphotransferase 1	0.771
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.868
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P21399	ACO1	Cytoplasmic aconitate hydratase	-0.739
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.784
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P51854	TKTL1	Transketolase-like protein 1	-0.753
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9BVK2	ALG8	Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase	-0.726
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P15907	ST6GAL1	Beta-galactoside alpha-2,6-sialyltransferase 1	-0.827
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	O96024	B3GALT4	Beta-1,3-galactosyltransferase 4	0.797
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P37837	TALDO1	Transaldolase	0.732
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P50213	IDH3A	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	-0.732
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.702
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q969G6	RFK	Riboflavin kinase	0.705
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q13029	PRDM2	PR domain zinc finger protein 2	0.744
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.721

Fludarabine

hsa01200

Carbon metabolism

3.30E-04

P04075, P51854, P04406, P08237, P60174, P37837, P06733, O14521, Q9P2R7, P50213, P21399, P10768, Q02252

ALDOA, TKTL1, GAPDH, PFKM, TPI1, TALDO1, ENO1, SDHD, SUCLA2, IDH3A, ACO1, ESD, ALDH6A1

Fludarabine

hsa01210

2-Oxocarboxylic acid metabolism

6.75E-04

P21399, P50213

ACO1, IDH3A

Fludarabine

hsa01230

Biosynthesis of amino acids

2.62E-05

P60174, P04406, P06733, P04075, P08237, P51854, P60891, Q99707, P21399, P50213, P05089, P15104, P37837

TPI1, GAPDH, ENO1, ALDOA, PFKM, TKTL1, PRPS1, MTR, ACO1, IDH3A, ARG1, GLUL, TALDO1

Fludarabine

hsa01521

EGFR tyrosine kinase inhibitor resistance

2.82E-02

P49841, P42338

GSK3B, PIK3CB

Fludarabine

hsa01522

Endocrine resistance

2.84E-02

P22694, Q9UM47, P46527

PRKACB, NOTCH3, CDKN1B

Fludarabine

hsa01524

Platinum drug resistance

6.95E-03

Q16772, P09211, P78417, P52701

GSTA3, GSTP1, GSTO1, MSH6

Fludarabine

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Fludarabine

hsa03008

Ribosome biogenesis in eukaryotes

8.16E-03

Q9NYH9, P78345, Q9GZY0

UTP6, RPP38, NXF2; NXF2B

Fludarabine

hsa03010

Ribosome

1.22E-02

P46777, P50914

RPL5, RPL14

Fludarabine

hsa03013

RNA transport

3.98E-02

P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Fludarabine

hsa03015

mRNA surveillance pathway

3.37E-02

O43148, Q9GZY0, P52298

RNMT, NXF2; NXF2B, NCBP2

Fludarabine

hsa03020

RNA polymerase

8.48E-06

P30876, P24928, P62487, Q9GZM3, P52435

POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J

Fludarabine

hsa03040

Spliceosome

1.93E-14

Q14562, O43143, O60508, O14776, P08579, P26368, O75940, P52298, P09651, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O95777, O43447, O75643, P61326

DHX8, DHX15, CDC40, TCERG1, SNRPB2, U2AF2, SMNDC1, NCBP2, HNRNPA1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, LSM8, PPIH, ASCC3L1, MAGOH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P27707	DCK	Deoxycytidine kinase	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.726
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.708
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.732
P27707	DCK	Deoxycytidine kinase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.816
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P11142	HSPA8	Heat shock cognate 71 kDa protein	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.789
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O60508	CDC40	Pre-mRNA-processing factor 17	-0.837
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P27707	DCK	Deoxycytidine kinase	O14776	TCERG1	Transcription elongation regulator 1	0.757
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.702
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P11142	HSPA8	Heat shock cognate 71 kDa protein	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P27707	DCK	Deoxycytidine kinase	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	0.84
P27707	DCK	Deoxycytidine kinase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.769
P27707	DCK	Deoxycytidine kinase	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	0.736
P27707	DCK	Deoxycytidine kinase	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	0.824
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P27707	DCK	Deoxycytidine kinase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.804
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.824
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.835
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P27707	DCK	Deoxycytidine kinase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.757
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.772
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P11142	HSPA8	Heat shock cognate 71 kDa protein	P11142	HSPA8	Heat shock cognate 71 kDa protein	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P27707	DCK	Deoxycytidine kinase	O95777	LSM8	U6 snRNA-associated Sm-like protein LSm8	0.797
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.761
P11142	HSPA8	Heat shock cognate 71 kDa protein	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.872
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P27707	DCK	Deoxycytidine kinase	P61326	MAGOH	Protein mago nashi homolog	0.732

Fludarabine

hsa03060

Protein export

2.65E-03

Q15070, P37108, Q15005

OXA1L, SRP14, SPCS2

Fludarabine

hsa03320

PPAR signaling pathway

1.62E-02

Q13133, Q02318

NR1H3, CYP27A1

Fludarabine

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Fludarabine

hsa04012

ErbB signaling pathway

2.82E-02

P49841, P42338

GSK3B, PIK3CB

Fludarabine

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Fludarabine

hsa04015

Rap1 signaling pathway

2.64E-03

P20827, P49767, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P19174

EFNA1, VEGFC, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, PLCG1

Fludarabine

hsa04020

Calcium signaling pathway

5.11E-04

P27987, P21796, P45880, Q13557, P30679, P19174, P0DP23, P05141, P23634

ITPKB, VDAC1, VDAC2, CAMK2D, GNA15, PLCG1, CALM1, SLC25A5, ATP2B4

Fludarabine

hsa04022

cGMP-PKG signaling pathway

2.26E-03

Q14814, Q99941, P18848, P05141, P21796, P45880, P0DP23, P01042

MEF2D, CREBL1, ATF4, SLC25A5, VDAC1, VDAC2, CALM1, KNG1

Fludarabine

hsa04024

cAMP signaling pathway

4.38E-02

P42338, P0DP23, Q13370, Q13009

PIK3CB, CALM1, PDE3B, TIAM1

Fludarabine

hsa04060

Cytokine-cytokine receptor interaction

3.03E-03

P27930, P14778, P26842, Q13651, P25024, P25025, Q9UBD3, P47992, O75509, P09341, P18510, P01730

IL1R2, IL1R1, CD27, IL10RA, CXCR1, CXCR2, XCL2, XCL1, TNFRSF21, CXCL1, IL1RN, CD4

Fludarabine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.68E-03

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB

Fludarabine

hsa04062

Chemokine signaling pathway

1.27E-06

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P49841, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, GSK3B, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51531	SMARCA2	Probable global transcription activator SNF2L2	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.715
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.843
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.892
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P47992	XCL1	Lymphotactin	-0.796
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P51531	SMARCA2	Probable global transcription activator SNF2L2	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.756
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.736
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.754
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P51531	SMARCA2	Probable global transcription activator SNF2L2	P49407	ARRB1	Beta-arrestin-1	0.75
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P51531	SMARCA2	Probable global transcription activator SNF2L2	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.81
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Fludarabine

hsa04064

NF-kappa B signaling pathway

4.58E-09

P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P19174, Q04759, Q9UDY8, Q16548, P07948, P06239, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7

BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, PLCG1, PRKCQ, MALT1, BCL2A1, LYN, LCK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04183	TK1	Thymidine kinase, cytosolic	P10415	BCL2	Apoptosis regulator Bcl-2	-0.763
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P04183	TK1	Thymidine kinase, cytosolic	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.756
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.786
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	O00463	TRAF5	TNF receptor-associated factor 5	-0.735
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.923
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P04183	TK1	Thymidine kinase, cytosolic	Q04759	PRKCQ	Protein kinase C theta type	-0.729
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P04183	TK1	Thymidine kinase, cytosolic	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.738
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16548	BCL2A1	Bcl-2-related protein A1	0.82
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16548	BCL2A1	Bcl-2-related protein A1	0.742
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.749
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P04183	TK1	Thymidine kinase, cytosolic	Q13315	ATM	Serine-protein kinase ATM	-0.765
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P04183	TK1	Thymidine kinase, cytosolic	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.718
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.793
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.758
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P04183	TK1	Thymidine kinase, cytosolic	P09341	CXCL1	Growth-regulated alpha protein	0.722
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P09341	CXCL1	Growth-regulated alpha protein	0.78
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Fludarabine

hsa04070

Phosphatidylinositol signaling system

1.67E-03

P19174, P0DP23, P42338, O14986, P23743, P27987

PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, ITPKB

Fludarabine

hsa04071

Sphingolipid signaling pathway

1.54E-04

Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Fludarabine

hsa04072

Phospholipase D signaling pathway

3.22E-03

P42338, Q9UQC2, P43657, P25024, P25025, P19174

PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1

Fludarabine

hsa04080

Neuroactive ligand-receptor interaction

8.70E-03

P00734, Q96G91, Q01726, P41968, P14416

F2, P2RY11, MC1R, MC3R, DRD2

Fludarabine

hsa04110

Cell cycle

3.57E-02

Q9UBD5, P06493, P33981

ORC3, CDK1, TTK

Fludarabine

hsa04115

p53 signaling pathway

1.37E-05

P24522, Q13315, Q7LG56, P31350, Q9HA38, P04637, O95067, P10415

GADD45A, ATM, RRM2B, RRM2, ZMAT3, TP53, CCNB2, BCL2

Fludarabine

hsa04141

Protein processing in endoplasmic reticulum

6.42E-03

P18848, P30101, Q15437, Q15436, Q99941, P11142, P07900, P08238

ATF4, PDIA3, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, HSP90AB1

Fludarabine

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Fludarabine

hsa04144

Endocytosis

1.13E-03

Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3

CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5

Fludarabine

hsa04145

Phagosome

1.73E-03

Q15080, P68371, P05164, P78380, P35443, P13765

NCF4, TUBB2C, MPO, OLR1, THBS4, HLA-DOB

Fludarabine

hsa04146

Peroxisome

2.42E-02

O43933, P56589, Q9UKG9, O75521, P33121

PEX1, PEX3, CROT, ECI2, ACSL1

Fludarabine

hsa04150

mTOR signaling pathway

3.46E-02

P42338, P49841

PIK3CB, GSK3B

Fludarabine

hsa04151

PI3K-Akt signaling pathway

1.64E-03

P62753, P42338, P43657, P27348, P20827, P49767, P07900, P08238, Q8WYR1, P62873, P63218, P50151, O15335, Q16363, Q13751, P22105, P14784, Q99941, P18848, P30279, P30281

RPS6, PIK3CB, P2RY5, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, CHAD, LAMA4, LAMB3, TNXB, IL2RB, CREBL1, ATF4, CCND2, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11142	HSPA8	Heat shock cognate 71 kDa protein	P62753	RPS6	40S ribosomal protein S6	0.75
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P11142	HSPA8	Heat shock cognate 71 kDa protein	P27348	YWHAQ	14-3-3 protein theta	0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P11142	HSPA8	Heat shock cognate 71 kDa protein	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
P11142	HSPA8	Heat shock cognate 71 kDa protein	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P11142	HSPA8	Heat shock cognate 71 kDa protein	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.746
P11142	HSPA8	Heat shock cognate 71 kDa protein	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q16363	LAMA4	Laminin subunit alpha-4	0.793
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P11142	HSPA8	Heat shock cognate 71 kDa protein	P22105	TNXB	Tenascin-X	0.715
P11142	HSPA8	Heat shock cognate 71 kDa protein	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.831
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.715
P11142	HSPA8	Heat shock cognate 71 kDa protein	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.83
P11142	HSPA8	Heat shock cognate 71 kDa protein	P30279	CCND2	G1/S-specific cyclin-D2	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Fludarabine

hsa04152

AMPK signaling pathway

2.34E-02

Q96EB6, P36956

SIRT1, SREBF1

Fludarabine

hsa04211

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Fludarabine

hsa04213

Longevity regulating pathway - multiple species

2.70E-03

P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547

PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1

Fludarabine

hsa04217

Necroptosis

1.06E-03

P01568, Q13489, Q13546, P42224, P07900, P08238, P15104, P05141, Q13557, P21796, P45880

IFNA21, BIRC3, RIPK1, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, CAMK2D, VDAC1, VDAC2

Fludarabine

hsa04261

Adrenergic signaling in cardiomyocytes

1.71E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Fludarabine

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Fludarabine

hsa04310

Wnt signaling pathway

5.60E-03

P30279, Q13485, O43318

CCND2, SMAD4, MAP3K7

Fludarabine

hsa04330

Notch signaling pathway

3.28E-03

Q92542, P49768, Q92830, P78504

NCSTN, PSEN1, KAT2A, JAG1

Fludarabine

hsa04340

Hedgehog signaling pathway

1.37E-03

P49841, P22694, Q13635, P49407, P10415

GSK3B, PRKACB, PTCH1, ARRB1, BCL2

Fludarabine

hsa04360

Axon guidance

2.47E-03

P16333, P20827, O95631, P42338, P07332, P23528, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1

Fludarabine

hsa04371

Apelin signaling pathway

1.23E-03

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Fludarabine

hsa04380

Osteoclast differentiation

1.79E-04

Q9UQC2, Q16539, P42338, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, PIK3CB, IL1R1, FCGR3B, TNF, LILRA2

Fludarabine

hsa04390

Hippo signaling pathway

4.35E-02

P63261, O15105

ACTG1, SMAD7

Fludarabine

hsa04510

Focal adhesion

4.60E-02

Q15942, P51636, P30281

ZYX, CAV2, CCND3

Fludarabine

hsa04520

Adherens junction

3.91E-02

Q13485, O43318

SMAD4, MAP3K7

Fludarabine

hsa04530

Tight junction

3.60E-03

P63261, P16989, P56750, Q92974, Q14247

ACTG1, CSDA, CLDN17, ARHGEF2, CTTN

Fludarabine

hsa04610

Complement and coagulation cascades

4.31E-07

P00734, P0C0L4, P05107, P21730

F2, C4A, ITGB2, C5AR1

Fludarabine

hsa04612

Antigen processing and presentation

4.72E-02

P13765, P48382, P26715, P26717

HLA-DOB, RFX5, KLRC1, KLRC2

Fludarabine

hsa04613

Neutrophil extracellular trap formation

6.68E-04

O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Fludarabine

hsa04620

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Fludarabine

hsa04621

NOD-like receptor signaling pathway

3.39E-03

P01568, P25963, Q13489, Q13546, Q05823, P01375, P49913, P12838

IFNA21, NFKBIA, BIRC3, RIPK1, RNASEL, TNF, CAMP, DEFA4

Fludarabine

hsa04622

RIG-I-like receptor signaling pathway

1.53E-03

P01568, Q13546, Q12933, P10145

IFNA21, RIPK1, TRAF2, IL8

Fludarabine

hsa04623

Cytosolic DNA-sensing pathway

9.06E-05

P01584, P01568, Q13546, Q8NHW4

IL1B, IFNA21, RIPK1, CCL4L2

Fludarabine

hsa04625

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Fludarabine

hsa04640

Hematopoietic cell lineage

1.48E-04

P13612, P14778, P27930, P11215, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765

ITGA4, IL1R1, IL1R2, ITGAM, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB

Fludarabine

hsa04650

Natural killer cell mediated cytotoxicity

3.17E-04

P19174, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015

PLCG1, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B

Fludarabine

hsa04657

IL-17 signaling pathway

2.40E-03

O00463, Q16539, P49841, P14780, Q9UJX4, P80188, P01375

TRAF5, MAPK14, GSK3B, MMP9, ANAPC5, LCN2, TNF

Fludarabine

hsa04658

Th1 and Th2 cell differentiation

8.97E-12

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01730	CD4	T-cell surface glycoprotein CD4	-0.766
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.714
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.867
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.738
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13761	RUNX3	Runt-related transcription factor 3	-0.744
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Fludarabine

hsa04659

Th17 cell differentiation

2.02E-13

Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, Q13485, P07900, P08238, P07766, P09693, P20963

PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AA1, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
P11142	HSPA8	Heat shock cognate 71 kDa protein	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.936
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01730	CD4	T-cell surface glycoprotein CD4	-0.766
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P11142	HSPA8	Heat shock cognate 71 kDa protein	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.754
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P11142	HSPA8	Heat shock cognate 71 kDa protein	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.831
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.738
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.923
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.867
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P11142	HSPA8	Heat shock cognate 71 kDa protein	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11142	HSPA8	Heat shock cognate 71 kDa protein	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P11142	HSPA8	Heat shock cognate 71 kDa protein	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.748
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778

Fludarabine

hsa04660

T cell receptor signaling pathway

1.28E-08

Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.727
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.709
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01730	CD4	T-cell surface glycoprotein CD4	-0.766
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.759
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.75
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.798
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.733

Fludarabine

hsa04662

B cell receptor signaling pathway

5.84E-08

P49841, P42338, P60033, P07948, P21854, Q8N149

GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51531	SMARCA2	Probable global transcription activator SNF2L2	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.81
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.798
P51531	SMARCA2	Probable global transcription activator SNF2L2	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.756
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
P07948	LYN	Tyrosine-protein kinase Lyn	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P60033	CD81	CD81 antigen	-0.835
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P60033	CD81	CD81 antigen	-0.714
P07948	LYN	Tyrosine-protein kinase Lyn	P60033	CD81	CD81 antigen	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.749
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07948	LYN	Tyrosine-protein kinase Lyn	0.735
P07948	LYN	Tyrosine-protein kinase Lyn	P07948	LYN	Tyrosine-protein kinase Lyn	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P21854	CD72	B-cell differentiation antigen CD72	-0.731
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P21854	CD72	B-cell differentiation antigen CD72	-0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P51531	SMARCA2	Probable global transcription activator SNF2L2	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.751
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.763
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.919
P07948	LYN	Tyrosine-protein kinase Lyn	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.843
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878

Fludarabine

hsa04664

Fc epsilon RI signaling pathway

1.75E-05

P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Fludarabine

hsa04666

Fc gamma R-mediated phagocytosis

3.17E-03

P42338, P23528, Q9UQC2, P14598

PIK3CB, CFL1, GAB2, NCF1

Fludarabine

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Fludarabine

hsa04713

Circadian entrainment

4.76E-02

P0DP23, Q13557, P62873, P63218

CALM1, CAMK2D, GNB1, GNG5

Fludarabine

hsa04721

Synaptic vesicle cycle

3.77E-02

P43003

SLC1A3

Fludarabine

hsa04724

Glutamatergic synapse

3.88E-04

O15399, P63218, P50151, P15104

GRIN2D, GNG5, GNG10, GLUL

Fludarabine

hsa04725

Cholinergic synapse

5.23E-03

P62873, P63218, P50151, P18848, Q13557, P42338

GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB

Fludarabine

hsa04727

GABAergic synapse

3.09E-04

P62873, P63218, P50151, P15104, P46459

GNB1, GNG5, GNG10, GLUL, NSF

Fludarabine

hsa04728

Dopaminergic synapse

1.82E-04

P14416, P62873, P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, P0DP23, P48058

DRD2, GNB1, GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, CALM1, GRIA4

Fludarabine

hsa04730

Long-term depression

3.20E-02

Q14344, P07948

GNA13, LYN

Fludarabine

hsa04740

Olfactory transduction

9.79E-03

P62873, Q13557, P0DP23

GNB1, CAMK2D, CALM1

Fludarabine

hsa04744

Phototransduction

5.26E-04

P62873, P0DP23

GNB1, CALM1

Fludarabine

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-06

P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP23, P01042

IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1, KNG1

Fludarabine

hsa04911

Insulin secretion

4.31E-02

P22694, P18848

PRKACB, ATF4

Fludarabine

hsa04913

Ovarian steroidogenesis

2.52E-02

P06213

INSR

Fludarabine

hsa04914

Progesterone-mediated oocyte maturation

3.92E-02

P42338, Q13370, P08238

PIK3CB, PDE3B, HSP90AB1

Fludarabine

hsa04915

Estrogen signaling pathway

1.27E-03

Q99941, P18848, Q08828, P51828, P07900, P08238, P0DMV8, P11142, P0DP23, Q15788

CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSP90AB1, HSPA1A, HSPA8, CALM1, NCOA1

Fludarabine

hsa04916

Melanogenesis

2.82E-02

P49841, Q01726

GSK3B, MC1R

Fludarabine

hsa04917

Prolactin signaling pathway

2.82E-02

P42338, P49841

PIK3CB, GSK3B

Fludarabine

hsa04918

Thyroid hormone synthesis

4.31E-02

P22694, P18848

PRKACB, ATF4

Fludarabine

hsa04923

Regulation of lipolysis in adipocytes

4.17E-04

P22694, P07550, P06213, P42338, Q9Y4H2

PRKACB, ADRB2, INSR, PIK3CB, IRS2

Fludarabine

hsa04924

Renin secretion

2.54E-04

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Fludarabine

hsa04925

Aldosterone synthesis and secretion

3.35E-02

Q99941, P18848, P0DP23, Q13557

CREBL1, ATF4, CALM1, CAMK2D

Fludarabine

hsa04926

Relaxin signaling pathway

8.02E-04

P42338, P63218, P50151, P49767, P30679, P49407

PIK3CB, GNG5, GNG10, VEGFC, GNA15, ARRB1

Fludarabine

hsa04927

Cortisol synthesis and secretion

1.86E-02

P18848, P22694

ATF4, PRKACB

Fludarabine

hsa04929

GnRH secretion

1.13E-03

P42338, P49407

PIK3CB, ARRB1

Fludarabine

hsa04930

Type II diabetes mellitus

3.14E-02

P06213

INSR

Fludarabine

hsa04932

Non-alcoholic fatty liver disease

1.39E-02

O43521, O75460, P01584, P13073, P12074, O95298

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2

Fludarabine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Fludarabine

hsa04934

Cushing syndrome

2.84E-02

P18848, P22694, P46527

ATF4, PRKACB, CDKN1B

Fludarabine

hsa04940

Type I diabetes mellitus

2.99E-02

P10747, P01375

CD28, TNF

Fludarabine

hsa04950

Maturity onset diabetes of the young

8.73E-04

P35557

GCK

Fludarabine

hsa04960

Aldosterone-regulated sodium reabsorption

6.19E-04

P06213, P42338, P48048

INSR, PIK3CB, KCNJ1

Fludarabine

hsa04964

Proximal tubule bicarbonate reclamation

4.53E-03

P00918, P49448

CA2, GLUD2

Fludarabine

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Fludarabine

hsa04970

Salivary secretion

1.77E-03

P07550, Q08828, P51828, P22694, P0DP23, P49913

ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMP

Fludarabine

hsa04971

Gastric acid secretion

3.46E-02

P48048, P78508

KCNJ1, KCNJ10

Fludarabine

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Fludarabine

hsa04975

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Fludarabine

hsa04976

Bile secretion

4.78E-02

Q08828, P51828, Q14032

ADCY1, ADCY7, BAAT

Fludarabine

hsa05010

Alzheimer disease

4.56E-02

P19404, P13073, P0DP23, P18848, Q71U36, Q13509, P05141, P21796, P45880

NDUFV2, COX4I1, CALM1, ATF4, TUBA1A, TUBB3, SLC25A5, VDAC1, VDAC2

Fludarabine

hsa05012

Parkinson disease

6.70E-04

P19404, P13073, P05141, P21796, P45880, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509

NDUFV2, COX4I1, SLC25A5, VDAC1, VDAC2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3

Fludarabine

hsa05016

Huntington disease

5.53E-06

O95298, P19404, P13073, P12074, Q13547, Q9GZM3, P24928, P30876, P62487, P52435, P05141, P21796, P45880, Q9NYC9, O75460, Q71U36, Q13509, P28070, O00232

NDUFC2, NDUFV2, COX4I1, COX6A1, HDAC1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, VDAC1, VDAC2, DNAH9, ERN1, TUBA1A, TUBB3, PSMB4, PSMD12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P11142	HSPA8	Heat shock cognate 71 kDa protein	P19404	NDUFV2	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	0.721
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P11142	HSPA8	Heat shock cognate 71 kDa protein	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.712
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q13547	HDAC1	Histone deacetylase 1	0.713
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9GZM3	POLR2J2	DNA-directed RNA polymerase II subunit RPB11-b1	0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P11142	HSPA8	Heat shock cognate 71 kDa protein	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P11142	HSPA8	Heat shock cognate 71 kDa protein	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.715
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	P52435	POLR2J	DNA-directed RNA polymerase II subunit RPB11-a	0.76
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9GZM3	POLR2J2	DNA-directed RNA polymerase II subunit RPB11-b1	0.76
P11142	HSPA8	Heat shock cognate 71 kDa protein	P05141	SLC25A5	ADP/ATP translocase 2	0.724
P11142	HSPA8	Heat shock cognate 71 kDa protein	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.741
P11142	HSPA8	Heat shock cognate 71 kDa protein	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.803
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9NYC9	DNAH9	Dynein axonemal heavy chain 9	0.785
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.76
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q13509	TUBB3	Tubulin beta-3 chain	0.724
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703

Fludarabine

hsa05017

Spinocerebellar ataxia

1.93E-03

Q92915, Q8TB72, O15399, P42338, P21796

FGF14, PUM2, GRIN2D, PIK3CB, VDAC1

Fludarabine

hsa05020

Prion disease

9.64E-03

P11142, P19404, P13073, P18848, P05141, P21796, P45880, Q71U36, Q13509, Q99941

HSPA8, NDUFV2, COX4I1, ATF4, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3, CREBL1

Fludarabine

hsa05022

Pathways of neurodegeneration - multiple diseases

1.36E-02

Q71U36, Q13509, P19404, P13073, P21796, P18848, P19174, P05141, P45880, P20333, P0DP23, Q13557

TUBA1A, TUBB3, NDUFV2, COX4I1, VDAC1, ATF4, PLCG1, SLC25A5, VDAC2, TNFRSF1B, CALM1, CAMK2D

Fludarabine

hsa05030

Cocaine addiction

4.31E-02

P22694, P18848

PRKACB, ATF4

Fludarabine

hsa05031

Amphetamine addiction

6.57E-03

P0DP23, Q13557, Q99941, P18848, Q13547

CALM1, CAMK2D, CREBL1, ATF4, HDAC1

Fludarabine

hsa05032

Morphine addiction

1.01E-02

P63218, P50151, Q07343, P43250

GNG5, GNG10, PDE4B, GRK6

Fludarabine

hsa05034

Alcoholism

2.40E-04

Q99941, P18848, Q13547, P0DP23, P62873, P63218, Q93077, P62807, O60814, P68431

CREBL1, ATF4, HDAC1, CALM1, GNB1, GNG5, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Fludarabine

hsa05100

Bacterial invasion of epithelial cells

4.50E-02

Q92529

SHC3

Fludarabine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.28E-07

Q16539, Q99437, P09341, P19875, P19174, P25024, P25025, P41240, P07948

MAPK14, ATP6V0B, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, CSK, LYN

Fludarabine

hsa05132

Salmonella infection

1.67E-04

P25963, P08238, Q13546, Q13489, P10415, P04406, O75369, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371, P49754

NFKBIA, HSP90AB1, RIPK1, BIRC3, BCL2, GAPDH, FLNB, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C, VPS41

Fludarabine

hsa05133

Pertussis

8.35E-05

P05107, P10145, P0C0L4

ITGB2, IL8, C4A

Fludarabine

hsa05134

Legionellosis

1.03E-04

P01584, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875

IL1B, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2

Fludarabine

hsa05135

Yersinia infection

1.66E-02

P13612, P06239, Q16539, P49841, P01730, P01732

ITGA4, LCK, MAPK14, GSK3B, CD4, CD8A

Fludarabine

hsa05140

Leishmaniasis

2.25E-02

P14598, P42224, O60603, P25963, P29350, Q15080

NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4

Fludarabine

hsa05143

African trypanosomiasis

7.35E-04

P69905, P68871

HBA2, HBB

Fludarabine

hsa05144

Malaria

4.24E-06

P69905, P68871, O60603, P01375, P05107, P35443, P10145, P26718

HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1

Fludarabine

hsa05146

Amoebiasis

2.52E-07

P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1, CTSG

Fludarabine

hsa05150

Staphylococcus aureus infection

5.16E-03

P0C0L4, P21730, P21462, P13646, P05107

C4A, C5AR1, FPR1, KRT13, ITGB2

Fludarabine

hsa05152

Tuberculosis

2.94E-04

Q13488, Q15075, P0DP23, P42224, P48382, P25208, O60603, P10415, P13765, P01568, Q9UDY8, P51617

TCIRG1, EEA1, CALM1, STAT1, RFX5, NFYB, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1

Fludarabine

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Fludarabine

hsa05163

Human cytomegalovirus infection

6.98E-07

P42338, P01375, P63218, P50151, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, O00463, P30101

PIK3CB, TNF, GNG5, GNG10, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TRAF5, PDIA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51531	SMARCA2	Probable global transcription activator SNF2L2	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.756
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.736
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.754
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.766
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P51531	SMARCA2	Probable global transcription activator SNF2L2	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.81
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.798
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.733
P51531	SMARCA2	Probable global transcription activator SNF2L2	P14778	IL1R1	Interleukin-1 receptor type 1	-0.746
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.923
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.713
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.797
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.892
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P25025	CXCR2	C-X-C chemokine receptor type 2	0.774
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.786
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	O00463	TRAF5	TNF receptor-associated factor 5	-0.735
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P30101	PDIA3	Protein disulfide-isomerase A3	-0.721

Fludarabine

hsa05165

Human papillomavirus infection

9.48E-04

P46527, P35443, P01375, Q08999, Q9UM47, P22694, Q13362, Q13315

CDKN1B, THBS4, TNF, RBL2, NOTCH3, PRKACB, PPP2R5C, ATM

Fludarabine

hsa05166

Human T-cell leukemia virus 1 infection

4.93E-02

P22694, P18848, P25963, P25208, Q13315, P01375

PRKACB, ATF4, NFKBIA, NFYB, ATM, TNF

Fludarabine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.15E-02

P42224, P62873, P63218, P19875, P19174, P07948, P0DP23

STAT1, GNB1, GNG5, CXCL2, PLCG1, LYN, CALM1

Fludarabine

hsa05168

Herpes simplex virus 1 infection

4.09E-05

O60603, P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P42338, Q13398, P51522, Q9NR11, Q9HCX3, P17097, Q03923, P52738, O75820, Q9UDV6, P10415

TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PIK3CB, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF85, ZNF140, ZNF189, ZNF212, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P27707	DCK	Deoxycytidine kinase	O60603	TLR2	Toll-like receptor 2	-0.781
P27707	DCK	Deoxycytidine kinase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.89
P27707	DCK	Deoxycytidine kinase	P01568	IFNA21	Interferon alpha-21	0.798
P27707	DCK	Deoxycytidine kinase	Q05823	RNASEL	2-5A-dependent ribonuclease	-0.752
P27707	DCK	Deoxycytidine kinase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.7
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P27707	DCK	Deoxycytidine kinase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.804
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P27707	DCK	Deoxycytidine kinase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.757
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P27707	DCK	Deoxycytidine kinase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P27707	DCK	Deoxycytidine kinase	Q13398	ZNF211	Zinc finger protein 211	-0.719
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
P27707	DCK	Deoxycytidine kinase	P51522	ZNF83	Zinc finger protein 83	0.811
P27707	DCK	Deoxycytidine kinase	Q9NR11	ZNF302	Zinc finger protein 302	0.759
P27707	DCK	Deoxycytidine kinase	Q9HCX3	ZNF304	Zinc finger protein 304	0.737
P27707	DCK	Deoxycytidine kinase	P17097	ZNF7	Zinc finger protein 7	0.8
P27707	DCK	Deoxycytidine kinase	Q03923	ZNF85	Zinc finger protein 85	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
P27707	DCK	Deoxycytidine kinase	P52738	ZNF140	Zinc finger protein 140	0.789
P27707	DCK	Deoxycytidine kinase	O75820	ZNF189	Zinc finger protein 189	0.801
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776
P27707	DCK	Deoxycytidine kinase	P10415	BCL2	Apoptosis regulator Bcl-2	0.781

Fludarabine

hsa05169

Epstein-Barr virus infection

3.52E-05

P13765, Q13547, O00463, Q16539, P42338, P07948, P30101, Q13761, P24522, O75293, P30279, P42224, P29728, P07766, P09693, P20963

HLA-DOB, HDAC1, TRAF5, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, CCND2, STAT1, OAS2, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.738
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13547	HDAC1	Histone deacetylase 1	-0.799
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13547	HDAC1	Histone deacetylase 1	-0.774
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q13547	HDAC1	Histone deacetylase 1	0.713
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.786
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.749
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07948	LYN	Tyrosine-protein kinase Lyn	0.735
P11142	HSPA8	Heat shock cognate 71 kDa protein	P07948	LYN	Tyrosine-protein kinase Lyn	-0.732
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P30101	PDIA3	Protein disulfide-isomerase A3	-0.721
P11142	HSPA8	Heat shock cognate 71 kDa protein	P30101	PDIA3	Protein disulfide-isomerase A3	0.881
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13761	RUNX3	Runt-related transcription factor 3	-0.744
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13761	RUNX3	Runt-related transcription factor 3	-0.708
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q13761	RUNX3	Runt-related transcription factor 3	0.772
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.793
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.768
P11142	HSPA8	Heat shock cognate 71 kDa protein	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.772
P11142	HSPA8	Heat shock cognate 71 kDa protein	P30279	CCND2	G1/S-specific cyclin-D2	0.731
P11142	HSPA8	Heat shock cognate 71 kDa protein	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.754
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.805
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.77
P11142	HSPA8	Heat shock cognate 71 kDa protein	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.748
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823

Fludarabine

hsa05170

Human immunodeficiency virus 1 infection

3.84E-02

P63218, P50151, O00463, P30101, P01730, Q16539, P07766, P09693, P20963

GNG5, GNG10, TRAF5, PDIA3, CD4, MAPK14, CD3E, CD3G, CD247

Fludarabine

hsa05200

Pathways in cancer

1.45E-06

Q16363, Q13751, P42338, P07900, P08238, P42224, P19174, P43246, P84022, Q13485, P20585, P52701, Q13547, P14923, P30279, P30281, P49767, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, Q13557, P14784, P40189, P01042

LAMA4, LAMB3, PIK3CB, HSP90AA1, HSP90AB1, STAT1, PLCG1, MSH2, SMAD3, SMAD4, MSH3, MSH6, HDAC1, JUP, CCND2, CCND3, VEGFC, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, CAMK2D, IL2RB, IL6ST, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q16363	LAMA4	Laminin subunit alpha-4	0.793
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P11142	HSPA8	Heat shock cognate 71 kDa protein	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11142	HSPA8	Heat shock cognate 71 kDa protein	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P11142	HSPA8	Heat shock cognate 71 kDa protein	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.754
P11142	HSPA8	Heat shock cognate 71 kDa protein	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.936
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
P11142	HSPA8	Heat shock cognate 71 kDa protein	P43246	MSH2	DNA mismatch repair protein Msh2	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P11142	HSPA8	Heat shock cognate 71 kDa protein	P20585	MSH3	DNA mismatch repair protein Msh3	0.715
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P52701	MSH6	DNA mismatch repair protein Msh6	0.91
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q13547	HDAC1	Histone deacetylase 1	0.713
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P30279	CCND2	G1/S-specific cyclin-D2	0.704
P11142	HSPA8	Heat shock cognate 71 kDa protein	P30279	CCND2	G1/S-specific cyclin-D2	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P11142	HSPA8	Heat shock cognate 71 kDa protein	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.746
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.707
P11142	HSPA8	Heat shock cognate 71 kDa protein	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P78417	GSTO1	Glutathione S-transferase omega-1	-0.849
P11142	HSPA8	Heat shock cognate 71 kDa protein	P78417	GSTO1	Glutathione S-transferase omega-1	-0.715
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P11142	HSPA8	Heat shock cognate 71 kDa protein	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.772
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P11142	HSPA8	Heat shock cognate 71 kDa protein	P0DP23	CALM1	Calmodulin-1	0.804
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.745
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P11142	HSPA8	Heat shock cognate 71 kDa protein	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.831
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
P11142	HSPA8	Heat shock cognate 71 kDa protein	P01042	KNG1	Kininogen-1	-0.742

Fludarabine

hsa05202

Transcriptional misregulation in cancer

6.60E-06

Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, O15550, P46527, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P24522

SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, UTX, CDKN1B, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21589	NT5E	5'-nucleotidase	Q15532	SS18	Protein SSXT	0.77
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
P04183	TK1	Thymidine kinase, cytosolic	Q13315	ATM	Serine-protein kinase ATM	-0.765
P49913	CAMP	Cathelicidin antimicrobial peptide	Q13315	ATM	Serine-protein kinase ATM	-0.775
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
P04183	TK1	Thymidine kinase, cytosolic	P14923	JUP	Junction plakoglobin	-0.774
P21589	NT5E	5'-nucleotidase	P14923	JUP	Junction plakoglobin	0.87
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P04183	TK1	Thymidine kinase, cytosolic	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.781
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
P21589	NT5E	5'-nucleotidase	O15550	UTX	Lysine-specific demethylase 6A	-0.78
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
P49913	CAMP	Cathelicidin antimicrobial peptide	P46527	CDKN1B	Cyclin-dependent kinase inhibitor 1B	-0.8
P21589	NT5E	5'-nucleotidase	P04637	TP53	Cellular tumor antigen p53	0.701
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P49913	CAMP	Cathelicidin antimicrobial peptide	P35226	BMI1	Polycomb complex protein BMI-1	-0.723
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P49913	CAMP	Cathelicidin antimicrobial peptide	P35226	BMI1	Polycomb complex protein BMI-1	-0.723
P04183	TK1	Thymidine kinase, cytosolic	P05164	MPO	Myeloperoxidase	0.917
P21589	NT5E	5'-nucleotidase	P05164	MPO	Myeloperoxidase	-0.706
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P49913	CAMP	Cathelicidin antimicrobial peptide	P12838	DEFA4	Neutrophil defensin 4	0.718
P04183	TK1	Thymidine kinase, cytosolic	P08246	ELA2	Neutrophil elastase	0.838
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P49913	CAMP	Cathelicidin antimicrobial peptide	P08246	ELA2	Neutrophil elastase	0.807
P04183	TK1	Thymidine kinase, cytosolic	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P04183	TK1	Thymidine kinase, cytosolic	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.718
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769

Fludarabine

hsa05203

Viral carcinogenesis

2.25E-06

Q08999, Q12933, Q99941, P18848, P42229, P06746, P07948, P30279, P27348, P29083, Q7KZF4, P46527, Q13547, Q15283, P06396, P25963, P22694, P62807, O60814

RBL2, TRAF2, CREBL1, ATF4, STAT5A, POLB, LYN, CCND2, YWHAQ, GTF2E1, SND1, CDKN1B, HDAC1, RASA2, GSN, NFKBIA, PRKACB, HIST1H2BC, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49913	CAMP	Cathelicidin antimicrobial peptide	Q08999	RBL2	Retinoblastoma-like protein 2	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.715
P11142	HSPA8	Heat shock cognate 71 kDa protein	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.83
P49913	CAMP	Cathelicidin antimicrobial peptide	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.796
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P11142	HSPA8	Heat shock cognate 71 kDa protein	P06746	POLB	DNA polymerase beta	0.722
P11142	HSPA8	Heat shock cognate 71 kDa protein	P07948	LYN	Tyrosine-protein kinase Lyn	-0.732
P11142	HSPA8	Heat shock cognate 71 kDa protein	P30279	CCND2	G1/S-specific cyclin-D2	0.731
P11142	HSPA8	Heat shock cognate 71 kDa protein	P27348	YWHAQ	14-3-3 protein theta	0.729
P11142	HSPA8	Heat shock cognate 71 kDa protein	P29083	GTF2E1	General transcription factor IIE subunit 1	0.753
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q7KZF4	SND1	Staphylococcal nuclease domain-containing protein 1	0.719
P49913	CAMP	Cathelicidin antimicrobial peptide	P46527	CDKN1B	Cyclin-dependent kinase inhibitor 1B	-0.8
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q13547	HDAC1	Histone deacetylase 1	0.713
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
P49913	CAMP	Cathelicidin antimicrobial peptide	P06396	GSN	Gelsolin	0.777
P49913	CAMP	Cathelicidin antimicrobial peptide	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.745
P49913	CAMP	Cathelicidin antimicrobial peptide	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.722
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11142	HSPA8	Heat shock cognate 71 kDa protein	O60814	H2BC12	Histone H2B type 1-K	-0.701
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Fludarabine

hsa05204

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Fludarabine

hsa05206

MicroRNAs in cancer

1.67E-02

P46527, Q9UM47, P35226, Q13315

CDKN1B, NOTCH3, BMI1, ATM

Fludarabine

hsa05210

Colorectal cancer

4.94E-02

Q13485, P52701

SMAD4, MSH6

Fludarabine

hsa05212

Pancreatic cancer

2.14E-03

P42338, P42224, P84022, Q13485, O75293

PIK3CB, STAT1, SMAD3, SMAD4, GADD45B

Fludarabine

hsa05213

Endometrial cancer

2.82E-02

P49841, P42338

GSK3B, PIK3CB

Fludarabine

hsa05214

Glioma

8.31E-04

P0DP23, Q13557, P42338, P19174, O75293

CALM1, CAMK2D, PIK3CB, PLCG1, GADD45B

Fludarabine

hsa05215

Prostate cancer

1.08E-02

P49841, P42338, P27930

GSK3B, PIK3CB, IL1R2

Fludarabine

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Fludarabine

hsa05221

Acute myeloid leukemia

3.29E-02

P14923, Q15744, P05164

JUP, CEBPE, MPO

Fludarabine

hsa05224

Breast cancer

4.88E-02

P42338, P49841

PIK3CB, GSK3B

Fludarabine

hsa05225

Hepatocellular carcinoma

3.69E-02

P42338, P49841, P51531

PIK3CB, GSK3B, SMARCA2

Fludarabine

hsa05231

Choline metabolism in cancer

2.00E-02

Q9Y259, P49619

CHKB, DGKG

Fludarabine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.72E-07

P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.727
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01730	CD4	T-cell surface glycoprotein CD4	-0.766
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857

Fludarabine

hsa05310

Asthma

3.01E-02

P13765, P12724

HLA-DOB, RNASE3

Fludarabine

hsa05321

Inflammatory bowel disease

4.92E-02

O60603, P01375, Q14765, Q9UL17

TLR2, TNF, STAT4, TBX21

Fludarabine

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Fludarabine

hsa05330

Allograft rejection

4.31E-02

P10747, P01375

CD28, TNF

Fludarabine

hsa05332

Graft-versus-host disease

1.80E-02

P10747, P01375, P26715, Q13241

CD28, TNF, KLRC1, KLRD1

Fludarabine

hsa05340

Primary immunodeficiency

3.99E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Fludarabine

hsa05410

Hypertrophic cardiomyopathy

2.60E-02

P26012, P09493

ITGB8, TPM1

Fludarabine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Fludarabine

hsa05418

Fluid shear stress and atherosclerosis

1.02E-05

Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P14778, P27930, P0DP23, P08238

MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, IL1R1, IL1R2, CALM1, HSP90AB1

Community members of Fludarabine (S_DC: 6.62)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

DCK

Deoxycytidine kinase

Reported

0.0574

0.0614

0.1653

0.3169

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P04406

GAPDH

GlyceraldehydeNone3Nonephosphate dehydrogenase

Predicted

0.4535

0.1223

0.4666

0.938

P20839

IMPDH1

InosineNone5'Nonemonophosphate dehydrogenase 1

Predicted

0.1928

0.1307

0.1653

0.5231

P11142

HSPA8

Heat shock cognate 71 kDa protein

Predicted

0.9682

0.0773

0.6729

1.3115

O43318

MAP3K7

MitogenNoneactivated protein kinase kinase kinase 7

Predicted

0.0059

0.3649

1.7327

P08235

NR3C2

Mineralocorticoid receptor

Predicted

0.1855

0.0137

2.1064

P04183

TK1

Thymidine kinase, cytosolic

Predicted

0.2717

0.1637

0.1653

0.6286

Q53EL6

PDCD4

Programmed cell death protein 4

Predicted

0.3899

0.0653

0.3202

0.6457

P15144

ANPEP

Aminopeptidase N

Predicted

0.1875

0.2365

0.2934

0.8601

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P11388

TOP2A

DNA topoisomerase 2Nonealpha

Predicted

0.1992

0.4659

0.1927

1.2242

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P06213

INSR

Insulin receptor

Predicted

0.2794

0.7813

0.7209

2.4232

P51813

BMX

Cytoplasmic tyrosineNoneprotein kinase BMX

Predicted

0.0597

0.3263

0.6825

P09769

FGR

TyrosineNoneprotein kinase Fgr

Predicted

0.0622

0.3244

0.225

0.9049

P07948

LYN

TyrosineNoneprotein kinase Lyn

Predicted

0.091

0.5319

0.606

1.7154

P43003

SLC1A3

Excitatory amino acid transporter 1

Predicted

0.0973

0.0774

0.1658

0.3692

P43005

SLC1A1

Excitatory amino acid transporter 3

Predicted

0.0827

0.0663

0.019

0.193

P21589

NT5E

5'Nonenucleotidase

Predicted

0.2924

0.0855

0.1539

0.4711

P29375

JARID1A

LysineNonespecific demethylase 5A

Predicted

0.3605

0.7052

1.5906

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P51531

SMARCA2

Probable global transcription activator SNF2L2

Predicted

0.2231

0.045

0.1375

0.3391

P35557

GCK

HexokinaseNone4

Predicted

0.0049

0.0558

0.3242

0.4382

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

P22748

CA4

Carbonic anhydrase 4

Predicted

0.0056

0.8267

0.1609

1.8171

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P22001

KCNA3

Potassium voltageNonegated channel subfamily A member 3

Predicted

0.1396

0.5055

1.0809

P15121

AKR1B1

AldoNoneketo reductase family 1 member B1

Predicted

0.5683

0.629

0.214

1.7562

O14684

PTGES

Prostaglandin E synthase

Predicted

0.4531

0.6358

0.1565

1.6547

Q9HB89

NMUR1

NeuromedinNoneU receptor 1

Predicted

0.0024

0.303

0.6072

P11169

SLC2A3

Solute carrier family 2, facilitated glucose transporter member 3

Predicted

0.1357

0.0658

0.1995

P49913

CAMP

Cathelicidin antimicrobial peptide

Predicted

0.3356

0.0407

0.5275

0.7766

PharmaCoNets of Fludarabine (SPCN: 158.06 )

Fludarabine regulated-network (SDN: 23.88)

Community members of Fludarabine (SDC: 6.62)

PharmaCoNets of Fludarabine (S_PCN: 158.06 )

Fludarabine regulated-network (S_DN: 23.88)

Community members of Fludarabine (S_DC: 6.62)