PharmaCoNets

PharmaCoNets of Floxuridine (S_PCN: 9.90 )

Floxuridine regulated-network (S_DN: 6.27)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Floxuridine

hsa00030

Pentose phosphate pathway

8.97E-03

P11413

G6PD

Floxuridine

hsa00190

Oxidative phosphorylation

3.20E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Floxuridine

hsa00230

Purine metabolism

4.02E-02

P31350, P21589

RRM2, NT5E

Floxuridine

hsa00240

Pyrimidine metabolism

6.80E-07

P31350, P21589, P32320, P04183, P04818

RRM2, NT5E, CDA, TK1, TYMS

Floxuridine

hsa00480

Glutathione metabolism

1.35E-02

P11413

G6PD

Floxuridine

hsa00983

Drug metabolism - other enzymes

3.83E-04

P04183, P32320, P31350, P05164

TK1, CDA, RRM2, MPO

Floxuridine

hsa01200

Carbon metabolism

2.91E-02

P11413

G6PD

Floxuridine

hsa01523

Antifolate resistance

6.06E-03

Q92820, P04818

GGH, TYMS

Floxuridine

hsa03040

Spliceosome

1.64E-03

Q14562, O43143, O14776, O75940, P52298, P09651, O75494, Q07955, Q13243, O95777, P61326

DHX8, DHX15, TCERG1, SMNDC1, NCBP2, HNRNPA1, FUSIP1, SFRS1, SFRS5, LSM8, MAGOH

Floxuridine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.28E-02

P51684, P09341, P25024, P25025, P47992, Q9UBD3, P01375

CCR6, CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNF

Floxuridine

hsa04064

NF-kappa B signaling pathway

2.37E-04

P10415, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522, P09341

BCL2, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A, CXCL1

Floxuridine

hsa04071

Sphingolipid signaling pathway

9.29E-03

P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Floxuridine

hsa04110

Cell cycle

2.34E-02

P06493, O60566, P33981

CDK1, BUB1B, TTK

Floxuridine

hsa04115

p53 signaling pathway

1.85E-04

P24522, Q13315, P31350, P06493, O95067, P10415

GADD45A, ATM, RRM2, CDK1, CCNB2, BCL2

Floxuridine

hsa04145

Phagosome

1.73E-03

Q15080, P68371, P05164, P78380, P35443, P13765

NCF4, TUBB2C, MPO, OLR1, THBS4, HLA-DOB

Floxuridine

hsa04612

Antigen processing and presentation

4.72E-02

P13765, P48382, P26715, P26717

HLA-DOB, RFX5, KLRC1, KLRC2

Floxuridine

hsa04613

Neutrophil extracellular trap formation

1.02E-02

O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Floxuridine

hsa04621

NOD-like receptor signaling pathway

4.83E-02

Q16539, Q14643, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P49913, P12838

MAPK14, ITPR1, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, CAMP, DEFA4

Floxuridine

hsa04658

Th1 and Th2 cell differentiation

8.47E-03

Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOB

Floxuridine

hsa04660

T cell receptor signaling pathway

2.57E-03

P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539

TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14

Floxuridine

hsa04744

Phototransduction

2.59E-02

P62873, P0DP23

GNB1, CALM1

Floxuridine

hsa05132

Salmonella infection

2.35E-03

P25963, P08238, Q13489, P10415, P04406, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P49754

NFKBIA, HSP90AB1, BIRC3, BCL2, GAPDH, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, VPS41

Floxuridine

hsa05140

Leishmaniasis

2.25E-02

P14598, P42224, O60603, P25963, P29350, Q15080

NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4

Floxuridine

hsa05146

Amoebiasis

3.11E-02

P09341, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Floxuridine

hsa05150

Staphylococcus aureus infection

2.53E-02

P21730, P21462, O75015, P13765, P12838, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, DEFA4, CAMP

Floxuridine

hsa05152

Tuberculosis

1.88E-05

Q13488, Q15075, P0DP23, O75015, P42224, P48382, P25208, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, Q16539, P51617

TCIRG1, EEA1, CALM1, FCGR3B, STAT1, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, MAPK14, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P27707	DCK	Deoxycytidine kinase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.828
P27707	DCK	Deoxycytidine kinase	Q15075	EEA1	Early endosome antigen 1	0.719
P27707	DCK	Deoxycytidine kinase	P0DP23	CALM1	Calmodulin-1	-0.759
P32320	CDA	Cytidine deaminase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.812
P27707	DCK	Deoxycytidine kinase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.7
P04183	TK1	Thymidine kinase, cytosolic	P48382	RFX5	DNA-binding protein RFX5	-0.739
P32320	CDA	Cytidine deaminase	P48382	RFX5	DNA-binding protein RFX5	-0.849
P27707	DCK	Deoxycytidine kinase	P25208	NFYB	Nuclear transcription factor Y subunit beta	0.767
P27707	DCK	Deoxycytidine kinase	O60603	TLR2	Toll-like receptor 2	-0.781
P32320	CDA	Cytidine deaminase	O60603	TLR2	Toll-like receptor 2	0.864
P32320	CDA	Cytidine deaminase	P01375	TNF	Tumor necrosis factor	0.806
P04183	TK1	Thymidine kinase, cytosolic	P10415	BCL2	Apoptosis regulator Bcl-2	-0.763
P27707	DCK	Deoxycytidine kinase	P10415	BCL2	Apoptosis regulator Bcl-2	0.781
P32320	CDA	Cytidine deaminase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.84
P04183	TK1	Thymidine kinase, cytosolic	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.75
P32320	CDA	Cytidine deaminase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.783
P27707	DCK	Deoxycytidine kinase	P01568	IFNA21	Interferon alpha-21	0.798
P32320	CDA	Cytidine deaminase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.735
P04183	TK1	Thymidine kinase, cytosolic	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.738
P27707	DCK	Deoxycytidine kinase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.828
P32320	CDA	Cytidine deaminase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.864
P32320	CDA	Cytidine deaminase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.701
P04183	TK1	Thymidine kinase, cytosolic	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.756

Floxuridine

hsa05168

Herpes simplex virus 1 infection

7.93E-04

O60603, P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, P51522, Q9NR11, Q9HCX3, P17097, Q03923, P52738, O75820, P10415

TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF85, ZNF140, ZNF189, BCL2

Floxuridine

hsa05170

Human immunodeficiency virus 1 infection

4.82E-02

P01375, O00463, Q14643, Q16539, O60603, Q13315, P09693, P20963, P10415, Q93034, Q9Y6Q5

TNF, TRAF5, ITPR1, MAPK14, TLR2, ATM, CD3G, CD247, BCL2, CUL5, AP1M2

Floxuridine

hsa05202

Transcriptional misregulation in cancer

1.01E-03

Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522

SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Floxuridine

hsa05221

Acute myeloid leukemia

3.29E-02

P14923, Q15744, P05164

JUP, CEBPE, MPO

Floxuridine

hsa05230

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Floxuridine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

3.11E-02

O95267, P20963, P09693, O60603, P10747, Q04759, Q16539

RASGRP1, CD247, CD3G, TLR2, CD28, PRKCQ, MAPK14

Floxuridine

hsa05310

Asthma

1.68E-03

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Floxuridine

hsa05321

Inflammatory bowel disease

2.47E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Floxuridine

hsa05322

Systemic lupus erythematosus

4.61E-02

O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455

FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSB

Floxuridine

hsa05323

Rheumatoid arthritis

2.84E-02

P01375, P13765, P10747, P09341, O60603

TNF, HLA-DOB, CD28, CXCL1, TLR2

Floxuridine

hsa05332

Graft-versus-host disease

3.93E-03

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Floxuridine

hsa05415

Diabetic cardiomyopathy

3.59E-02

P11413

G6PD

Community members of Floxuridine (S_DC: 1.58)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

TYMS

Thymidylate synthase

Reported

0.4553

0.2706

0.1893

0.9582

P04183

TK1

Thymidine kinase, cytosolic

Predicted

0.2717

0.1637

0.1653

0.6286

P11413

G6PD

GlucoseNone6Nonephosphate 1Nonedehydrogenase

Predicted

0.4435

0.6369

0.2929

1.7884

P27707

DCK

Deoxycytidine kinase

Predicted

0.0574

0.0614

0.1653

0.3169

P32320

CDA

Cytidine deaminase

Predicted

0.0516

0.0569

0.1653

0.3049

PharmaCoNets of Floxuridine (SPCN: 9.90 )

Floxuridine regulated-network (SDN: 6.27)

Community members of Floxuridine (SDC: 1.58)

PharmaCoNets of Floxuridine (S_PCN: 9.90 )

Floxuridine regulated-network (S_DN: 6.27)

Community members of Floxuridine (S_DC: 1.58)