PharmaCoNets

PharmaCoNets of Flortaucipir-f-18 (S_PCN: )

Flortaucipir-f-18 regulated-network (S_DN: )

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Flortaucipir-F-18

hsa00030

Pentose phosphate pathway

1.65E-05

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Flortaucipir-F-18

hsa00040

Pentose and glucuronate interconversions

3.53E-02

O60701

UGDH

Flortaucipir-F-18

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Flortaucipir-F-18

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Flortaucipir-F-18

hsa00190

Oxidative phosphorylation

2.62E-05

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Flortaucipir-F-18

hsa00220

Arginine biosynthesis

2.40E-05

P05089, P49448

ARG1, GLUD2

Flortaucipir-F-18

hsa00230

Purine metabolism

4.02E-02

P31350, P21589

RRM2, NT5E

Flortaucipir-F-18

hsa00240

Pyrimidine metabolism

2.09E-06

P31350, P21589, P04818

RRM2, NT5E, TYMS

Flortaucipir-F-18

hsa00280

Valine, leucine and isoleucine degradation

1.67E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Flortaucipir-F-18

hsa00310

Lysine degradation

2.93E-05

Q96KQ7, Q8NEZ4, Q13029, Q02809, P51648

EHMT2, MLL3, PRDM2, PLOD1, ALDH3A2

Flortaucipir-F-18

hsa00340

Histidine metabolism

4.52E-02

O95954

FTCD

Flortaucipir-F-18

hsa00350

Tyrosine metabolism

3.40E-02

P28332

ADH6

Flortaucipir-F-18

hsa00500

Starch and sucrose metabolism

1.83E-06

O43451, P46976, P35573, P06737

MGAM, GYG1, AGL, PYGL

Flortaucipir-F-18

hsa00510

N-Glycan biosynthesis

3.15E-02

P15907, Q9NR34

ST6GAL1, MAN1C1

Flortaucipir-F-18

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Flortaucipir-F-18

hsa00520

Amino sugar and nucleotide sugar metabolism

3.11E-05

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Flortaucipir-F-18

hsa00531

Glycosaminoglycan degradation

8.18E-04

P15586, P34059

GNS, GALNS

Flortaucipir-F-18

hsa00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

1.07E-03

Q9Y2C2

UST

Flortaucipir-F-18

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

6.96E-04

Q9NY97

B3GNT2

Flortaucipir-F-18

hsa00561

Glycerolipid metabolism

2.21E-02

O14494, P06280, P23743

PLPP1, GLA, DGKA

Flortaucipir-F-18

hsa00562

Inositol phosphate metabolism

2.00E-02

P27987, P19174, P42338, Q02252

ITPKB, PLCG1, PIK3CB, ALDH6A1

Flortaucipir-F-18

hsa00564

Glycerophospholipid metabolism

9.70E-03

Q9Y259, P49619

CHKB, DGKG

Flortaucipir-F-18

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Flortaucipir-F-18

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Flortaucipir-F-18

hsa00591

Linoleic acid metabolism

1.48E-03

P11712

CYP2C9

Flortaucipir-F-18

hsa00600

Sphingolipid metabolism

3.96E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Flortaucipir-F-18

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Flortaucipir-F-18

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

4.91E-05

P06865, O75752

HEXA, B3GALNT1

Flortaucipir-F-18

hsa00630

Glyoxylate and dicarboxylate metabolism

1.89E-04

P40925, P15104

MDH1, GLUL

Flortaucipir-F-18

hsa00640

Propanoate metabolism

3.83E-02

Q02252, Q9P2R7

ALDH6A1, SUCLA2

Flortaucipir-F-18

hsa00670

One carbon pool by folate

9.61E-05

O95954, P04818, Q99707

FTCD, TYMS, MTR

Flortaucipir-F-18

hsa00730

Thiamine metabolism

1.55E-03

P05186, P24666

ALPL, ACP1

Flortaucipir-F-18

hsa00740

Riboflavin metabolism

4.77E-02

P30043

BLVRB

Flortaucipir-F-18

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Flortaucipir-F-18

hsa00790

Folate biosynthesis

1.04E-02

Q92820, P05186, P42330

GGH, ALPL, AKR1C3

Flortaucipir-F-18

hsa00830

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Flortaucipir-F-18

hsa00860

Porphyrin and chlorophyll metabolism

3.73E-03

P36551, P53004, P30043

CPOX, BLVRA, BLVRB

Flortaucipir-F-18

hsa00910

Nitrogen metabolism

2.93E-02

P22748, P49448

CA4, GLUD2

Flortaucipir-F-18

hsa00970

Aminoacyl-tRNA biosynthesis

2.41E-05

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Flortaucipir-F-18

hsa00980

Metabolism of xenobiotics by cytochrome P450

8.40E-04

P78417, P28332, P11712

GSTO1, ADH6, CYP2C9

Flortaucipir-F-18

hsa00982

Drug metabolism - cytochrome P450

8.40E-04

P11712, P78417, P28332

CYP2C9, GSTO1, ADH6

Flortaucipir-F-18

hsa00983

Drug metabolism - other enzymes

3.07E-03

P04183, P32320, P05164

TK1, CDA, MPO

Flortaucipir-F-18

hsa01100

Metabolic pathways

6.99E-03

Q9NR34, Q9Y259, P05089, P32320, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, P49619, O95954, Q9HCC0, P33121, Q02318, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737

MAN1C1, CHKB, ARG1, CDA, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, DGKG, FTCD, MCCC2, ACSL1, CYP27A1, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Flortaucipir-F-18

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Flortaucipir-F-18

hsa01210

2-Oxocarboxylic acid metabolism

6.96E-04

P50213

IDH3A

Flortaucipir-F-18

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Flortaucipir-F-18

hsa01240

Biosynthesis of cofactors

2.05E-02

P36551, O60701

CPOX, UGDH

Flortaucipir-F-18

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P04049

RAF1

Flortaucipir-F-18

hsa01522

Endocrine resistance

2.16E-02

P04049

RAF1

Flortaucipir-F-18

hsa01523

Antifolate resistance

3.45E-07

P41439, P41440, Q92820, P04818, P01375

FOLR3, SLC19A1, GGH, TYMS, TNF

Flortaucipir-F-18

hsa02010

ABC transporters

1.66E-04

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Flortaucipir-F-18

hsa03008

Ribosome biogenesis in eukaryotes

1.86E-03

Q9NYH9, P19784, P67870, Q9BVP2

UTP6, CSNK2A2, CSNK2B, GNL3

Flortaucipir-F-18

hsa03010

Ribosome

7.52E-03

P46777, Q9UHA3

RPL5, RSL24D1

Flortaucipir-F-18

hsa03013

RNA transport

7.42E-08

P62826, O14980, P52298, Q09161, O14893, P61326, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114

RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q9UBU7	DBF4	Protein DBF4 homolog A	O14980	XPO1	Exportin-1	0.943
P08246	ELA2	Neutrophil elastase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.852
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
P08246	ELA2	Neutrophil elastase	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.732
Q9UBU7	DBF4	Protein DBF4 homolog A	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.742
P08246	ELA2	Neutrophil elastase	O14893	GEMIN2	Gem-associated protein 2	-0.785
P49759	CLK1	Dual specificity protein kinase CLK1	O14893	GEMIN2	Gem-associated protein 2	0.76
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
Q9UBU7	DBF4	Protein DBF4 homolog A	P61326	MAGOH	Protein mago nashi homolog	0.737
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q9UBU7	DBF4	Protein DBF4 homolog A	Q9H307	PNN	Pinin	0.722
P08246	ELA2	Neutrophil elastase	Q7Z3B4	NUP54	Nucleoporin p54	-0.723
Q9UBU7	DBF4	Protein DBF4 homolog A	Q7Z3B4	NUP54	Nucleoporin p54	0.787
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
P08246	ELA2	Neutrophil elastase	P35658	NUP214	Nuclear pore complex protein Nup214	0.765
Q9UBU7	DBF4	Protein DBF4 homolog A	P35658	NUP214	Nuclear pore complex protein Nup214	-0.781
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
P08246	ELA2	Neutrophil elastase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.722
Q9UBU7	DBF4	Protein DBF4 homolog A	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.902
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
P08246	ELA2	Neutrophil elastase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.825
Q9UBU7	DBF4	Protein DBF4 homolog A	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.83
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
P08246	ELA2	Neutrophil elastase	P78345	RPP38	Ribonuclease P protein subunit p38	-0.795
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
Q9UBU7	DBF4	Protein DBF4 homolog A	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.867
P49759	CLK1	Dual specificity protein kinase CLK1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.704
P49759	CLK1	Dual specificity protein kinase CLK1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.758
P08246	ELA2	Neutrophil elastase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.849
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
Q9UBU7	DBF4	Protein DBF4 homolog A	Q06787	FMR1	Synaptic functional regulator FMR1	0.772
P49759	CLK1	Dual specificity protein kinase CLK1	Q06787	FMR1	Synaptic functional regulator FMR1	0.793
Q9UBU7	DBF4	Protein DBF4 homolog A	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.854

Flortaucipir-F-18

hsa03015

mRNA surveillance pathway

4.81E-02

Q9BZI7, O94913

UPF3B, PCF11

Flortaucipir-F-18

hsa03020

RNA polymerase

5.54E-06

P30876, P24928, P62487, Q9Y535

POLR2B, POLR2A, POLR2G, POLR3H

Flortaucipir-F-18

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Flortaucipir-F-18

hsa03040

Spliceosome

1.23E-09

Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.888
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.953
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O60508	CDC40	Pre-mRNA-processing factor 17	0.838
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.935
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.882
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.886
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Flortaucipir-F-18

hsa03050

Proteasome

1.79E-03

P55036

PSMD4

Flortaucipir-F-18

hsa03060

Protein export

2.33E-04

P37108, Q15005

SRP14, SPCS2

Flortaucipir-F-18

hsa03320

PPAR signaling pathway

2.42E-03

Q6PCB7, Q9UNU6, Q13133, Q02318

SLC27A1, CYP8B1, NR1H3, CYP27A1

Flortaucipir-F-18

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Flortaucipir-F-18

hsa04010

MAPK signaling pathway

4.15E-02

P04049

RAF1

Flortaucipir-F-18

hsa04012

ErbB signaling pathway

7.11E-04

P16333, P17252, P19174, P42338, P01106, P04049

NCK1, PRKCA, PLCG1, PIK3CB, MYC, RAF1

Flortaucipir-F-18

hsa04014

Ras signaling pathway

5.57E-05

P04049, P42338, P20827, P49767, Q13009, P17252, P14921, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174

RAF1, PIK3CB, EFNA1, VEGFC, TIAM1, PRKCA, ETS1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P20827	EFNA1	Ephrin-A1	-0.872
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14921	ETS1	Protein C-ets-1	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Flortaucipir-F-18

hsa04015

Rap1 signaling pathway

2.09E-04

P04049, P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P0DP23, P17252, P19174

RAF1, EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, CALM1, PRKCA, PLCG1

Flortaucipir-F-18

hsa04020

Calcium signaling pathway

5.71E-03

P27987, Q08828, P17252, O15399, P19174, P0DP23, P05141, P51828, P49767

ITPKB, ADCY1, PRKCA, GRIN2D, PLCG1, CALM1, SLC25A5, ADCY7, VEGFC

Flortaucipir-F-18

hsa04022

cGMP-PKG signaling pathway

1.31E-03

P04049, P18848, P31751, Q08828, P51828, P05141, P0DP23

RAF1, ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1

Flortaucipir-F-18

hsa04024

cAMP signaling pathway

2.06E-04

P63092, Q08828, P51828, P42338, P31751, P26678, P0DP23, P04049, P61586, Q13370, O15399, P25963, Q13009

GNAS, ADCY1, ADCY7, PIK3CB, AKT2, PLN, CALM1, RAF1, RHOA, PDE3B, GRIN2D, NFKBIA, TIAM1

Flortaucipir-F-18

hsa04060

Cytokine-cytokine receptor interaction

1.91E-05

P14784, P27930, P14778, P37173, P08476, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P01375, P09341, P80075, P18510, P01730, Q93038

IL2RB, IL1R2, IL1R1, TGFBR2, INHBA, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, TNF, CXCL1, CCL8, IL1RN, CD4, TNFRSF25

Flortaucipir-F-18

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.81E-07

Q8NHW4, P09341, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P14784, P01375

CCL4L2, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, IL2RB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P09341	CXCL1	Growth-regulated alpha protein	0.716
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09341	CXCL1	Growth-regulated alpha protein	-0.927
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.905
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.772
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P47992	XCL1	Lymphotactin	-0.827
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P47992	XCL1	Lymphotactin	0.83
P08311	CTSG	Cathepsin G	P47992	XCL1	Lymphotactin	-0.823
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.827
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.83
P08311	CTSG	Cathepsin G	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.823
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
P08311	CTSG	Cathepsin G	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.736
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01375	TNF	Tumor necrosis factor	0.761
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733

Flortaucipir-F-18

hsa04062

Chemokine signaling pathway

5.12E-06

P25024, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P14598, P42224, P04049, P25963, Q8WYR1

CXCR1, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, NCF1, STAT1, RAF1, NFKBIA, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P43250	GRK6	G protein-coupled receptor kinase 6	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14598	NCF1	Neutrophil cytosol factor 1	0.908
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Flortaucipir-F-18

hsa04064

NF-kappa B signaling pathway

1.13E-15

P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, P29965, Q04759, Q9UDY8, Q13077, P67870, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, CD40LG, PRKCQ, MALT1, TRAF1, CSNK2B, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P10415	BCL2	Apoptosis regulator Bcl-2	0.744
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O00463	TRAF5	TNF receptor-associated factor 5	0.945
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08311	CTSG	Cathepsin G	O00463	TRAF5	TNF receptor-associated factor 5	-0.853
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753

Flortaucipir-F-18

hsa04068

FoxO signaling pathway

1.99E-02

P04049

RAF1

Flortaucipir-F-18

hsa04070

Phosphatidylinositol signaling system

1.09E-06

P19174, P0DP23, Q14643, P42338, O14986, P23743, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252

PLCG1, CALM1, ITPR1, PIK3CB, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCA

Flortaucipir-F-18

hsa04071

Sphingolipid signaling pathway

4.87E-07

P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P08246	ELA2	Neutrophil elastase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.865
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P08246	ELA2	Neutrophil elastase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.847
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863

Flortaucipir-F-18

hsa04072

Phospholipase D signaling pathway

4.94E-05

P04049, P31751, P61586, O14986, Q15438, P63092, Q08828, P51828, Q16760

RAF1, AKT2, RHOA, PIP5K1B, PSCD1, GNAS, ADCY1, ADCY7, DGKD

Flortaucipir-F-18

hsa04080

Neuroactive ligand-receptor interaction

1.34E-06

P08311, P28472, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P14416, P07550, P35318

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, DRD2, ADRB2, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P08311	CTSG	Cathepsin G	0.715
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.796
P08246	ELA2	Neutrophil elastase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.846
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.777
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.744
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.859
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.92
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.714
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.768
P08246	ELA2	Neutrophil elastase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.793
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.779
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.923
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.852
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P14416	DRD2	D(2) dopamine receptor	-0.71
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P07550	ADRB2	Beta-2 adrenergic receptor	0.737
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.814
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	-0.734

Flortaucipir-F-18

hsa04110

Cell cycle

8.49E-09

Q9UBD5, P06493, O60566, Q14683, O75293, P30304, P33981, P42773, P01106

ORC3, CDK1, BUB1B, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P33981	TTK	Dual specificity protein kinase TTK	Q9UBD5	ORC3	Origin recognition complex subunit 3	0.804
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBD5	ORC3	Origin recognition complex subunit 3	0.718
P04818	TYMS	Thymidylate synthase	P06493	CDK1	Cyclin-dependent kinase 1	0.753
P33981	TTK	Dual specificity protein kinase TTK	P06493	CDK1	Cyclin-dependent kinase 1	0.893
P11388	TOP2A	DNA topoisomerase 2-alpha	P06493	CDK1	Cyclin-dependent kinase 1	0.861
P52732	KIF11	Kinesin-like protein KIF11	P06493	CDK1	Cyclin-dependent kinase 1	0.869
P06493	CDK1	Cyclin-dependent kinase 1	P06493	CDK1	Cyclin-dependent kinase 1	1
P04818	TYMS	Thymidylate synthase	O60566	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	0.749
P06493	CDK1	Cyclin-dependent kinase 1	O60566	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	0.726
P33981	TTK	Dual specificity protein kinase TTK	Q14683	SMC1A	Structural maintenance of chromosomes protein 1A	0.781
P52732	KIF11	Kinesin-like protein KIF11	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.716
P33981	TTK	Dual specificity protein kinase TTK	P30304	CDC25A	M-phase inducer phosphatase 1	0.825
P52732	KIF11	Kinesin-like protein KIF11	P30304	CDC25A	M-phase inducer phosphatase 1	0.881
P06493	CDK1	Cyclin-dependent kinase 1	P30304	CDC25A	M-phase inducer phosphatase 1	0.724
P04818	TYMS	Thymidylate synthase	P33981	TTK	Dual specificity protein kinase TTK	0.721
P33981	TTK	Dual specificity protein kinase TTK	P33981	TTK	Dual specificity protein kinase TTK	1
P11388	TOP2A	DNA topoisomerase 2-alpha	P33981	TTK	Dual specificity protein kinase TTK	0.806
P52732	KIF11	Kinesin-like protein KIF11	P33981	TTK	Dual specificity protein kinase TTK	0.849
P06493	CDK1	Cyclin-dependent kinase 1	P33981	TTK	Dual specificity protein kinase TTK	0.893
P52732	KIF11	Kinesin-like protein KIF11	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.793
P06493	CDK1	Cyclin-dependent kinase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.722
P33981	TTK	Dual specificity protein kinase TTK	P01106	MYC	Myc proto-oncogene protein	-0.749
P52732	KIF11	Kinesin-like protein KIF11	P01106	MYC	Myc proto-oncogene protein	-0.834
P06493	CDK1	Cyclin-dependent kinase 1	P01106	MYC	Myc proto-oncogene protein	-0.733

Flortaucipir-F-18

hsa04114

Oocyte meiosis

2.17E-08

Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738

MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.815
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q9HAZ1	CLK4	Dual specificity protein kinase CLK4	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.822
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	1
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9HAZ1	CLK4	Dual specificity protein kinase CLK4	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.922
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.93
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q9HAZ1	CLK4	Dual specificity protein kinase CLK4	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.911
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.93
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q9HAZ1	CLK4	Dual specificity protein kinase CLK4	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.861
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.938
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q9HAZ1	CLK4	Dual specificity protein kinase CLK4	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.92
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781

Flortaucipir-F-18

hsa04115

p53 signaling pathway

7.31E-04

P24522, Q13315, P31350, Q53FA7, P06493, O95067, P10415

GADD45A, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2

Flortaucipir-F-18

hsa04120

Ubiquitin mediated proteolysis

1.08E-03

Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669

SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12

Flortaucipir-F-18

hsa04137

Mitophagy - animal

2.52E-02

P19784, P67870

CSNK2A2, CSNK2B

Flortaucipir-F-18

hsa04140

Autophagy - animal

4.56E-03

P31751, P04049, Q7L523, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9

AKT2, RAF1, RRAGA, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8

Flortaucipir-F-18

hsa04141

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Flortaucipir-F-18

hsa04142

Lysosome

1.41E-05

P43234, P06865, P15586, P22304, P34059, P38571, Q13510, P07602, Q9NRA2, P61916, Q04900, Q9Y227

CTSO, HEXA, GNS, IDS, GALNS, LIPA, ASAH1, PSAP, SLC17A5, NPC2, CD164, ENTPD4

Flortaucipir-F-18

hsa04144

Endocytosis

6.05E-06

Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P42566, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7

CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, EPS15, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07948	LYN	Tyrosine-protein kinase Lyn	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.774
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.792
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.783
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P62491	RAB11A	Ras-related protein Rab-11A	0.816
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P42566	EPS15	Epidermal growth factor receptor substrate 15	0.711
P07948	LYN	Tyrosine-protein kinase Lyn	P25024	CXCR1	C-X-C chemokine receptor type 1	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P07948	LYN	Tyrosine-protein kinase Lyn	P43250	GRK6	G protein-coupled receptor kinase 6	0.764
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q15438	PSCD1	Cytohesin-1	0.794
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.833
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q96QK1	VPS35	Vacuolar protein sorting-associated protein 35	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9UMY4	SNX12	Sorting nexin-12	0.764
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y5X3	SNX5	Sorting nexin-5	-0.782
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9UNH7	SNX6	Sorting nexin-6	0.723

Flortaucipir-F-18

hsa04145

Phagosome

4.11E-06

O75015, P60709, Q15075, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765

FCGR3B, ACTB, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15080	NCF4	Neutrophil cytosol factor 4	-0.74
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05164	MPO	Myeloperoxidase	-0.811
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P78380	OLR1	Oxidized low-density lipoprotein receptor 1	-0.702
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35443	THBS4	Thrombospondin-4	-0.903
P08246	ELA2	Neutrophil elastase	P35443	THBS4	Thrombospondin-4	0.871
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729

Flortaucipir-F-18

hsa04146

Peroxisome

2.42E-02

O43933, P56589, Q9UKG9, O75521, P33121

PEX1, PEX3, CROT, ECI2, ACSL1

Flortaucipir-F-18

hsa04150

mTOR signaling pathway

7.74E-03

P04049, Q02750, Q9NQL2, P51812

RAF1, MAP2K1, RRAGD, RPS6KA3

Flortaucipir-F-18

hsa04151

PI3K-Akt signaling pathway

6.49E-05

P42338, P43657, P25116, P20827, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, P02452, P24821, Q13751, O60603, P14784, P01568, P10415, P17252, P30281

PIK3CB, P2RY5, F2R, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, COL1A1, TNC, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P20827	EFNA1	Ephrin-A1	-0.872
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P16144	ITGB4	Integrin beta-4	-0.705
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O15335	CHAD	Chondroadherin	-0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P49760	CLK2	Dual specificity protein kinase CLK2	P02452	COL1A1	Collagen alpha-1(I) chain	-0.776
P49760	CLK2	Dual specificity protein kinase CLK2	P24821	TNC	Tenascin	-0.718
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13751	LAMB3	Laminin subunit beta-3	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P49760	CLK2	Dual specificity protein kinase CLK2	P01568	IFNA21	Interferon alpha-21	-0.752
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Flortaucipir-F-18

hsa04210

Apoptosis

2.14E-04

Q13315, P04637, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, P43234, Q14643, P63261, P04049

ATM, TP53, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ITPR1, ACTG1, RAF1

Flortaucipir-F-18

hsa04211

Longevity regulating pathway

1.88E-02

P31751, Q08828, P51828, P18848

AKT2, ADCY1, ADCY7, ATF4

Flortaucipir-F-18

hsa04213

Longevity regulating pathway - multiple species

3.11E-03

P31751, Q08828, P51828, P0DMV8

AKT2, ADCY1, ADCY7, HSPA1A

Flortaucipir-F-18

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Flortaucipir-F-18

hsa04217

Necroptosis

3.17E-06

P01375, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P08238, P15104, P01584, Q9BTM1, Q6FI13, Q99878, P10415, Q9H444, O43633, O75351, Q08752

TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AB1, GLUL, IL1B, H2AFJ, H2AC18; H2AC19, H2AC14, BCL2, CHMP4B, CHMP2A, VPS4B, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P49760	CLK2	Dual specificity protein kinase CLK2	P01568	IFNA21	Interferon alpha-21	-0.752
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P23458	JAK1	Tyrosine-protein kinase JAK1	0.896
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P49760	CLK2	Dual specificity protein kinase CLK2	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.741
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P15104	GLUL	Glutamine synthetase	-0.729
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P01584	IL1B	Interleukin-1 beta	0.723
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9BTM1	H2AFJ	Histone H2A.J	-0.701
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.756
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.792
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O43633	CHMP2A	Charged multivesicular body protein 2a	0.894
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.783
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725

Flortaucipir-F-18

hsa04218

Cellular senescence

8.08E-03

P01106, P04049, O75293, P30304, P06493

MYC, RAF1, GADD45B, CDC25A, CDK1

Flortaucipir-F-18

hsa04260

Cardiac muscle contraction

4.60E-03

P67936, P13073, P12074

TPM4, COX4I1, COX6A1

Flortaucipir-F-18

hsa04261

Adrenergic signaling in cardiomyocytes

6.17E-06

P09493, P07550, Q08828, P51828, P22694, P31751, P18848, Q13362, Q14738, P0DP23, P17252, P10415

TPM1, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1, PRKCA, BCL2

Flortaucipir-F-18

hsa04270

Vascular smooth muscle contraction

8.88E-05

P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318

PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADM

Flortaucipir-F-18

hsa04310

Wnt signaling pathway

2.00E-04

P61586, P17612, P19784, P67870

RHOA, PRKACA, CSNK2A2, CSNK2B

Flortaucipir-F-18

hsa04340

Hedgehog signaling pathway

1.95E-03

P49841, P17612, P22694, Q13635, P10415

GSK3B, PRKACA, PRKACB, PTCH1, BCL2

Flortaucipir-F-18

hsa04360

Axon guidance

1.42E-05

P16333, P20827, O95631, P17252, P42338, P07332, P23528, P04049, P19174, Q06124

NCK1, EFNA1, NTN1, PRKCA, PIK3CB, FES, CFL1, RAF1, PLCG1, PTPN11

Flortaucipir-F-18

hsa04370

VEGF signaling pathway

5.70E-11

P19174, P16298, P42338, P17252, Q05397, Q02750, P04049

PLCG1, PPP3CB, PIK3CB, PRKCA, PTK2, MAP2K1, RAF1

Flortaucipir-F-18

hsa04371

Apelin signaling pathway

4.80E-04

P63218, P50151, Q8WYR1, P31751, P04049, Q08828, P51828, Q14814, Q14344, Q13485, P84022, P0DP23

GNG5, GNG10, PIK3R5, AKT2, RAF1, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CALM1

Flortaucipir-F-18

hsa04380

Osteoclast differentiation

5.27E-04

Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149

CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2

Flortaucipir-F-18

hsa04390

Hippo signaling pathway

1.51E-04

P63261, P84022, Q13485, O15105, P04628, O43623, Q13489

ACTG1, SMAD3, SMAD4, SMAD7, WNT1, SNAI2, BIRC3

Flortaucipir-F-18

hsa04392

Hippo signaling pathway - multiple species

3.01E-02

Q6V0I7

FAT4

Flortaucipir-F-18

hsa04510

Focal adhesion

3.32E-04

P16144, O75369, P42338, Q15942, O14986, P17252, P61586, O15335, Q16363, Q13751, Q13489, P04049, P49767

ITGB4, FLNB, PIK3CB, ZYX, PIP5K1B, PRKCA, RHOA, CHAD, LAMA4, LAMB3, BIRC3, RAF1, VEGFC

Flortaucipir-F-18

hsa04512

ECM-receptor interaction

7.53E-03

P02452, P24821

COL1A1, TNC

Flortaucipir-F-18

hsa04520

Adherens junction

1.38E-04

P19784, P67870, P61586

CSNK2A2, CSNK2B, RHOA

Flortaucipir-F-18

hsa04530

Tight junction

2.07E-04

P63261, P16989, P56750, Q9Y478, Q92974, Q14247

ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTN

Flortaucipir-F-18

hsa04540

Gap junction

2.79E-03

P17252, Q13509, P68371, P04049, Q14643

PRKCA, TUBB3, TUBB2C, RAF1, ITPR1

Flortaucipir-F-18

hsa04550

Signaling pathways regulating pluripotency of stem cells

9.61E-03

Q13873, P04049, Q02750, Q86SE9

BMPR2, RAF1, MAP2K1, PCGF5

Flortaucipir-F-18

hsa04610

Complement and coagulation cascades

3.71E-08

P00734, P0C0L4

F2, C4A

Flortaucipir-F-18

hsa04611

Platelet activation

2.12E-02

Q9Y490, P17612

TLN1, PRKACA

Flortaucipir-F-18

hsa04612

Antigen processing and presentation

6.03E-13

P13765, P48382, P01730, Q14953, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P48382	RFX5	DNA-binding protein RFX5	-0.747
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P48382	RFX5	DNA-binding protein RFX5	0.826
P08311	CTSG	Cathepsin G	P48382	RFX5	DNA-binding protein RFX5	-0.794
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26717	KLRC2	NKG2-C type II integral membrane protein	0.915
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.718
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.718
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.704
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.892
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01375	TNF	Tumor necrosis factor	0.761
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755

Flortaucipir-F-18

hsa04613

Neutrophil extracellular trap formation

7.99E-11

P17252, P04049, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O60603	TLR2	Toll-like receptor 2	0.762
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P05164	MPO	Myeloperoxidase	0.717
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.736
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q13547	HDAC1	Histone deacetylase 1	-0.759
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.706
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P08311	CTSG	Cathepsin G	0.715
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.892
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.923
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.779
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O43315	AQP9	Aquaporin-9	0.918
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.839
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767

Flortaucipir-F-18

hsa04620

Toll-like receptor signaling pathway

1.84E-04

Q13546, P01568, P01584, P31751, Q8NHW4

RIPK1, IFNA21, IL1B, AKT2, CCL4L2

Flortaucipir-F-18

hsa04621

NOD-like receptor signaling pathway

2.68E-04

Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838

MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4

Flortaucipir-F-18

hsa04622

RIG-I-like receptor signaling pathway

6.07E-03

P01568, Q13546

IFNA21, RIPK1

Flortaucipir-F-18

hsa04623

Cytosolic DNA-sensing pathway

2.16E-10

P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4

IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2

Flortaucipir-F-18

hsa04625

C-type lectin receptor signaling pathway

1.93E-04

Q9ULY5, P04049, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539

CLEC4E, RAF1, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14

Flortaucipir-F-18

hsa04630

JAK-STAT signaling pathway

8.73E-03

P31751, P23458, Q13651, P04049

AKT2, JAK1, IL10RA, RAF1

Flortaucipir-F-18

hsa04640

Hematopoietic cell lineage

1.29E-09

P13612, P21926, P14778, P27930, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375

ITGA4, CD9, IL1R1, IL1R2, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13612	ITGA4	Integrin alpha-4	0.774
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13612	ITGA4	Integrin alpha-4	0.735
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P27930	IL1R2	Interleukin-1 receptor type 2	-0.813
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P15144	ANPEP	Aminopeptidase N	-0.757
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P15144	ANPEP	Aminopeptidase N	-0.765
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P25063	CD24	Signal transducer CD24	-0.839
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P25063	CD24	Signal transducer CD24	-0.838
P08311	CTSG	Cathepsin G	P25063	CD24	Signal transducer CD24	0.902
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.892
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733

Flortaucipir-F-18

hsa04650

Natural killer cell mediated cytotoxicity

2.90E-21

P16298, P50591, P01375, P06239, O60880, P20963, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, Q07444, Q14953, P26715

PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01375	TNF	Tumor necrosis factor	0.761
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P11766	ADH5	Alcohol dehydrogenase class-3	P01375	TNF	Tumor necrosis factor	-0.709
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60880	SH2D1A	SH2 domain-containing protein 1A	0.862
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O60880	SH2D1A	SH2 domain-containing protein 1A	0.922
P08311	CTSG	Cathepsin G	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.92
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.707
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P11766	ADH5	Alcohol dehydrogenase class-3	Q13241	KLRD1	Natural killer cells antigen CD94	0.726
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.773
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26718	KLRK1	NKG2-D type II integral membrane protein	0.922
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26718	KLRK1	NKG2-D type II integral membrane protein	0.858
P08311	CTSG	Cathepsin G	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.875
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.767
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P11766	ADH5	Alcohol dehydrogenase class-3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.71
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.818
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.892
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.716
P11766	ADH5	Alcohol dehydrogenase class-3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.833
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26717	KLRC2	NKG2-C type II integral membrane protein	0.915
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P11766	ADH5	Alcohol dehydrogenase class-3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.737
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.718
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P11766	ADH5	Alcohol dehydrogenase class-3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737

Flortaucipir-F-18

hsa04657

IL-17 signaling pathway

1.92E-08

O00463, Q16539, P49841, P09341, P19875, P14780, Q9UJX4, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, ANAPC5, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.805
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P08311	CTSG	Cathepsin G	O00463	TRAF5	TNF receptor-associated factor 5	-0.853
P22748	CA4	Carbonic anhydrase 4	O00463	TRAF5	TNF receptor-associated factor 5	-0.826
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.839
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.857
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P09341	CXCL1	Growth-regulated alpha protein	0.716
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P14780	MMP9	Matrix metalloproteinase-9	0.901
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P08311	CTSG	Cathepsin G	P14780	MMP9	Matrix metalloproteinase-9	0.79
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
P22748	CA4	Carbonic anhydrase 4	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.723
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P08311	CTSG	Cathepsin G	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.745
P22748	CA4	Carbonic anhydrase 4	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P07550	ADRB2	Beta-2 adrenergic receptor	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.757
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01375	TNF	Tumor necrosis factor	0.761
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755

Flortaucipir-F-18

hsa04658

Th1 and Th2 cell differentiation

1.17E-19

Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q04759	PRKCQ	Protein kinase C theta type	0.869
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.904
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q14765	STAT4	Signal transducer and activator of transcription 4	0.821
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.878
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UL17	TBX21	T-box transcription factor TBX21	0.858
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13761	RUNX3	Runt-related transcription factor 3	0.702
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13761	RUNX3	Runt-related transcription factor 3	0.73

Flortaucipir-F-18

hsa04659

Th17 cell differentiation

2.10E-16

P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q04759	PRKCQ	Protein kinase C theta type	0.869
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9HBE5	IL21R	Interleukin-21 receptor	0.713
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UL17	TBX21	T-box transcription factor TBX21	0.858
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.878
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797

Flortaucipir-F-18

hsa04660

T cell receptor signaling pathway

1.12E-15

P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841

TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q04759	PRKCQ	Protein kinase C theta type	0.869
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.737
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	1
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.808
P08311	CTSG	Cathepsin G	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.892
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.795
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75

Flortaucipir-F-18

hsa04662

B cell receptor signaling pathway

5.19E-05

P42338, P60033, P13164, P07948, P21854, Q8N149, P04049

PIK3CB, CD81, IFITM1, LYN, CD72, LILRA2, RAF1

Flortaucipir-F-18

hsa04664

Fc epsilon RI signaling pathway

2.34E-06

P01375, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P04049, P09917, P20292

TNF, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, RAF1, ALOX5, ALOX5AP

Flortaucipir-F-18

hsa04666

Fc gamma R-mediated phagocytosis

7.95E-03

P42338, P19174, P04049, P23528, P14598, P17252

PIK3CB, PLCG1, RAF1, CFL1, NCF1, PRKCA

Flortaucipir-F-18

hsa04668

TNF signaling pathway

2.13E-04

P01375, O00463, Q13489, Q16539, P25963, P18848, P19875, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, MAPK14, NFKBIA, ATF4, CXCL2, BCL3, TRAF1, MMP9

Flortaucipir-F-18

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Flortaucipir-F-18

hsa04672

Intestinal immune network for IgA production

3.36E-04

P29965, P10747, P13765, P13612

CD40LG, CD28, HLA-DOB, ITGA4

Flortaucipir-F-18

hsa04713

Circadian entrainment

1.62E-05

O15399, P0DP23, P17252, P62873, P50151, Q14643, Q08828, P51828, P63092

GRIN2D, CALM1, PRKCA, GNB1, GNG10, ITPR1, ADCY1, ADCY7, GNAS

Flortaucipir-F-18

hsa04714

Thermogenesis

1.73E-04

Q16539, P15336, P63261, P33121, Q9Y478, Q16718, O14521

MAPK14, ATF2, ACTG1, ACSL1, PRKAB1, NDUFA5, SDHD

Flortaucipir-F-18

hsa04720

Long-term potentiation

1.10E-07

P17252, P16298, P0DP23, P51812, P18848, Q08828, Q02750, P04049, Q14643

PRKCA, PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.93
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q9HAZ1	CLK4	Dual specificity protein kinase CLK4	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.861
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	1
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9HAZ1	CLK4	Dual specificity protein kinase CLK4	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.922
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.93
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q9HAZ1	CLK4	Dual specificity protein kinase CLK4	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.911
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786

Flortaucipir-F-18

hsa04722

Neurotrophin signaling pathway

7.10E-03

P04049, P49841, O43524, P48023

RAF1, GSK3B, FOXO3, FASLG

Flortaucipir-F-18

hsa04723

Retrograde endocannabinoid signaling

2.51E-03

Q14643, P17252, P48169, P62873, Q16718

ITPR1, PRKCA, GABRA4, GNB1, NDUFA5

Flortaucipir-F-18

hsa04724

Glutamatergic synapse

5.16E-05

O15399, P63092, P17252, P62873, P63218, P50151, P15104

GRIN2D, GNAS, PRKCA, GNB1, GNG5, GNG10, GLUL

Flortaucipir-F-18

hsa04725

Cholinergic synapse

1.05E-04

Q08828, P51828, Q14643, P17252, P62873, P50151, P18848, P42338, P31751, P10415

ADCY1, ADCY7, ITPR1, PRKCA, GNB1, GNG10, ATF4, PIK3CB, AKT2, BCL2

Flortaucipir-F-18

hsa04726

Serotonergic synapse

3.05E-04

P63092, P17252, P62873, P50151, P33260, P09917, P04049

GNAS, PRKCA, GNB1, GNG10, CYP2C18, ALOX5, RAF1

Flortaucipir-F-18

hsa04727

GABAergic synapse

1.30E-03

P62873, P63218, P50151, P15104, P17252

GNB1, GNG5, GNG10, GLUL, PRKCA

Flortaucipir-F-18

hsa04728

Dopaminergic synapse

9.19E-04

Q14643, P17252, P62873, P31751, P18848, Q13362, Q14738, P0DP23

ITPR1, PRKCA, GNB1, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1

Flortaucipir-F-18

hsa04730

Long-term depression

1.16E-02

P04049

RAF1

Flortaucipir-F-18

hsa04742

Taste transduction

3.91E-02

P17612

PRKACA

Flortaucipir-F-18

hsa04744

Phototransduction

1.74E-04

P62873, P0DP23

GNB1, CALM1

Flortaucipir-F-18

hsa04750

Inflammatory mediator regulation of TRP channels

1.17E-03

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Flortaucipir-F-18

hsa04810

Regulation of actin cytoskeleton

3.81E-02

P04049

RAF1

Flortaucipir-F-18

hsa04910

Insulin signaling pathway

1.49E-02

P04049

RAF1

Flortaucipir-F-18

hsa04911

Insulin secretion

2.40E-02

Q08828, P51828, P18848

ADCY1, ADCY7, ATF4

Flortaucipir-F-18

hsa04912

GnRH signaling pathway

6.90E-04

P17252, Q08828, P51828, P18848, Q14643, P0DP23, P04049

PRKCA, ADCY1, ADCY7, ATF4, ITPR1, CALM1, RAF1

Flortaucipir-F-18

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Flortaucipir-F-18

hsa04914

Progesterone-mediated oocyte maturation

7.56E-08

Q17RY0, P42338, Q13370, Q9UJX4, Q9Y6D9, P30304, P08238, P51812, Q02750, P04049

CPEB4, PIK3CB, PDE3B, ANAPC5, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1, RAF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.938
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q9HAZ1	CLK4	Dual specificity protein kinase CLK4	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.92
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.813
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.804
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.815
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q9HAZ1	CLK4	Dual specificity protein kinase CLK4	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.822
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30304	CDC25A	M-phase inducer phosphatase 1	-0.748
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	1
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9HAZ1	CLK4	Dual specificity protein kinase CLK4	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.922
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.93
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q9HAZ1	CLK4	Dual specificity protein kinase CLK4	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.911
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1

Flortaucipir-F-18

hsa04915

Estrogen signaling pathway

7.20E-04

P04049, P18848, Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788

RAF1, ATF4, ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1

Flortaucipir-F-18

hsa04916

Melanogenesis

4.54E-03

P0DP23, Q08828, P51828, P04049

CALM1, ADCY1, ADCY7, RAF1

Flortaucipir-F-18

hsa04917

Prolactin signaling pathway

6.63E-03

P04049

RAF1

Flortaucipir-F-18

hsa04919

Thyroid hormone signaling pathway

1.82E-02

P04049

RAF1

Flortaucipir-F-18

hsa04920

Adipocytokine signaling pathway

4.71E-03

P25963, Q06124, P33121, Q9Y478, Q04759, P01375

NFKBIA, PTPN11, ACSL1, PRKAB1, PRKCQ, TNF

Flortaucipir-F-18

hsa04921

Oxytocin signaling pathway

2.32E-02

P04049

RAF1

Flortaucipir-F-18

hsa04922

Glucagon signaling pathway

3.47E-02

Q12778, Q13370, P0DP23, Q14643

FOXO1, PDE3B, CALM1, ITPR1

Flortaucipir-F-18

hsa04923

Regulation of lipolysis in adipocytes

5.15E-03

Q08828, P51828, P31751

ADCY1, ADCY7, AKT2

Flortaucipir-F-18

hsa04924

Renin secretion

4.30E-05

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Flortaucipir-F-18

hsa04925

Aldosterone synthesis and secretion

9.86E-03

P18848, Q08828, P51828, P0DP23

ATF4, ADCY1, ADCY7, CALM1

Flortaucipir-F-18

hsa04926

Relaxin signaling pathway

3.24E-05

P31751, P25963, P42338, P62873, P50151, P18848, P22694, P49767, P14780, Q08828, P51828, P04049, P17252, P30679

AKT2, NFKBIA, PIK3CB, GNB1, GNG10, ATF4, PRKACB, VEGFC, MMP9, ADCY1, ADCY7, RAF1, PRKCA, GNA15

Flortaucipir-F-18

hsa04927

Cortisol synthesis and secretion

7.43E-04

P18848, Q08828, P51828, P22694

ATF4, ADCY1, ADCY7, PRKACB

Flortaucipir-F-18

hsa04928

Parathyroid hormone synthesis, secretion and action

1.99E-02

P04049

RAF1

Flortaucipir-F-18

hsa04929

GnRH secretion

4.98E-03

P04049

RAF1

Flortaucipir-F-18

hsa04932

Non-alcoholic fatty liver disease

8.30E-08

P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521

AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Flortaucipir-F-18

hsa04933

AGE-RAGE signaling pathway in diabetic complications

9.13E-06

P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174

SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Flortaucipir-F-18

hsa04934

Cushing syndrome

4.54E-02

P18848, Q08828, P51828

ATF4, ADCY1, ADCY7

Flortaucipir-F-18

hsa04935

Growth hormone synthesis, secretion and action

5.00E-03

Q08828, P51828, P04049, P18848, P31751

ADCY1, ADCY7, RAF1, ATF4, AKT2

Flortaucipir-F-18

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Flortaucipir-F-18

hsa04962

Vasopressin-regulated water reabsorption

7.22E-03

P52566, P62491

ARHGDIB, RAB11A

Flortaucipir-F-18

hsa04964

Proximal tubule bicarbonate reclamation

2.08E-04

P22748, P00918, P49448

CA4, CA2, GLUD2

Flortaucipir-F-18

hsa04966

Collecting duct acid secretion

1.26E-04

Q13488, P00918, Q9Y666

TCIRG1, CA2, SLC12A7

Flortaucipir-F-18

hsa04970

Salivary secretion

1.88E-05

P07550, Q08828, P51828, P22694, Q14643, P17252, P0DP23, P49913

ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM1, CAMP

Flortaucipir-F-18

hsa04971

Gastric acid secretion

2.54E-03

Q08828, P51828, P15311, P0DP23

ADCY1, ADCY7, VIL2, CALM1

Flortaucipir-F-18

hsa04972

Pancreatic secretion

3.65E-02

P63092, P61586

GNAS, RHOA

Flortaucipir-F-18

hsa04974

Protein digestion and absorption

2.78E-02

P02452

COL1A1

Flortaucipir-F-18

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Flortaucipir-F-18

hsa04976

Bile secretion

1.67E-05

O43315, Q08828, P51828, P22694, P08183, Q14032

AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAAT

Flortaucipir-F-18

hsa05010

Alzheimer disease

5.16E-05

O15239, Q16718, O95298, O14521, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P01584, O95197, P18848, Q13509, P68371, P67870, P31751, P05141, Q08752, P28070

NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, IL1B, RTN3, ATF4, TUBB3, TUBB2C, CSNK2B, AKT2, SLC25A5, PPID, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.783
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O95197	RTN3	Reticulon-3	0.702
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P28070	PSMB4	Proteasome subunit beta type-4	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736

Flortaucipir-F-18

hsa05012

Parkinson disease

2.25E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C

Flortaucipir-F-18

hsa05016

Huntington disease

1.51E-04

O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.714
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.777
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.705
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
Q00535	CDK5	Cyclin-dependent-like kinase 5	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.709
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.721
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
Q00535	CDK5	Cyclin-dependent-like kinase 5	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.703
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.719
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.758
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.805
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.77
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P28070	PSMB4	Proteasome subunit beta type-4	0.841
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.773

Flortaucipir-F-18

hsa05017

Spinocerebellar ataxia

2.86E-03

Q92915, O75460, O15399, P42338, P31751, P28070, P05141, P21796

FGF14, ERN1, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1

Flortaucipir-F-18

hsa05020

Prion disease

2.20E-04

Q16718, O14521, Q92736, Q14643, O60282, Q13509, P68371, P49841, P14598, Q15080, Q16539

NDUFA5, SDHD, RYR2, ITPR1, KIF5C, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14

Flortaucipir-F-18

hsa05022

Pathways of neurodegeneration - multiple diseases

7.73E-06

Q14643, Q13509, P68371, P49841, P10415, Q16718, O95298, O14521, Q06055, Q8TEV9, O75460, P18848, Q13561, P05141, P17252, Q16539, Q00535, P01584, Q08752, O15020, P0DP23, P28070

ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, NDUFC2, SDHD, ATP5G2, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, MAPK14, CDK5, IL1B, PPID, SPTBN2, CALM1, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P30530	AXL	Tyrosine-protein kinase receptor UFO	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P30530	AXL	Tyrosine-protein kinase receptor UFO	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	0.738
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736

Flortaucipir-F-18

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Flortaucipir-F-18

hsa05032

Morphine addiction

1.74E-04

P62873, P50151, Q13370, P48169, P63092, P17252, P43250

GNB1, GNG10, PDE3B, GABRA4, GNAS, PRKCA, GRK6

Flortaucipir-F-18

hsa05034

Alcoholism

2.25E-05

Q96RR4, P04049, Q93077, P62807, O60814, P84243, P68431

CAMKK2, RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Flortaucipir-F-18

hsa05100

Bacterial invasion of epithelial cells

3.14E-03

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Flortaucipir-F-18

hsa05110

Vibrio cholerae infection

5.80E-06

Q13488, Q99437, P17252, P19174, P17612, P60709

TCIRG1, ATP6V0B, PRKCA, PLCG1, PRKACA, ACTB

Flortaucipir-F-18

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.32E-03

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Flortaucipir-F-18

hsa05130

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Flortaucipir-F-18

hsa05131

Shigellosis

2.83E-04

P01375, P25963, O00463, P68431, Q04759, Q9UDY8, Q9NQL2, Q9H1Y0, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q08752, Q96A32

TNF, NFKBIA, TRAF5, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCQ, MALT1, RRAGD, ATG5, UBB, SEPT6, CTTN, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, PPID, MYLPF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.88
P08246	ELA2	Neutrophil elastase	Q9H1Y0	ATG5	Autophagy protein 5	-0.759
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P0CG47	UBB	Polyubiquitin-B	-0.875
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q14141	SEPT6	Septin-6	-0.81
P17252	PRKCA	Protein kinase C alpha type	Q14247	CTTN	Src substrate cortactin	0.771
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.912
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q05397	PTK2	Focal adhesion kinase 1	0.932
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q13315	ATM	Serine-protein kinase ATM	-0.748
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08246	ELA2	Neutrophil elastase	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.724

Flortaucipir-F-18

hsa05132

Salmonella infection

1.88E-05

P51617, P25963, P01375, P04049, Q9UJU2, O00471, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371

IRAK1, NFKBIA, TNF, RAF1, LEF1, EXOC5, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P08246	ELA2	Neutrophil elastase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.771
Q9UGN5	PARP2	Poly [ADP-ribose] polymerase 2	O00471	EXOC5	Exocyst complex component 5	0.74
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.724
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08246	ELA2	Neutrophil elastase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	-0.949
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08246	ELA2	Neutrophil elastase	Q13561	DCTN2	Dynactin subunit 2	0.78
Q9UGN5	PARP2	Poly [ADP-ribose] polymerase 2	O60282	KIF5C	Kinesin heavy chain isoform 5C	-0.748
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842

Flortaucipir-F-18

hsa05133

Pertussis

2.60E-04

P0DP23, P0C0L4

CALM1, C4A

Flortaucipir-F-18

hsa05134

Legionellosis

1.92E-03

P01584, Q9NR31, P0DMV8

IL1B, SAR1A, HSPA1A

Flortaucipir-F-18

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Flortaucipir-F-18

hsa05140

Leishmaniasis

2.64E-09

P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13612	ITGA4	Integrin alpha-4	0.774
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.892
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O60603	TLR2	Toll-like receptor 2	0.762
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01375	TNF	Tumor necrosis factor	0.761
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.839
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.706
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15080	NCF4	Neutrophil cytosol factor 4	-0.74
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945

Flortaucipir-F-18

hsa05143

African trypanosomiasis

1.11E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Flortaucipir-F-18

hsa05144

Malaria

6.42E-06

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Flortaucipir-F-18

hsa05145

Toxoplasmosis

1.81E-05

P51617, P25963, P01375, P10415, Q13489, P42224, P13765, P09917, Q13751, P11142, O60603, P29965

IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, ALOX5, LAMB3, HSPA8, TLR2, CD40LG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.781
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13751	LAMB3	Laminin subunit beta-3	-0.705
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.746
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788

Flortaucipir-F-18

hsa05146

Amoebiasis

8.20E-13

P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P09341	CXCL1	Growth-regulated alpha protein	0.716
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09341	CXCL1	Growth-regulated alpha protein	-0.927
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09341	CXCL1	Growth-regulated alpha protein	-0.796
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.822
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.953
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P27930	IL1R2	Interleukin-1 receptor type 2	-0.813
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01375	TNF	Tumor necrosis factor	0.761
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O60603	TLR2	Toll-like receptor 2	0.762
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P05089	ARG1	Arginase-1	0.819
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05089	ARG1	Arginase-1	-0.868
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P05089	ARG1	Arginase-1	-0.905
P08311	CTSG	Cathepsin G	P05089	ARG1	Arginase-1	0.931
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P05089	ARG1	Arginase-1	-0.703
P07550	ADRB2	Beta-2 adrenergic receptor	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	-0.8
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.708
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.873
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.894
P08311	CTSG	Cathepsin G	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.847
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12814	ACTN1	Alpha-actinin-1	-0.76
P08311	CTSG	Cathepsin G	P12814	ACTN1	Alpha-actinin-1	0.708
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P12814	ACTN1	Alpha-actinin-1	-0.8
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P08311	CTSG	Cathepsin G	0.715
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08311	CTSG	Cathepsin G	-0.866
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898
P08311	CTSG	Cathepsin G	P08311	CTSG	Cathepsin G	1
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P08311	CTSG	Cathepsin G	-0.733

Flortaucipir-F-18

hsa05150

Staphylococcus aureus infection

1.16E-03

P0C0L4, P13646, Q14532, P59665, P59666, P49913

C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMP

Flortaucipir-F-18

hsa05152

Tuberculosis

1.54E-05

P04049, Q13488, Q15075, P0DP23, P42224, P48382, O60603, P01375, P10415, P13765, Q13651, P01568, P49913, Q9UDY8, P51617

RAF1, TCIRG1, EEA1, CALM1, STAT1, RFX5, TLR2, TNF, BCL2, HLA-DOB, IL10RA, IFNA21, CAMP, MALT1, IRAK1

Flortaucipir-F-18

hsa05160

Hepatitis C

1.31E-04

Q13546, P01568, P60033, P04049, P49841, P01375, P48023

RIPK1, IFNA21, CD81, RAF1, GSK3B, TNF, FASLG

Flortaucipir-F-18

hsa05161

Hepatitis B

2.67E-04

P17252, P04049, P14780, P25963, Q13485, P01375, P10415, P84022, P51617, O60603, Q14765

PRKCA, RAF1, MMP9, NFKBIA, SMAD4, TNF, BCL2, SMAD3, IRAK1, TLR2, STAT4

Flortaucipir-F-18

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Flortaucipir-F-18

hsa05163

Human cytomegalovirus infection

6.58E-10

P31751, P42338, P04049, P01375, P25963, P62873, P50151, Q14643, P0DP23, P61586, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, P17252, Q13651, P25025, Q16539, P18848, P63092, P04637, O00463, P30101, P61769, P01568

AKT2, PIK3CB, RAF1, TNF, NFKBIA, GNB1, GNG10, ITPR1, CALM1, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, GNAS, TP53, TRAF5, PDIA3, B2M, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868

Flortaucipir-F-18

hsa05164

Influenza A

1.49E-02

P31751, P01584, P23458, P05141, P04049, Q9UBU9

AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1

Flortaucipir-F-18

hsa05165

Human papillomavirus infection

9.67E-04

P16144, P02452, P24821, Q05086, P01568, P42224, Q13488, Q13362, Q12778, P04628, Q13315

ITGB4, COL1A1, TNC, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, WNT1, ATM

Flortaucipir-F-18

hsa05166

Human T-cell leukemia virus 1 infection

3.90E-02

P23458, P05141, P62826, Q08828, P51828, P18848, P31751

JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2

Flortaucipir-F-18

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.59E-05

P01568, P42224, P25963, P42338, P40189, P62873, P62879, P50151, P19174, P16298, Q14643, P04049, Q02750, P0DP23, P0CG47, Q9UJU2

IFNA21, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNB2, GNG10, PLCG1, PPP3CB, ITPR1, RAF1, MAP2K1, CALM1, UBB, LEF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881

Flortaucipir-F-18

hsa05168

Herpes simplex virus 1 infection

1.03E-03

P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.825
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.935
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.882
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.781
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.886
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q9Y2A4	ZNF443	Zinc finger protein 443	0.731
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13398	ZNF211	Zinc finger protein 211	0.956
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P51522	ZNF83	Zinc finger protein 83	0.851
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P17038	ZNF43	Zinc finger protein 43	0.718
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q03923	ZNF85	Zinc finger protein 85	-0.731
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P52738	ZNF140	Zinc finger protein 140	0.71
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O75820	ZNF189	Zinc finger protein 189	-0.756
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	O75820	ZNF189	Zinc finger protein 189	0.768
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q9UDV6	ZNF212	Zinc finger protein 212	0.798

Flortaucipir-F-18

hsa05169

Epstein-Barr virus infection

5.02E-04

P20023, P13765, P01106, Q13547, Q92769, O00463, P07948, Q13761, P24522, P07766, P09693, P20963

CR2, HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247

Flortaucipir-F-18

hsa05170

Human immunodeficiency virus 1 infection

4.37E-10

P42338, P04049, Q02750, P62873, P62879, P50151, P16298, P0DP23, P01375, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P10415, Q13619, Q93034, Q9Y6Q5, P20333

PIK3CB, RAF1, MAP2K1, GNB1, GNB2, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.93
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.96
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.93
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q05397	PTK2	Focal adhesion kinase 1	0.932
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q13315	ATM	Serine-protein kinase ATM	-0.748
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	O95067	CCNB2	G2/mitotic-specific cyclin-B2	0.711
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P23528	CFL1	Cofilin-1	-0.853
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13619	CUL4A	Cullin-4A	-0.707
P08246	ELA2	Neutrophil elastase	Q93034	CUL5	Cullin-5	-0.744
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P08246	ELA2	Neutrophil elastase	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.811
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Flortaucipir-F-18

hsa05171

Coronavirus disease - COVID-19

3.30E-02

P25963, P42224, P01568, P40189, P42338, P19174, P17252

NFKBIA, STAT1, IFNA21, IL6ST, PIK3CB, PLCG1, PRKCA

Flortaucipir-F-18

hsa05200

Pathways in cancer

1.48E-06

Q13751, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P10826, P14923, P30281, P10415, Q13489, P49767, P14921, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P40189

LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, RARB, JUP, CCND3, BCL2, BIRC3, VEGFC, ETS1, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13751	LAMB3	Laminin subunit beta-3	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P43246	MSH2	DNA mismatch repair protein Msh2	0.925
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P10826	RARB	Retinoic acid receptor beta	0.779
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14923	JUP	Junction plakoglobin	-0.716
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14921	ETS1	Protein C-ets-1	0.731
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P78417	GSTO1	Glutathione S-transferase omega-1	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.919
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748

Flortaucipir-F-18

hsa05202

Transcriptional misregulation in cancer

1.86E-10

Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522

FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P14780	MMP9	Matrix metalloproteinase-9	-0.855
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P14780	MMP9	Matrix metalloproteinase-9	-0.869
P08311	CTSG	Cathepsin G	P14780	MMP9	Matrix metalloproteinase-9	0.79
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P27930	IL1R2	Interleukin-1 receptor type 2	-0.813
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.833
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.844
P08311	CTSG	Cathepsin G	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.909
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q16548	BCL2A1	Bcl-2-related protein A1	-0.762
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05164	MPO	Myeloperoxidase	-0.811
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P05164	MPO	Myeloperoxidase	-0.867
P08311	CTSG	Cathepsin G	P05164	MPO	Myeloperoxidase	0.956
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P12838	DEFA4	Neutrophil defensin 4	-0.86
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12838	DEFA4	Neutrophil defensin 4	-0.852
P08311	CTSG	Cathepsin G	P12838	DEFA4	Neutrophil defensin 4	0.817
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08246	ELA2	Neutrophil elastase	-0.782
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08246	ELA2	Neutrophil elastase	-0.742
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.9
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.822
P08311	CTSG	Cathepsin G	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.853
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13547	HDAC1	Histone deacetylase 1	0.83
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12980	LYL1	Protein lyl-1	-0.73
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.787
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769

Flortaucipir-F-18

hsa05203

Viral carcinogenesis

4.52E-03

Q15283, P62807, P33778, O60814

RASA2, HIST1H2BC, H2BC3, H2BC12

Flortaucipir-F-18

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Flortaucipir-F-18

hsa05205

Proteoglycans in cancer

1.36E-03

P63261, P04049, P04637, P14780, P01375, P23588, Q06124, Q13635, P22694

ACTG1, RAF1, TP53, MMP9, TNF, EIF4B, PTPN11, PTCH1, PRKACB

Flortaucipir-F-18

hsa05206

MicroRNAs in cancer

3.15E-02

P04049

RAF1

Flortaucipir-F-18

hsa05210

Colorectal cancer

1.46E-04

Q9UKG1, P84022, Q13485, P04049, P10415, P37173

APPL1, SMAD3, SMAD4, RAF1, BCL2, TGFBR2

Flortaucipir-F-18

hsa05211

Renal cell carcinoma

2.89E-05

Q06124, Q99814, P04049

PTPN11, EPAS1, RAF1

Flortaucipir-F-18

hsa05212

Pancreatic cancer

5.23E-06

P42338, P31751, P04049, Q15311, P23458, P84022, Q13485, P04637, P24522, O75293

PIK3CB, AKT2, RAF1, RALBP1, JAK1, SMAD3, SMAD4, TP53, GADD45A, GADD45B

Flortaucipir-F-18

hsa05213

Endometrial cancer

2.58E-04

O15169, Q02750, P04049, P04637, P24522

AXIN1, MAP2K1, RAF1, TP53, GADD45A

Flortaucipir-F-18

hsa05214

Glioma

3.39E-05

P0DP23, P17252, P04049, P42338, P04637, P19174, P24522, O75293

CALM1, PRKCA, RAF1, PIK3CB, TP53, PLCG1, GADD45A, GADD45B

Flortaucipir-F-18

hsa05215

Prostate cancer

1.33E-02

P04049

RAF1

Flortaucipir-F-18

hsa05216

Thyroid cancer

1.08E-03

P01106, P04637, P24522, O75293

MYC, TP53, GADD45A, GADD45B

Flortaucipir-F-18

hsa05217

Basal cell carcinoma

1.76E-03

Q13635, Q9UJU2, P04637, P24522

PTCH1, LEF1, TP53, GADD45A

Flortaucipir-F-18

hsa05218

Melanoma

5.02E-04

P04637, P04049, P24522

TP53, RAF1, GADD45A

Flortaucipir-F-18

hsa05219

Bladder cancer

5.65E-03

P14780, P04637, P04049

MMP9, TP53, RAF1

Flortaucipir-F-18

hsa05220

Chronic myeloid leukemia

6.04E-06

Q06124, P04637, Q13547, Q13485, P25963, P84022, P42338, P04049, P24522, O75293

PTPN11, TP53, HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, RAF1, GADD45A, GADD45B

Flortaucipir-F-18

hsa05221

Acute myeloid leukemia

8.29E-03

P04049

RAF1

Flortaucipir-F-18

hsa05222

Small cell lung cancer

8.29E-05

P10826, P42338, Q13751, Q13489, P10415, P25963, Q13077, O00463, P24522, O75293

RARB, PIK3CB, LAMB3, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A, GADD45B

Flortaucipir-F-18

hsa05223

Non-small cell lung cancer

2.74E-07

P17252, O43524, P42338, P19174, P10826, P04049, Q9HC35, P04637, P24522, O75293

PRKCA, FOXO3, PIK3CB, PLCG1, RARB, RAF1, EML4, TP53, GADD45A, GADD45B

Flortaucipir-F-18

hsa05224

Breast cancer

1.67E-03

P04049, P49841, Q92837, P04637, P24522

RAF1, GSK3B, FRAT1, TP53, GADD45A

Flortaucipir-F-18

hsa05225

Hepatocellular carcinoma

2.00E-03

P04049, P04637, P24522, P63261

RAF1, TP53, GADD45A, ACTG1

Flortaucipir-F-18

hsa05226

Gastric cancer

2.93E-04

P04049, Q02750, O15169, P84022, Q13485, P10415

RAF1, MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Flortaucipir-F-18

hsa05230

Central carbon metabolism in cancer

9.95E-03

P04049

RAF1

Flortaucipir-F-18

hsa05231

Choline metabolism in cancer

1.24E-07

P04049, P31751, P42338, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494, P17252

RAF1, AKT2, PIK3CB, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1, PRKCA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P33981	TTK	Dual specificity protein kinase TTK	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.701
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q9Y259	CHKB	Choline/ethanolamine kinase	0.819
P33981	TTK	Dual specificity protein kinase TTK	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.745
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P23743	DGKA	Diacylglycerol kinase alpha	0.764
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P33981	TTK	Dual specificity protein kinase TTK	P49619	DGKG	Diacylglycerol kinase gamma	0.836
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754

Flortaucipir-F-18

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.06E-08

O95267, P07766, P20963, P09693, P06239, P04049, O60603, Q04759, Q16539, Q9HC35, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, RAF1, TLR2, PRKCQ, MAPK14, EML4, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.737
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719

Flortaucipir-F-18

hsa05310

Asthma

8.82E-07

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Flortaucipir-F-18

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Flortaucipir-F-18

hsa05321

Inflammatory bowel disease

1.44E-13

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.904
P08246	ELA2	Neutrophil elastase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.783
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q14765	STAT4	Signal transducer and activator of transcription 4	0.821
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P07550	ADRB2	Beta-2 adrenergic receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.826
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UL17	TBX21	T-box transcription factor TBX21	0.858
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P07550	ADRB2	Beta-2 adrenergic receptor	Q9UL17	TBX21	T-box transcription factor TBX21	0.758
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P08246	ELA2	Neutrophil elastase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.724
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.878
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9HBE5	IL21R	Interleukin-21 receptor	0.713
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763

Flortaucipir-F-18

hsa05322

Systemic lupus erythematosus

6.51E-10

O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, P33778, Q16778, O60814, P68431, P12814, P05455

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.716
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08246	ELA2	Neutrophil elastase	-0.742
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898
P08311	CTSG	Cathepsin G	P08311	CTSG	Cathepsin G	1
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P08311	CTSG	Cathepsin G	-0.733
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P49281	SLC11A2	Natural resistance-associated macrophage protein 2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.725
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.826
P49281	SLC11A2	Natural resistance-associated macrophage protein 2	P33778	H2BC3	Histone H2B type 1-B	0.776
P49281	SLC11A2	Natural resistance-associated macrophage protein 2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.725
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.826
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q16778	HIST2H2BE	Histone H2B type 2-E	-0.712
P08311	CTSG	Cathepsin G	Q16778	HIST2H2BE	Histone H2B type 2-E	0.786
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q16778	HIST2H2BE	Histone H2B type 2-E	-0.799
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12814	ACTN1	Alpha-actinin-1	-0.76
P08311	CTSG	Cathepsin G	P12814	ACTN1	Alpha-actinin-1	0.708
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P12814	ACTN1	Alpha-actinin-1	-0.8
P08246	ELA2	Neutrophil elastase	P05455	SSB	Lupus La protein	-0.717

Flortaucipir-F-18

hsa05323

Rheumatoid arthritis

1.29E-02

P13765, Q13488, P10747, O60603

HLA-DOB, TCIRG1, CD28, TLR2

Flortaucipir-F-18

hsa05330

Allograft rejection

1.04E-03

P13765, P29965, P48023, P10747, P01375

HLA-DOB, CD40LG, FASLG, CD28, TNF

Flortaucipir-F-18

hsa05332

Graft-versus-host disease

1.05E-12

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P11766	ADH5	Alcohol dehydrogenase class-3	P01375	TNF	Tumor necrosis factor	-0.709
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
P08246	ELA2	Neutrophil elastase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.775
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P11766	ADH5	Alcohol dehydrogenase class-3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
P08246	ELA2	Neutrophil elastase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.7
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P11766	ADH5	Alcohol dehydrogenase class-3	Q13241	KLRD1	Natural killer cells antigen CD94	0.726

Flortaucipir-F-18

hsa05340

Primary immunodeficiency

1.31E-04

P01730, P01732, P11912, P07766, P06239

CD4, CD8A, CD79A, CD3E, LCK

Flortaucipir-F-18

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

2.17E-03

P54284

CACNB3

Flortaucipir-F-18

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Flortaucipir-F-18

hsa05415

Diabetic cardiomyopathy

4.74E-05

P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P49841, P37173, P04406

PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, TGFBR2, GAPDH

Flortaucipir-F-18

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Flortaucipir-F-18

hsa05418

Fluid shear stress and atherosclerosis

2.60E-05

Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

UniProtAC	Gene Name	Protein Name	Reported/ Predicted	DisGeNET	S_PV	S_drugability	S_HiSBiN	S_DisG

PharmaCoNets of Flortaucipir-f-18 (SPCN: )

Flortaucipir-f-18 regulated-network (SDN: )

Community members of Flortaucipir-f-18 (SDC: )

PharmaCoNets of Flortaucipir-f-18 (S_PCN: )

Flortaucipir-f-18 regulated-network (S_DN: )

Community members of Flortaucipir-f-18 (S_DC: )