PharmaCoNets

PharmaCoNets of Flibanserin (S_PCN: 230.08 )

Flibanserin regulated-network (S_DN: 26.85)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Flibanserin

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Flibanserin

hsa00040

Pentose and glucuronate interconversions

4.00E-02

P15121

AKR1B1

Flibanserin

hsa00051

Fructose and mannose metabolism

4.00E-02

P60174, P04075

TPI1, ALDOA

Flibanserin

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Flibanserin

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Flibanserin

hsa00220

Arginine biosynthesis

1.43E-02

P05089, P49448

ARG1, GLUD2

Flibanserin

hsa00310

Lysine degradation

4.57E-02

Q96KQ7, Q02809

EHMT2, PLOD1

Flibanserin

hsa00350

Tyrosine metabolism

3.40E-02

P28332

ADH6

Flibanserin

hsa00500

Starch and sucrose metabolism

1.91E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Flibanserin

hsa00562

Inositol phosphate metabolism

2.00E-02

P27987, P19174, P42338, Q02252

ITPKB, PLCG1, PIK3CB, ALDH6A1

Flibanserin

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Flibanserin

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Flibanserin

hsa00630

Glyoxylate and dicarboxylate metabolism

1.03E-04

P40925, P15104

MDH1, GLUL

Flibanserin

hsa00730

Thiamine metabolism

1.55E-03

P05186, P24666

ALPL, ACP1

Flibanserin

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Flibanserin

hsa00790

Folate biosynthesis

2.02E-02

P15121

AKR1B1

Flibanserin

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Flibanserin

hsa00980

Metabolism of xenobiotics by cytochrome P450

6.26E-05

P78417, P28332, P09211, P11712

GSTO1, ADH6, GSTP1, CYP2C9

Flibanserin

hsa00982

Drug metabolism - cytochrome P450

8.40E-04

P11712, P78417, P28332

CYP2C9, GSTO1, ADH6

Flibanserin

hsa00983

Drug metabolism - other enzymes

3.50E-02

P04183, P32320, P05164

TK1, CDA, MPO

Flibanserin

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Flibanserin

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Flibanserin

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Flibanserin

hsa01240

Biosynthesis of cofactors

2.95E-02

P13716, P14618

ALAD, PKM2

Flibanserin

hsa01523

Antifolate resistance

1.43E-03

Q92820, P04818

GGH, TYMS

Flibanserin

hsa01524

Platinum drug resistance

1.47E-03

O15392, P11388, P31751

BIRC5, TOP2A, AKT2

Flibanserin

hsa02010

ABC transporters

1.98E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Flibanserin

hsa03010

Ribosome

1.13E-06

P26373, P42677, P40429, P62917, P46776, Q9H0U6, Q07020, Q02878, P27635, P05386, P62249, P23396

RPL13, RPS27, RPL13A, RPL8, RPL27A, MRPL18, RPL18, RPL6, RPL10, RPLP1, RPS16, RPS3

Flibanserin

hsa03013

RNA transport

4.21E-04

P52298, Q09161, O14893, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q9Y6A5

NCBP2, NCBP1, GEMIN2, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, TACC3

Flibanserin

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Flibanserin

hsa03020

RNA polymerase

5.59E-03

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Flibanserin

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Flibanserin

hsa03040

Spliceosome

2.30E-04

Q14562, O43143, O60508, P08579, Q15427, P38159, P61978, Q07955, Q01130, Q13243, P11142, O43447

DHX8, DHX15, CDC40, SNRPB2, SF3B4, RBMX, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8, PPIH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.888
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.708
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.953
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O60508	CDC40	Pre-mRNA-processing factor 17	0.838
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O60508	CDC40	Pre-mRNA-processing factor 17	-0.837
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.788
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.702
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.935
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.882
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.835
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.886
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.746
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.761

Flibanserin

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Flibanserin

hsa03060

Protein export

1.20E-03

P37108, Q15005

SRP14, SPCS2

Flibanserin

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Flibanserin

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Flibanserin

hsa04012

ErbB signaling pathway

1.11E-03

P21860, Q13153, P16333, P17252, Q13557, P19174, O14944, P42338

ERBB3, PAK1, NCK1, PRKCA, CAMK2D, PLCG1, EREG, PIK3CB

Flibanserin

hsa04014

Ras signaling pathway

1.48E-04

P31751, P42338, P20827, P49767, Q13009, P17252, P14921, P0DP23, P62873, P50151, P19174

AKT2, PIK3CB, EFNA1, VEGFC, TIAM1, PRKCA, ETS1, CALM1, GNB1, GNG10, PLCG1

Flibanserin

hsa04015

Rap1 signaling pathway

1.52E-03

P20827, P49767, P11215, Q13009, P42338, P31751, P0DP23, P17252, P19174

EFNA1, VEGFC, ITGAM, TIAM1, PIK3CB, AKT2, CALM1, PRKCA, PLCG1

Flibanserin

hsa04020

Calcium signaling pathway

2.34E-04

P27987, Q96DU7, P45880, Q13557, P17252, P21860, O15399, P19174, P0DP23, P51828, P23634, P49767

ITPKB, ITPKC, VDAC2, CAMK2D, PRKCA, ERBB3, GRIN2D, PLCG1, CALM1, ADCY7, ATP2B4, VEGFC

Flibanserin

hsa04022

cGMP-PKG signaling pathway

3.48E-03

Q99941, P23634, P31751, P51828, P45880, P0DP23

CREBL1, ATP2B4, AKT2, ADCY7, VDAC2, CALM1

Flibanserin

hsa04024

cAMP signaling pathway

1.17E-03

P42338, P31751, P0DP23, Q13370, O15399, P25963, Q13009, Q13153

PIK3CB, AKT2, CALM1, PDE3B, GRIN2D, NFKBIA, TIAM1, PAK1

Flibanserin

hsa04062

Chemokine signaling pathway

1.25E-02

P42338, P19174, P62873, P50151, P43250, Q13009, P14598, P42224, P25963

PIK3CB, PLCG1, GNB1, GNG10, GRK6, TIAM1, NCF1, STAT1, NFKBIA

Flibanserin

hsa04064

NF-kappa B signaling pathway

8.89E-09

P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q9UNE0, Q9NQC7

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Flibanserin

hsa04070

Phosphatidylinositol signaling system

2.95E-04

P19174, P0DP23, P42338, P23743, Q86XP1, P27987, Q96DU7, P17252

PLCG1, CALM1, PIK3CB, DGKA, DGKH, ITPKB, ITPKC, PRKCA

Flibanserin

hsa04071

Sphingolipid signaling pathway

3.82E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Flibanserin

hsa04080

Neuroactive ligand-receptor interaction

8.77E-05

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2

Flibanserin

hsa04110

Cell cycle

1.97E-05

P06493, O60566, O75293, P30304, P33981, P42773, P01106

CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC

Flibanserin

hsa04114

Oocyte meiosis

2.21E-04

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Flibanserin

hsa04115

p53 signaling pathway

3.32E-03

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Flibanserin

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Flibanserin

hsa04141

Protein processing in endoplasmic reticulum

3.64E-02

Q99941, O75460, P11142, Q9H3Z4, P07900

CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1

Flibanserin

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Flibanserin

hsa04144

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Flibanserin

hsa04145

Phagosome

1.98E-02

Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Flibanserin

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Flibanserin

hsa04151

PI3K-Akt signaling pathway

1.43E-02

P42338, P20827, P49767, P08238, P62873, P50151, P16144, O15335, Q13751, P14784, P01568, P17252

PIK3CB, EFNA1, VEGFC, HSP90AB1, GNB1, GNG10, ITGB4, CHAD, LAMB3, IL2RB, IFNA21, PRKCA

Flibanserin

hsa04210

Apoptosis

1.53E-03

Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, P18848, Q14643

ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ATF4, ITPR1

Flibanserin

hsa04211

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Flibanserin

hsa04213

Longevity regulating pathway - multiple species

2.82E-02

Q08828, P51828, P0DMV8

ADCY1, ADCY7, HSPA1A

Flibanserin

hsa04217

Necroptosis

3.61E-04

P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, P15104, Q6FI13, Q99878, O43633

TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, GLUL, H2AC18; H2AC19, H2AC14, CHMP2A

Flibanserin

hsa04218

Cellular senescence

1.92E-04

P01106, P31751, P30281, O75293, P30304, P06493, P0DP23, P01889, P10321, P12236

MYC, AKT2, CCND3, GADD45B, CDC25A, CDK1, CALM1, HLA-B, HLA-C, SLC25A6

Flibanserin

hsa04261

Adrenergic signaling in cardiomyocytes

3.21E-04

P07550, P51828, P22694, P31751, Q99941, P18848, Q13362, P0DP23, Q13557, P23634

ADRB2, ADCY7, PRKACB, AKT2, CREBL1, ATF4, PPP2R5C, CALM1, CAMK2D, ATP2B4

Flibanserin

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Flibanserin

hsa04330

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Flibanserin

hsa04360

Axon guidance

2.13E-03

P16333, P20827, O95631, P17252, P42338, P23528, P19174

NCK1, EFNA1, NTN1, PRKCA, PIK3CB, CFL1, PLCG1

Flibanserin

hsa04370

VEGF signaling pathway

3.18E-07

P19174, P16298, P31751, P42338, P17252, Q05397, Q02750

PLCG1, PPP3CB, AKT2, PIK3CB, PRKCA, PTK2, MAP2K1

Flibanserin

hsa04371

Apelin signaling pathway

3.23E-03

P31751, P0DP23

AKT2, CALM1

Flibanserin

hsa04380

Osteoclast differentiation

2.72E-04

Q9NQC7, Q9UQC2, Q16539, P31751, P14778, O75015, P01375, Q8N149

CYLD, GAB2, MAPK14, AKT2, IL1R1, FCGR3B, TNF, LILRA2

Flibanserin

hsa04392

Hippo signaling pathway - multiple species

1.51E-02

Q13153

PAK1

Flibanserin

hsa04510

Focal adhesion

7.77E-03

P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P49767

ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, VEGFC

Flibanserin

hsa04512

ECM-receptor interaction

1.90E-02

P26012, P16070

ITGB8, CD44

Flibanserin

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Flibanserin

hsa04610

Complement and coagulation cascades

1.91E-03

P0C0L4

C4A

Flibanserin

hsa04612

Antigen processing and presentation

5.99E-06

P13765, P48382, Q14953, P26715, P26717, Q07444, Q13241, P01732, P01375

HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, TNF

Flibanserin

hsa04613

Neutrophil extracellular trap formation

2.55E-05

P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1, AQP9, MAPK14

Flibanserin

hsa04620

Toll-like receptor signaling pathway

4.81E-03

Q13546, P01568, P31751

RIPK1, IFNA21, AKT2

Flibanserin

hsa04621

NOD-like receptor signaling pathway

7.18E-04

Q14643, P01568, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q13546, Q05823, P01375, P49913, P12838

ITPR1, IFNA21, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RIPK1, RNASEL, TNF, CAMP, DEFA4

Flibanserin

hsa04622

RIG-I-like receptor signaling pathway

1.02E-03

P01568, Q9NQC7, Q13546

IFNA21, CYLD, RIPK1

Flibanserin

hsa04623

Cytosolic DNA-sensing pathway

1.32E-05

P01584, P01568, Q13546, P25963, Q8NHW4

IL1B, IFNA21, RIPK1, NFKBIA, CCL4L2

Flibanserin

hsa04625

C-type lectin receptor signaling pathway

3.64E-05

Q9ULY5, Q13153, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539

CLEC4E, PAK1, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14

Flibanserin

hsa04640

Hematopoietic cell lineage

4.71E-03

P21926, P07766, P01730, P06127, P09564

CD9, CD3E, CD4, CD5, CD7

Flibanserin

hsa04650

Natural killer cell mediated cytotoxicity

1.90E-10

P16298, P50591, P01375, P06239, P20963, Q02750, Q13153, Q13241, P26718, O14931, P26717, Q07444, Q14953, P26715

PPP3CB, TNFSF10, TNF, LCK, CD247, MAP2K1, PAK1, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.774
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.9
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.799
Q13153	PAK1	Serine/threonine-protein kinase PAK 1	Q13153	PAK1	Serine/threonine-protein kinase PAK 1	1
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.767
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.818
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Flibanserin

hsa04657

IL-17 signaling pathway

1.46E-04

O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF

Flibanserin

hsa04658

Th1 and Th2 cell differentiation

7.09E-05

Q04759, P20963, P09693, P06239, P23771, Q9UL17, Q13761

PRKCQ, CD247, CD3G, LCK, GATA3, TBX21, RUNX3

Flibanserin

hsa04659

Th17 cell differentiation

5.26E-04

P25963, Q04759, P19174, P06239, P42224, P14784, P40189, Q9UL17, P23771, P08238, P09693, P20963

NFKBIA, PRKCQ, PLCG1, LCK, STAT1, IL2RB, IL6ST, TBX21, GATA3, HSP90AB1, CD3G, CD247

Flibanserin

hsa04660

T cell receptor signaling pathway

4.59E-05

P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, Q13153, P20963, P09693, P01732, P06239

TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, PAK1, CD247, CD3G, CD8A, LCK

Flibanserin

hsa04662

B cell receptor signaling pathway

1.60E-04

P31751, P42338, P60033, P07948, P21854, Q8N149

AKT2, PIK3CB, CD81, LYN, CD72, LILRA2

Flibanserin

hsa04664

Fc epsilon RI signaling pathway

3.91E-05

P01375, P31751, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P09917

TNF, AKT2, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, ALOX5

Flibanserin

hsa04666

Fc gamma R-mediated phagocytosis

8.08E-03

P42338, P19174, P23528, P14598, P17252

PIK3CB, PLCG1, CFL1, NCF1, PRKCA

Flibanserin

hsa04668

TNF signaling pathway

2.91E-05

P01375, O00463, Q13489, Q16539, P25963, Q99941, P18848, P19875, P01584, P20749, Q13077, P14780, O95429

TNF, TRAF5, BIRC3, MAPK14, NFKBIA, CREBL1, ATF4, CXCL2, IL1B, BCL3, TRAF1, MMP9, BAG4

Flibanserin

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Flibanserin

hsa04713

Circadian entrainment

1.24E-02

O15399, P0DP23, P17252, P62873, P50151

GRIN2D, CALM1, PRKCA, GNB1, GNG10

Flibanserin

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Flibanserin

hsa04720

Long-term potentiation

9.52E-04

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Flibanserin

hsa04722

Neurotrophin signaling pathway

1.26E-03

P31751, P49841, O43524, P48023, P0DP23

AKT2, GSK3B, FOXO3, FASLG, CALM1

Flibanserin

hsa04724

Glutamatergic synapse

1.44E-04

O15399, P17252, P62873, P63218, P50151, P15104

GRIN2D, PRKCA, GNB1, GNG5, GNG10, GLUL

Flibanserin

hsa04725

Cholinergic synapse

6.02E-04

P22694, Q14643, P17252, P62873, P63218, P50151, P18848, P42338, P10415

PRKACB, ITPR1, PRKCA, GNB1, GNG5, GNG10, ATF4, PIK3CB, BCL2

Flibanserin

hsa04726

Serotonergic synapse

2.54E-02

P17252, P62873, P50151, P33260, P09917

PRKCA, GNB1, GNG10, CYP2C18, ALOX5

Flibanserin

hsa04727

GABAergic synapse

5.11E-04

P62873, P63218, P50151, P15104, P17252

GNB1, GNG5, GNG10, GLUL, PRKCA

Flibanserin

hsa04728

Dopaminergic synapse

3.23E-03

P31751, P0DP23

AKT2, CALM1

Flibanserin

hsa04740

Olfactory transduction

9.46E-04

Q9H255, P0DP23

OR51E2, CALM1

Flibanserin

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Flibanserin

hsa04744

Phototransduction

3.44E-03

P62873, P0DP23

GNB1, CALM1

Flibanserin

hsa04750

Inflammatory mediator regulation of TRP channels

3.89E-03

P01584, Q08828, P51828, Q13557, P0DP23

IL1B, ADCY1, ADCY7, CAMK2D, CALM1

Flibanserin

hsa04910

Insulin signaling pathway

9.82E-04

P0DP23, P31751

CALM1, AKT2

Flibanserin

hsa04911

Insulin secretion

1.48E-02

P51828, Q99941, Q13557

ADCY7, CREBL1, CAMK2D

Flibanserin

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Flibanserin

hsa04914

Progesterone-mediated oocyte maturation

5.49E-05

Q17RY0, P42338, Q13370, Q9UJX4, Q9Y6D9, P30304, P08238, P51812, Q02750

CPEB4, PIK3CB, PDE3B, ANAPC5, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1

Flibanserin

hsa04915

Estrogen signaling pathway

1.36E-04

P14780, P22694, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, Q14643, P0DP23, Q15788, P10415

MMP9, PRKACB, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, ITPR1, CALM1, NCOA1, BCL2

Flibanserin

hsa04916

Melanogenesis

4.78E-02

P0DP23

CALM1

Flibanserin

hsa04917

Prolactin signaling pathway

2.41E-02

P31751

AKT2

Flibanserin

hsa04918

Thyroid hormone synthesis

3.50E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Flibanserin

hsa04920

Adipocytokine signaling pathway

1.22E-02

P25963, P33121, Q04759, P31751, P01375

NFKBIA, ACSL1, PRKCQ, AKT2, TNF

Flibanserin

hsa04922

Glucagon signaling pathway

4.86E-04

P14618, P06737, P31751, P0DP23

PKM2, PYGL, AKT2, CALM1

Flibanserin

hsa04923

Regulation of lipolysis in adipocytes

3.01E-02

P31751

AKT2

Flibanserin

hsa04924

Renin secretion

6.02E-03

P22694, P07550, P0DP23

PRKACB, ADRB2, CALM1

Flibanserin

hsa04925

Aldosterone synthesis and secretion

5.19E-03

Q99941, P51828, Q13557, P23634

CREBL1, ADCY7, CAMK2D, ATP2B4

Flibanserin

hsa04926

Relaxin signaling pathway

2.34E-05

P25963, P42338, P62873, P63218, P50151, P18848, P22694, P49767, P14780, P17252, P30679, P49407

NFKBIA, PIK3CB, GNB1, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, PRKCA, GNA15, ARRB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.747
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.752
P07550	ADRB2	Beta-2 adrenergic receptor	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	-0.704
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P49767	VEGFC	Vascular endothelial growth factor C	0.73
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P07550	ADRB2	Beta-2 adrenergic receptor	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	-0.8
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P49407	ARRB1	Beta-arrestin-1	-0.709

Flibanserin

hsa04927

Cortisol synthesis and secretion

4.44E-04

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Flibanserin

hsa04928

Parathyroid hormone synthesis, secretion and action

2.13E-02

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Flibanserin

hsa04929

GnRH secretion

3.61E-03

P42338, P31751, P49407

PIK3CB, AKT2, ARRB1

Flibanserin

hsa04932

Non-alcoholic fatty liver disease

7.01E-05

P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521

TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHD

Flibanserin

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.43E-02

P42224, P42338, P49767, P17252, P19174

STAT1, PIK3CB, VEGFC, PRKCA, PLCG1

Flibanserin

hsa04934

Cushing syndrome

3.48E-03

Q99941, P51828, O15169, Q13557

CREBL1, ADCY7, AXIN1, CAMK2D

Flibanserin

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Flibanserin

hsa04964

Proximal tubule bicarbonate reclamation

4.48E-02

P00918

CA2

Flibanserin

hsa04966

Collecting duct acid secretion

4.48E-02

P00918

CA2

Flibanserin

hsa04970

Salivary secretion

9.54E-05

P07550, Q08828, P51828, P22694, Q14643, P17252, P0DP23, P49913

ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM1, CAMP

Flibanserin

hsa04971

Gastric acid secretion

2.57E-03

P51828, P15311, P0DP23, Q13557

ADCY7, VIL2, CALM1, CAMK2D

Flibanserin

hsa04973

Carbohydrate digestion and absorption

2.41E-02

P31751

AKT2

Flibanserin

hsa04975

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Flibanserin

hsa04976

Bile secretion

3.14E-03

O43315, Q08828, P51828, P08183, Q14032

AQP9, ADCY1, ADCY7, ABCB1, BAAT

Flibanserin

hsa05010

Alzheimer disease

7.84E-04

Q92542, P05496, P12074, Q00535, O75460, P0DP23, P01584, O15169, P31751, P45880

NCSTN, ATP5G1, COX6A1, CDK5, ERN1, CALM1, IL1B, AXIN1, AKT2, VDAC2

Flibanserin

hsa05016

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Flibanserin

hsa05020

Prion disease

1.01E-04

P01584, P46531, P11142, Q16718, O14521, P05496, P12074, Q92736, P45880, O60282, P49841, Q99941, Q16539

IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, RYR2, VDAC2, KIF5C, GSK3B, CREBL1, MAPK14

Flibanserin

hsa05022

Pathways of neurodegeneration - multiple diseases

4.25E-03

P49841, Q16718, O14521, Q13561, Q16539, Q00535, Q08752, P0DP23

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, CDK5, PPID, CALM1

Flibanserin

hsa05030

Cocaine addiction

4.19E-02

Q00535

CDK5

Flibanserin

hsa05031

Amphetamine addiction

6.98E-03

P0DP23, P22694, P18848, Q13547

CALM1, PRKACB, ATF4, HDAC1

Flibanserin

hsa05032

Morphine addiction

1.24E-02

P62873, P50151, Q13370, P17252, P43250

GNB1, GNG10, PDE3B, PRKCA, GRK6

Flibanserin

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Flibanserin

hsa05110

Vibrio cholerae infection

3.15E-02

Q13488, P17252, P19174

TCIRG1, PRKCA, PLCG1

Flibanserin

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

3.10E-03

Q16539, Q13153, P09341, P25024, P25025

MAPK14, PAK1, CXCL1, CXCR1, CXCR2

Flibanserin

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Flibanserin

hsa05132

Salmonella infection

4.28E-04

P51617, P25963, P01375, Q9UJU2, O00471, Q13546, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371

IRAK1, NFKBIA, TNF, LEF1, EXOC5, RIPK1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C

Flibanserin

hsa05133

Pertussis

3.51E-02

P0C0L4

C4A

Flibanserin

hsa05134

Legionellosis

2.82E-02

P01584, Q9NR31, P0DMV8

IL1B, SAR1A, HSPA1A

Flibanserin

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Flibanserin

hsa05140

Leishmaniasis

9.33E-04

O75015, P14598, P13765, O60603, P25963, P01375, P49006, Q16539, P51617, Q15080

FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, MAPK14, IRAK1, NCF4

Flibanserin

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Flibanserin

hsa05144

Malaria

1.91E-02

P01375, P35443, P26718

TNF, THBS4, KLRK1

Flibanserin

hsa05145

Toxoplasmosis

2.98E-03

P51617, P25963, P01375, P10415, Q13489, P42224, P13765, P09917, Q13751, P11142, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, ALOX5, LAMB3, HSPA8, TLR2

Flibanserin

hsa05146

Amoebiasis

2.80E-04

P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSG

Flibanserin

hsa05150

Staphylococcus aureus infection

1.31E-02

P0C0L4, P13646

C4A, KRT13

Flibanserin

hsa05152

Tuberculosis

7.36E-03

Q13488, P0DP23, P48382, O60603, P01375, P31751, P10415, P13765, P49913, Q9UDY8, P51617

TCIRG1, CALM1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Flibanserin

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Flibanserin

hsa05161

Hepatitis B

2.33E-02

P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Flibanserin

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Flibanserin

hsa05163

Human cytomegalovirus infection

1.00E-05

P31751, P42338, P01375, P25963, P62873, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, P04637, O00463, P30101, P01568

AKT2, PIK3CB, TNF, NFKBIA, GNB1, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, TP53, TRAF5, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868

Flibanserin

hsa05165

Human papillomavirus infection

2.26E-02

Q16363, P30281, Q9UM47, P01889, P10321, Q99437

LAMA4, CCND3, NOTCH3, HLA-B, HLA-C, ATP6V0B

Flibanserin

hsa05167

Kaposi sarcoma-associated herpesvirus infection

2.73E-06

P01568, P31751, P42224, P25963, P42338, P40189, P62873, P62879, P50151, P19174, P16298, Q02750, P0DP23, P0CG47

IFNA21, AKT2, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNB2, GNG10, PLCG1, PPP3CB, MAP2K1, CALM1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.872
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.799
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P0CG47	UBB	Polyubiquitin-B	-0.731

Flibanserin

hsa05168

Herpes simplex virus 1 infection

6.31E-03

P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q03923, O75820, Q9UDV6

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF85, ZNF189, ZNF212

Flibanserin

hsa05169

Epstein-Barr virus infection

3.72E-02

Q13547, P42338, P07948, Q13761, O75293, P07766

HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3E

Flibanserin

hsa05170

Human immunodeficiency virus 1 infection

6.52E-08

P31751, P42338, Q02750, P62873, P62879, P50151, P16298, P0DP23, P01375, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P10415, Q13619, Q93034, Q9Y6Q5, P20333

AKT2, PIK3CB, MAP2K1, GNB1, GNB2, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	O95067	CCNB2	G2/mitotic-specific cyclin-B2	0.711
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P23528	CFL1	Cofilin-1	-0.853
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13619	CUL4A	Cullin-4A	-0.707
P08246	ELA2	Neutrophil elastase	Q93034	CUL5	Cullin-5	-0.744
P08246	ELA2	Neutrophil elastase	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.811
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Flibanserin

hsa05171

Coronavirus disease - COVID-19

1.86E-04

P25963, P42224, P01568, P23396, P62249, P42677, P40429, Q02878, P62917, P27635, P26373, Q07020, P46776, P05386, P40189, P42338, P19174, P17252

NFKBIA, STAT1, IFNA21, RPS3, RPS16, RPS27, RPL13A, RPL6, RPL8, RPL10, RPL13, RPL18, RPL27A, RPLP1, IL6ST, PIK3CB, PLCG1, PRKCA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
Q9NQU5	PAK6	Serine/threonine-protein kinase PAK 6	P23396	RPS3	40S ribosomal protein S3	0.803
P09211	GSTP1	Glutathione S-transferase P	P62249	RPS16	40S ribosomal protein S16	0.702
Q9NQU5	PAK6	Serine/threonine-protein kinase PAK 6	P42677	RPS27	40S ribosomal protein S27	0.731
P09211	GSTP1	Glutathione S-transferase P	P40429	RPL13A	60S ribosomal protein L13a	0.741
Q9NQU5	PAK6	Serine/threonine-protein kinase PAK 6	Q02878	RPL6	60S ribosomal protein L6	0.762
Q9NQU5	PAK6	Serine/threonine-protein kinase PAK 6	P62917	RPL8	60S ribosomal protein L8	0.824
Q9NQU5	PAK6	Serine/threonine-protein kinase PAK 6	P27635	RPL10	60S ribosomal protein L10	0.715
P09211	GSTP1	Glutathione S-transferase P	P27635	RPL10	60S ribosomal protein L10	0.772
Q9NQU5	PAK6	Serine/threonine-protein kinase PAK 6	P26373	RPL13	60S ribosomal protein L13	0.752
Q9NQU5	PAK6	Serine/threonine-protein kinase PAK 6	Q07020	RPL18	60S ribosomal protein L18	0.74
P09211	GSTP1	Glutathione S-transferase P	Q07020	RPL18	60S ribosomal protein L18	0.779
Q9NQU5	PAK6	Serine/threonine-protein kinase PAK 6	P46776	RPL27A	60S ribosomal protein L27a	0.719
Q9NQU5	PAK6	Serine/threonine-protein kinase PAK 6	P05386	RPLP1	60S acidic ribosomal protein P1	0.77
P09211	GSTP1	Glutathione S-transferase P	P05386	RPLP1	60S acidic ribosomal protein P1	0.707
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725

Flibanserin

hsa05200

Pathways in cancer

8.39E-06

Q13751, P42338, P08238, P42224, P25963, P19174, P17252, P43246, P10826, P14923, Q13489, P49767, P14921, P31751, P62873, P50151, P78417, O75293, P0DP23, P01568, P14784, P40189

LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, RARB, JUP, BIRC3, VEGFC, ETS1, AKT2, GNB1, GNG10, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13751	LAMB3	Laminin subunit beta-3	-0.705
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P43246	MSH2	DNA mismatch repair protein Msh2	0.925
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P10826	RARB	Retinoic acid receptor beta	0.779
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14923	JUP	Junction plakoglobin	-0.716
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14921	ETS1	Protein C-ets-1	0.731
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P78417	GSTO1	Glutathione S-transferase omega-1	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.919
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748

Flibanserin

hsa05202

Transcriptional misregulation in cancer

1.07E-05

Q12778, Q15532, Q13315, P14780, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, MMP9, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Flibanserin

hsa05203

Viral carcinogenesis

6.35E-03

P30281, Q15283, P06396, P01889, P10321, P62807, O60814

CCND3, RASA2, GSN, HLA-B, HLA-C, HIST1H2BC, H2BC12

Flibanserin

hsa05204

Chemical carcinogenesis

1.09E-03

P09211, P78417, P11712

GSTP1, GSTO1, CYP2C9

Flibanserin

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Flibanserin

hsa05206

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Flibanserin

hsa05211

Renal cell carcinoma

2.02E-03

Q13153, P31751

PAK1, AKT2

Flibanserin

hsa05212

Pancreatic cancer

4.78E-02

P31751

AKT2

Flibanserin

hsa05213

Endometrial cancer

4.72E-03

O15169, P31751, Q02750

AXIN1, AKT2, MAP2K1

Flibanserin

hsa05214

Glioma

6.17E-05

P0DP23, P17252, P42338, P31751, P19174, O75293

CALM1, PRKCA, PIK3CB, AKT2, PLCG1, GADD45B

Flibanserin

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Flibanserin

hsa05218

Melanoma

3.01E-02

P31751

AKT2

Flibanserin

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Flibanserin

hsa05220

Chronic myeloid leukemia

4.19E-02

P31751

AKT2

Flibanserin

hsa05221

Acute myeloid leukemia

4.19E-02

P31751

AKT2

Flibanserin

hsa05222

Small cell lung cancer

1.36E-04

P10826, P31751, P42338, Q13751, Q13489, P10415, P25963, Q13077, O00463, P24522, O75293

RARB, AKT2, PIK3CB, LAMB3, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A, GADD45B

Flibanserin

hsa05223

Non-small cell lung cancer

1.14E-05

P17252, P31751, P42338, P19174, P10826, Q9HC35, O75293

PRKCA, AKT2, PIK3CB, PLCG1, RARB, EML4, GADD45B

Flibanserin

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Flibanserin

hsa05226

Gastric cancer

4.72E-03

Q02750, P31751, O15169

MAP2K1, AKT2, AXIN1

Flibanserin

hsa05230

Central carbon metabolism in cancer

4.78E-02

P31751

AKT2

Flibanserin

hsa05231

Choline metabolism in cancer

4.91E-03

P42338, Q9Y259, P19174, P23743, P17252

PIK3CB, CHKB, PLCG1, DGKA, PRKCA

Flibanserin

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

3.61E-05

O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, Q9HC35, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, EML4, CD4

Flibanserin

hsa05310

Asthma

3.88E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Flibanserin

hsa05321

Inflammatory bowel disease

4.75E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Flibanserin

hsa05322

Systemic lupus erythematosus

1.11E-05

P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455

ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSB

Flibanserin

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Flibanserin

hsa05332

Graft-versus-host disease

6.57E-07

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Flibanserin

hsa05340

Primary immunodeficiency

1.28E-03

P01730, P11912, P07766, P06239

CD4, CD79A, CD3E, LCK

Flibanserin

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.48E-02

P54284

CACNB3

Flibanserin

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Flibanserin

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Flibanserin

hsa05418

Fluid shear stress and atherosclerosis

1.27E-05

Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23

MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1

Community members of Flibanserin (S_DC: 8.57)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

O95271

TNKS

Poly [ADPNoneribose] polymerase tankyraseNone1

Predicted

0.1017

0.2224

0.4957

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

Q9P1W9

PIM2

Serine/threonineNoneprotein kinase pimNone2

Predicted

0.1267

0.7674

0.2638

1.8619

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

P07947

YES1

TyrosineNoneprotein kinase Yes

Predicted

0.1212

0.4345

0.165

1.0947

P05164

MPO

Myeloperoxidase

Predicted

0.2035

0.5368

0.5502

1.7255

P09211

GSTP1

Glutathione SNonetransferase P

Predicted

0.3204

0.3523

0.4566

1.3213

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

P31751

AKT2

RACNonebeta serine/threonineNoneprotein kinase

Predicted

0.4662

0.4856

2.2044

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

Q9UGN5

PARP2

Poly [ADPNoneribose] polymerase 2

Predicted

0.0435

0.2635

0.2461

0.7947

Q13133

NR1H3

Oxysterols receptor LXRNonealpha

Predicted

0.0162

0.439

0.2086

1.0947

P08235

NR3C2

Mineralocorticoid receptor

Predicted

0.1855

0.0137

2.1064

O14786

NRP1

NeuropilinNone1

Predicted

0.3834

0.2026

0.5153

1.1123

Q9NQU5

PAK6

Serine/threonineNoneprotein kinase PAK 6

Predicted

0.409

0.2669

0.5003

1.2386

Q13153

PAK1

Serine/threonineNoneprotein kinase PAK 1

Predicted

0.4647

0.3471

0.7819

1.7084

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P00352

ALDH1A1

Aldehyde dehydrogenase 1A1

Predicted

0.3208

0.2925

0.1543

0.8998

P49354

FNTA

Protein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alpha

Predicted

0.5303

0.7588

1.7827

Q6PCB7

SLC27A1

LongNonechain fatty acid transport protein 1

Predicted

0.2915

0.0768

0.0992

0.3985

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

PharmaCoNets of Flibanserin (SPCN: 230.08 )

Flibanserin regulated-network (SDN: 26.85)

Community members of Flibanserin (SDC: 8.57)

PharmaCoNets of Flibanserin (S_PCN: 230.08 )

Flibanserin regulated-network (S_DN: 26.85)

Community members of Flibanserin (S_DC: 8.57)