| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Flavoxate | hsa00030 | Pentose phosphate pathway | 3.06E-04 | 3 | P60891, P51854, P37837 | PRPS1, TKTL1, TALDO1 | More | | | Flavoxate | hsa00052 | Galactose metabolism | 1.03E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | | Flavoxate | hsa00190 | Oxidative phosphorylation | 1.28E-05 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Flavoxate | hsa00240 | Pyrimidine metabolism | 4.29E-02 | 2 | P21589, P04183 | NT5E, TK1 | More | | | Flavoxate | hsa00310 | Lysine degradation | 2.59E-02 | 2 | Q96KQ7, P51648 | EHMT2, ALDH3A2 | More | | | Flavoxate | hsa00500 | Starch and sucrose metabolism | 1.67E-02 | 2 | O43451, P06737 | MGAM, PYGL | More | | | Flavoxate | hsa00512 | Mucin type O-glycan biosynthesis | 3.19E-03 | 3 | O95395, Q8N4A0, Q9NY28 | GCNT3, GALNT4, GALNT8 | More | | | Flavoxate | hsa00513 | Various types of N-glycan biosynthesis | 4.96E-02 | 1 | Q9NR34 | MAN1C1 | More | | | Flavoxate | hsa00564 | Glycerophospholipid metabolism | 4.29E-02 | 2 | Q6P1A2, P23743 | MBOAT5, DGKA | More | | | Flavoxate | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Flavoxate | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Flavoxate | hsa00600 | Sphingolipid metabolism | 2.77E-02 | 3 | Q9BX95, Q8TCT0, P15289 | SGPP1, CERK, ARSA | More | | | Flavoxate | hsa00630 | Glyoxylate and dicarboxylate metabolism | 9.21E-03 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Flavoxate | hsa00730 | Thiamine metabolism | 5.29E-03 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Flavoxate | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Flavoxate | hsa00970 | Aminoacyl-tRNA biosynthesis | 2.24E-03 | 3 | O95363, P14868, Q15046 | FARS2, DARS, KARS | More | | | Flavoxate | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Flavoxate | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Flavoxate | hsa00983 | Drug metabolism - other enzymes | 9.82E-04 | 3 | P04183, P32320, P05164 | TK1, CDA, MPO | More | | | Flavoxate | hsa01040 | Biosynthesis of unsaturated fatty acids | 2.92E-02 | 2 | P22307, Q9H5J4 | SCP2, ELOVL6 | More | | | Flavoxate | hsa01200 | Carbon metabolism | 4.32E-02 | 3 | P51854, P37837, P60891 | TKTL1, TALDO1, PRPS1 | More | | | Flavoxate | hsa01230 | Biosynthesis of amino acids | 2.60E-02 | 3 | P51854, P60891, P37837 | TKTL1, PRPS1, TALDO1 | More | | | Flavoxate | hsa01522 | Endocrine resistance | 5.79E-03 | 6 | P22694, Q02750, Q9UM47, P46527, P10415, Q13323 | PRKACB, MAP2K1, NOTCH3, CDKN1B, BCL2, BIK | More | | | Flavoxate | hsa01523 | Antifolate resistance | 1.68E-02 | 2 | Q92820, P04818 | GGH, TYMS | More | | | Flavoxate | hsa02010 | ABC transporters | 1.98E-03 | 3 | P45844, P08183, Q8IZY2 | ABCG1, ABCB1, ABCA7 | More | | | Flavoxate | hsa03013 | RNA transport | 3.53E-02 | 6 | P62826, Q15287, Q9UBU9, P63279, P20042, Q14232 | RAN, RNPS1, NXF1, UBE2I, EIF2S2, EIF2B1 | More | | | Flavoxate | hsa03020 | RNA polymerase | 9.86E-07 | 2 | Q9GZM3, P52435 | POLR2J2, POLR2J | More | | | Flavoxate | hsa03022 | Basal transcription factors | 3.32E-02 | 2 | O00268, Q15544 | TAF4, TAF11 | More | | | Flavoxate | hsa03040 | Spliceosome | 6.63E-08 | 16 | Q14562, O43143, O60508, P08579, P26368, O75940, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643 | DHX8, DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | -0.853 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.775 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.818 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.871 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.716 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | O75940 | SMNDC1 | Survival of motor neuron-related-splicing factor 30 | 0.786 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | O75494 | FUSIP1 | Serine/arginine-rich splicing factor 10 | 0.73 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.776 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.827 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.758 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.783 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.87 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.943 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.876 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 |
| | Flavoxate | hsa03060 | Protein export | 3.20E-02 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | | Flavoxate | hsa03450 | Non-homologous end-joining | 1.02E-03 | 2 | P78527, P13010 | PRKDC, XRCC5 | More | | | Flavoxate | hsa04014 | Ras signaling pathway | 6.83E-06 | 17 | Q02750, P42338, P20827, Q15389, Q9NRA1, P49767, Q13009, P17252, Q7LDG7, P21359, P0DP23, P62873, P62879, P63218, P50151, P19174, P22694 | MAP2K1, PIK3CB, EFNA1, ANGPT1, PDGFC, VEGFC, TIAM1, PRKCA, RASGRP2, NF1, CALM1, GNB1, GNB2, GNG5, GNG10, PLCG1, PRKACB | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q13315 | ATM | Serine-protein kinase ATM | Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | -0.797 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P20827 | EFNA1 | Ephrin-A1 | 0.783 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | | Q13315 | ATM | Serine-protein kinase ATM | Q15389 | ANGPT1 | Angiopoietin-1 | 0.726 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q9NRA1 | PDGFC | Platelet-derived growth factor C | 0.766 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q9NRA1 | PDGFC | Platelet-derived growth factor C | -0.776 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P49767 | VEGFC | Vascular endothelial growth factor C | 0.761 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.746 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P17252 | PRKCA | Protein kinase C alpha type | 0.832 | | Q13315 | ATM | Serine-protein kinase ATM | P17252 | PRKCA | Protein kinase C alpha type | 0.739 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | Q13315 | ATM | Serine-protein kinase ATM | P21359 | NF1 | Neurofibromin | 0.762 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P0DP23 | CALM1 | Calmodulin-1 | -0.761 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.833 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | Q13315 | ATM | Serine-protein kinase ATM | P62879 | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | -0.716 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.739 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | Q13315 | ATM | Serine-protein kinase ATM | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | 0.858 |
| | Flavoxate | hsa04015 | Rap1 signaling pathway | 2.83E-04 | 14 | P20827, Q9NRA1, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P0DP23, P08514, P17252, P19174 | EFNA1, PDGFC, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, CALM1, ITGA2B, PRKCA, PLCG1 | More | | | Flavoxate | hsa04020 | Calcium signaling pathway | 2.01E-02 | 6 | P17252, P19174, P0DP23, P20020, Q9NRA1, P49767 | PRKCA, PLCG1, CALM1, ATP2B1, PDGFC, VEGFC | More | | | Flavoxate | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 4.48E-02 | 5 | P09341, P19875, P25024, P25025, P14784 | CXCL1, CXCL2, CXCR1, CXCR2, IL2RB | More | | | Flavoxate | hsa04062 | Chemokine signaling pathway | 4.82E-06 | 18 | P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q7LDG7, Q13009, P14598, P42224, P25963, Q8WYR1 | CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, PIK3R5 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P09769 | FGR | Tyrosine-protein kinase Fgr | 0.796 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.782 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.971 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | Q13547 | HDAC1 | Histone deacetylase 1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.864 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | Q13547 | HDAC1 | Histone deacetylase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.716 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43250 | GRK6 | G protein-coupled receptor kinase 6 | 0.818 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.746 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.785 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 |
| | Flavoxate | hsa04064 | NF-kappa B signaling pathway | 2.15E-02 | 7 | P14778, P19174, Q04759, P06239, P09341, P19875, Q06643 | IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTB | More | | | Flavoxate | hsa04066 | HIF-1 signaling pathway | 4.48E-02 | 4 | P17252, Q15389, Q02750, P46527 | PRKCA, ANGPT1, MAP2K1, CDKN1B | More | | | Flavoxate | hsa04070 | Phosphatidylinositol signaling system | 3.27E-03 | 5 | P19174, P0DP23, P23743, P27987, P17252 | PLCG1, CALM1, DGKA, ITPKB, PRKCA | More | | | Flavoxate | hsa04071 | Sphingolipid signaling pathway | 6.08E-04 | 5 | P21453, Q9H228, P01375, Q13362, Q9UQC2 | S1PR1, EDG8, TNF, PPP2R5C, GAB2 | More | | | Flavoxate | hsa04072 | Phospholipase D signaling pathway | 4.48E-02 | 5 | P42338, P43657, P25024, P25025, P19174 | PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1 | More | | | Flavoxate | hsa04080 | Neuroactive ligand-receptor interaction | 2.95E-04 | 8 | P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, P07550 | CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2 | More | | | Flavoxate | hsa04110 | Cell cycle | 1.71E-05 | 7 | P06493, O60566, P78527, P30304, P33981, P42773, P01106 | CDK1, BUB1B, PRKDC, CDC25A, TTK, CDKN2C, MYC | More | | | Flavoxate | hsa04120 | Ubiquitin mediated proteolysis | 1.08E-03 | 6 | Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669 | SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12 | More | | | Flavoxate | hsa04140 | Autophagy - animal | 4.74E-02 | 3 | P22694, Q14643, P10415 | PRKACB, ITPR1, BCL2 | More | | | Flavoxate | hsa04141 | Protein processing in endoplasmic reticulum | 8.60E-03 | 6 | P30101, P60604, P11142, P08238, Q9H173, Q9UNL2 | PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3 | More | | | Flavoxate | hsa04145 | Phagosome | 9.95E-04 | 7 | P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488 | ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1 | More | | | Flavoxate | hsa04151 | PI3K-Akt signaling pathway | 3.70E-02 | 12 | P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281 | PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3 | More | | | Flavoxate | hsa04210 | Apoptosis | 3.58E-02 | 4 | O76075, P01375, Q9NR28, Q16548 | DFFB, TNF, DIABLO, BCL2A1 | More | | | Flavoxate | hsa04213 | Longevity regulating pathway - multiple species | 3.85E-02 | 4 | P42338, Q9Y4H2, P11142, Q13547 | PIK3CB, IRS2, HSPA8, HDAC1 | More | | | Flavoxate | hsa04217 | Necroptosis | 7.57E-07 | 18 | P01375, P01568, P23458, P48023, Q13489, Q9NQC7, P42224, Q14765, P08238, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q9H444, O43633, O75351, Q08752 | TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AB1, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP4B, CHMP2A, VPS4B, PPID | More | | | Flavoxate | hsa04261 | Adrenergic signaling in cardiomyocytes | 2.95E-02 | 4 | P07550, P22694, P18848, Q13362 | ADRB2, PRKACB, ATF4, PPP2R5C | More | | | Flavoxate | hsa04340 | Hedgehog signaling pathway | 7.27E-04 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Flavoxate | hsa04360 | Axon guidance | 3.14E-03 | 7 | P16333, P20827, O95631, P17252, P42338, P07332, P19174 | NCK1, EFNA1, NTN1, PRKCA, PIK3CB, FES, PLCG1 | More | | | Flavoxate | hsa04371 | Apelin signaling pathway | 3.84E-05 | 10 | P62873, P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022, P0DP23 | GNB1, GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CALM1 | More | | | Flavoxate | hsa04380 | Osteoclast differentiation | 4.17E-02 | 4 | Q9NQC7, Q9UQC2, P23458, P01584 | CYLD, GAB2, JAK1, IL1B | More | | | Flavoxate | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | | Flavoxate | hsa04540 | Gap junction | 3.04E-06 | 8 | P17252, P22694, Q13509, P68371, Q71U36, Q02750, Q9NRA1, Q14643 | PRKCA, PRKACB, TUBB3, TUBB2C, TUBA1A, MAP2K1, PDGFC, ITPR1 | More | | | Flavoxate | hsa04610 | Complement and coagulation cascades | 1.91E-03 | 1 | P0C0L4 | C4A | More | | | Flavoxate | hsa04611 | Platelet activation | 3.39E-02 | 3 | P25116, P08514, P07359 | F2R, ITGA2B, GP1BA | More | | | Flavoxate | hsa04612 | Antigen processing and presentation | 1.07E-03 | 6 | Q14953, P26715, P26717, Q13241, P01732, P01375 | KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF | More | | | Flavoxate | hsa04613 | Neutrophil extracellular trap formation | 2.18E-03 | 7 | P04908, Q93077, P62807, O60814, P68431, O43315, Q16539 | H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14 | More | | | Flavoxate | hsa04623 | Cytosolic DNA-sensing pathway | 7.74E-05 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Flavoxate | hsa04640 | Hematopoietic cell lineage | 2.18E-03 | 9 | P14778, P27930, P11215, P25063, P07766, P01732, P01730, P06127, P09564 | IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD5, CD7 | More | | | Flavoxate | hsa04650 | Natural killer cell mediated cytotoxicity | 5.49E-06 | 12 | P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q14953, P26715 | PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1 | More | | | Flavoxate | hsa04657 | IL-17 signaling pathway | 2.19E-04 | 10 | P25963, P08238, Q07955, P49841, P19875, P14780, P04141, P80188, P01375, P06702 | NFKBIA, HSP90AB1, SFRS1, GSK3B, CXCL2, MMP9, CSF2, LCN2, TNF, S100A9 | More | | | Flavoxate | hsa04658 | Th1 and Th2 cell differentiation | 2.21E-04 | 8 | Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761 | PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3 | More | | | Flavoxate | hsa04659 | Th17 cell differentiation | 3.46E-06 | 13 | P25963, Q04759, P19174, P06239, P42224, P14784, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P20963 | NFKBIA, PRKCQ, PLCG1, LCK, STAT1, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247 | More | | | Flavoxate | hsa04660 | T cell receptor signaling pathway | 4.48E-04 | 13 | P04141, P25963, Q04759, P42338, P10747, P19174, P16333, P07766, P20963, P01732, Q13191, P06239, P29350 | CSF2, NFKBIA, PRKCQ, PIK3CB, CD28, PLCG1, NCK1, CD3E, CD247, CD8A, CBLB, LCK, PTPN6 | More | | | Flavoxate | hsa04662 | B cell receptor signaling pathway | 1.74E-02 | 5 | P42338, P60033, P07948, P21854, Q8N149 | PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Flavoxate | hsa04664 | Fc epsilon RI signaling pathway | 5.14E-04 | 5 | P04141, P42338, P07948, P19174, P09917 | CSF2, PIK3CB, LYN, PLCG1, ALOX5 | More | | | Flavoxate | hsa04668 | TNF signaling pathway | 3.55E-02 | 4 | P01375, P18848, P19875, P14780 | TNF, ATF4, CXCL2, MMP9 | More | | | Flavoxate | hsa04672 | Intestinal immune network for IgA production | 1.35E-02 | 2 | P29965, P13765 | CD40LG, HLA-DOB | More | | | Flavoxate | hsa04713 | Circadian entrainment | 1.85E-03 | 6 | P0DP23, P17252, P62873, P63218, P50151, O15055 | CALM1, PRKCA, GNB1, GNG5, GNG10, PER2 | More | | | Flavoxate | hsa04714 | Thermogenesis | 5.21E-03 | 4 | Q16539, P33121, Q16718, O14521 | MAPK14, ACSL1, NDUFA5, SDHD | More | | | Flavoxate | hsa04720 | Long-term potentiation | 1.09E-02 | 4 | P17252, P51812, P22694, Q02750 | PRKCA, RPS6KA3, PRKACB, MAP2K1 | More | | | Flavoxate | hsa04721 | Synaptic vesicle cycle | 3.15E-02 | 2 | Q13488, P31645 | TCIRG1, SLC6A4 | More | | | Flavoxate | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | | Flavoxate | hsa04724 | Glutamatergic synapse | 1.57E-02 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Flavoxate | hsa04725 | Cholinergic synapse | 2.37E-03 | 6 | P22694, Q14643, P17252, P62879, P10415, Q02750 | PRKACB, ITPR1, PRKCA, GNB2, BCL2, MAP2K1 | More | | | Flavoxate | hsa04726 | Serotonergic synapse | 2.16E-03 | 8 | P22694, P17252, P62873, P62879, P63218, P50151, P09917, Q02750 | PRKACB, PRKCA, GNB1, GNB2, GNG5, GNG10, ALOX5, MAP2K1 | More | | | Flavoxate | hsa04727 | GABAergic synapse | 4.07E-04 | 8 | P62873, P62879, P63218, P50151, P15104, P22694, O60296, P17252 | GNB1, GNB2, GNG5, GNG10, GLUL, PRKACB, TRAK2, PRKCA | More | | | Flavoxate | hsa04730 | Long-term depression | 4.86E-02 | 2 | Q14344, P07948 | GNA13, LYN | More | | | Flavoxate | hsa04744 | Phototransduction | 1.09E-04 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Flavoxate | hsa04750 | Inflammatory mediator regulation of TRP channels | 7.24E-03 | 5 | P14778, P19174, P42338, P24723, Q04759 | IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ | More | | | Flavoxate | hsa04910 | Insulin signaling pathway | 2.35E-02 | 3 | P22694, P06737, P49841 | PRKACB, PYGL, GSK3B | More | | | Flavoxate | hsa04913 | Ovarian steroidogenesis | 1.27E-03 | 2 | P42330, P22694 | AKR1C3, PRKACB | More | | | Flavoxate | hsa04918 | Thyroid hormone synthesis | 3.16E-02 | 2 | P17252, P27824 | PRKCA, CANX | More | | | Flavoxate | hsa04919 | Thyroid hormone signaling pathway | 6.35E-04 | 8 | P17252, P49841, Q02750, P22694, O60244, Q9NVC6, Q12778, Q9UM47 | PRKCA, GSK3B, MAP2K1, PRKACB, MED14, MED17, FOXO1, NOTCH3 | More | | | Flavoxate | hsa04923 | Regulation of lipolysis in adipocytes | 2.24E-02 | 3 | P07550, P42338, Q9Y4H2 | ADRB2, PIK3CB, IRS2 | More | | | Flavoxate | hsa04924 | Renin secretion | 2.90E-04 | 3 | P22694, P07550, Q14643 | PRKACB, ADRB2, ITPR1 | More | | | Flavoxate | hsa04926 | Relaxin signaling pathway | 2.41E-02 | 4 | P18848, P22694, P14780, P30679 | ATF4, PRKACB, MMP9, GNA15 | More | | | Flavoxate | hsa04927 | Cortisol synthesis and secretion | 1.27E-03 | 3 | Q14643, P18848, P22694 | ITPR1, ATF4, PRKACB | More | | | Flavoxate | hsa04928 | Parathyroid hormone synthesis, secretion and action | 1.57E-03 | 7 | Q14643, P22694, P23771, Q02750, P17252, P10415, Q9Y5Q3 | ITPR1, PRKACB, GATA3, MAP2K1, PRKCA, BCL2, MAFB | More | | | Flavoxate | hsa04931 | Insulin resistance | 1.94E-02 | 3 | P01375, P49841, P06737 | TNF, GSK3B, PYGL | More | | | Flavoxate | hsa04932 | Non-alcoholic fatty liver disease | 1.53E-04 | 10 | P01375, P49841, O43521, P48023, O75460, P01584, P12074, Q16718, O95298, O14521 | TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX6A1, NDUFA5, NDUFC2, SDHD | More | | | Flavoxate | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.52E-03 | 8 | P84022, Q13485, P42224, P42338, Q12778, P49767, P17252, P19174 | SMAD3, SMAD4, STAT1, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1 | More | | | Flavoxate | hsa04934 | Cushing syndrome | 4.74E-02 | 3 | Q14643, P22694, P04628 | ITPR1, PRKACB, WNT1 | More | | | Flavoxate | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Flavoxate | hsa04964 | Proximal tubule bicarbonate reclamation | 4.48E-02 | 1 | P00918 | CA2 | More | | | Flavoxate | hsa04966 | Collecting duct acid secretion | 4.48E-02 | 1 | P00918 | CA2 | More | | | Flavoxate | hsa04970 | Salivary secretion | 1.18E-04 | 5 | P07550, P22694, Q14643, P17252, P49913 | ADRB2, PRKACB, ITPR1, PRKCA, CAMP | More | | | Flavoxate | hsa04971 | Gastric acid secretion | 4.51E-02 | 3 | Q08828, P15311, P0DP23 | ADCY1, VIL2, CALM1 | More | | | Flavoxate | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Flavoxate | hsa04976 | Bile secretion | 1.67E-03 | 3 | O43315, P22694, P08183 | AQP9, PRKACB, ABCB1 | More | | | Flavoxate | hsa05012 | Parkinson disease | 1.62E-03 | 8 | Q16718, O14521, P60604, P19174, P0DP23, Q71U36, Q13509, P68371 | NDUFA5, SDHD, UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C | More | | | Flavoxate | hsa05016 | Huntington disease | 2.46E-05 | 3 | Q9GZM3, P52435, Q9NYC9 | POLR2J2, POLR2J, DNAH9 | More | | | Flavoxate | hsa05020 | Prion disease | 3.80E-02 | 4 | Q16718, O14521, P49841, Q16539 | NDUFA5, SDHD, GSK3B, MAPK14 | More | | | Flavoxate | hsa05022 | Pathways of neurodegeneration - multiple diseases | 1.14E-03 | 11 | Q13509, P68371, P49841, Q16718, O14521, Q13561, P19174, P17252, Q16539, Q08752, P0DP23 | TUBB3, TUBB2C, GSK3B, NDUFA5, SDHD, DCTN2, PLCG1, PRKCA, MAPK14, PPID, CALM1 | More | | | Flavoxate | hsa05031 | Amphetamine addiction | 4.32E-02 | 3 | P22694, P18848, Q13547 | PRKACB, ATF4, HDAC1 | More | | | Flavoxate | hsa05032 | Morphine addiction | 2.18E-02 | 4 | P62873, P63218, P50151, Q13370 | GNB1, GNG5, GNG10, PDE3B | More | | | Flavoxate | hsa05034 | Alcoholism | 2.89E-03 | 4 | Q93077, P62807, O60814, P68431 | HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Flavoxate | hsa05100 | Bacterial invasion of epithelial cells | 4.50E-02 | 1 | Q92529 | SHC3 | More | | | Flavoxate | hsa05110 | Vibrio cholerae infection | 1.98E-02 | 3 | Q13488, P17252, P19174 | TCIRG1, PRKCA, PLCG1 | More | | | Flavoxate | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 7.88E-05 | 8 | P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948 | NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN | More | | | Flavoxate | hsa05130 | Pathogenic Escherichia coli infection | 3.19E-02 | 6 | Q71U36, P16333, Q13509, P68371, Q14344, P25963 | TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA | More | | | Flavoxate | hsa05132 | Salmonella infection | 1.42E-03 | 9 | P25963, P08238, P04406, O75369, Q13561, Q71U36, Q13509, P68371, P49754 | NFKBIA, HSP90AB1, GAPDH, FLNB, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41 | More | | | Flavoxate | hsa05133 | Pertussis | 3.51E-02 | 1 | P0C0L4 | C4A | More | | | Flavoxate | hsa05134 | Legionellosis | 1.49E-03 | 5 | P25963, P11215, P11142, P09341, P19875 | NFKBIA, ITGAM, HSPA8, CXCL1, CXCL2 | More | | | Flavoxate | hsa05140 | Leishmaniasis | 1.06E-04 | 6 | P14598, P11215, P42224, P25963, P29350, Q15080 | NCF1, ITGAM, STAT1, NFKBIA, PTPN6, NCF4 | More | | | Flavoxate | hsa05143 | African trypanosomiasis | 2.72E-02 | 2 | P01375, P48023 | TNF, FASLG | More | | | Flavoxate | hsa05144 | Malaria | 1.91E-02 | 3 | P01375, P35443, P26718 | TNF, THBS4, KLRK1 | More | | | Flavoxate | hsa05146 | Amoebiasis | 2.05E-05 | 11 | P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814 | CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1 | More | | | Flavoxate | hsa05150 | Staphylococcus aureus infection | 1.31E-02 | 2 | P0C0L4, P13646 | C4A, KRT13 | More | | | Flavoxate | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Flavoxate | hsa05163 | Human cytomegalovirus infection | 2.56E-03 | 8 | P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568 | NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21 | More | | | Flavoxate | hsa05165 | Human papillomavirus infection | 4.71E-03 | 10 | P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315 | CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATM | More | | | Flavoxate | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 2.43E-06 | 11 | P01568, P42224, P25963, P40189, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23 | IFNA21, STAT1, NFKBIA, IL6ST, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1 | More | | | Flavoxate | hsa05168 | Herpes simplex virus 1 infection | 8.20E-06 | 16 | P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13489, P30101, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6 | NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.739 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.768 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P01568 | IFNA21 | Interferon alpha-21 | 0.729 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P01568 | IFNA21 | Interferon alpha-21 | -0.764 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q05823 | RNASEL | 2-5A-dependent ribonuclease | 0.752 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q9GZY0 | NXF2; NXF2B | Nuclear RNA export factor 2 | 0.704 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.912 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.787 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.776 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.732 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.827 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.758 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.783 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.87 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.819 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.943 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.721 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.83 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q13398 | ZNF211 | Zinc finger protein 211 | -0.759 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13398 | ZNF211 | Zinc finger protein 211 | 0.729 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13398 | ZNF211 | Zinc finger protein 211 | 0.849 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q9HCX3 | ZNF304 | Zinc finger protein 304 | -0.746 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q03923 | ZNF85 | Zinc finger protein 85 | 0.79 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P52738 | ZNF140 | Zinc finger protein 140 | 0.717 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P52738 | ZNF140 | Zinc finger protein 140 | -0.724 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | O75820 | ZNF189 | Zinc finger protein 189 | 0.715 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | O75820 | ZNF189 | Zinc finger protein 189 | -0.722 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O75820 | ZNF189 | Zinc finger protein 189 | -0.766 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q9UDV6 | ZNF212 | Zinc finger protein 212 | -0.808 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.824 |
| | Flavoxate | hsa05170 | Human immunodeficiency virus 1 infection | 1.19E-02 | 8 | P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174 | GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1 | More | | | Flavoxate | hsa05171 | Coronavirus disease - COVID-19 | 1.36E-02 | 7 | P25963, P42224, P01568, P40189, P04141, P19174, P17252 | NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCA | More | | | Flavoxate | hsa05200 | Pathways in cancer | 6.06E-06 | 27 | Q13751, P42338, P08238, P42224, P25963, P19174, P17252, P43246, P84022, Q13485, P20585, Q13547, P14923, P30281, P49767, Q12778, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784, P40189 | LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, HDAC1, JUP, CCND3, VEGFC, FOXO1, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB, IL6ST | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.826 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.912 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.739 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.739 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P17252 | PRKCA | Protein kinase C alpha type | 0.832 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.768 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.816 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.811 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P20585 | MSH3 | DNA mismatch repair protein Msh3 | 0.825 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.754 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P14923 | JUP | Junction plakoglobin | 0.735 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P49767 | VEGFC | Vascular endothelial growth factor C | 0.761 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q12778 | FOXO1 | Forkhead box protein O1 | 0.753 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.833 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.756 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.713 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.742 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.731 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P0DP23 | CALM1 | Calmodulin-1 | -0.761 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P01568 | IFNA21 | Interferon alpha-21 | 0.729 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.717 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P40189 | IL6ST | Interleukin-6 receptor subunit beta | -0.746 |
| | Flavoxate | hsa05202 | Transcriptional misregulation in cancer | 3.76E-02 | 7 | Q12778, Q13315, Q15744, P46527, P05164, P08246, Q9C0K0 | FOXO1, ATM, CEBPE, CDKN1B, MPO, ELA2, BCL11B | More | | | Flavoxate | hsa05203 | Viral carcinogenesis | 4.85E-02 | 3 | Q15283, P62807, O60814 | RASA2, HIST1H2BC, H2BC12 | More | | | Flavoxate | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Flavoxate | hsa05205 | Proteoglycans in cancer | 4.46E-03 | 9 | Q12955, Q14247, P14780, P17252, P01375, P23588, Q13635, P22694, P08962 | ANK3, CTTN, MMP9, PRKCA, TNF, EIF4B, PTCH1, PRKACB, CD63 | More | | | Flavoxate | hsa05206 | MicroRNAs in cancer | 3.66E-02 | 6 | P46527, Q9UM47, P16070, Q13315, P17252, Q02750 | CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1 | More | | | Flavoxate | hsa05212 | Pancreatic cancer | 4.73E-03 | 5 | P42338, P42224, P84022, Q13485, O75293 | PIK3CB, STAT1, SMAD3, SMAD4, GADD45B | More | | | Flavoxate | hsa05214 | Glioma | 1.29E-03 | 4 | P0DP23, P17252, P19174, O75293 | CALM1, PRKCA, PLCG1, GADD45B | More | | | Flavoxate | hsa05220 | Chronic myeloid leukemia | 2.16E-02 | 5 | Q13547, Q13485, P84022, P42338, O75293 | HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B | More | | | Flavoxate | hsa05231 | Choline metabolism in cancer | 2.25E-03 | 5 | Q9NRA1, Q9Y259, P19174, P23743, P17252 | PDGFC, CHKB, PLCG1, DGKA, PRKCA | More | | | Flavoxate | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 7.13E-04 | 10 | P25963, P42338, P19174, P07766, P20963, P06239, P29350, P42224, P10747, Q04759 | NFKBIA, PIK3CB, PLCG1, CD3E, CD247, LCK, PTPN6, STAT1, CD28, PRKCQ | More | | | Flavoxate | hsa05310 | Asthma | 1.35E-02 | 2 | P13765, P29965 | HLA-DOB, CD40LG | More | | | Flavoxate | hsa05320 | Autoimmune thyroid disease | 3.16E-02 | 2 | P13765, P29965 | HLA-DOB, CD40LG | More | | | Flavoxate | hsa05321 | Inflammatory bowel disease | 1.91E-02 | 3 | P01375, Q14765, Q9UL17 | TNF, STAT4, TBX21 | More | | | Flavoxate | hsa05322 | Systemic lupus erythematosus | 1.31E-04 | 5 | P09871, Q93077, P62807, O60814, P68431 | C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Flavoxate | hsa05330 | Allograft rejection | 1.76E-03 | 4 | P13765, P29965, P48023, P01375 | HLA-DOB, CD40LG, FASLG, TNF | More | | | Flavoxate | hsa05332 | Graft-versus-host disease | 7.27E-04 | 4 | P48023, P01375, P26715, Q13241 | FASLG, TNF, KLRC1, KLRD1 | More | | | Flavoxate | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 2.45E-03 | 4 | P54284, P14923, P08514, Q9UJU2 | CACNB3, JUP, ITGA2B, LEF1 | More | | | Flavoxate | hsa05414 | Dilated cardiomyopathy | 4.55E-02 | 2 | P54284, P26678 | CACNB3, PLN | More | | | Flavoxate | hsa05415 | Diabetic cardiomyopathy | 1.87E-05 | 8 | P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406 | PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH | More | | | Flavoxate | hsa05416 | Viral myocarditis | 4.29E-02 | 2 | P13765, P29965 | HLA-DOB, CD40LG | More | |
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