PharmaCoNets of Flavone (SPCN: 187.33 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Flavonehsa00010Glycolysis / Gluconeogenesis5.80E-036P04075, P06733, P07738, P04406, P60174, P19367ALDOA, ENO1, BPGM, GAPDH, TPI1, HK1More
Flavonehsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Flavonehsa00051Fructose and mannose metabolism2.21E-023O14772, P60174, P04075FPGT, TPI1, ALDOAMore
Flavonehsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Flavonehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Flavonehsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Flavonehsa00220Arginine biosynthesis9.96E-042P05089, P49448ARG1, GLUD2More
Flavonehsa00240Pyrimidine metabolism3.59E-032P31350, P04818RRM2, TYMSMore
Flavonehsa00260Glycine, serine and threonine metabolism2.42E-021P07738BPGMMore
Flavonehsa00310Lysine degradation4.57E-022Q96KQ7, Q02809EHMT2, PLOD1More
Flavonehsa00340Histidine metabolism4.52E-021O95954FTCDMore
Flavonehsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Flavonehsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Flavonehsa00500Starch and sucrose metabolism1.05E-074P19367, O43451, P46976, P06737HK1, MGAM, GYG1, PYGLMore
Flavonehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Flavonehsa00520Amino sugar and nucleotide sugar metabolism4.36E-043Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Flavonehsa00524Neomycin, kanamycin and gentamicin biosynthesis1.21E-021P19367HK1More
Flavonehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate3.56E-021Q9Y2C2USTMore
Flavonehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Flavonehsa00562Inositol phosphate metabolism2.00E-024P27987, P19174, P42338, Q02252ITPKB, PLCG1, PIK3CB, ALDH6A1More
Flavonehsa00564Glycerophospholipid metabolism6.26E-043Q9Y259, P49619, Q8TCT1CHKB, DGKG, PHOSPHO1More
Flavonehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Flavonehsa00590Arachidonic acid metabolism2.95E-033P11712, P18054, P09960CYP2C9, ALOX12, LTA4HMore
Flavonehsa00591Linoleic acid metabolism1.58E-031P11712CYP2C9More
Flavonehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Flavonehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.30E-032P06865, O75752HEXA, B3GALNT1More
Flavonehsa00604Glycosphingolipid biosynthesis - ganglio series3.60E-021Q9H4F1ST6GALNAC4More
Flavonehsa00630Glyoxylate and dicarboxylate metabolism1.26E-042P40925, P15104MDH1, GLULMore
Flavonehsa00670One carbon pool by folate4.14E-021P04818TYMSMore
Flavonehsa00730Thiamine metabolism2.39E-052P05186, P24666ALPL, ACP1More
Flavonehsa00830Retinol metabolism3.62E-033P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Flavonehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Flavonehsa00920Sulfur metabolism3.18E-021Q16762TSTMore
Flavonehsa00970Aminoacyl-tRNA biosynthesis9.31E-074O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Flavonehsa00980Metabolism of xenobiotics by cytochrome P4501.96E-075Q16772, P78417, P28332, P09211, P11712GSTA3, GSTO1, ADH6, GSTP1, CYP2C9More
Flavonehsa00982Drug metabolism - cytochrome P4503.40E-075P11712, Q16772, P09211, P78417, P28332CYP2C9, GSTA3, GSTP1, GSTO1, ADH6More
Flavonehsa00983Drug metabolism - other enzymes1.28E-045P04183, P32320, P05164, Q16772, P09211TK1, CDA, MPO, GSTA3, GSTP1More
Flavonehsa01100Metabolic pathways1.13E-0445Q9NR34, P35790, Q9Y259, P05089, Q16772, P09211, Q9UJ14, P30041, P19367, P48426, P32320, Q13956, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, P07738, P05186, P24666, P15121, P49619, O95954, Q9HCC0, P33121, Q02318, Q9UHK6, Q86VZ5, P57054, Q9UBX8, Q9UNP4, Q9H4F1, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737, Q9BQB6MAN1C1, CHKA, CHKB, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, HK1, PIP4K2A, CDA, PDE6H, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, BPGM, ALPL, ACP1, AKR1B1, DGKG, FTCD, MCCC2, ACSL1, CYP27A1, AMACR, SGMS1, PIGP, B4GALT6, ST3GAL5, ST6GALNAC4, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL, VKORC1More
Flavonehsa01200Carbon metabolism5.71E-037P04075, P04406, P60174, P06733, O14521, Q9P2R7, Q02252ALDOA, GAPDH, TPI1, ENO1, SDHD, SUCLA2, ALDH6A1More
Flavonehsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Flavonehsa01230Biosynthesis of amino acids8.65E-047P60174, P04406, P06733, P04075, P60891, Q99707, P37837TPI1, GAPDH, ENO1, ALDOA, PRPS1, MTR, TALDO1More
Flavonehsa01524Platinum drug resistance4.38E-036Q13489, P98170, Q16772, P09211, P78417, P43246BIRC3, BIRC4, GSTA3, GSTP1, GSTO1, MSH2More
Flavonehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Flavonehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Flavonehsa03013RNA transport1.03E-0618P62826, O14980, P52298, Q09161, O14893, P61326, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5, Q14232RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, EIF2B1More
Flavonehsa03015mRNA surveillance pathway4.42E-024O60942, O43148, P52298, Q53GS7RNGTT, RNMT, NCBP2, GLE1More
Flavonehsa03020RNA polymerase6.21E-044P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Flavonehsa03040Spliceosome2.51E-0814Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Flavonehsa03320PPAR signaling pathway2.00E-034Q6PCB7, Q9UNU6, Q13133, Q02318SLC27A1, CYP8B1, NR1H3, CYP27A1More
Flavonehsa03450Non-homologous end-joining1.02E-032P78527, P13010PRKDC, XRCC5More
Flavonehsa04012ErbB signaling pathway2.00E-024P16333, P17252, P19174, P42338NCK1, PRKCA, PLCG1, PIK3CBMore
Flavonehsa04014Ras signaling pathway7.14E-0613P42338, P20827, P49767, Q13009, P17252, P14921, Q7LDG7, Q14644, P0DP23, P62873, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, PRKCA, ETS1, RASGRP2, RASA3, CALM1, GNB1, GNG5, GNG10, PLCG1More
Flavonehsa04015Rap1 signaling pathway1.00E-0413P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P0DP23, P08514, P17252, P19174EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, CALM1, ITGA2B, PRKCA, PLCG1More
Flavonehsa04020Calcium signaling pathway1.56E-0512P27987, Q08828, P17252, O15399, Q93086, P19174, Q15746, P0DP23, P05141, P51828, P23634, P49767ITPKB, ADCY1, PRKCA, GRIN2D, P2RX5, PLCG1, MYLK, CALM1, SLC25A5, ADCY7, ATP2B4, VEGFCMore
Flavonehsa04022cGMP-PKG signaling pathway3.25E-048P18848, P23634, P31751, Q08828, P51828, P05141, Q15746, P0DP23ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, MYLK, CALM1More
Flavonehsa04024cAMP signaling pathway4.64E-039Q08828, P51828, P42338, P31751, P0DP23, Q13370, O15399, P25963, Q13009ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PDE3B, GRIN2D, NFKBIA, TIAM1More
Flavonehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Flavonehsa04061Viral protein interaction with cytokine and cytokine receptor1.69E-0510Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Flavonehsa04062Chemokine signaling pathway5.68E-0923P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P14598, P42224, P25963, P49841, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, GSK3B, PIK3R5More
Flavonehsa04064NF-kappa B signaling pathway5.86E-1124P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Flavonehsa04070Phosphatidylinositol signaling system9.28E-059P19174, P0DP23, P42338, O14986, P23743, Q16760, P48426, P27987, P17252PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, DGKD, PIP4K2A, ITPKB, PRKCAMore
Flavonehsa04071Sphingolipid signaling pathway4.84E-069P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Flavonehsa04072Phospholipase D signaling pathway4.96E-0411P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Flavonehsa04080Neuroactive ligand-receptor interaction3.18E-0511P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, Q16581, P14416, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, C3AR1, DRD2, ADMMore
Flavonehsa04110Cell cycle2.57E-059Q9UBD5, P06493, P78527, Q09472, P24522, P49918, P33981, P42773, P01106ORC3, CDK1, PRKDC, EP300, GADD45A, CDKN1C, TTK, CDKN2C, MYCMore
Flavonehsa04114Oocyte meiosis8.00E-0610Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Flavonehsa04115p53 signaling pathway6.81E-047P24522, Q13315, P31350, Q53FA7, P06493, O95067, P10415GADD45A, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2More
Flavonehsa04120Ubiquitin mediated proteolysis4.82E-032Q9UBT2, Q14669SAE2, TRIP12More
Flavonehsa04122Sulfur relay system3.18E-021Q16762TSTMore
Flavonehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Flavonehsa04140Autophagy - animal1.71E-025P31751, Q7L523, O75460, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, TMEM49, SMCR8More
Flavonehsa04142Lysosome1.96E-023Q9UBR2, P34059, P17900CTSZ, GALNS, GM2AMore
Flavonehsa04145Phagosome1.61E-0310P63261, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Flavonehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Flavonehsa04150mTOR signaling pathway7.55E-046P42338, Q02750, Q9NQL2, P51812, Q13322, P49841PIK3CB, MAP2K1, RRAGD, RPS6KA3, GRB10, GSK3BMore
Flavonehsa04151PI3K-Akt signaling pathway2.03E-0316P42338, P43657, P20827, P49767, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, P14784, P01568, P17252, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, IL2RB, IFNA21, PRKCA, CCND3More
Flavonehsa04210Apoptosis2.93E-0413Q13315, P10415, Q13489, O76075, P25963, P01375, Q9NR28, P24522, Q16548, Q13077, P43234, P18848, Q14643ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, DIABLO, GADD45A, BCL2A1, TRAF1, CTSO, ATF4, ITPR1More
Flavonehsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Flavonehsa04213Longevity regulating pathway - multiple species4.29E-037P31751, P42338, Q9Y4H2, Q08828, P51828, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA8, HDAC1More
Flavonehsa04217Necroptosis3.42E-0512P01568, Q13489, P98170, Q13546, P42224, P08238, P15104, P07384, Q6FI13, P10415, O43633, P21796IFNA21, BIRC3, BIRC4, RIPK1, STAT1, HSP90AB1, GLUL, CAPN1, H2AC18; H2AC19, BCL2, CHMP2A, VDAC1More
Flavonehsa04261Adrenergic signaling in cardiomyocytes3.38E-059Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23, P17252, P23634ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1, PRKCA, ATP2B4More
Flavonehsa04270Vascular smooth muscle contraction1.50E-023Q15746, P17252, P0DP23MYLK, PRKCA, CALM1More
Flavonehsa04340Hedgehog signaling pathway2.43E-033P49841, P22694, P49407GSK3B, PRKACB, ARRB1More
Flavonehsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Flavonehsa04360Axon guidance5.10E-048P16333, P20827, O95631, P17252, P42338, P07332, P23528, P19174NCK1, EFNA1, NTN1, PRKCA, PIK3CB, FES, CFL1, PLCG1More
Flavonehsa04370VEGF signaling pathway7.34E-076P19174, P16298, P42338, P17252, Q05397, Q02750PLCG1, PPP3CB, PIK3CB, PRKCA, PTK2, MAP2K1More
Flavonehsa04371Apelin signaling pathway2.59E-0613P62873, P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1More
Flavonehsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Flavonehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Flavonehsa04510Focal adhesion1.16E-0412P16144, O75369, Q15746, P42338, Q15942, P17252, O15335, Q13751, Q13489, P10415, P49767, P63261ITGB4, FLNB, MYLK, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, BCL2, VEGFC, ACTG1More
Flavonehsa04512ECM-receptor interaction3.73E-022P07359, P08514GP1BA, ITGA2BMore
Flavonehsa04514Cell adhesion molecules8.19E-033P16109, P56750, O00501SELP, CLDN17, CLDN5More
Flavonehsa04530Tight junction3.02E-067Q8TEU7, P63261, P16989, P56750, O00501, Q92974, Q14247RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, ARHGEF2, CTTNMore
Flavonehsa04610Complement and coagulation cascades1.99E-054P25116, P09871, P00734, P0C0L4F2R, C1S, F2, C4AMore
Flavonehsa04611Platelet activation5.18E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Flavonehsa04612Antigen processing and presentation2.07E-0610P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Flavonehsa04613Neutrophil extracellular trap formation3.50E-0824P17252, P16109, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PRKCA, SELP, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Flavonehsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Flavonehsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Flavonehsa04621NOD-like receptor signaling pathway3.10E-0311Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Flavonehsa04623Cytosolic DNA-sensing pathway1.52E-066P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Flavonehsa04625C-type lectin receptor signaling pathway1.14E-038Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Flavonehsa04630JAK-STAT signaling pathway1.00E-026P01106, P31751, Q09472, P23458, P16871, Q13651MYC, AKT2, EP300, JAK1, IL7R, IL10RAMore
Flavonehsa04640Hematopoietic cell lineage4.55E-0713P13612, P14778, P27930, P11215, P20023, P25063, P07766, P09693, P01732, P01730, P09564, P16871, P13765ITGA4, IL1R1, IL1R2, ITGAM, CR2, CD24, CD3E, CD3G, CD8A, CD4, CD7, IL7R, HLA-DOBMore
Flavonehsa04650Natural killer cell mediated cytotoxicity2.53E-1216P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Flavonehsa04657IL-17 signaling pathway3.38E-068O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNFMore
Flavonehsa04658Th1 and Th2 cell differentiation9.50E-1412Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Flavonehsa04659Th17 cell differentiation1.64E-1118P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Flavonehsa04660T cell receptor signaling pathway1.54E-0816P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Flavonehsa04662B cell receptor signaling pathway1.11E-036P49841, P42338, P60033, P07948, P21854, Q8N149GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Flavonehsa04664Fc epsilon RI signaling pathway1.34E-048P01375, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P09917TNF, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, ALOX5More
Flavonehsa04666Fc gamma R-mediated phagocytosis8.08E-035P42338, P19174, P23528, P14598, P17252PIK3CB, PLCG1, CFL1, NCF1, PRKCAMore
Flavonehsa04668TNF signaling pathway1.83E-038P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9More
Flavonehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Flavonehsa04713Circadian entrainment1.01E-058O15399, P0DP23, P17252, P62873, P63218, P50151, Q08828, P51828GRIN2D, CALM1, PRKCA, GNB1, GNG5, GNG10, ADCY1, ADCY7More
Flavonehsa04720Long-term potentiation6.61E-079P17252, Q16566, P16298, P0DP23, P51812, P18848, O15399, Q08828, Q02750PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, ATF4, GRIN2D, ADCY1, MAP2K1More
Flavonehsa04724Glutamatergic synapse3.06E-056O15399, P17252, P62873, P63218, P50151, P15104GRIN2D, PRKCA, GNB1, GNG5, GNG10, GLULMore
Flavonehsa04725Cholinergic synapse9.58E-0613Q08828, P51828, P22694, Q14643, P17252, P62873, P63218, P50151, P18848, Q16566, P42338, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNG5, GNG10, ATF4, CAMK4, PIK3CB, AKT2, BCL2More
Flavonehsa04726Serotonergic synapse1.06E-048P17252, P62873, P63218, P50151, P11712, P33260, P18054, P09917PRKCA, GNB1, GNG5, GNG10, CYP2C9, CYP2C18, ALOX12, ALOX5More
Flavonehsa04727GABAergic synapse8.72E-055P62873, P63218, P50151, P15104, P17252GNB1, GNG5, GNG10, GLUL, PRKCAMore
Flavonehsa04728Dopaminergic synapse1.04E-038P50151, P31751, P49841, P18848, P49407, Q13362, Q14738, P0DP23GNG10, AKT2, GSK3B, ATF4, ARRB1, PPP2R5C, PPP2R5D, CALM1More
Flavonehsa04744Phototransduction1.26E-042P62873, P0DP23GNB1, CALM1More
Flavonehsa04750Inflammatory mediator regulation of TRP channels7.06E-0611P14778, P01584, P18054, Q08828, P51828, P19174, P42338, P17252, P24723, Q04759, P0DP23IL1R1, IL1B, ALOX12, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCA, PRKCH, PRKCQ, CALM1More
Flavonehsa04810Regulation of actin cytoskeleton2.58E-023Q15746, P08514, P25116MYLK, ITGA2B, F2RMore
Flavonehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Flavonehsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Flavonehsa04912GnRH signaling pathway7.82E-045P17252, Q08828, P51828, P18848, P0DP23PRKCA, ADCY1, ADCY7, ATF4, CALM1More
Flavonehsa04914Progesterone-mediated oocyte maturation4.64E-059Q17RY0, P42338, Q13370, Q9UJX4, Q9Y6D9, P30304, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, ANAPC5, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1More
Flavonehsa04915Estrogen signaling pathway2.83E-039P14780, P22694, P18848, Q08828, P51828, P31751, Q14643, P0DP23, P10415MMP9, PRKACB, ATF4, ADCY1, ADCY7, AKT2, ITPR1, CALM1, BCL2More
Flavonehsa04916Melanogenesis2.89E-045P0DP23, Q9UJU2, Q08828, P51828, P17252CALM1, LEF1, ADCY1, ADCY7, PRKCAMore
Flavonehsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Flavonehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Flavonehsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Flavonehsa04921Oxytocin signaling pathway2.19E-023Q15746, P0DP23, P17252MYLK, CALM1, PRKCAMore
Flavonehsa04923Regulation of lipolysis in adipocytes2.89E-046Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Flavonehsa04925Aldosterone synthesis and secretion1.31E-046P18848, Q08828, P51828, P0DP23, P17252, P23634ATF4, ADCY1, ADCY7, CALM1, PRKCA, ATP2B4More
Flavonehsa04926Relaxin signaling pathway1.29E-0411P31751, P25963, P42338, P62873, P50151, P18848, P49767, Q08828, P51828, P17252, P49407AKT2, NFKBIA, PIK3CB, GNB1, GNG10, ATF4, VEGFC, ADCY1, ADCY7, PRKCA, ARRB1More
Flavonehsa04927Cortisol synthesis and secretion5.17E-045Q14643, P18848, Q08828, P51828, P22694ITPR1, ATF4, ADCY1, ADCY7, PRKACBMore
Flavonehsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Flavonehsa04929GnRH secretion1.77E-022P42338, P49407PIK3CB, ARRB1More
Flavonehsa04930Type II diabetes mellitus4.78E-021P19367HK1More
Flavonehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Flavonehsa04932Non-alcoholic fatty liver disease1.04E-025P31751, P18848, O75460, P01584, O95298AKT2, ATF4, ERN1, IL1B, NDUFC2More
Flavonehsa04933AGE-RAGE signaling pathway in diabetic complications2.76E-037P84022, Q13485, P42224, P42338, P49767, P17252, P19174SMAD3, SMAD4, STAT1, PIK3CB, VEGFC, PRKCA, PLCG1More
Flavonehsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Flavonehsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Flavonehsa04961Endocrine and other factor-regulated calcium reabsorption1.40E-022P23634, P17252ATP2B4, PRKCAMore
Flavonehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Flavonehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Flavonehsa04970Salivary secretion6.07E-058Q08828, P51828, P22694, Q14643, P23634, P17252, P0DP23, P49913ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM1, CAMPMore
Flavonehsa04971Gastric acid secretion4.16E-056Q08828, P51828, P17252, P15311, P0DP23, Q15746ADCY1, ADCY7, PRKCA, VIL2, CALM1, MYLKMore
Flavonehsa04972Pancreatic secretion1.40E-022P23634, P17252ATP2B4, PRKCAMore
Flavonehsa04973Carbohydrate digestion and absorption5.20E-033O43451, P19367, P42338MGAM, HK1, PIK3CBMore
Flavonehsa04976Bile secretion1.15E-046O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Flavonehsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Flavonehsa05016Huntington disease2.24E-027O95298, P24928, P30876, P62487, P05141, O75460, P28070NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Flavonehsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Flavonehsa05020Prion disease3.28E-022Q92736, O60282RYR2, KIF5CMore
Flavonehsa05022Pathways of neurodegeneration - multiple diseases1.59E-0316O15399, Q13509, P68371, P10415, O95298, Q8TEV9, O75460, P18848, Q13561, P05141, P07384, Q00535, P04628, P01584, P0DP23, P28070GRIN2D, TUBB3, TUBB2C, BCL2, NDUFC2, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, CAPN1, CDK5, WNT1, IL1B, CALM1, PSMB4More
Flavonehsa05032Morphine addiction4.62E-046P62873, P63218, P50151, Q13370, P17252, P43250GNB1, GNG5, GNG10, PDE3B, PRKCA, GRK6More
Flavonehsa05034Alcoholism1.73E-0613O15399, P07101, Q16566, P0DP23, P62873, P63218, P50151, Q93077, P62807, P33778, Q93079, O60814, P68431GRIN2D, TH, CAMK4, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC3, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Flavonehsa05110Vibrio cholerae infection3.15E-023Q13488, P17252, P19174TCIRG1, PRKCA, PLCG1More
Flavonehsa05120Epithelial cell signaling in Helicobacter pylori infection2.39E-056Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Flavonehsa05130Pathogenic Escherichia coli infection7.39E-034Q14247, P56750, O00501, P25116CTTN, CLDN17, CLDN5, F2RMore
Flavonehsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Flavonehsa05132Salmonella infection2.16E-0417P51617, P25963, P01375, Q9UJU2, P63261, O00471, Q13546, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371IRAK1, NFKBIA, TNF, LEF1, ACTG1, EXOC5, RIPK1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Flavonehsa05133Pertussis1.17E-054P0DP23, P09871, P0C0L4, Q02556CALM1, C1S, C4A, IRF8More
Flavonehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Flavonehsa05135Yersinia infection1.67E-037Q05397, P51812, Q02750, P42338, P49841, Q96JJ3, P01730PTK2, RPS6KA3, MAP2K1, PIK3CB, GSK3B, ELMO2, CD4More
Flavonehsa05140Leishmaniasis1.34E-0410O75015, P14598, P13765, O60603, P25963, P01375, P49006, Q16539, P51617, Q15080FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, MAPK14, IRAK1, NCF4More
Flavonehsa05143African trypanosomiasis1.93E-042P69905, P68871HBA2, HBBMore
Flavonehsa05144Malaria2.98E-036P69905, P68871, O60603, P01375, P35443, P26718HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Flavonehsa05145Toxoplasmosis2.98E-0311P51617, P25963, P01375, P10415, Q13489, P42224, P13765, P09917, Q13751, P11142, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, ALOX5, LAMB3, HSPA8, TLR2More
Flavonehsa05146Amoebiasis1.04E-1012P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Flavonehsa05152Tuberculosis3.31E-0311Q13488, Q15075, P48382, O60603, P01375, P10415, P13765, Q13651, P49913, Q9UDY8, P51617TCIRG1, EEA1, RFX5, TLR2, TNF, BCL2, HLA-DOB, IL10RA, CAMP, MALT1, IRAK1More
Flavonehsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Flavonehsa05163Human cytomegalovirus infection2.00E-0925P31751, P42338, P01375, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568AKT2, PIK3CB, TNF, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21More
Flavonehsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Flavonehsa05166Human T-cell leukemia virus 1 infection2.98E-0312P23458, P01106, P05141, P62826, Q08828, P51828, P18848, P09693, P31751, Q09472, P42773, P01730JAK1, MYC, SLC25A5, RAN, ADCY1, ADCY7, ATF4, CD3G, AKT2, EP300, CDKN2C, CD4More
Flavonehsa05167Kaposi sarcoma-associated herpesvirus infection1.81E-0515P01568, P42224, P25963, P42338, P40189, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P0DP23, P0CG47IFNA21, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, CALM1, UBBMore
Flavonehsa05168Herpes simplex virus 1 infection4.27E-0519Q9UKJ0, Q06124, P25963, P01568, P42224, Q07955, Q01130, P84103, Q13243, Q13489, P30101, P42338, Q13398, Q9NR11, Q03923, O75820, Q9NZL3, Q9UDV6, P10415PILRB, PTPN11, NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF302, ZNF85, ZNF189, ZNF224, ZNF212, BCL2More
Flavonehsa05169Epstein-Barr virus infection1.57E-0412P20023, P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, Q14790, P07766, P09693, P20963CR2, HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CASP8, CD3E, CD3G, CD247More
Flavonehsa05170Human immunodeficiency virus 1 infection6.73E-0927P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, P01375, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P10415, Q13619, Q93034, Q9Y6Q5, P20333PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Flavonehsa05171Coronavirus disease - COVID-193.30E-027P25963, P42224, P01568, P40189, P42338, P19174, P17252NFKBIA, STAT1, IFNA21, IL6ST, PIK3CB, PLCG1, PRKCAMore
Flavonehsa05200Pathways in cancer1.51E-0831Q13751, P42338, P08238, P42224, P25963, P19174, P17252, P43246, P84022, Q13485, Q13547, P10826, P14923, P30281, Q13489, P98170, P49767, P14921, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P40189, P01042LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, RARB, JUP, CCND3, BIRC3, BIRC4, VEGFC, ETS1, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST, KNG1More
Flavonehsa05202Transcriptional misregulation in cancer5.92E-0718Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Flavonehsa05203Viral carcinogenesis1.45E-048Q14790, Q12933, P42229, Q09472, Q15283, P62807, P33778, O60814CASP8, TRAF2, STAT5A, EP300, RASA2, HIST1H2BC, H2BC3, H2BC12More
Flavonehsa05204Chemical carcinogenesis5.65E-064Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Flavonehsa05210Colorectal cancer4.67E-024P84022, Q13485, P43246, O75293SMAD3, SMAD4, MSH2, GADD45BMore
Flavonehsa05212Pancreatic cancer5.98E-058P42338, P31751, Q15311, P23458, P37173, P84022, Q13485, O75293PIK3CB, AKT2, RALBP1, JAK1, TGFBR2, SMAD3, SMAD4, GADD45BMore
Flavonehsa05213Endometrial cancer3.30E-034O15169, P01106, Q02750, P24522AXIN1, MYC, MAP2K1, GADD45AMore
Flavonehsa05214Glioma3.41E-056P0DP23, Q16566, P17252, P42338, P19174, O75293CALM1, CAMK4, PRKCA, PIK3CB, PLCG1, GADD45BMore
Flavonehsa05215Prostate cancer3.03E-023P49841, P42338, P27930GSK3B, PIK3CB, IL1R2More
Flavonehsa05216Thyroid cancer1.08E-033P01106, Q13772, P24522MYC, NCOA4, GADD45AMore
Flavonehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Flavonehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Flavonehsa05222Small cell lung cancer1.12E-0411P10826, P42338, Q13751, Q13489, P98170, P10415, P25963, Q13077, O00463, P24522, O75293RARB, PIK3CB, LAMB3, BIRC3, BIRC4, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A, GADD45BMore
Flavonehsa05223Non-small cell lung cancer4.91E-035P17252, P42338, P19174, P10826, O75293PRKCA, PIK3CB, PLCG1, RARB, GADD45BMore
Flavonehsa05224Breast cancer2.45E-035P42338, P49841, Q92837, P04637, P24522PIK3CB, GSK3B, FRAT1, TP53, GADD45AMore
Flavonehsa05225Hepatocellular carcinoma2.13E-024P42338, P49841, Q92837, P51531PIK3CB, GSK3B, FRAT1, SMARCA2More
Flavonehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Flavonehsa05231Choline metabolism in cancer3.84E-059P31751, P42338, Q9Y259, P19174, P23743, P49619, Q16760, O14986, P17252AKT2, PIK3CB, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PRKCAMore
Flavonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.10E-0711P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4More
Flavonehsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Flavonehsa05321Inflammatory bowel disease7.73E-046O60603, P01375, P13765, Q14765, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, GATA3, IL21RMore
Flavonehsa05322Systemic lupus erythematosus1.61E-0615P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, P33778, Q16778, O60814, P68431, P12814, P05455ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSBMore
Flavonehsa05332Graft-versus-host disease2.42E-055P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Flavonehsa05340Primary immunodeficiency2.89E-035P01730, P01732, P16871, P07766, P06239CD4, CD8A, IL7R, CD3E, LCKMore
Flavonehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Flavonehsa05418Fluid shear stress and atherosclerosis1.30E-069Q16539, P42338, Q14145, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, PIK3CB, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Flavone (SDC: 7.50)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
O95271TNKSPoly [ADPNoneribose] polymerase tankyraseNone1Predicted00.10170.222400.4957
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P18054ALOX12Polyunsaturated fatty acid lipoxygenase ALOX12Predicted00.00750.37030.24160.986
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P04406GAPDHGlyceraldehydeNone3Nonephosphate dehydrogenasePredicted00.45350.12230.46660.938
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
Q06609RAD51DNA repair protein RAD51 homolog 1Predicted00.10220.09540.27250.5144
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q8TCT1PHOSPHO1Phosphoethanolamine/phosphocholine phosphatasePredicted00.35580.04750.15910.432
P19367HK1HexokinaseNone1Predicted10.37230.01670.39970.6193
P49407ARRB1BetaNonearrestinNone1Predicted00.02010.00540.41110.432
Q14376GALEUDPNoneglucose 4NoneepimerasePredicted00.00460.03090.23130.2953
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
Q9GZR1SENP6SentrinNonespecific protease 6Predicted00.38440.078400.349
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P09871C1SComplement C1s subcomponentPredicted10.09720.02820.54030.6452
P33260CYP2C18Cytochrome P450 2C18Predicted10.02390.07560.15280.316
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P10588NR2F6Nuclear receptor subfamily 2 group F member 6Predicted00.39230.06800.3321
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)