PharmaCoNets of Fingolimod (SPCN: 36.86 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Fingolimodhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Fingolimodhsa00051Fructose and mannose metabolism3.92E-033P15121, P19367, P08237AKR1B1, HK1, PFKMMore
Fingolimodhsa00052Galactose metabolism3.92E-033P08237, P15121, P19367PFKM, AKR1B1, HK1More
Fingolimodhsa00564Glycerophospholipid metabolism3.56E-023P48651, Q9Y6K0, P35790PTDSS1, CEPT1, CHKAMore
Fingolimodhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Fingolimodhsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Fingolimodhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Fingolimodhsa00983Drug metabolism - other enzymes2.61E-033P04183, P32320, P05164TK1, CDA, MPOMore
Fingolimodhsa01100Metabolic pathways1.28E-0216Q9Y234, P35790, Q16772, P30041, P19367, P48426, P22557, P20839, Q9Y6K0, P15121, P08237, O95861, Q86VZ5, P48651, Q969G6, P14927LIPT1, CHKA, GSTA3, PRDX6, HK1, PIP4K2A, ALAS2, IMPDH1, CEPT1, AKR1B1, PFKM, BPNT1, SGMS1, PTDSS1, RFK, UQCRBMore
Fingolimodhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Fingolimodhsa01240Biosynthesis of cofactors4.63E-023Q969G6, P22557, Q9Y234RFK, ALAS2, LIPT1More
Fingolimodhsa01522Endocrine resistance4.74E-023P22694, P10415, Q13323PRKACB, BCL2, BIKMore
Fingolimodhsa01523Antifolate resistance4.16E-023P41440, Q92820, P01375SLC19A1, GGH, TNFMore
Fingolimodhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Fingolimodhsa03010Ribosome5.85E-048P62753, P25398, P32969, P46776, P62899, P18077, P61927, P36578RPS6, RPS12, RPL9, RPL27A, RPL31, RPL35A, RPL37, RPL4More
Fingolimodhsa03013RNA transport1.44E-0719O14980, P52298, O14893, P61326, Q15287, Q9H307, Q7Z3B4, P35658, P68104, P47813, Q14152, O15371, P11940, Q14240, Q9BZI7, P23588, Q9Y6A5, Q06787, P51114XPO1, NCBP2, GEMIN2, MAGOH, RNPS1, PNN, NUP54, NUP214, EEF1A1, EIF1AX, EIF3A, EIF3D, PABPC1, EIF4A2, UPF3B, EIF4B, TACC3, FMR1, FXR1More
Fingolimodhsa03420Nucleotide excision repair4.17E-022P49005, P15927POLD2, RPA2More
Fingolimodhsa04060Cytokine-cytokine receptor interaction2.61E-0210P27930, P08476, P25024, P25025, Q9UBD3, P47992, P01375, P09341, P18510, Q93038IL1R2, INHBA, CXCR1, CXCR2, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25More
Fingolimodhsa04061Viral protein interaction with cytokine and cytokine receptor2.39E-048P09341, P19875, P25024, P25025, P47992, Q9UBD3, P14784, P01375CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL2RB, TNFMore
Fingolimodhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Fingolimodhsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Fingolimodhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Fingolimodhsa04080Neuroactive ligand-receptor interaction2.50E-0510P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, ADRB2, ADMMore
Fingolimodhsa04120Ubiquitin mediated proteolysis1.74E-038Q14145, Q9UJX2, Q13042, Q93034, Q13191, P61088, Q15751, Q7Z6Z7KEAP1, CDC23, CDC16, CUL5, CBLB, UBE2N, HERC1, HUWE1More
Fingolimodhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Fingolimodhsa04140Autophagy - animal4.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Fingolimodhsa04141Protein processing in endoplasmic reticulum8.43E-035P18848, Q12933, Q15436, Q99941, P07900ATF4, TRAF2, SEC23A, CREBL1, HSP90AA1More
Fingolimodhsa04151PI3K-Akt signaling pathway2.73E-037P62753, P27348, P07900, Q16363, P22105, Q99941, P18848RPS6, YWHAQ, HSP90AA1, LAMA4, TNXB, CREBL1, ATF4More
Fingolimodhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Fingolimodhsa04217Necroptosis1.71E-024Q12933, P07900, P05141, Q13557TRAF2, HSP90AA1, SLC25A5, CAMK2DMore
Fingolimodhsa04270Vascular smooth muscle contraction3.82E-025P24723, Q04759, Q14643, P22694, P35318PRKCH, PRKCQ, ITPR1, PRKACB, ADMMore
Fingolimodhsa04340Hedgehog signaling pathway9.74E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Fingolimodhsa04540Gap junction2.86E-023P22694, P68371, Q14643PRKACB, TUBB2C, ITPR1More
Fingolimodhsa04610Complement and coagulation cascades3.19E-021P0C0L4C4AMore
Fingolimodhsa04612Antigen processing and presentation8.50E-048P13765, P48382, P26715, P26717, Q07444, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, TNFMore
Fingolimodhsa04613Neutrophil extracellular trap formation6.26E-0311P05164, P08246, Q9UM07, Q13547, Q16778, P20160, P08311, P49913, O75015, P21730, P21462MPO, ELA2, PADI4, HDAC1, HIST2H2BE, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1More
Fingolimodhsa04640Hematopoietic cell lineage5.96E-0412P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P09564, P13765, P01375ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNFMore
Fingolimodhsa04650Natural killer cell mediated cytotoxicity9.30E-0813P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Fingolimodhsa04657IL-17 signaling pathway4.36E-022P07900, Q12933HSP90AA1, TRAF2More
Fingolimodhsa04658Th1 and Th2 cell differentiation1.26E-0712Q04759, P07766, P20963, P09693, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Fingolimodhsa04659Th17 cell differentiation1.10E-0411Q04759, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Fingolimodhsa04660T cell receptor signaling pathway1.67E-0411P01375, Q04759, P42338, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239TNF, PRKCQ, PIK3CB, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Fingolimodhsa04668TNF signaling pathway1.85E-023Q12933, Q99941, P18848TRAF2, CREBL1, ATF4More
Fingolimodhsa04723Retrograde endocannabinoid signaling3.54E-023P62873, Q08828, O15239GNB1, ADCY1, NDUFA1More
Fingolimodhsa04725Cholinergic synapse3.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Fingolimodhsa04728Dopaminergic synapse4.10E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Fingolimodhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Fingolimodhsa04911Insulin secretion5.41E-033Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Fingolimodhsa04913Ovarian steroidogenesis2.72E-022P42330, P22694AKR1C3, PRKACBMore
Fingolimodhsa04918Thyroid hormone synthesis1.44E-023Q99941, P18848, P02768CREBL1, ATF4, ALBMore
Fingolimodhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Fingolimodhsa04924Renin secretion2.05E-043P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Fingolimodhsa04925Aldosterone synthesis and secretion1.44E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Fingolimodhsa04927Cortisol synthesis and secretion3.17E-034Q14643, Q99941, P18848, P22694ITPR1, CREBL1, ATF4, PRKACBMore
Fingolimodhsa04928Parathyroid hormone synthesis, secretion and action1.02E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Fingolimodhsa04934Cushing syndrome2.11E-047Q14643, Q99941, P18848, P22694, O15169, Q13557, P04628ITPR1, CREBL1, ATF4, PRKACB, AXIN1, CAMK2D, WNT1More
Fingolimodhsa04970Salivary secretion2.11E-023P07550, P22694, Q14643ADRB2, PRKACB, ITPR1More
Fingolimodhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Fingolimodhsa05016Huntington disease7.64E-037O15239, P12074, P05496, P24928, P62487, P05141, P43686NDUFA1, COX6A1, ATP5G1, POLR2A, POLR2G, SLC25A5, PSMC4More
Fingolimodhsa05020Prion disease1.62E-027P46531, O15239, P05496, P12074, P05141, P43686, P67870NOTCH1, NDUFA1, ATP5G1, COX6A1, SLC25A5, PSMC4, CSNK2BMore
Fingolimodhsa05022Pathways of neurodegeneration - multiple diseases4.57E-027P67870, O15239, P12074, P05496, P05141, P20333, P43686CSNK2B, NDUFA1, COX6A1, ATP5G1, SLC25A5, TNFRSF1B, PSMC4More
Fingolimodhsa05030Cocaine addiction4.36E-022Q99941, P18848CREBL1, ATF4More
Fingolimodhsa05031Amphetamine addiction5.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Fingolimodhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Fingolimodhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Fingolimodhsa05143African trypanosomiasis3.19E-022P69905, P68871HBA2, HBBMore
Fingolimodhsa05146Amoebiasis2.95E-0711P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Fingolimodhsa05150Staphylococcus aureus infection8.72E-048P21730, P21462, O75015, Q14532, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Fingolimodhsa05161Hepatitis B2.86E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Fingolimodhsa05168Herpes simplex virus 1 infection4.79E-028P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189More
Fingolimodhsa05171Coronavirus disease - COVID-193.22E-0415P23458, P62753, P25398, P39019, P42677, P62906, P36578, P32969, P30050, P46776, P62899, P18077, P61927, P61513, P05386JAK1, RPS6, RPS12, RPS19, RPS27, RPL10A, RPL4, RPL9, RPL12, RPL27A, RPL31, RPL35A, RPL37, RPL37A, RPLP1More
Fingolimodhsa05202Transcriptional misregulation in cancer2.67E-0311P14780, P27930, Q15744, Q16548, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Fingolimodhsa05203Viral carcinogenesis1.19E-024Q12933, Q99941, P18848, P27348TRAF2, CREBL1, ATF4, YWHAQMore
Fingolimodhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Fingolimodhsa05310Asthma1.04E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Fingolimodhsa05321Inflammatory bowel disease2.08E-045P01375, P13765, Q14765, Q9UL17, P23771TNF, HLA-DOB, STAT4, TBX21, GATA3More
Fingolimodhsa05322Systemic lupus erythematosus2.78E-027O75015, P08246, P08311, P01375, P13765, Q16778, P12814FCGR3B, ELA2, CTSG, TNF, HLA-DOB, HIST2H2BE, ACTN1More
Fingolimodhsa05332Graft-versus-host disease1.12E-034P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More

Community members of Fingolimod (SDC: 3.56)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9H228EDG8Sphingosine 1Nonephosphate receptor 5Reported00.09250.05520.10030.2569
Q13547HDAC1Histone deacetylase 1Reported00.044710.9863.0084
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Reported10.14340.38470.2211.0621
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13564APPBP1NEDD8Noneactivating enzyme E1 regulatory subunitPredicted00.19880.00560.15030.261
Q15843NEDD8NEDD8Predicted00.55640.005600.2895
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
EDG8Q9H228IC502100
S1PR1P21453IC50840