PharmaCoNets of Finasteride (SPCN: 55.46 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Finasteridehsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Finasteridehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Finasteridehsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Finasteridehsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Finasteridehsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Finasteridehsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Finasteridehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Finasteridehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Finasteridehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Finasteridehsa00620Pyruvate metabolism3.19E-022P40926, P14550MDH2, AKR1A1More
Finasteridehsa00670One carbon pool by folate3.15E-022O95954, Q99707FTCD, MTRMore
Finasteridehsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Finasteridehsa00830Retinol metabolism2.27E-035P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Finasteridehsa00860Porphyrin and chlorophyll metabolism8.96E-042P36551, P30043CPOX, BLVRBMore
Finasteridehsa00920Sulfur metabolism3.18E-021Q16762TSTMore
Finasteridehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-054Q16772, P78417, P09211, P11712GSTA3, GSTO1, GSTP1, CYP2C9More
Finasteridehsa00982Drug metabolism - cytochrome P4501.77E-044P11712, Q16772, P09211, P78417CYP2C9, GSTA3, GSTP1, GSTO1More
Finasteridehsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Finasteridehsa01100Metabolic pathways3.55E-0334Q9NR34, P35790, P05089, Q16772, P09211, Q9UJ14, P30041, P32320, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, P05186, P24666, P15121, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9BQB6MAN1C1, CHKA, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, CDA, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, ALPL, ACP1, AKR1B1, MCCC2, ACSL1, AMACR, SGMS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, VKORC1More
Finasteridehsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Finasteridehsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Finasteridehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Finasteridehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Finasteridehsa03013RNA transport7.74E-0915O14980, P52298, Q09161, O14893, P61326, Q9H307, Q7Z3B4, P35658, Q14152, O75822, Q14240, P23588, Q9Y6A5, Q06787, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, PNN, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, EIF4B, TACC3, FMR1, FXR1More
Finasteridehsa04015Rap1 signaling pathway4.10E-023P25116, Q8TEU7, P08514F2R, RAPGEF6, ITGA2BMore
Finasteridehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Finasteridehsa04061Viral protein interaction with cytokine and cytokine receptor1.70E-038P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Finasteridehsa04062Chemokine signaling pathway4.01E-0413P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITKMore
Finasteridehsa04064NF-kappa B signaling pathway5.60E-0819P10415, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9NQC7BCL2, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, CYLDMore
Finasteridehsa04071Sphingolipid signaling pathway1.19E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Finasteridehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Finasteridehsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Finasteridehsa04122Sulfur relay system3.18E-021Q16762TSTMore
Finasteridehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Finasteridehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Finasteridehsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Finasteridehsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Finasteridehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Finasteridehsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Finasteridehsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Finasteridehsa04512ECM-receptor interaction3.73E-022P07359, P08514GP1BA, ITGA2BMore
Finasteridehsa04514Cell adhesion molecules8.19E-033P16109, P56750, O00501SELP, CLDN17, CLDN5More
Finasteridehsa04530Tight junction2.47E-055Q8TEU7, P16989, P56750, O00501, Q14247RAPGEF6, CSDA, CLDN17, CLDN5, CTTNMore
Finasteridehsa04610Complement and coagulation cascades1.29E-043P25116, P09871, P0C0L4F2R, C1S, C4AMore
Finasteridehsa04611Platelet activation5.18E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Finasteridehsa04612Antigen processing and presentation2.20E-036P13765, P01730, P26715, P26717, Q13241, P01732HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8AMore
Finasteridehsa04613Neutrophil extracellular trap formation1.51E-0422P16109, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P08514, P21462, P07359, O43315, Q16539SELP, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Finasteridehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Finasteridehsa04625C-type lectin receptor signaling pathway8.11E-039Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Finasteridehsa04640Hematopoietic cell lineage6.03E-0615P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, IL1BMore
Finasteridehsa04650Natural killer cell mediated cytotoxicity7.89E-0713P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Finasteridehsa04657IL-17 signaling pathway2.25E-038O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Finasteridehsa04658Th1 and Th2 cell differentiation1.53E-1215Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Finasteridehsa04659Th17 cell differentiation1.01E-0915Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1More
Finasteridehsa04660T cell receptor signaling pathway4.20E-0817P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Finasteridehsa04750Inflammatory mediator regulation of TRP channels3.14E-0411P14778, P01584, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2More
Finasteridehsa04810Regulation of actin cytoskeleton2.58E-023Q15746, P08514, P25116MYLK, ITGA2B, F2RMore
Finasteridehsa04912GnRH signaling pathway4.33E-026P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Finasteridehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Finasteridehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Finasteridehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Finasteridehsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Finasteridehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Finasteridehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Finasteridehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Finasteridehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Finasteridehsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Finasteridehsa05130Pathogenic Escherichia coli infection7.39E-034Q14247, P56750, O00501, P25116CTTN, CLDN17, CLDN5, F2RMore
Finasteridehsa05133Pertussis1.35E-044P10145, P09871, P0C0L4, Q02556IL8, C1S, C4A, IRF8More
Finasteridehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Finasteridehsa05140Leishmaniasis1.93E-0310P13612, O75015, P23458, P13765, O60603, P01375, P01584, P49006, Q16539, Q15080ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MARCKSL1, MAPK14, NCF4More
Finasteridehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Finasteridehsa05144Malaria3.81E-038P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Finasteridehsa05146Amoebiasis7.88E-0713P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Finasteridehsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Finasteridehsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Finasteridehsa05202Transcriptional misregulation in cancer8.91E-0418Q12778, Q13315, P17844, P14780, P27930, Q16548, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, ATM, DDX5, MMP9, IL1R2, BCL2A1, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Finasteridehsa05203Viral carcinogenesis6.22E-035Q12933, P42229, Q15283, P62807, O60814TRAF2, STAT5A, RASA2, HIST1H2BC, H2BC12More
Finasteridehsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Finasteridehsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Finasteridehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Finasteridehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Finasteridehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.65E-0713P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, P10747, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, CD28, PRKCQ, MAPK14, CD4More
Finasteridehsa05321Inflammatory bowel disease8.20E-057O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Finasteridehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Finasteridehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Finasteridehsa05332Graft-versus-host disease3.63E-044P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Finasteridehsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Finasteridehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Finasteridehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Finasteride (SDC: 5.37)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P18054ALOX12Polyunsaturated fatty acid lipoxygenase ALOX12Predicted00.00750.37030.24160.986
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P14550AKR1A1AldoNoneketo reductase family 1 member A1Predicted10.30560.06210.17370.4508
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)