PharmaCoNets of Finafloxacin (SPCN: 15.78 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Finafloxacinhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Finafloxacinhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Finafloxacinhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Finafloxacinhsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Finafloxacinhsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Finafloxacinhsa01100Metabolic pathways2.25E-027Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGLMore
Finafloxacinhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Finafloxacinhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Finafloxacinhsa03040Spliceosome4.19E-025Q14562, O60508, P08579, Q01130, O43447DHX8, CDC40, SNRPB2, SFRS2, PPIHMore
Finafloxacinhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Finafloxacinhsa04064NF-kappa B signaling pathway1.60E-028P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Finafloxacinhsa04071Sphingolipid signaling pathway2.96E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Finafloxacinhsa04080Neuroactive ligand-receptor interaction3.22E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1More
Finafloxacinhsa04110Cell cycle3.57E-023Q9UBD5, P06493, P33981ORC3, CDK1, TTKMore
Finafloxacinhsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Finafloxacinhsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Finafloxacinhsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Finafloxacinhsa04612Antigen processing and presentation3.21E-026P13765, P48382, P26715, P26717, Q13241, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8AMore
Finafloxacinhsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Finafloxacinhsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Finafloxacinhsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Finafloxacinhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Finafloxacinhsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Finafloxacinhsa04725Cholinergic synapse5.17E-037P22694, Q14643, P63218, P50151, P18848, P42338, P10415PRKACB, ITPR1, GNG5, GNG10, ATF4, PIK3CB, BCL2More
Finafloxacinhsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Finafloxacinhsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Finafloxacinhsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Finafloxacinhsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P49407PIK3CB, GNG5, GNG10, VEGFC, ARRB1More
Finafloxacinhsa04927Cortisol synthesis and secretion8.60E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Finafloxacinhsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Finafloxacinhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Finafloxacinhsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Finafloxacinhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Finafloxacinhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Finafloxacinhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Finafloxacinhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Finafloxacinhsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Finafloxacinhsa05202Transcriptional misregulation in cancer1.77E-0211Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Finafloxacinhsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore
Finafloxacinhsa05321Inflammatory bowel disease2.29E-024P13765, Q14765, P23771, Q9HBE5HLA-DOB, STAT4, GATA3, IL21RMore
Finafloxacinhsa05332Graft-versus-host disease7.89E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Finafloxacinhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Finafloxacin (SDC: 3.60)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11388TOP2ADNA topoisomerase 2NonealphaReported00.19920.46590.19271.2242
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)