PharmaCoNets of Fexofenadine (SPCN: 29.00 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Fexofenadinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Fexofenadinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Fexofenadinehsa00190Oxidative phosphorylation3.56E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Fexofenadinehsa00220Arginine biosynthesis1.97E-022P15104, P49448GLUL, GLUD2More
Fexofenadinehsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Fexofenadinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Fexofenadinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Fexofenadinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Fexofenadinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Fexofenadinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Fexofenadinehsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Fexofenadinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Fexofenadinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Fexofenadinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Fexofenadinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Fexofenadinehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Fexofenadinehsa03013RNA transport4.61E-0310P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Fexofenadinehsa03050Proteasome3.93E-021P62195PSMC5More
Fexofenadinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Fexofenadinehsa04071Sphingolipid signaling pathway1.53E-037Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Fexofenadinehsa04145Phagosome1.66E-039Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Fexofenadinehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Fexofenadinehsa04151PI3K-Akt signaling pathway3.96E-028P43657, P09603, Q9GZP0, P63218, P50151, P13612, O15335, Q13751P2RY5, CSF1, PDGFD, GNG5, GNG10, ITGA4, CHAD, LAMB3More
Fexofenadinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Fexofenadinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Fexofenadinehsa04512ECM-receptor interaction4.41E-023Q13751, P13612, O15335LAMB3, ITGA4, CHADMore
Fexofenadinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Fexofenadinehsa04610Complement and coagulation cascades6.23E-061P0C0L4C4AMore
Fexofenadinehsa04613Neutrophil extracellular trap formation6.68E-0417O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Fexofenadinehsa04657IL-17 signaling pathway6.64E-037O00463, Q16539, P49841, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, MMP9, ANAPC5, LCN2, TNFMore
Fexofenadinehsa04666Fc gamma R-mediated phagocytosis2.42E-025P23528, P06396, O14494, P14598, P17252CFL1, GSN, PLPP1, NCF1, PRKCAMore
Fexofenadinehsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Fexofenadinehsa04724Glutamatergic synapse9.51E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Fexofenadinehsa04727GABAergic synapse2.33E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Fexofenadinehsa04730Long-term depression3.72E-022Q14344, P07948GNA13, LYNMore
Fexofenadinehsa04744Phototransduction2.80E-022P62873, P0DP23GNB1, CALM1More
Fexofenadinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Fexofenadinehsa04916Melanogenesis4.80E-024P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Fexofenadinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Fexofenadinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Fexofenadinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Fexofenadinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Fexofenadinehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Fexofenadinehsa05010Alzheimer disease2.27E-028O15399, Q9NZJ5, Q13564, Q71U36, P09603, P21796, P17861, P62195GRIN2D, EIF2AK3, APPBP1, TUBA1A, CSF1, VDAC1, XBP1, PSMC5More
Fexofenadinehsa05012Parkinson disease7.44E-032P17861, P62195XBP1, PSMC5More
Fexofenadinehsa05014Amyotrophic lateral sclerosis2.32E-043P17861, P62195, Q53GS7XBP1, PSMC5, GLE1More
Fexofenadinehsa05017Spinocerebellar ataxia1.95E-032P17861, P62195XBP1, PSMC5More
Fexofenadinehsa05022Pathways of neurodegeneration - multiple diseases1.63E-022P17861, P62195XBP1, PSMC5More
Fexofenadinehsa05032Morphine addiction1.34E-024P63218, P50151, Q07343, P43250GNG5, GNG10, PDE4B, GRK6More
Fexofenadinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Fexofenadinehsa05132Salmonella infection2.93E-0210P51617, Q9UJU2, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, LEF1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Fexofenadinehsa05133Pertussis4.24E-031P0C0L4C4AMore
Fexofenadinehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Fexofenadinehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Fexofenadinehsa05152Tuberculosis5.68E-039Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Fexofenadinehsa05170Human immunodeficiency virus 1 infection5.94E-0312P62873, P0DP23, P17252, O00463, Q14643, P01568, P51617, O60603, P23528, P10415, Q93034, Q9Y6Q5GNB1, CALM1, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, BCL2, CUL5, AP1M2More
Fexofenadinehsa05202Transcriptional misregulation in cancer1.69E-0315Q12778, Q15532, P41732, P14780, P27930, P14923, Q16548, Q13489, Q13077, O15550, P35226, P05164, P08246, Q9C0K0, P24522FOXO1, SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, ELA2, BCL11B, GADD45AMore
Fexofenadinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Fexofenadinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Fexofenadinehsa05205Proteoglycans in cancer1.09E-0210Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63More
Fexofenadinehsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Fexofenadinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Fexofenadinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Fexofenadine (SDC: 4.21)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P17861XBP1XNoneboxNonebinding protein 1Predicted00.29140.06510.46080.7367
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)