PharmaCoNets of Ferric-maltol (SPCN: 2.10 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ferric-maltolhsa00030Pentose phosphate pathway2.40E-022P60891, P37837PRPS1, TALDO1More
Ferric-maltolhsa00440Phosphonate and phosphinate metabolism2.16E-021Q9Y6K0CEPT1More
Ferric-maltolhsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate3.68E-021Q9Y2C2USTMore
Ferric-maltolhsa00564Glycerophospholipid metabolism2.52E-023P48651, Q9Y6K0, Q86XP1PTDSS1, CEPT1, DGKHMore
Ferric-maltolhsa00565Ether lipid metabolism4.27E-021Q9Y6K0CEPT1More
Ferric-maltolhsa00591Linoleic acid metabolism3.68E-021P11712CYP2C9More
Ferric-maltolhsa00740Riboflavin metabolism2.16E-021Q969G6RFKMore
Ferric-maltolhsa00785Lipoic acid metabolism4.27E-021Q9Y234LIPT1More
Ferric-maltolhsa00790Folate biosynthesis4.50E-022P05186, P42330ALPL, AKR1C3More
Ferric-maltolhsa00983Drug metabolism - other enzymes3.10E-022P20839, Q16772IMPDH1, GSTA3More
Ferric-maltolhsa01100Metabolic pathways2.79E-0214Q9Y234, Q16772, Q02153, P20839, O94777, Q9Y6K0, Q86XP1, Q9UHK6, Q86VZ5, P48651, Q969G6, P14927, Q06055, Q9NVH6LIPT1, GSTA3, GUCY1B3, IMPDH1, DPM2, CEPT1, DGKH, AMACR, SGMS1, PTDSS1, RFK, UQCRB, ATP5G2, TMLHEMore
Ferric-maltolhsa01240Biosynthesis of cofactors1.75E-022Q969G6, Q9Y234RFK, LIPT1More
Ferric-maltolhsa03010Ribosome7.52E-032P46777, Q9UHA3RPL5, RSL24D1More
Ferric-maltolhsa03050Proteasome3.68E-021P55036PSMD4More
Ferric-maltolhsa03420Nucleotide excision repair4.91E-022P07992, P54727ERCC1, RAD23BMore
Ferric-maltolhsa04140Autophagy - animal1.90E-024Q9Y4H2, Q96RR4, Q14643, Q04759IRS2, CAMKK2, ITPR1, PRKCQMore
Ferric-maltolhsa04330Notch signaling pathway4.91E-022P49768, P78504PSEN1, JAG1More
Ferric-maltolhsa04520Adherens junction4.91E-022P07947, P19784YES1, CSNK2A2More
Ferric-maltolhsa04612Antigen processing and presentation5.31E-036P13765, P23511, P26715, P26717, Q13241, P01732HLA-DOB, NFYA, KLRC1, KLRC2, KLRD1, CD8AMore
Ferric-maltolhsa04622RIG-I-like receptor signaling pathway1.63E-022Q12933, P10145TRAF2, IL8More
Ferric-maltolhsa04650Natural killer cell mediated cytotoxicity3.24E-037P78314, O60880, P20963, Q13241, P26718, P26717, P26715SH3BP2, SH2D1A, CD247, KLRD1, KLRK1, KLRC2, KLRC1More
Ferric-maltolhsa04658Th1 and Th2 cell differentiation1.53E-025Q04759, P20963, P09693, Q9UL17, P13765PRKCQ, CD247, CD3G, TBX21, HLA-DOBMore
Ferric-maltolhsa04659Th17 cell differentiation3.74E-025Q04759, P13765, Q9UL17, P09693, P20963PRKCQ, HLA-DOB, TBX21, CD3G, CD247More
Ferric-maltolhsa04660T cell receptor signaling pathway4.23E-037Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLBMore
Ferric-maltolhsa04910Insulin signaling pathway4.23E-024Q14642, P06737, Q13191, Q9Y4H2INPP5A, PYGL, CBLB, IRS2More
Ferric-maltolhsa04920Adipocytokine signaling pathway3.05E-023Q04759, Q96RR4, Q9Y4H2PRKCQ, CAMKK2, IRS2More
Ferric-maltolhsa05144Malaria1.36E-036P68871, O60603, P05107, P35443, P10145, P26718HBB, TLR2, ITGB2, THBS4, IL8, KLRK1More
Ferric-maltolhsa05203Viral carcinogenesis3.52E-023Q15283, P62807, P33778RASA2, HIST1H2BC, H2BC3More
Ferric-maltolhsa05217Basal cell carcinoma3.05E-023Q13635, Q9UJU2, P24522PTCH1, LEF1, GADD45AMore
Ferric-maltolhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.53E-025O95267, P20963, P09693, O60603, Q04759RASGRP1, CD247, CD3G, TLR2, PRKCQMore
Ferric-maltolhsa05321Inflammatory bowel disease4.28E-023O60603, P13765, Q9UL17TLR2, HLA-DOB, TBX21More
Ferric-maltolhsa05322Systemic lupus erythematosus4.32E-022P62807, P33778HIST1H2BC, H2BC3More
Ferric-maltolhsa05332Graft-versus-host disease2.04E-023P13765, P26715, Q13241HLA-DOB, KLRC1, KLRD1More

Community members of Ferric-maltol (SDC: 0.67)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)