PharmaCoNets

PharmaCoNets of Fenofibrate (S_PCN: 67.83 )

Fenofibrate regulated-network (S_DN: 14.28)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Fenofibrate

hsa00040

Pentose and glucuronate interconversions

3.53E-02

Q9UEF7

Fenofibrate

hsa00220

Arginine biosynthesis

1.54E-02

P05089, P49448

ARG1, GLUD2

Fenofibrate

hsa00480

Glutathione metabolism

3.29E-04

Q9UJ14, Q16772, P09211, P30041

GGTL3, GSTA3, GSTP1, PRDX6

Fenofibrate

hsa00515

Mannose type O-glycan biosynthesis

1.78E-02

O75072

FCMD

Fenofibrate

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Fenofibrate

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Fenofibrate

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Fenofibrate

hsa00910

Nitrogen metabolism

2.93E-02

P22748, P49448

CA4, GLUD2

Fenofibrate

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Fenofibrate

hsa00982

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Fenofibrate

hsa00983

Drug metabolism - other enzymes

1.75E-04

P04183, P32320, P05164, Q16772, P09211

TK1, CDA, MPO, GSTA3, GSTP1

Fenofibrate

hsa01100

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Fenofibrate

hsa01522

Endocrine resistance

4.55E-02

P14780, P22694, Q9UM47, P10415, Q13323

MMP9, PRKACB, NOTCH3, BCL2, BIK

Fenofibrate

hsa01524

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Fenofibrate

hsa03008

Ribosome biogenesis in eukaryotes

1.46E-02

Q9NYH9, P78345, Q9BVP2, Q9GZY0

UTP6, RPP38, GNL3, NXF2; NXF2B

Fenofibrate

hsa03013

RNA transport

6.07E-06

P52298, Q09161, O14893, P61326, P38919, Q15287, Q9UBU9, Q9GZY0, P37198, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q9Y6A5, Q53GS7

NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, RNPS1, NXF1, NXF2; NXF2B, NUP62, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, TACC3, GLE1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.915
P08246	ELA2	Neutrophil elastase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.852
P08246	ELA2	Neutrophil elastase	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.732
P08246	ELA2	Neutrophil elastase	O14893	GEMIN2	Gem-associated protein 2	-0.785
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P61326	MAGOH	Protein mago nashi homolog	0.764
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.746
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P08246	ELA2	Neutrophil elastase	Q7Z3B4	NUP54	Nucleoporin p54	-0.723
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P08246	ELA2	Neutrophil elastase	P35658	NUP214	Nuclear pore complex protein Nup214	0.765
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.707
P08246	ELA2	Neutrophil elastase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.722
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.788
P08246	ELA2	Neutrophil elastase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.825
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P78345	RPP38	Ribonuclease P protein subunit p38	0.869
P08246	ELA2	Neutrophil elastase	P78345	RPP38	Ribonuclease P protein subunit p38	-0.795
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.815
P08246	ELA2	Neutrophil elastase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.849
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q53GS7	GLE1	mRNA export factor GLE1	-0.723

Fenofibrate

hsa03015

mRNA surveillance pathway

9.78E-03

O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7

RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1

Fenofibrate

hsa03040

Spliceosome

3.98E-02

Q15427, P38159, P61978, P11142

SF3B4, RBMX, HNRPK, HSPA8

Fenofibrate

hsa03050

Proteasome

1.21E-02

P28074

PSMB5

Fenofibrate

hsa03060

Protein export

1.43E-02

P37108, Q15005

SRP14, SPCS2

Fenofibrate

hsa03450

Non-homologous end-joining

1.78E-02

Q9NP87

POLM

Fenofibrate

hsa04012

ErbB signaling pathway

3.74E-02

P21860, Q13557, O14944

ERBB3, CAMK2D, EREG

Fenofibrate

hsa04020

Calcium signaling pathway

6.50E-04

Q96DU7, P45880, Q13557, P21860, P51828, P23634

ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4

Fenofibrate

hsa04022

cGMP-PKG signaling pathway

4.72E-02

Q99941, P23634, P51828, P45880

CREBL1, ATP2B4, ADCY7, VDAC2

Fenofibrate

hsa04060

Cytokine-cytokine receptor interaction

5.39E-03

P27930, P08476, Q13651, Q9HBE5, Q9UBD3, P47992, P01375, P09341, P18510, Q93038

IL1R2, INHBA, IL10RA, IL21R, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25

Fenofibrate

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.81E-03

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNF

Fenofibrate

hsa04062

Chemokine signaling pathway

1.83E-02

P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151

CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10

Fenofibrate

hsa04064

NF-kappa B signaling pathway

1.31E-08

P10415, Q13489, P25963, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08311	CTSG	Cathepsin G	O00463	TRAF5	TNF receptor-associated factor 5	-0.853
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74

Fenofibrate

hsa04071

Sphingolipid signaling pathway

1.97E-05

P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2

Fenofibrate

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Fenofibrate

hsa04080

Neuroactive ligand-receptor interaction

1.11E-03

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Fenofibrate

hsa04114

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Fenofibrate

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Fenofibrate

hsa04140

Autophagy - animal

4.55E-02

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Fenofibrate

hsa04141

Protein processing in endoplasmic reticulum

2.79E-03

P30101, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900

PDIA3, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1

Fenofibrate

hsa04145

Phagosome

2.47E-06

O75015, P63261, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

FCGR3B, ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P35443	THBS4	Thrombospondin-4	-0.744
P08246	ELA2	Neutrophil elastase	P35443	THBS4	Thrombospondin-4	0.871
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797

Fenofibrate

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Fenofibrate

hsa04210

Apoptosis

1.52E-02

Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643

ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1

Fenofibrate

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Fenofibrate

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Fenofibrate

hsa04260

Cardiac muscle contraction

3.80E-02

P09493, P14927

TPM1, UQCRB

Fenofibrate

hsa04261

Adrenergic signaling in cardiomyocytes

3.98E-02

P51828, Q99941, Q13557, P23634

ADCY7, CREBL1, CAMK2D, ATP2B4

Fenofibrate

hsa04330

Notch signaling pathway

2.46E-03

Q92542, P49768, P46531

NCSTN, PSEN1, NOTCH1

Fenofibrate

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Fenofibrate

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Fenofibrate

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Fenofibrate

hsa04540

Gap junction

3.53E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Fenofibrate

hsa04612

Antigen processing and presentation

9.89E-03

P13765, P48382, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Fenofibrate

hsa04613

Neutrophil extracellular trap formation

2.51E-07

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, P63261

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, ACTG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.771
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.859
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P21462	FPR1	fMet-Leu-Phe receptor	-0.723
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719

Fenofibrate

hsa04621

NOD-like receptor signaling pathway

3.10E-03

Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838

ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4

Fenofibrate

hsa04640

Hematopoietic cell lineage

2.01E-03

P14778, P27930, P11215, P25063, P07766, P09693, P01732, P09564, P13765, P01375

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF

Fenofibrate

hsa04650

Natural killer cell mediated cytotoxicity

1.57E-06

P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC1

Fenofibrate

hsa04657

IL-17 signaling pathway

2.29E-02

O00463, P09341, P14780, P80188, P01375

TRAF5, CXCL1, MMP9, LCN2, TNF

Fenofibrate

hsa04658

Th1 and Th2 cell differentiation

1.40E-06

Q04759, P07766, P20963, P09693, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Fenofibrate

hsa04659

Th17 cell differentiation

2.02E-06

P25963, Q04759, P19174, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P07766, P09693, P20963

NFKBIA, PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, CD3E, CD3G, CD247

Fenofibrate

hsa04660

T cell receptor signaling pathway

6.70E-06

P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239

TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
P08311	CTSG	Cathepsin G	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816

Fenofibrate

hsa04666

Fc gamma R-mediated phagocytosis

8.54E-04

O75015, P23528, P49006, P06396, O14494, P14598, P17252

FCGR3B, CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCA

Fenofibrate

hsa04668

TNF signaling pathway

3.42E-03

P01375, O00463, Q13489, P25963, Q99941, P01584, P20749, Q13077, P14780, O95429

TNF, TRAF5, BIRC3, NFKBIA, CREBL1, IL1B, BCL3, TRAF1, MMP9, BAG4

Fenofibrate

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Fenofibrate

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Fenofibrate

hsa04720

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Fenofibrate

hsa04750

Inflammatory mediator regulation of TRP channels

7.62E-04

P14778, P01584, P51828, Q13557, P19174, P42338, P24723, Q04759

IL1R1, IL1B, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ

Fenofibrate

hsa04911

Insulin secretion

1.48E-02

P51828, Q99941, Q13557

ADCY7, CREBL1, CAMK2D

Fenofibrate

hsa04914

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Fenofibrate

hsa04915

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Fenofibrate

hsa04920

Adipocytokine signaling pathway

5.84E-03

P25963, P33121, Q9Y478, Q04759, Q96RR4, P01375

NFKBIA, ACSL1, PRKAB1, PRKCQ, CAMKK2, TNF

Fenofibrate

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Fenofibrate

hsa04925

Aldosterone synthesis and secretion

5.19E-03

Q99941, P51828, Q13557, P23634

CREBL1, ADCY7, CAMK2D, ATP2B4

Fenofibrate

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Fenofibrate

hsa04934

Cushing syndrome

3.48E-03

Q99941, P51828, O15169, Q13557

CREBL1, ADCY7, AXIN1, CAMK2D

Fenofibrate

hsa04940

Type I diabetes mellitus

4.18E-02

P10747, P13765, P01375

CD28, HLA-DOB, TNF

Fenofibrate

hsa04964

Proximal tubule bicarbonate reclamation

2.93E-02

P22748, P49448

CA4, GLUD2

Fenofibrate

hsa04970

Salivary secretion

4.49E-02

P22694, Q14643, P17252, P49913

PRKACB, ITPR1, PRKCA, CAMP

Fenofibrate

hsa04971

Gastric acid secretion

1.48E-02

P51828, P15311, Q13557

ADCY7, VIL2, CAMK2D

Fenofibrate

hsa04972

Pancreatic secretion

1.99E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Fenofibrate

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Fenofibrate

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Fenofibrate

hsa05010

Alzheimer disease

2.07E-02

Q92542, P05496, P12074, O75460, P01584, O15169, P45880

NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2

Fenofibrate

hsa05017

Spinocerebellar ataxia

2.43E-02

P28074

PSMB5

Fenofibrate

hsa05020

Prion disease

1.81E-02

P01584, P46531, P11142, P05496, P12074, P45880, Q99941

IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1

Fenofibrate

hsa05022

Pathways of neurodegeneration - multiple diseases

3.00E-02

O60282, P12036, P60604

KIF5C, NEFH, UBE2G2

Fenofibrate

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Fenofibrate

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P25025

CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Fenofibrate

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Fenofibrate

hsa05132

Salmonella infection

2.51E-04

P51617, P25963, P01375, Q9UJU2, P63261, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P68371

IRAK1, NFKBIA, TNF, LEF1, ACTG1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.787
P08246	ELA2	Neutrophil elastase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.771
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.724
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.737
P08246	ELA2	Neutrophil elastase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	-0.949
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13561	DCTN2	Dynactin subunit 2	-0.862
P08246	ELA2	Neutrophil elastase	Q13561	DCTN2	Dynactin subunit 2	0.78
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726

Fenofibrate

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Fenofibrate

hsa05140

Leishmaniasis

4.80E-05

O75015, P14598, P13765, O60603, P25963, P01375, P49006, P51617, Q15080

FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, IRAK1, NCF4

Fenofibrate

hsa05143

African trypanosomiasis

1.63E-02

P69905, P68871

HBA2, HBB

Fenofibrate

hsa05145

Toxoplasmosis

4.06E-03

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Fenofibrate

hsa05146

Amoebiasis

1.01E-05

P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Fenofibrate

hsa05150

Staphylococcus aureus infection

1.65E-02

P21730, P21462, O75015, P13765, Q16581, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMP

Fenofibrate

hsa05152

Tuberculosis

8.50E-04

Q13488, O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

TCIRG1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Fenofibrate

hsa05161

Hepatitis B

1.61E-03

P17252, P14780, P25963, Q13485, P01375, P10415, P84022, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, SMAD4, TNF, BCL2, SMAD3, IRAK1, TLR2, STAT4

Fenofibrate

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Fenofibrate

hsa05170

Human immunodeficiency virus 1 infection

2.58E-05

Q02750, P62879, P16298, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333

MAP2K1, GNB2, PPP3CB, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1B

Fenofibrate

hsa05202

Transcriptional misregulation in cancer

6.89E-09

Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q12778	FOXO1	Forkhead box protein O1	0.714
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15532	SS18	Protein SSXT	0.893
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P41732	TSPAN7	Tetraspanin-7	-0.834
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P08311	CTSG	Cathepsin G	P14780	MMP9	Matrix metalloproteinase-9	0.79
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14923	JUP	Junction plakoglobin	0.914
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
P08311	CTSG	Cathepsin G	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.909
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O15550	UTX	Lysine-specific demethylase 6A	-0.808
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P08311	CTSG	Cathepsin G	P05164	MPO	Myeloperoxidase	0.956
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P08311	CTSG	Cathepsin G	P12838	DEFA4	Neutrophil defensin 4	0.817
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
P08311	CTSG	Cathepsin G	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.853
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.768
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766

Fenofibrate

hsa05203

Viral carcinogenesis

6.22E-03

Q12933, P42229, Q15283, P62807, O60814

TRAF2, STAT5A, RASA2, HIST1H2BC, H2BC12

Fenofibrate

hsa05204

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Fenofibrate

hsa05205

Proteoglycans in cancer

2.66E-02

Q14643, P63261, P04637, P14780, P17252, O60603, Q13635, P08962

ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63

Fenofibrate

hsa05206

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Fenofibrate

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Fenofibrate

hsa05212

Pancreatic cancer

3.52E-02

P84022, Q13485

SMAD3, SMAD4

Fenofibrate

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Fenofibrate

hsa05216

Thyroid cancer

3.59E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Fenofibrate

hsa05217

Basal cell carcinoma

1.46E-02

Q13635, Q9UJU2, P04637, P24522

PTCH1, LEF1, TP53, GADD45A

Fenofibrate

hsa05220

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Fenofibrate

hsa05222

Small cell lung cancer

2.38E-03

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Fenofibrate

hsa05226

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Fenofibrate

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.13E-03

P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ

Fenofibrate

hsa05310

Asthma

2.50E-04

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Fenofibrate

hsa05321

Inflammatory bowel disease

2.94E-06

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Fenofibrate

hsa05322

Systemic lupus erythematosus

3.66E-06

O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P08311	CTSG	Cathepsin G	P08311	CTSG	Cathepsin G	1
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P08311	CTSG	Cathepsin G	Q16778	HIST2H2BE	Histone H2B type 2-E	0.786
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08311	CTSG	Cathepsin G	P12814	ACTN1	Alpha-actinin-1	0.708
P08246	ELA2	Neutrophil elastase	P05455	SSB	Lupus La protein	-0.717
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725