| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Febuxostat | hsa00030 | Pentose phosphate pathway | 1.95E-02 | 3 | P51854, P08237, P37837 | TKTL1, PFKM, TALDO1 | More | | | Febuxostat | hsa00190 | Oxidative phosphorylation | 1.00E-02 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Febuxostat | hsa01100 | Metabolic pathways | 1.03E-02 | 28 | Q9Y234, P35790, Q16772, P15144, P30041, O14732, Q02153, Q16774, P20839, P00918, P10768, P55809, P06280, Q9Y6K0, P08237, P21399, Q9UHK6, P51854, Q86VZ5, Q9BVK2, P15907, O96024, P37837, P50213, P43490, Q969G6, Q13029, Q9NVH6 | LIPT1, CHKA, GSTA3, ANPEP, PRDX6, IMPA2, GUCY1B3, GUK1, IMPDH1, CA2, ESD, OXCT1, GLA, CEPT1, PFKM, ACO1, AMACR, TKTL1, SGMS1, ALG8, ST6GAL1, B3GALT4, TALDO1, IDH3A, PBEF1, RFK, PRDM2, TMLHE | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9Y234 | LIPT1 | Lipoyltransferase 1, mitochondrial | 0.778 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P35790 | CHKA | Choline kinase alpha | -0.856 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q16772 | GSTA3 | Glutathione S-transferase A3 | -0.768 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P15144 | ANPEP | Aminopeptidase N | 0.846 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P30041 | PRDX6 | Peroxiredoxin-6 | 0.785 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | O14732 | IMPA2 | Inositol monophosphatase 2 | 0.738 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q02153 | GUCY1B3 | Guanylate cyclase soluble subunit beta-1 | -0.774 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q16774 | GUK1 | Guanylate kinase | 0.757 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | 1 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P00918 | CA2 | Carbonic anhydrase 2 | 0.772 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P10768 | ESD | S-formylglutathione hydrolase | -0.701 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P55809 | OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | -0.744 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P06280 | GLA | Alpha-galactosidase A | 0.728 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9Y6K0 | CEPT1 | Choline/ethanolaminephosphotransferase 1 | 0.771 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P08237 | PFKM | ATP-dependent 6-phosphofructokinase, muscle type | 0.868 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P21399 | ACO1 | Cytoplasmic aconitate hydratase | -0.739 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9UHK6 | AMACR | Alpha-methylacyl-CoA racemase | -0.784 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P51854 | TKTL1 | Transketolase-like protein 1 | -0.753 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q86VZ5 | SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | -0.81 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9BVK2 | ALG8 | Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase | -0.726 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P15907 | ST6GAL1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | -0.827 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | O96024 | B3GALT4 | Beta-1,3-galactosyltransferase 4 | 0.797 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P37837 | TALDO1 | Transaldolase | 0.732 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P50213 | IDH3A | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | -0.732 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.702 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q969G6 | RFK | Riboflavin kinase | 0.705 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q13029 | PRDM2 | PR domain zinc finger protein 2 | 0.744 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9NVH6 | TMLHE | Trimethyllysine dioxygenase, mitochondrial | -0.721 |
| | Febuxostat | hsa01200 | Carbon metabolism | 1.81E-02 | 6 | P51854, P08237, P37837, P50213, P21399, P10768 | TKTL1, PFKM, TALDO1, IDH3A, ACO1, ESD | More | | | Febuxostat | hsa01210 | 2-Oxocarboxylic acid metabolism | 1.73E-02 | 2 | P21399, P50213 | ACO1, IDH3A | More | | | Febuxostat | hsa01230 | Biosynthesis of amino acids | 7.71E-03 | 5 | P08237, P51854, P21399, P50213, P37837 | PFKM, TKTL1, ACO1, IDH3A, TALDO1 | More | | | Febuxostat | hsa03010 | Ribosome | 6.06E-03 | 8 | P62753, P25398, P32969, P62829, P46777, P18077, P36578, P50914 | RPS6, RPS12, RPL9, RPL23, RPL5, RPL35A, RPL4, RPL14 | More | | | Febuxostat | hsa03013 | RNA transport | 8.19E-04 | 7 | Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042 | RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2 | More | | | Febuxostat | hsa03020 | RNA polymerase | 3.59E-02 | 2 | P30876, P62487 | POLR2B, POLR2G | More | | | Febuxostat | hsa03040 | Spliceosome | 3.98E-02 | 4 | Q15427, P38159, P61978, P11142 | SF3B4, RBMX, HNRPK, HSPA8 | More | | | Febuxostat | hsa03060 | Protein export | 1.43E-02 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | | Febuxostat | hsa04012 | ErbB signaling pathway | 1.60E-04 | 6 | P21860, P16333, Q13557, P19174, O14944, P01106 | ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYC | More | | | Febuxostat | hsa04015 | Rap1 signaling pathway | 4.78E-02 | 5 | P09603, Q9GZP0, P11215, Q86WV1, P19174 | CSF1, PDGFD, ITGAM, SKAP1, PLCG1 | More | | | Febuxostat | hsa04020 | Calcium signaling pathway | 6.50E-04 | 6 | Q96DU7, P45880, Q13557, P21860, P51828, P23634 | ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4 | More | | | Febuxostat | hsa04022 | cGMP-PKG signaling pathway | 4.72E-02 | 4 | Q99941, P23634, P51828, P45880 | CREBL1, ATP2B4, ADCY7, VDAC2 | More | | | Febuxostat | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 4.48E-02 | 5 | P09341, P19875, P25024, P25025, P14784 | CXCL1, CXCL2, CXCR1, CXCR2, IL2RB | More | | | Febuxostat | hsa04062 | Chemokine signaling pathway | 1.83E-02 | 8 | P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151 | CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10 | More | | | Febuxostat | hsa04064 | NF-kappa B signaling pathway | 2.15E-02 | 7 | P14778, P19174, Q04759, P06239, P09341, P19875, Q06643 | IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTB | More | | | Febuxostat | hsa04072 | Phospholipase D signaling pathway | 4.48E-02 | 5 | P42338, P43657, P25024, P25025, P19174 | PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1 | More | | | Febuxostat | hsa04114 | Oocyte meiosis | 1.33E-02 | 4 | P51812, Q02750, P16298, Q17RY0 | RPS6KA3, MAP2K1, PPP3CB, CPEB4 | More | | | Febuxostat | hsa04141 | Protein processing in endoplasmic reticulum | 4.76E-03 | 7 | P18848, O60337, Q99941, O75460, P11142, Q9H3Z4, P07900 | ATF4, MARH6, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1 | More | | | Febuxostat | hsa04150 | mTOR signaling pathway | 3.60E-02 | 3 | Q02750, Q9NQL2, P51812 | MAP2K1, RRAGD, RPS6KA3 | More | | | Febuxostat | hsa04151 | PI3K-Akt signaling pathway | 1.27E-02 | 9 | P43657, P01106, P09603, Q9GZP0, P63218, P50151, P13612, Q13751, P14784 | P2RY5, MYC, CSF1, PDGFD, GNG5, GNG10, ITGA4, LAMB3, IL2RB | More | | | Febuxostat | hsa04213 | Longevity regulating pathway - multiple species | 4.41E-03 | 4 | P42338, Q9Y4H2, P11142, Q13547 | PIK3CB, IRS2, HSPA8, HDAC1 | More | | | Febuxostat | hsa04217 | Necroptosis | 7.72E-06 | 14 | P01568, Q13489, P42224, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q93077, Q13557, O43633, Q08752 | IFNA21, BIRC3, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, HIST1H2AC, CAMK2D, CHMP2A, PPID | More | | | Febuxostat | hsa04261 | Adrenergic signaling in cardiomyocytes | 3.98E-02 | 4 | P51828, Q99941, Q13557, P23634 | ADCY7, CREBL1, CAMK2D, ATP2B4 | More | | | Febuxostat | hsa04330 | Notch signaling pathway | 3.14E-04 | 5 | Q92542, P49768, Q92830, P78504, P46531 | NCSTN, PSEN1, KAT2A, JAG1, NOTCH1 | More | | | Febuxostat | hsa04370 | VEGF signaling pathway | 2.68E-03 | 3 | P16298, Q05397, Q02750 | PPP3CB, PTK2, MAP2K1 | More | | | Febuxostat | hsa04610 | Complement and coagulation cascades | 2.46E-02 | 3 | P00734, P0C0L4, P21730 | F2, C4A, C5AR1 | More | | | Febuxostat | hsa04623 | Cytosolic DNA-sensing pathway | 3.15E-02 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Febuxostat | hsa04640 | Hematopoietic cell lineage | 1.16E-04 | 10 | P13612, P14778, P27930, P11215, P20023, P25063, P07766, P01732, P09564, P09603 | ITGA4, IL1R1, IL1R2, ITGAM, CR2, CD24, CD3E, CD8A, CD7, CSF1 | More | | | Febuxostat | hsa04650 | Natural killer cell mediated cytotoxicity | 1.30E-04 | 11 | P16298, P50591, P19174, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931 | PPP3CB, TNFSF10, PLCG1, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3 | More | | | Febuxostat | hsa04657 | IL-17 signaling pathway | 4.87E-02 | 2 | P07900, P01584 | HSP90AA1, IL1B | More | | | Febuxostat | hsa04658 | Th1 and Th2 cell differentiation | 7.45E-06 | 8 | Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761 | PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3 | More | | | Febuxostat | hsa04659 | Th17 cell differentiation | 1.25E-03 | 8 | Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963 | PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247 | More | | | Febuxostat | hsa04660 | T cell receptor signaling pathway | 3.37E-03 | 8 | Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239 | PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCK | More | | | Febuxostat | hsa04664 | Fc epsilon RI signaling pathway | 3.15E-02 | 3 | P07948, P19174, P09917 | LYN, PLCG1, ALOX5 | More | | | Febuxostat | hsa04668 | TNF signaling pathway | 4.74E-02 | 3 | Q99941, P01584, O95429 | CREBL1, IL1B, BAG4 | More | | | Febuxostat | hsa04670 | Leukocyte transendothelial migration | 1.19E-02 | 5 | P13612, P11215, P60709, P19174, P12814 | ITGA4, ITGAM, ACTB, PLCG1, ACTN1 | More | | | Febuxostat | hsa04720 | Long-term potentiation | 1.38E-02 | 3 | P16298, P51812, Q02750 | PPP3CB, RPS6KA3, MAP2K1 | More | | | Febuxostat | hsa04721 | Synaptic vesicle cycle | 3.15E-02 | 2 | Q13488, P31645 | TCIRG1, SLC6A4 | More | | | Febuxostat | hsa04750 | Inflammatory mediator regulation of TRP channels | 7.62E-04 | 8 | P14778, P01584, P51828, Q13557, P19174, P42338, P24723, Q04759 | IL1R1, IL1B, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ | More | | | Febuxostat | hsa04911 | Insulin secretion | 1.48E-02 | 3 | P51828, Q99941, Q13557 | ADCY7, CREBL1, CAMK2D | More | | | Febuxostat | hsa04914 | Progesterone-mediated oocyte maturation | 2.94E-02 | 3 | Q17RY0, P51812, Q02750 | CPEB4, RPS6KA3, MAP2K1 | More | | | Febuxostat | hsa04915 | Estrogen signaling pathway | 4.72E-02 | 4 | Q99941, P51828, P07900, P11142 | CREBL1, ADCY7, HSP90AA1, HSPA8 | More | | | Febuxostat | hsa04919 | Thyroid hormone signaling pathway | 3.76E-02 | 4 | P19174, P60709, Q13547, P01106 | PLCG1, ACTB, HDAC1, MYC | More | | | Febuxostat | hsa04923 | Regulation of lipolysis in adipocytes | 2.24E-02 | 3 | P07550, P42338, Q9Y4H2 | ADRB2, PIK3CB, IRS2 | More | | | Febuxostat | hsa04925 | Aldosterone synthesis and secretion | 5.19E-03 | 4 | Q99941, P51828, Q13557, P23634 | CREBL1, ADCY7, CAMK2D, ATP2B4 | More | | | Febuxostat | hsa04932 | Non-alcoholic fatty liver disease | 9.70E-03 | 4 | P18848, P01584, P13073, O15239 | ATF4, IL1B, COX4I1, NDUFA1 | More | | | Febuxostat | hsa04934 | Cushing syndrome | 3.48E-03 | 4 | Q99941, P51828, O15169, Q13557 | CREBL1, ADCY7, AXIN1, CAMK2D | More | | | Febuxostat | hsa04971 | Gastric acid secretion | 1.48E-02 | 3 | P51828, P15311, Q13557 | ADCY7, VIL2, CAMK2D | More | | | Febuxostat | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Febuxostat | hsa05010 | Alzheimer disease | 2.07E-02 | 7 | Q92542, P05496, P12074, O75460, P01584, O15169, P45880 | NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2 | More | | | Febuxostat | hsa05012 | Parkinson disease | 2.53E-02 | 5 | O15239, P13073, P05141, P18848, Q13557 | NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D | More | | | Febuxostat | hsa05016 | Huntington disease | 3.21E-02 | 5 | O15239, P13073, P30876, P62487, P05141 | NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5 | More | | | Febuxostat | hsa05020 | Prion disease | 2.29E-04 | 12 | P13591, P01584, P46531, P11142, O15239, P05496, P13073, P12074, P18848, P05141, P45880, Q99941 | NCAM1, IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, VDAC2, CREBL1 | More | | | Febuxostat | hsa05022 | Pathways of neurodegeneration - multiple diseases | 3.80E-02 | 6 | O15239, P13073, P18848, P05141, P01584, Q13557 | NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2D | More | | | Febuxostat | hsa05032 | Morphine addiction | 1.27E-02 | 4 | P63218, P50151, Q07343, P43250 | GNG5, GNG10, PDE4B, GRK6 | More | | | Febuxostat | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.78E-03 | 5 | P09341, P19875, P19174, P25024, P25025 | CXCL1, CXCL2, PLCG1, CXCR1, CXCR2 | More | | | Febuxostat | hsa05134 | Legionellosis | 6.38E-04 | 6 | P01584, P11215, P68104, P11142, P09341, P19875 | IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2 | More | | | Febuxostat | hsa05135 | Yersinia infection | 2.07E-02 | 4 | P60709, P13612, P06239, P19174 | ACTB, ITGA4, LCK, PLCG1 | More | | | Febuxostat | hsa05140 | Leishmaniasis | 1.56E-02 | 5 | P14598, P42224, P25963, P29350, Q15080 | NCF1, STAT1, NFKBIA, PTPN6, NCF4 | More | | | Febuxostat | hsa05144 | Malaria | 3.09E-02 | 4 | P69905, P68871, O60603, P10145 | HBA2, HBB, TLR2, IL8 | More | | | Febuxostat | hsa05146 | Amoebiasis | 2.21E-04 | 8 | P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814 | CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1 | More | | | Febuxostat | hsa05150 | Staphylococcus aureus infection | 4.66E-02 | 4 | P0C0L4, P21730, P21462, P13646 | C4A, C5AR1, FPR1, KRT13 | More | | | Febuxostat | hsa05162 | Measles | 4.02E-02 | 3 | P11142, P01584, Q9NP90 | HSPA8, IL1B, RAB9B | More | | | Febuxostat | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 1.94E-02 | 4 | P62879, P16298, Q02750, P0CG47 | GNB2, PPP3CB, MAP2K1, UBB | More | | | Febuxostat | hsa05168 | Herpes simplex virus 1 infection | 3.38E-03 | 12 | P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6 | NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212 | More | | | Febuxostat | hsa05170 | Human immunodeficiency virus 1 infection | 6.02E-03 | 5 | Q02750, P62879, P16298, Q05397, P20333 | MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B | More | | | Febuxostat | hsa05171 | Coronavirus disease - COVID-19 | 9.72E-03 | 7 | P01584, P62753, P25398, P36578, P32969, P18077, P62829 | IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23 | More | | | Febuxostat | hsa05206 | MicroRNAs in cancer | 3.80E-04 | 11 | P30304, P15311, P21860, P01106, P61978, Q9Y4H2, P46531, Q13547, P63279, P22105, P19174 | CDC25A, VIL2, ERBB3, MYC, HNRPK, IRS2, NOTCH1, HDAC1, UBE2I, TNXB, PLCG1 | More | | | Febuxostat | hsa05213 | Endometrial cancer | 3.79E-02 | 2 | O15169, Q02750 | AXIN1, MAP2K1 | More | | | Febuxostat | hsa05226 | Gastric cancer | 3.79E-02 | 2 | Q02750, O15169 | MAP2K1, AXIN1 | More | | | Febuxostat | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 8.27E-03 | 6 | P42338, P19174, P07766, P20963, P06239, Q04759 | PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ | More | | | Febuxostat | hsa05340 | Primary immunodeficiency | 2.73E-02 | 3 | P11912, P07766, P06239 | CD79A, CD3E, LCK | More | | | Febuxostat | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.53E-02 | 3 | P13612, P60709, P35609 | ITGA4, ACTB, ACTN2 | More | | | Febuxostat | hsa05415 | Diabetic cardiomyopathy | 1.49E-03 | 10 | P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q13557, P04406 | PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, CAMK2D, GAPDH | More | |
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