PharmaCoNets of Ezetimibe (SPCN: 13.13 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ezetimibehsa00480Glutathione metabolism3.02E-021P48506GCLCMore
Ezetimibehsa00630Glyoxylate and dicarboxylate metabolism3.90E-043P40925, P40926, P15104MDH1, MDH2, GLULMore
Ezetimibehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Ezetimibehsa02010ABC transporters3.76E-021Q99758ABCA3More
Ezetimibehsa03018RNA degradation3.02E-021Q13901C1DMore
Ezetimibehsa03040Spliceosome1.29E-039O60508, P17844, P08579, P51991, P61978, Q07955, Q01130, P11142, Q9Y2W2CDC40, DDX5, SNRPB2, HNRPA3, HNRPK, SFRS1, SFRS2, HSPA8, WBP11More
Ezetimibehsa04014Ras signaling pathway2.54E-025P42338, P20827, P49767, Q13009, P50151PIK3CB, EFNA1, VEGFC, TIAM1, GNG10More
Ezetimibehsa04071Sphingolipid signaling pathway1.94E-026Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Ezetimibehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Ezetimibehsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Ezetimibehsa04151PI3K-Akt signaling pathway1.69E-0415P62753, P42338, P43657, P27348, P20827, P49767, P07900, P50151, O15335, Q13751, P22105, P14784, Q99941, P18848, O00141RPS6, PIK3CB, P2RY5, YWHAQ, EFNA1, VEGFC, HSP90AA1, GNG10, CHAD, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGKMore
Ezetimibehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Ezetimibehsa04216Ferroptosis4.50E-021P48506GCLCMore
Ezetimibehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Ezetimibehsa04261Adrenergic signaling in cardiomyocytes1.46E-024P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Ezetimibehsa04340Hedgehog signaling pathway1.80E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Ezetimibehsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Ezetimibehsa04662B cell receptor signaling pathway9.78E-045P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Ezetimibehsa04664Fc epsilon RI signaling pathway1.82E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Ezetimibehsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Ezetimibehsa04724Glutamatergic synapse3.24E-023P43003, P50151, P15104SLC1A3, GNG10, GLULMore
Ezetimibehsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Ezetimibehsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Ezetimibehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Ezetimibehsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Ezetimibehsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Ezetimibehsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Ezetimibehsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Ezetimibehsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Ezetimibehsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Ezetimibehsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Ezetimibehsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Ezetimibehsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Ezetimibehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Ezetimibehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Ezetimibehsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Ezetimibehsa05144Malaria4.92E-024O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Ezetimibehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Ezetimibehsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Ezetimibehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Ezetimibehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Ezetimibehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Ezetimibehsa05321Inflammatory bowel disease4.92E-024O60603, P01375, Q14765, Q9UL17TLR2, TNF, STAT4, TBX21More
Ezetimibehsa05332Graft-versus-host disease1.80E-024P10747, P01375, P26715, Q13241CD28, TNF, KLRC1, KLRD1More
Ezetimibehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore

Community members of Ezetimibe (SDC: 2.24)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P35610SOAT1Sterol ONoneacyltransferase 1Reported10.38550.29360.01650.7964
P15144ANPEPAminopeptidase NReported10.18750.23650.29340.8601
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
Q6P179ERAP2Endoplasmic reticulum aminopeptidase 2Predicted10.06950.040200.1151
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)