PharmaCoNets of Etoricoxib (SPCN: 239.19 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Etoricoxibhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Etoricoxibhsa00051Fructose and mannose metabolism3.92E-033P15121, P19367, P08237AKR1B1, HK1, PFKMMore
Etoricoxibhsa00052Galactose metabolism3.92E-033P08237, P15121, P19367PFKM, AKR1B1, HK1More
Etoricoxibhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Etoricoxibhsa00071Fatty acid degradation3.65E-034O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Etoricoxibhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Etoricoxibhsa00220Arginine biosynthesis5.77E-043P15104, P05089, P49448GLUL, ARG1, GLUD2More
Etoricoxibhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Etoricoxibhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Etoricoxibhsa00500Starch and sucrose metabolism7.71E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Etoricoxibhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Etoricoxibhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Etoricoxibhsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Etoricoxibhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Etoricoxibhsa00564Glycerophospholipid metabolism3.56E-023P48651, Q9Y6K0, P35790PTDSS1, CEPT1, CHKAMore
Etoricoxibhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Etoricoxibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Etoricoxibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Etoricoxibhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Etoricoxibhsa00620Pyruvate metabolism3.19E-022P40926, P14550MDH2, AKR1A1More
Etoricoxibhsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Etoricoxibhsa00670One carbon pool by folate7.39E-043O95954, P04818, Q99707FTCD, TYMS, MTRMore
Etoricoxibhsa00730Thiamine metabolism3.27E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Etoricoxibhsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Etoricoxibhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Etoricoxibhsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Etoricoxibhsa00860Porphyrin and chlorophyll metabolism8.96E-042P36551, P30043CPOX, BLVRBMore
Etoricoxibhsa00910Nitrogen metabolism2.66E-033P22748, P15104, P49448CA4, GLUL, GLUD2More
Etoricoxibhsa00970Aminoacyl-tRNA biosynthesis2.93E-053O95363, P14868, Q15046FARS2, DARS, KARSMore
Etoricoxibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-054Q16772, P78417, P09211, P11712GSTA3, GSTO1, GSTP1, CYP2C9More
Etoricoxibhsa00982Drug metabolism - cytochrome P4501.77E-044P11712, Q16772, P09211, P78417CYP2C9, GSTA3, GSTP1, GSTO1More
Etoricoxibhsa00983Drug metabolism - other enzymes1.75E-045P04183, P32320, P05164, Q16772, P09211TK1, CDA, MPO, GSTA3, GSTP1More
Etoricoxibhsa01100Metabolic pathways1.94E-0445Q9NR34, Q9Y234, P35790, P05089, Q16772, P09211, Q9UJ14, P30041, P19367, P48426, P22557, P32320, P20839, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, Q9Y6K0, P05186, P24666, P15121, P08237, O95861, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P48651, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9BQB6, Q969G6, P14927MAN1C1, LIPT1, CHKA, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, HK1, PIP4K2A, ALAS2, CDA, IMPDH1, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, CEPT1, ALPL, ACP1, AKR1B1, PFKM, BPNT1, MCCC2, ACSL1, AMACR, SGMS1, PTDSS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, VKORC1, RFK, UQCRBMore
Etoricoxibhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Etoricoxibhsa01230Biosynthesis of amino acids1.90E-034P60891, Q99707, P15104, P37837PRPS1, MTR, GLUL, TALDO1More
Etoricoxibhsa01240Biosynthesis of cofactors4.63E-023Q969G6, P22557, Q9Y234RFK, ALAS2, LIPT1More
Etoricoxibhsa01522Endocrine resistance4.74E-023P22694, P10415, Q13323PRKACB, BCL2, BIKMore
Etoricoxibhsa01523Antifolate resistance6.12E-056P41439, P41440, Q92820, P04818, P01375, P18054FOLR3, SLC19A1, GGH, TYMS, TNF, ALOX12More
Etoricoxibhsa01524Platinum drug resistance3.80E-034O15392, Q16772, P09211, P11388BIRC5, GSTA3, GSTP1, TOP2AMore
Etoricoxibhsa02010ABC transporters1.66E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Etoricoxibhsa03008Ribosome biogenesis in eukaryotes6.93E-046Q9NYH9, O14980, O60832, P78345, Q9BVP2, Q9GZY0UTP6, XPO1, DKC1, RPP38, GNL3, NXF2; NXF2BMore
Etoricoxibhsa03013RNA transport3.51E-1329P62826, O14980, P52298, Q09161, O14893, P61326, P38919, Q15287, Q9UBU9, Q9GZY0, Q9H307, P37198, Q7Z3B4, P35658, P63279, P68104, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, P23588, Q9Y6A5, Q14232, Q06787, P51114, Q53GS7RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, RNPS1, NXF1, NXF2; NXF2B, PNN, NUP62, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, EIF4B, TACC3, EIF2B1, FMR1, FXR1, GLE1More
Etoricoxibhsa03015mRNA surveillance pathway9.78E-036O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Etoricoxibhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Etoricoxibhsa03020RNA polymerase6.63E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Etoricoxibhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Etoricoxibhsa03030DNA replication5.00E-021P27694RPA1More
Etoricoxibhsa03040Spliceosome4.67E-0817Q14562, O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Etoricoxibhsa03050Proteasome4.83E-021P55036PSMD4More
Etoricoxibhsa03060Protein export1.20E-032P37108, Q15005SRP14, SPCS2More
Etoricoxibhsa03320PPAR signaling pathway4.55E-022O00767, Q02318SCD, CYP27A1More
Etoricoxibhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Etoricoxibhsa04012ErbB signaling pathway1.74E-036P21860, P16333, Q13557, P19174, O14944, P01106ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYCMore
Etoricoxibhsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Etoricoxibhsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Etoricoxibhsa04020Calcium signaling pathway1.48E-049Q96DU7, Q08828, P45880, Q13557, P21860, P0DP23, P05141, P51828, P23634ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CALM1, SLC25A5, ADCY7, ATP2B4More
Etoricoxibhsa04022cGMP-PKG signaling pathway6.39E-049Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP23CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM1More
Etoricoxibhsa04024cAMP signaling pathway4.63E-037Q08828, P51828, P42338, P31751, P0DP23, Q13370, Q13009ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PDE3B, TIAM1More
Etoricoxibhsa04060Cytokine-cytokine receptor interaction5.39E-0310P27930, P08476, Q13651, Q9HBE5, Q9UBD3, P47992, P01375, P09341, P18510, Q93038IL1R2, INHBA, IL10RA, IL21R, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25More
Etoricoxibhsa04061Viral protein interaction with cytokine and cytokine receptor9.66E-0511Q8NHW4, P09341, P19875, P25024, P02775, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Etoricoxibhsa04062Chemokine signaling pathway5.65E-0414P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Etoricoxibhsa04064NF-kappa B signaling pathway6.64E-1223P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Etoricoxibhsa04070Phosphatidylinositol signaling system9.45E-058P0DP23, P42338, O14986, Q86XP1, Q16760, P48426, P27987, Q96DU7CALM1, PIK3CB, PIP5K1B, DGKH, DGKD, PIP4K2A, ITPKB, ITPKCMore
Etoricoxibhsa04071Sphingolipid signaling pathway8.72E-049P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2More
Etoricoxibhsa04072Phospholipase D signaling pathway4.96E-0411P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Etoricoxibhsa04080Neuroactive ligand-receptor interaction2.98E-048P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, ADRB2More
Etoricoxibhsa04110Cell cycle8.83E-058Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, CDKN2C, MYCMore
Etoricoxibhsa04114Oocyte meiosis5.20E-049P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Etoricoxibhsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Etoricoxibhsa04120Ubiquitin mediated proteolysis1.61E-046Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Etoricoxibhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Etoricoxibhsa04140Autophagy - animal1.76E-038P31751, Q7L523, O75460, P22694, Q14643, P10415, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, TMEM49, SMCR8More
Etoricoxibhsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Etoricoxibhsa04142Lysosome2.45E-039Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Etoricoxibhsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Etoricoxibhsa04145Phagosome3.44E-0512P63261, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, O60603, P35443, P13765, P25774ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, TLR2, THBS4, HLA-DOB, CTSSMore
Etoricoxibhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Etoricoxibhsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Etoricoxibhsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Etoricoxibhsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Etoricoxibhsa04213Longevity regulating pathway - multiple species3.34E-048P31751, P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Etoricoxibhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Etoricoxibhsa04261Adrenergic signaling in cardiomyocytes7.88E-0510Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557, P23634ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2D, ATP2B4More
Etoricoxibhsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Etoricoxibhsa04330Notch signaling pathway2.46E-033Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Etoricoxibhsa04340Hedgehog signaling pathway9.74E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Etoricoxibhsa04360Axon guidance2.47E-037P16333, P20827, O95631, P42338, P07332, P23528, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1More
Etoricoxibhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Etoricoxibhsa04371Apelin signaling pathway1.11E-0311P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q14814, Q14344, Q13485, P84022, P0DP23GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CALM1More
Etoricoxibhsa04380Osteoclast differentiation1.11E-0413Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Etoricoxibhsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Etoricoxibhsa04514Cell adhesion molecules1.22E-022P23229, P30511ITGA6, HLA-FMore
Etoricoxibhsa04530Tight junction3.00E-048Q8TEU7, P63261, P16989, P56750, O00501, Q92974, Q14247, P24844RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, ARHGEF2, CTTN, MYL9More
Etoricoxibhsa04540Gap junction2.71E-035P17252, P22694, Q13509, P68371, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, ITPR1More
Etoricoxibhsa04610Complement and coagulation cascades6.40E-102P00734, P0C0L4F2, C4AMore
Etoricoxibhsa04612Antigen processing and presentation9.13E-058P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Etoricoxibhsa04613Neutrophil extracellular trap formation6.46E-0725P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, P63261, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, ACTG1, AQP9, MAPK14More
Etoricoxibhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Etoricoxibhsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Etoricoxibhsa04621NOD-like receptor signaling pathway2.20E-0413Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P59665, P59666, P12838ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Etoricoxibhsa04623Cytosolic DNA-sensing pathway1.21E-053P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Etoricoxibhsa04625C-type lectin receptor signaling pathway3.25E-0411Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Etoricoxibhsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Etoricoxibhsa04640Hematopoietic cell lineage1.06E-0416P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Etoricoxibhsa04650Natural killer cell mediated cytotoxicity1.50E-1016P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Etoricoxibhsa04657IL-17 signaling pathway1.59E-048O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Etoricoxibhsa04658Th1 and Th2 cell differentiation1.98E-0714Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Etoricoxibhsa04659Th17 cell differentiation1.88E-0820Q04759, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Etoricoxibhsa04660T cell receptor signaling pathway2.49E-0817P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Etoricoxibhsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Etoricoxibhsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Etoricoxibhsa04666Fc gamma R-mediated phagocytosis8.47E-046P42338, P23528, P49006, P06396, P14598, P17252PIK3CB, CFL1, MARCKSL1, GSN, NCF1, PRKCAMore
Etoricoxibhsa04668TNF signaling pathway3.42E-0310P01375, O00463, Q13489, P25963, Q99941, P01584, P20749, Q13077, P14780, O95429TNF, TRAF5, BIRC3, NFKBIA, CREBL1, IL1B, BCL3, TRAF1, MMP9, BAG4More
Etoricoxibhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Etoricoxibhsa04713Circadian entrainment4.54E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Etoricoxibhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Etoricoxibhsa04720Long-term potentiation1.71E-036P16298, P0DP23, P51812, P18848, Q08828, Q02750PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1More
Etoricoxibhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Etoricoxibhsa04725Cholinergic synapse1.20E-037Q08828, P51828, P22694, Q14643, P18848, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, ATF4, AKT2, BCL2More
Etoricoxibhsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Etoricoxibhsa04730Long-term depression5.00E-021Q14344GNA13More
Etoricoxibhsa04750Inflammatory mediator regulation of TRP channels1.99E-0714P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Etoricoxibhsa04810Regulation of actin cytoskeleton2.68E-022P23229, Q14344ITGA6, GNA13More
Etoricoxibhsa04911Insulin secretion8.29E-045Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Etoricoxibhsa04912GnRH signaling pathway3.22E-039Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACBMore
Etoricoxibhsa04913Ovarian steroidogenesis2.72E-022P42330, P22694AKR1C3, PRKACBMore
Etoricoxibhsa04914Progesterone-mediated oocyte maturation2.97E-036Q17RY0, P42338, Q13370, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1More
Etoricoxibhsa04915Estrogen signaling pathway2.87E-0410Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, Q15788CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1More
Etoricoxibhsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Etoricoxibhsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Etoricoxibhsa04923Regulation of lipolysis in adipocytes2.89E-046Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Etoricoxibhsa04924Renin secretion2.65E-045P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Etoricoxibhsa04925Aldosterone synthesis and secretion1.35E-047Q99941, P18848, Q08828, P51828, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2D, ATP2B4More
Etoricoxibhsa04926Relaxin signaling pathway2.46E-024P31751, P18848, Q08828, P51828AKT2, ATF4, ADCY1, ADCY7More
Etoricoxibhsa04927Cortisol synthesis and secretion8.09E-045Q14643, P18848, Q08828, P51828, P22694ITPR1, ATF4, ADCY1, ADCY7, PRKACBMore
Etoricoxibhsa04928Parathyroid hormone synthesis, secretion and action1.02E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Etoricoxibhsa04932Non-alcoholic fatty liver disease2.20E-0613P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Etoricoxibhsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Etoricoxibhsa04934Cushing syndrome6.88E-059Q14643, Q99941, P18848, Q08828, P51828, P22694, O15169, Q13557, P04628ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1More
Etoricoxibhsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Etoricoxibhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Etoricoxibhsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Etoricoxibhsa04964Proximal tubule bicarbonate reclamation2.08E-043P22748, P00918, P49448CA4, CA2, GLUD2More
Etoricoxibhsa04966Collecting duct acid secretion2.17E-031P00918CA2More
Etoricoxibhsa04970Salivary secretion2.01E-058P07550, Q08828, P51828, P22694, Q14643, P17252, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM1, CAMPMore
Etoricoxibhsa04971Gastric acid secretion9.27E-055Q08828, P51828, P15311, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM1, CAMK2DMore
Etoricoxibhsa04972Pancreatic secretion1.99E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Etoricoxibhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Etoricoxibhsa04976Bile secretion1.26E-045O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Etoricoxibhsa05010Alzheimer disease3.34E-0414Q92542, O95298, P05496, P12074, Q00535, O75460, P0DP23, P01584, P18848, O15169, P31751, P05141, P45880, P28070NCSTN, NDUFC2, ATP5G1, COX6A1, CDK5, ERN1, CALM1, IL1B, ATF4, AXIN1, AKT2, SLC25A5, VDAC2, PSMB4More
Etoricoxibhsa05016Huntington disease1.76E-0310O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Etoricoxibhsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Etoricoxibhsa05020Prion disease1.37E-0311P01584, P46531, P11142, Q16718, O14521, P05496, P12074, P45880, P49841, Q99941, Q16539IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, VDAC2, GSK3B, CREBL1, MAPK14More
Etoricoxibhsa05022Pathways of neurodegeneration - multiple diseases4.63E-0415P49841, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, Q16539, Q00535, P01584, Q08752, P0DP23, P28070GSK3B, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4More
Etoricoxibhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Etoricoxibhsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Etoricoxibhsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Etoricoxibhsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Etoricoxibhsa05132Salmonella infection2.36E-0313P51617, P25963, P01375, Q9UJU2, P63261, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, NFKBIA, TNF, LEF1, ACTG1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Etoricoxibhsa05133Pertussis1.89E-053P0DP23, P10145, P0C0L4CALM1, IL8, C4AMore
Etoricoxibhsa05134Legionellosis8.80E-047P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Etoricoxibhsa05140Leishmaniasis1.06E-0513P13612, O75015, P14598, P23458, P13765, O60603, P25963, P01375, P01584, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, MARCKSL1, MAPK14, IRAK1, NCF4More
Etoricoxibhsa05143African trypanosomiasis8.39E-064P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Etoricoxibhsa05144Malaria3.13E-058P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Etoricoxibhsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Etoricoxibhsa05146Amoebiasis7.50E-0713P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Etoricoxibhsa05150Staphylococcus aureus infection1.48E-049P0C0L4, P21730, P21462, O75015, P13646, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3B, KRT13, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Etoricoxibhsa05152Tuberculosis9.13E-0311Q13488, Q99437, P48382, O60603, P01375, P10415, P13765, P25774, P49913, Q9UDY8, P51617TCIRG1, ATP6V0B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CTSS, CAMP, MALT1, IRAK1More
Etoricoxibhsa05160Hepatitis C1.52E-037P60033, O00501, P29728, P49841, P01375, P48023, P01106CD81, CLDN5, OAS2, GSK3B, TNF, FASLG, MYCMore
Etoricoxibhsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Etoricoxibhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Etoricoxibhsa05163Human cytomegalovirus infection6.31E-0718P31751, P30511, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463AKT2, HLA-F, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5More
Etoricoxibhsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Etoricoxibhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Etoricoxibhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Etoricoxibhsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Etoricoxibhsa05170Human immunodeficiency virus 1 infection2.58E-0518Q02750, P62879, P16298, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333MAP2K1, GNB2, PPP3CB, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Etoricoxibhsa05200Pathways in cancer1.31E-0321Q13751, P42338, P08238, P42224, P19174, P43246, P84022, Q13485, Q13547, P14923, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784, P40189LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RB, IL6STMore
Etoricoxibhsa05202Transcriptional misregulation in cancer4.64E-0924Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Etoricoxibhsa05203Viral carcinogenesis6.22E-035Q12933, P42229, Q15283, P62807, O60814TRAF2, STAT5A, RASA2, HIST1H2BC, H2BC12More
Etoricoxibhsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Etoricoxibhsa05205Proteoglycans in cancer2.66E-028Q14643, P63261, P04637, P14780, P17252, O60603, Q13635, P08962ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63More
Etoricoxibhsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Etoricoxibhsa05212Pancreatic cancer1.45E-048P42338, P31751, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Etoricoxibhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Etoricoxibhsa05214Glioma1.72E-023P0DP23, P42338, O75293CALM1, PIK3CB, GADD45BMore
Etoricoxibhsa05216Thyroid cancer3.59E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Etoricoxibhsa05217Basal cell carcinoma1.39E-035Q13635, P49841, Q9UJU2, P04637, P24522PTCH1, GSK3B, LEF1, TP53, GADD45AMore
Etoricoxibhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Etoricoxibhsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Etoricoxibhsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Etoricoxibhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Etoricoxibhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Etoricoxibhsa05231Choline metabolism in cancer2.02E-036P31751, Q9Y259, P19174, P49619, Q16760, O14986AKT2, CHKB, PLCG1, DGKG, DGKD, PIP5K1BMore
Etoricoxibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.15E-0512P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14, CD4More
Etoricoxibhsa05310Asthma3.13E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Etoricoxibhsa05321Inflammatory bowel disease3.09E-068O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Etoricoxibhsa05322Systemic lupus erythematosus3.30E-0514P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSBMore
Etoricoxibhsa05323Rheumatoid arthritis3.53E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Etoricoxibhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Etoricoxibhsa05332Graft-versus-host disease8.15E-066P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Etoricoxibhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Etoricoxibhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Etoricoxibhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Etoricoxibhsa05418Fluid shear stress and atherosclerosis3.97E-0413Q16539, P42338, P14598, P10599, P14780, P63261, P04637, P10415, P14778, P27930, P0DP23, P08238, Q92974MAPK14, PIK3CB, NCF1, TXN, MMP9, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, HSP90AB1, ARHGEF2More

Community members of Etoricoxib (SDC: 9.47)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P14550AKR1A1AldoNoneketo reductase family 1 member A1Predicted10.30560.06210.17370.4508
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P11766ADH5Alcohol dehydrogenase classNone3Predicted00.2650.13970.21460.6265
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P27694RPA1Replication protein A 70 kDa DNANonebinding subunitPredicted00.22730.17560.27460.7395
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P08311CTSGCathepsin GPredicted00.49490.18740.64781.2701
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)