PharmaCoNets of Etoposide (SPCN: 6.30 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Etoposidehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Etoposidehsa00340Histidine metabolism4.52E-021O95954FTCDMore
Etoposidehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Etoposidehsa00531Glycosaminoglycan degradation4.51E-022P22304, P06865IDS, HEXAMore
Etoposidehsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Etoposidehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Etoposidehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Etoposidehsa01100Metabolic pathways2.25E-027Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGLMore
Etoposidehsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Etoposidehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Etoposidehsa04072Phospholipase D signaling pathway3.55E-024Q9UQC2, Q8WYR1, Q15438, P51828GAB2, PIK3R5, PSCD1, ADCY7More
Etoposidehsa04110Cell cycle3.57E-023Q9UBD5, P06493, P33981ORC3, CDK1, TTKMore
Etoposidehsa04142Lysosome3.32E-036P06865, P22304, Q13510, P07602, P61916, Q04900HEXA, IDS, ASAH1, PSAP, NPC2, CD164More
Etoposidehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Etoposidehsa04213Longevity regulating pathway - multiple species3.03E-022P51828, P0DMV8ADCY7, HSPA1AMore
Etoposidehsa04261Adrenergic signaling in cardiomyocytes8.89E-035P67936, P51828, Q8WYR1, Q13362, P0DP24TPM4, ADCY7, PIK3R5, PPP2R5C, CALM2More
Etoposidehsa04270Vascular smooth muscle contraction1.86E-024P0DP24, P51828, P35579, P35749CALM2, ADCY7, MYH9, MYH11More
Etoposidehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Etoposidehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Etoposidehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Etoposidehsa04915Estrogen signaling pathway1.12E-024P51828, P0DMV8, P0DP24, Q15788ADCY7, HSPA1A, CALM2, NCOA1More
Etoposidehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Etoposidehsa04921Oxytocin signaling pathway2.92E-024P0DP24, P51828, Q96RR4, Q8WYR1CALM2, ADCY7, CAMKK2, PIK3R5More
Etoposidehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Etoposidehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Etoposidehsa05145Toxoplasmosis3.55E-023P23458, Q8WYR1, P0DMV8JAK1, PIK3R5, HSPA1AMore
Etoposidehsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore

Community members of Etoposide (SDC: 2.16)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11388TOP2ADNA topoisomerase 2NonealphaReported00.19920.46590.19271.2242
Q15788NCOA1Nuclear receptor coactivator 1Predicted00.43680.08280.31140.6954
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
TOP2AP11388IC5021800
TOP2AP11388IC5022000
TOP2AP11388IC5028200