PharmaCoNets

PharmaCoNets of Etomidate (S_PCN: 162.56 )

Etomidate regulated-network (S_DN: 22.15)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Etomidate

hsa00030

Pentose phosphate pathway

8.52E-04

P60891, P51854, P08237, P37837

PRPS1, TKTL1, PFKM, TALDO1

Etomidate

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Etomidate

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Etomidate

hsa00120

Primary bile acid biosynthesis

3.72E-02

P22680, P22307

CYP7A1, SCP2

Etomidate

hsa00280

Valine, leucine and isoleucine degradation

3.41E-03

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Etomidate

hsa00330

Arginine and proline metabolism

4.86E-02

P17707

AMD1

Etomidate

hsa00380

Tryptophan metabolism

4.14E-02

Q16613

AANAT

Etomidate

hsa00480

Glutathione metabolism

3.29E-04

Q9UJ14, Q16772, P09211, P30041

GGTL3, GSTA3, GSTP1, PRDX6

Etomidate

hsa00500

Starch and sucrose metabolism

8.96E-06

O43451, P46976, P06737

MGAM, GYG1, PYGL

Etomidate

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Etomidate

hsa00531

Glycosaminoglycan degradation

8.18E-04

P15586, P34059

GNS, GALNS

Etomidate

hsa00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

2.92E-02

Q9Y2C2

UST

Etomidate

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Etomidate

hsa00561

Glycerolipid metabolism

3.35E-02

P14550, Q86XP1

AKR1A1, DGKH

Etomidate

hsa00565

Ether lipid metabolism

1.77E-04

Q9Y6K0, Q8N661

CEPT1, TMEM86B

Etomidate

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Etomidate

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Etomidate

hsa00630

Glyoxylate and dicarboxylate metabolism

3.01E-05

P40925, P15104

MDH1, GLUL

Etomidate

hsa00670

One carbon pool by folate

3.15E-02

O95954, Q99707

FTCD, MTR

Etomidate

hsa00730

Thiamine metabolism

1.44E-03

P05186, P24666

ALPL, ACP1

Etomidate

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Etomidate

hsa00860

Porphyrin and chlorophyll metabolism

8.96E-04

P36551, P30043

CPOX, BLVRB

Etomidate

hsa00970

Aminoacyl-tRNA biosynthesis

9.57E-03

O95363, P54136, P14868

FARS2, RARS1, DARS

Etomidate

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Etomidate

hsa00982

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Etomidate

hsa00983

Drug metabolism - other enzymes

1.92E-03

P04183, P32320, P05164, Q16772, P09211

TK1, CDA, MPO, GSTA3, GSTP1

Etomidate

hsa01100

Metabolic pathways

5.27E-05

Q9Y234, P35790, Q16772, P09211, Q9UJ14, P15144, P30041, O14732, Q6ZQY3, Q02153, Q16774, P20839, P00918, P40926, P10768, P55809, P06280, Q7KZN9, Q9Y6K0, P15121, P08237, Q86XP1, P21399, P14550, Q9UHK6, P51854, Q86VZ5, Q9BVK2, P15907, O96024, P37837, P50213, P43490, Q9BQB6, Q969G6, Q99437, Q13029, Q9NVH6

LIPT1, CHKA, GSTA3, GSTP1, GGTL3, ANPEP, PRDX6, IMPA2, GADL1, GUCY1B3, GUK1, IMPDH1, CA2, MDH2, ESD, OXCT1, GLA, COX15, CEPT1, AKR1B1, PFKM, DGKH, ACO1, AKR1A1, AMACR, TKTL1, SGMS1, ALG8, ST6GAL1, B3GALT4, TALDO1, IDH3A, PBEF1, VKORC1, RFK, ATP6V0B, PRDM2, TMLHE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.778
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.738
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P35790	CHKA	Choline kinase alpha	-0.856
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q16772	GSTA3	Glutathione S-transferase A3	-0.768
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P15144	ANPEP	Aminopeptidase N	0.846
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P30041	PRDX6	Peroxiredoxin-6	0.785
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	O14732	IMPA2	Inositol monophosphatase 2	0.738
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q6ZQY3	GADL1	Acidic amino acid decarboxylase GADL1	0.743
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q02153	GUCY1B3	Guanylate cyclase soluble subunit beta-1	-0.774
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q02153	GUCY1B3	Guanylate cyclase soluble subunit beta-1	-0.741
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q16774	GUK1	Guanylate kinase	0.757
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	1
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.788
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P00918	CA2	Carbonic anhydrase 2	0.772
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P10768	ESD	S-formylglutathione hydrolase	-0.701
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.744
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P06280	GLA	Alpha-galactosidase A	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9Y6K0	CEPT1	Choline/ethanolaminephosphotransferase 1	0.771
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q9Y6K0	CEPT1	Choline/ethanolaminephosphotransferase 1	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.868
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.792
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P21399	ACO1	Cytoplasmic aconitate hydratase	-0.739
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	0.733
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.784
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.768
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P51854	TKTL1	Transketolase-like protein 1	-0.753
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.81
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.78
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9BVK2	ALG8	Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase	-0.726
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q9BVK2	ALG8	Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase	-0.754
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P15907	ST6GAL1	Beta-galactoside alpha-2,6-sialyltransferase 1	-0.827
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	O96024	B3GALT4	Beta-1,3-galactosyltransferase 4	0.797
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P37837	TALDO1	Transaldolase	0.732
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	P37837	TALDO1	Transaldolase	0.746
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P50213	IDH3A	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	-0.732
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.702
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q969G6	RFK	Riboflavin kinase	0.705
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q99437	ATP6V0B	V-type proton ATPase 21 kDa proteolipid subunit c''	0.72
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q13029	PRDM2	PR domain zinc finger protein 2	0.744
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.721
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.799

Etomidate

hsa01200

Carbon metabolism

1.81E-02

P51854, P08237, P37837, P50213, P21399, P10768

TKTL1, PFKM, TALDO1, IDH3A, ACO1, ESD

Etomidate

hsa01210

2-Oxocarboxylic acid metabolism

1.73E-02

P21399, P50213

ACO1, IDH3A

Etomidate

hsa01230

Biosynthesis of amino acids

7.09E-04

P08237, P51854, P60891, Q99707, P21399, P50213, P37837

PFKM, TKTL1, PRPS1, MTR, ACO1, IDH3A, TALDO1

Etomidate

hsa01521

EGFR tyrosine kinase inhibitor resistance

2.18E-02

P49841, Q9NRA1

GSK3B, PDGFC

Etomidate

hsa01524

Platinum drug resistance

4.38E-03

Q13489, P98170, Q16772, P09211, P78417, P43246

BIRC3, BIRC4, GSTA3, GSTP1, GSTO1, MSH2

Etomidate

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Etomidate

hsa03008

Ribosome biogenesis in eukaryotes

1.24E-04

Q9NYH9, P19784, P67870, O14980, O60832, Q9BVP2

UTP6, CSNK2A2, CSNK2B, XPO1, DKC1, GNL3

Etomidate

hsa03010

Ribosome

2.63E-02

P46777, P50914

RPL5, RPL14

Etomidate

hsa03013

RNA transport

9.35E-10

O14980, P52298, Q09161, O14893, P61326, Q9H307, Q7Z3B4, P35658, P47813, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5, Q06787, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, PNN, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, FMR1, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q9UBU7	DBF4	Protein DBF4 homolog A	O14980	XPO1	Exportin-1	0.943
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
P08246	ELA2	Neutrophil elastase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.852
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
P08246	ELA2	Neutrophil elastase	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.732
P26358	DNMT1	DNA	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.81
Q9UBU7	DBF4	Protein DBF4 homolog A	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.742
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
P08246	ELA2	Neutrophil elastase	O14893	GEMIN2	Gem-associated protein 2	-0.785
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q9UBU7	DBF4	Protein DBF4 homolog A	P61326	MAGOH	Protein mago nashi homolog	0.737
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
Q9UBU7	DBF4	Protein DBF4 homolog A	Q9H307	PNN	Pinin	0.722
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
P08246	ELA2	Neutrophil elastase	Q7Z3B4	NUP54	Nucleoporin p54	-0.723
Q9UBU7	DBF4	Protein DBF4 homolog A	Q7Z3B4	NUP54	Nucleoporin p54	0.787
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
P08246	ELA2	Neutrophil elastase	P35658	NUP214	Nuclear pore complex protein Nup214	0.765
P26358	DNMT1	DNA	P35658	NUP214	Nuclear pore complex protein Nup214	-0.717
Q9UBU7	DBF4	Protein DBF4 homolog A	P35658	NUP214	Nuclear pore complex protein Nup214	-0.781
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
P26358	DNMT1	DNA	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.738
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
P08246	ELA2	Neutrophil elastase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.722
P26358	DNMT1	DNA	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.749
Q9UBU7	DBF4	Protein DBF4 homolog A	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.902
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
P08246	ELA2	Neutrophil elastase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.825
P26358	DNMT1	DNA	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.7
Q9UBU7	DBF4	Protein DBF4 homolog A	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.83
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
P08246	ELA2	Neutrophil elastase	P78345	RPP38	Ribonuclease P protein subunit p38	-0.795
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q9UBU7	DBF4	Protein DBF4 homolog A	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.867
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P08246	ELA2	Neutrophil elastase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.849
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912
Q9UBU7	DBF4	Protein DBF4 homolog A	Q06787	FMR1	Synaptic functional regulator FMR1	0.772
P26358	DNMT1	DNA	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.841
Q9UBU7	DBF4	Protein DBF4 homolog A	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.854

Etomidate

hsa03020

RNA polymerase

9.80E-05

Q9GZM3, P52435

POLR2J2, POLR2J

Etomidate

hsa03040

Spliceosome

9.74E-05

Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243

DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5

Etomidate

hsa03050

Proteasome

4.81E-04

P55036

PSMD4

Etomidate

hsa03460

Fanconi anemia pathway

4.83E-02

Q9BXW9, P07992

FANCD2, ERCC1

Etomidate

hsa04012

ErbB signaling pathway

2.01E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Etomidate

hsa04020

Calcium signaling pathway

4.45E-02

P0DP24, P51828, P23634

CALM2, ADCY7, ATP2B4

Etomidate

hsa04024

cAMP signaling pathway

4.28E-04

P63092, P51828, P42338, P26678, P0DP24, P0DP23, P23634, P61586, Q13370, Q13009

GNAS, ADCY7, PIK3CB, PLN, CALM2, CALM1, ATP2B4, RHOA, PDE3B, TIAM1

Etomidate

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.53E-03

P09341, P19875, P25024, P25025, P47992, Q9UBD3, P14784, P01375

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL2RB, TNF

Etomidate

hsa04062

Chemokine signaling pathway

2.08E-03

P25024, P25025, P09341, P19875, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q13009

CXCR1, CXCR2, CXCL1, CXCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, TIAM1

Etomidate

hsa04064

NF-kappa B signaling pathway

9.83E-07

P10415, Q13489, P25963, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74

Etomidate

hsa04070

Phosphatidylinositol signaling system

3.21E-03

P0DP23, P42338, Q86XP1, P27987, Q96DU7

CALM1, PIK3CB, DGKH, ITPKB, ITPKC

Etomidate

hsa04071

Sphingolipid signaling pathway

1.19E-06

P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13510	ASAH1	Acid ceramidase	0.82
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.723
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P08246	ELA2	Neutrophil elastase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.865
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P08246	ELA2	Neutrophil elastase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.847
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863
O95551	TTRAP	Tyrosyl-DNA phosphodiesterase 2	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.707

Etomidate

hsa04072

Phospholipase D signaling pathway

5.37E-03

P42338, P61586, P43657, P25024, P25025, P19174, O14986, P63092

PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNAS

Etomidate

hsa04080

Neuroactive ligand-receptor interaction

3.18E-05

P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, Q16581, P14416, P35318

CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, C3AR1, DRD2, ADM

Etomidate

hsa04114

Oocyte meiosis

3.15E-04

P51812, Q02750, P0DP24, P16298, Q17RY0, P51828, P27348, Q13362

RPS6KA3, MAP2K1, CALM2, PPP3CB, CPEB4, ADCY7, YWHAQ, PPP2R5C

Etomidate

hsa04115

p53 signaling pathway

3.32E-03

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Etomidate

hsa04120

Ubiquitin mediated proteolysis

2.12E-05

Q9UBT2, Q14145, Q13042, Q13191, P62837, Q15751, Q14669, Q7Z6Z7

SAE2, KEAP1, CDC16, CBLB, UBE2D2, HERC1, TRIP12, HUWE1

Etomidate

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Etomidate

hsa04137

Mitophagy - animal

2.52E-02

P19784, P67870

CSNK2A2, CSNK2B

Etomidate

hsa04142

Lysosome

1.14E-02

P43234, P15586, P34059

CTSO, GNS, GALNS

Etomidate

hsa04145

Phagosome

1.98E-02

Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Etomidate

hsa04146

Peroxisome

2.42E-02

O43933, P56589, Q9UKG9, O75521, P33121

PEX1, PEX3, CROT, ECI2, ACSL1

Etomidate

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Etomidate

hsa04210

Apoptosis

1.63E-04

Q13315, P04637, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, P18848, Q14643, P63261

ATM, TP53, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ATF4, ITPR1, ACTG1

Etomidate

hsa04213

Longevity regulating pathway - multiple species

4.41E-03

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Etomidate

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Etomidate

hsa04217

Necroptosis

9.70E-04

P01375, P01568, P48023, Q13489, P98170, Q14765, P08238, P15104, Q99878, P21796

TNF, IFNA21, FASLG, BIRC3, BIRC4, STAT4, HSP90AB1, GLUL, H2AC14, VDAC1

Etomidate

hsa04261

Adrenergic signaling in cardiomyocytes

1.06E-02

P51828, Q13362, P0DP24, P23634

ADCY7, PPP2R5C, CALM2, ATP2B4

Etomidate

hsa04310

Wnt signaling pathway

4.17E-03

P61586, P19784, P67870

RHOA, CSNK2A2, CSNK2B

Etomidate

hsa04330

Notch signaling pathway

3.28E-03

Q92542, P49768, Q92830, P78504

NCSTN, PSEN1, KAT2A, JAG1

Etomidate

hsa04340

Hedgehog signaling pathway

3.46E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Etomidate

hsa04360

Axon guidance

1.71E-02

P20827, O95631, P42338, P23528

EFNA1, NTN1, PIK3CB, CFL1

Etomidate

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Etomidate

hsa04371

Apelin signaling pathway

3.23E-04

P62873, P63218, P50151, Q13485, P84022, Q16566, P0DP23

GNB1, GNG5, GNG10, SMAD4, SMAD3, CAMK4, CALM1

Etomidate

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Etomidate

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Etomidate

hsa04510

Focal adhesion

4.07E-02

O14986, P61586, Q16363

PIP5K1B, RHOA, LAMA4

Etomidate

hsa04520

Adherens junction

1.38E-04

P19784, P67870, P61586

CSNK2A2, CSNK2B, RHOA

Etomidate

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Etomidate

hsa04610

Complement and coagulation cascades

1.07E-05

P00734, P0C0L4, P21730

F2, C4A, C5AR1

Etomidate

hsa04612

Antigen processing and presentation

1.32E-05

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P48382	RFX5	DNA-binding protein RFX5	-0.747
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.719
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.718
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.704
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01375	TNF	Tumor necrosis factor	0.761
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897

Etomidate

hsa04613

Neutrophil extracellular trap formation

3.26E-08

P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O60603	TLR2	Toll-like receptor 2	0.762
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P05164	MPO	Myeloperoxidase	0.717
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.736
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q13547	HDAC1	Histone deacetylase 1	-0.759
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.706
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P08311	CTSG	Cathepsin G	0.715
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.892
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.923
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.779
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O43315	AQP9	Aquaporin-9	0.918
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.839
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767

Etomidate

hsa04621

NOD-like receptor signaling pathway

4.77E-06

Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P08246	ELA2	Neutrophil elastase	Q9H1Y0	ATG5	Autophagy protein 5	-0.759
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P08246	ELA2	Neutrophil elastase	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.702
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P08246	ELA2	Neutrophil elastase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.734
P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	P01375	TNF	Tumor necrosis factor	0.753
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.708
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	P59666	DEFA3	Neutrophil defensin 3	0.708
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	P12838	DEFA4	Neutrophil defensin 4	0.8
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709

Etomidate

hsa04625

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Etomidate

hsa04640

Hematopoietic cell lineage

8.93E-04

P13612, P14778, P27930, P11215, P20023, P25063, P07766, P01732, P09564

ITGA4, IL1R1, IL1R2, ITGAM, CR2, CD24, CD3E, CD8A, CD7

Etomidate

hsa04650

Natural killer cell mediated cytotoxicity

3.61E-08

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01375	TNF	Tumor necrosis factor	0.761
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P78314	SH3BP2	SH3 domain-binding protein 2	0.718
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.786
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.764
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.707
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.719
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.773
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.803
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.892
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721

Etomidate

hsa04657

IL-17 signaling pathway

2.32E-05

O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.805
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P22748	CA4	Carbonic anhydrase 4	O00463	TRAF5	TNF receptor-associated factor 5	-0.826
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.839
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.857
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P09341	CXCL1	Growth-regulated alpha protein	0.716
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P14780	MMP9	Matrix metalloproteinase-9	0.901
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.723
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P22748	CA4	Carbonic anhydrase 4	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01375	TNF	Tumor necrosis factor	0.761
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744

Etomidate

hsa04658

Th1 and Th2 cell differentiation

5.38E-07

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q9UL17	TBX21	T-box transcription factor TBX21	-0.73
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Etomidate

hsa04659

Th17 cell differentiation

6.21E-07

P25963, Q04759, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P14778	IL1R1	Interleukin-1 receptor type 1	0.909
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q9UL17	TBX21	T-box transcription factor TBX21	-0.73
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703

Etomidate

hsa04660

T cell receptor signaling pathway

7.14E-06

P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75

Etomidate

hsa04664

Fc epsilon RI signaling pathway

3.98E-02

P01375, Q16539, Q9UQC2

TNF, MAPK14, GAB2

Etomidate

hsa04666

Fc gamma R-mediated phagocytosis

3.08E-02

P42338, P23528, P14598

PIK3CB, CFL1, NCF1

Etomidate

hsa04668

TNF signaling pathway

1.83E-03

P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9

Etomidate

hsa04670

Leukocyte transendothelial migration

2.19E-03

P14780, P13612, P11215, P60709, Q96A32, P17252, P14598, Q15080, Q08881, P42681, P19174, P12814

MMP9, ITGA4, ITGAM, ACTB, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK, PLCG1, ACTN1

Etomidate

hsa04713

Circadian entrainment

2.14E-04

O15399, P0DP23, P62873, P63218, P50151, P63092

GRIN2D, CALM1, GNB1, GNG5, GNG10, GNAS

Etomidate

hsa04720

Long-term potentiation

9.85E-04

Q16566, P16298, P0DP23, P51812, O15399, Q02750

CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1

Etomidate

hsa04721

Synaptic vesicle cycle

4.83E-02

Q99437, P43005

ATP6V0B, SLC1A1

Etomidate

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Etomidate

hsa04723

Retrograde endocannabinoid signaling

4.94E-02

P48169, P62873

GABRA4, GNB1

Etomidate

hsa04724

Glutamatergic synapse

9.34E-05

O15399, P63092, P62873, P63218, P50151, P15104

GRIN2D, GNAS, GNB1, GNG5, GNG10, GLUL

Etomidate

hsa04725

Cholinergic synapse

1.44E-03

P22694, Q14643, P62873, P63218, P50151, P18848, Q16566, P10415

PRKACB, ITPR1, GNB1, GNG5, GNG10, ATF4, CAMK4, BCL2

Etomidate

hsa04726

Serotonergic synapse

1.60E-03

P63092, P62873, P63218, P50151, P09917

GNAS, GNB1, GNG5, GNG10, ALOX5

Etomidate

hsa04727

GABAergic synapse

2.45E-03

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Etomidate

hsa04744

Phototransduction

6.94E-03

P62873, P0DP23

GNB1, CALM1

Etomidate

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Etomidate

hsa04914

Progesterone-mediated oocyte maturation

2.97E-03

Q17RY0, P42338, Q13370, P08238, P51812, Q02750

CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1

Etomidate

hsa04915

Estrogen signaling pathway

2.96E-02

P14780, P22694, P18848, Q14643, P10415

MMP9, PRKACB, ATF4, ITPR1, BCL2

Etomidate

hsa04916

Melanogenesis

2.18E-02

P49841, Q01726

GSK3B, MC1R

Etomidate

hsa04918

Thyroid hormone synthesis

3.50E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Etomidate

hsa04919

Thyroid hormone signaling pathway

3.76E-02

P19174, P60709, Q13547, P01106

PLCG1, ACTB, HDAC1, MYC

Etomidate

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Etomidate

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Etomidate

hsa04924

Renin secretion

3.77E-02

Q13370, P0DP23

PDE3B, CALM1

Etomidate

hsa04925

Aldosterone synthesis and secretion

1.32E-02

P51828, P0DP24, P23634

ADCY7, CALM2, ATP2B4

Etomidate

hsa04927

Cortisol synthesis and secretion

8.60E-03

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Etomidate

hsa04928

Parathyroid hormone synthesis, secretion and action

2.13E-02

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Etomidate

hsa04932

Non-alcoholic fatty liver disease

2.74E-02

P01375, P49841, P48023

TNF, GSK3B, FASLG

Etomidate

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Etomidate

hsa04940

Type I diabetes mellitus

6.87E-04

P48023, P01375

FASLG, TNF

Etomidate

hsa04961

Endocrine and other factor-regulated calcium reabsorption

2.09E-02

P23634, P62491

ATP2B4, RAB11A

Etomidate

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Etomidate

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Etomidate

hsa04970

Salivary secretion

1.06E-03

P51828, P22694, Q14643, P23634, P17252, P0DP24, P49913

ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM2, CAMP

Etomidate

hsa04972

Pancreatic secretion

3.95E-04

P23634, P63092, P51828, P62491, P61586

ATP2B4, GNAS, ADCY7, RAB11A, RHOA

Etomidate

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Etomidate

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Etomidate

hsa04976

Bile secretion

3.87E-02

O43315, P22694, P08183

AQP9, PRKACB, ABCB1

Etomidate

hsa05016

Huntington disease

1.07E-02

Q9GZM3, P52435, P55036

POLR2J2, POLR2J, PSMD4

Etomidate

hsa05032

Morphine addiction

8.15E-06

P62873, P63218, P50151, P48169, P78334, P63092, P32298, P43250

GNB1, GNG5, GNG10, GABRA4, GABRE, GNAS, GRK4, GRK6

Etomidate

hsa05034

Alcoholism

4.45E-05

O15399, Q16566, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431

GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Etomidate

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

3.27E-05

Q16539, Q99437, P09341, P19875, P10145, P19174, P25024, P25025

MAPK14, ATP6V0B, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2

Etomidate

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Etomidate

hsa05132

Salmonella infection

2.83E-03

P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509

IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3

Etomidate

hsa05133

Pertussis

2.64E-03

P0DP23, P0C0L4

CALM1, C4A

Etomidate

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Etomidate

hsa05135

Yersinia infection

2.07E-02

P60709, P13612, P06239, P19174

ACTB, ITGA4, LCK, PLCG1

Etomidate

hsa05140

Leishmaniasis

1.10E-04

P13612, O75015, P14598, P13765, O60603, P25963, P01375, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MAPK14, IRAK1, NCF4

Etomidate

hsa05142

Chagas disease

2.26E-02

P01375, P30679, P48023

TNF, GNA15, FASLG

Etomidate

hsa05143

African trypanosomiasis

3.74E-07

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Etomidate

hsa05144

Malaria

7.93E-08

P60033, P69905, P68871, O60603, P01375, P35443, P10145, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, IL8, KLRK1

Etomidate

hsa05145

Toxoplasmosis

4.06E-03

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Etomidate

hsa05146

Amoebiasis

2.71E-07

P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Etomidate

hsa05150

Staphylococcus aureus infection

1.73E-06

P0C0L4, P21730, P21462, O75015, P13646, Q14532, P59665, P59666, P12838, P49913

C4A, C5AR1, FPR1, FCGR3B, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Etomidate

hsa05152

Tuberculosis

2.07E-02

Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Etomidate

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Etomidate

hsa05161

Hepatitis B

1.61E-03

P17252, P14780, P25963, Q13485, P01375, P10415, P84022, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, SMAD4, TNF, BCL2, SMAD3, IRAK1, TLR2, STAT4

Etomidate

hsa05163

Human cytomegalovirus infection

1.70E-04

P01375, P62873, P63218, P50151, P0DP23, P61586, P49841, P14778, P25025, Q16539, P63092, O00463, P30101, P61769, P01568

TNF, GNB1, GNG5, GNG10, CALM1, RHOA, GSK3B, IL1R1, CXCR2, MAPK14, GNAS, TRAF5, PDIA3, B2M, IFNA21

Etomidate

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.12E-03

P01568, P62873, P62879, P63218, P50151, P16298, Q02750, P07948, P0DP23, P0CG47

IFNA21, GNB1, GNB2, GNG5, GNG10, PPP3CB, MAP2K1, LYN, CALM1, UBB

Etomidate

hsa05168

Herpes simplex virus 1 infection

1.78E-03

P01568, P42224, Q07955, Q01130, P84103, Q13243, Q13489, P30101, P42338, Q13398, Q03923, Q9NZL3, Q9UDV6

IFNA21, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF85, ZNF224, ZNF212

Etomidate

hsa05169

Epstein-Barr virus infection

4.41E-02

P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963

HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247

Etomidate

hsa05170

Human immunodeficiency virus 1 infection

1.85E-06

Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, P01375, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P23528, P10415, Q13619, Q93034, Q9Y6Q5, P20333

MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, CFL1, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	O95067	CCNB2	G2/mitotic-specific cyclin-B2	0.711
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P23528	CFL1	Cofilin-1	0.738
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13619	CUL4A	Cullin-4A	-0.707
P08246	ELA2	Neutrophil elastase	Q93034	CUL5	Cullin-5	-0.744
P08246	ELA2	Neutrophil elastase	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.811
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Etomidate

hsa05171

Coronavirus disease - COVID-19

4.47E-02

Q9UHA3, O14786

RSL24D1, NRP1

Etomidate

hsa05200

Pathways in cancer

7.68E-05

Q13751, P42338, P08238, P42224, P43246, P84022, Q13485, P14923, Q13489, P98170, P62873, P63218, P50151, P78417, O75293, P0DP23, P01568, P14784, P40189, P01042

LAMB3, PIK3CB, HSP90AB1, STAT1, MSH2, SMAD3, SMAD4, JUP, BIRC3, BIRC4, GNB1, GNG5, GNG10, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13751	LAMB3	Laminin subunit beta-3	0.868
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43246	MSH2	DNA mismatch repair protein Msh2	-0.742
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P78417	GSTO1	Glutathione S-transferase omega-1	0.754
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.708
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01042	KNG1	Kininogen-1	0.708

Etomidate

hsa05202

Transcriptional misregulation in cancer

3.62E-09

Q92570, Q12778, Q15532, Q13315, O94812, P41732, P58340, P10145, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

NR4A3, FOXO1, SS18, ATM, BAIAP3, TSPAN7, MLF1, IL8, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q92570	NR4A3	Nuclear receptor subfamily 4 group A member 3	-0.754
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	O94812	BAIAP3	BAI1-associated protein 3	0.73
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	P58340	MLF1	Myeloid leukemia factor 1	0.7
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	P10145	IL8	Interleukin-8	0.941
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769

Etomidate

hsa05203

Viral carcinogenesis

6.22E-03

Q12933, P42229, Q15283, P62807, O60814

TRAF2, STAT5A, RASA2, HIST1H2BC, H2BC12

Etomidate

hsa05204

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Etomidate

hsa05205

Proteoglycans in cancer

4.43E-02

P63261, P04637, Q06124

ACTG1, TP53, PTPN11

Etomidate

hsa05206

MicroRNAs in cancer

3.42E-02

P30304, P01106, Q9Y4H2, Q13547, P19174

CDC25A, MYC, IRS2, HDAC1, PLCG1

Etomidate

hsa05210

Colorectal cancer

2.90E-03

P84022, Q13485, P43246, P10415, O75293

SMAD3, SMAD4, MSH2, BCL2, GADD45B

Etomidate

hsa05211

Renal cell carcinoma

7.75E-03

Q06124, Q99814

PTPN11, EPAS1

Etomidate

hsa05212

Pancreatic cancer

1.09E-05

P42338, P42224, P84022, Q13485, P04637, P24522, O75293

PIK3CB, STAT1, SMAD3, SMAD4, TP53, GADD45A, GADD45B

Etomidate

hsa05213

Endometrial cancer

2.44E-03

O15169, Q02750, P04637, P24522

AXIN1, MAP2K1, TP53, GADD45A

Etomidate

hsa05214

Glioma

1.12E-04

P0DP23, Q16566, P42338, P04637, P24522, O75293

CALM1, CAMK4, PIK3CB, TP53, GADD45A, GADD45B

Etomidate

hsa05216

Thyroid cancer

1.14E-02

P04637, P24522

TP53, GADD45A

Etomidate

hsa05217

Basal cell carcinoma

2.06E-02

P04637, P24522

TP53, GADD45A

Etomidate

hsa05218

Melanoma

1.14E-02

P04637, P24522

TP53, GADD45A

Etomidate

hsa05220

Chronic myeloid leukemia

2.51E-04

Q06124, P04637, Q13485, P25963, P84022, P24522

PTPN11, TP53, SMAD4, NFKBIA, SMAD3, GADD45A

Etomidate

hsa05222

Small cell lung cancer

2.62E-04

Q13751, Q13489, P98170, P10415, P25963, Q13077, O00463, P24522, O75293

LAMB3, BIRC3, BIRC4, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A, GADD45B

Etomidate

hsa05223

Non-small cell lung cancer

3.19E-02

P04637, P24522

TP53, GADD45A

Etomidate

hsa05224

Breast cancer

4.51E-02

P04637, P24522

TP53, GADD45A

Etomidate

hsa05225

Hepatocellular carcinoma

3.30E-02

P04637, P24522, P63261

TP53, GADD45A, ACTG1

Etomidate

hsa05226

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Etomidate

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.00E-03

P42338, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539

PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14

Etomidate

hsa05310

Asthma

3.11E-03

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Etomidate

hsa05321

Inflammatory bowel disease

9.61E-06

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Etomidate

hsa05322

Systemic lupus erythematosus

2.09E-04

P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455

ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB

Etomidate

hsa05330

Allograft rejection

1.51E-03

P48023, P01375

FASLG, TNF

Etomidate

hsa05332

Graft-versus-host disease

3.92E-07

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Etomidate

hsa05340

Primary immunodeficiency

2.73E-02

P11912, P07766, P06239

CD79A, CD3E, LCK

Etomidate

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

6.53E-03

P54284, P13612, P60709, P35609

CACNB3, ITGA4, ACTB, ACTN2

Etomidate

hsa05418

Fluid shear stress and atherosclerosis

3.57E-05

Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P14778, P27930, P0DP23, P08238

MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, IL1R1, IL1R2, CALM1, HSP90AB1

Community members of Etomidate (S_DC: 7.34)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

GABRA4

GammaNoneaminobutyric acid receptor subunit alphaNone4

Reported

0.3253

0.565

0.1579

1.4506

P28472

GABRB3

GammaNoneaminobutyric acid receptor subunit betaNone3

Reported

0.1559

0.4387

0.1695

1.1248

P78334

GABRE

GammaNoneaminobutyric acid receptor subunit epsilon

Reported

0.1394

0.4097

0.1579

1.0469

P14780

MMP9

Matrix metalloproteinaseNone9

Predicted

0.1696

0.8424

0.7315

2.5012

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P38919

EIF4A3

Eukaryotic initiation factor 4ANoneIII

Predicted

0.3646

0.0334

0.4886

0.7378

P15121

AKR1B1

AldoNoneketo reductase family 1 member B1

Predicted

0.5683

0.629

0.214

1.7562

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

P98170

BIRC4

E3 ubiquitinNoneprotein ligase XIAP

Predicted

0.2974

0.2298

0.79

1.3984

P05186

ALPL

Alkaline phosphatase, tissueNonenonspecific isozyme

Predicted

0.3064

0.4143

0.1992

1.181

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P01375

TNF

Tumor necrosis factor

Predicted

0.1865

0.551

2.1953

P22748

CA4

Carbonic anhydrase 4

Predicted

0.0056

0.8267

0.1609

1.8171

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

Q9UBU7

DBF4

Protein DBF4 homolog A

Predicted

0.0075

0.1961

0.259

0.655

Q15078

CDK5R1

CyclinNonedependent kinase 5 activator 1

Predicted

0.1358

0.5004

0.2575

1.3263

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

O75469

NR1I2

Nuclear receptor subfamily 1 group I member 2

Predicted

0.0315

0.9493

1.9143

Q9P1W9

PIM2

Serine/threonineNoneprotein kinase pimNone2

Predicted

0.1267

0.7674

0.2638

1.8619

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

P29375

JARID1A

LysineNonespecific demethylase 5A

Predicted

0.3605

0.7052

1.5906

P05164

MPO

Myeloperoxidase

Predicted

0.2035

0.5368

0.5502

1.7255

P20839

IMPDH1

InosineNone5'Nonemonophosphate dehydrogenase 1

Predicted

0.1928

0.1307

0.1653

0.5231

O95551

TTRAP

TyrosylNoneDNA phosphodiesterase 2

Predicted

0.2092

0.2569

0.6184

Q9Y4K0

LOXL2

Lysyl oxidase homolog 2

Predicted

0.0269

0.1198

0.253

P26358

DNMT1

DNA

Predicted

0.3404

0.2809

0.2659

0.998

Q96KQ7

EHMT2

HistoneNonelysine NNonemethyltransferase EHMT2

Predicted

0.0728

0.2165

0.2909

0.7603

P41968

MC3R

Melanocortin receptor 3

Predicted

0.2235

0.2637

0.6392

Q16769

QPCT

GlutaminylNonepeptide cyclotransferase

Predicted

0.0245

0.2416

0.4954

O60551

NMT2

Glycylpeptide NNonetetradecanoyltransferase 2

Predicted

0.2565

0.0114

0.1511

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

PharmaCoNets of Etomidate (SPCN: 162.56 )

Etomidate regulated-network (SDN: 22.15)

Community members of Etomidate (SDC: 7.34)

PharmaCoNets of Etomidate (S_PCN: 162.56 )

Etomidate regulated-network (S_DN: 22.15)

Community members of Etomidate (S_DC: 7.34)