PharmaCoNets of Ethynodiol-diacetate (SPCN: 22.40 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ethynodiol-diacetatehsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Ethynodiol-diacetatehsa03013RNA transport2.99E-024P38919, P37198, P35658, P55884EIF4A3, NUP62, NUP214, EIF3BMore
Ethynodiol-diacetatehsa04064NF-kappa B signaling pathway1.09E-0411P10415, Q13489, O00463, Q13546, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341, Q9UNE0BCL2, BIRC3, TRAF5, RIPK1, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1, EDARMore
Ethynodiol-diacetatehsa04071Sphingolipid signaling pathway1.19E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Ethynodiol-diacetatehsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Ethynodiol-diacetatehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Ethynodiol-diacetatehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Ethynodiol-diacetatehsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Ethynodiol-diacetatehsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Ethynodiol-diacetatehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Ethynodiol-diacetatehsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Ethynodiol-diacetatehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Ethynodiol-diacetatehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Ethynodiol-diacetatehsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Ethynodiol-diacetatehsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Ethynodiol-diacetatehsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Ethynodiol-diacetatehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Ethynodiol-diacetatehsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Ethynodiol-diacetatehsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Ethynodiol-diacetatehsa04613Neutrophil extracellular trap formation4.93E-028O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, P21730TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, C5AR1More
Ethynodiol-diacetatehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Ethynodiol-diacetatehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Ethynodiol-diacetatehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Ethynodiol-diacetatehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Ethynodiol-diacetatehsa04650Natural killer cell mediated cytotoxicity2.02E-039P16298, P50591, O60880, P20963, Q02750, Q13241, P26718, P26717, P26715PPP3CB, TNFSF10, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, KLRC2, KLRC1More
Ethynodiol-diacetatehsa04658Th1 and Th2 cell differentiation1.07E-037Q04759, P20963, P09693, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, STAT4, GATA3, TBX21, HLA-DOBMore
Ethynodiol-diacetatehsa04659Th17 cell differentiation1.90E-026Q04759, P13765, Q9UL17, P23771, P09693, P20963PRKCQ, HLA-DOB, TBX21, GATA3, CD3G, CD247More
Ethynodiol-diacetatehsa04660T cell receptor signaling pathway1.00E-027Q9UDY8, Q04759, P10747, Q08881, P20963, P09693, P01732MALT1, PRKCQ, CD28, ITK, CD247, CD3G, CD8AMore
Ethynodiol-diacetatehsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Ethynodiol-diacetatehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Ethynodiol-diacetatehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Ethynodiol-diacetatehsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Ethynodiol-diacetatehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Ethynodiol-diacetatehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Ethynodiol-diacetatehsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Ethynodiol-diacetatehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Ethynodiol-diacetatehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Ethynodiol-diacetatehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Ethynodiol-diacetatehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Ethynodiol-diacetatehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Ethynodiol-diacetatehsa05202Transcriptional misregulation in cancer2.90E-029Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45AMore
Ethynodiol-diacetatehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Ethynodiol-diacetatehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Ethynodiol-diacetatehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Ethynodiol-diacetatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.84E-025P20963, P09693, O60603, P10747, Q04759CD247, CD3G, TLR2, CD28, PRKCQMore
Ethynodiol-diacetatehsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Ethynodiol-diacetatehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Ethynodiol-diacetatehsa05332Graft-versus-host disease3.45E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More

Community members of Ethynodiol-diacetate (SDC: 3.79)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)