PharmaCoNets of Ethotoin (SPCN: 37.65 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ethotoinhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Ethotoinhsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Ethotoinhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Ethotoinhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Ethotoinhsa00600Sphingolipid metabolism2.44E-022Q9BX95, Q06136SGPP1, FVT1More
Ethotoinhsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Ethotoinhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Ethotoinhsa00983Drug metabolism - other enzymes3.59E-023P04183, P32320, P05164TK1, CDA, MPOMore
Ethotoinhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Ethotoinhsa03008Ribosome biogenesis in eukaryotes1.46E-024Q9NYH9, P78345, Q9BVP2, Q9GZY0UTP6, RPP38, GNL3, NXF2; NXF2BMore
Ethotoinhsa03013RNA transport4.11E-0312P52298, Q09161, O14893, P61326, Q9GZY0, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5, Q53GS7NCBP2, NCBP1, GEMIN2, MAGOH, NXF2; NXF2B, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3, GLE1More
Ethotoinhsa03015mRNA surveillance pathway9.78E-036O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Ethotoinhsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Ethotoinhsa04064NF-kappa B signaling pathway1.91E-0412P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45AMore
Ethotoinhsa04071Sphingolipid signaling pathway8.72E-049P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2More
Ethotoinhsa04080Neuroactive ligand-receptor interaction1.18E-027P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1More
Ethotoinhsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Ethotoinhsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Ethotoinhsa04145Phagosome5.27E-0510P63261, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Ethotoinhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Ethotoinhsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Ethotoinhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Ethotoinhsa04217Necroptosis1.93E-024P01568, Q13489, Q13546, Q6FI13IFNA21, BIRC3, RIPK1, H2AC18; H2AC19More
Ethotoinhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Ethotoinhsa04390Hippo signaling pathway3.20E-046P84022, Q13485, P04628, Q9UJU2, O43623, Q13489SMAD3, SMAD4, WNT1, LEF1, SNAI2, BIRC3More
Ethotoinhsa04540Gap junction3.53E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Ethotoinhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Ethotoinhsa04613Neutrophil extracellular trap formation1.25E-0414P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, P21730, P21462, P63261PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1, ACTG1More
Ethotoinhsa04621NOD-like receptor signaling pathway3.10E-0311Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Ethotoinhsa04623Cytosolic DNA-sensing pathway5.29E-032P01568, Q13546IFNA21, RIPK1More
Ethotoinhsa04650Natural killer cell mediated cytotoxicity3.18E-039P16298, P50591, P78314, P06239, O60880, P20963, Q02750, P26718, O75015PPP3CB, TNFSF10, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRK1, FCGR3BMore
Ethotoinhsa04658Th1 and Th2 cell differentiation9.73E-036P20963, P09693, Q16539, P06239, Q9UL17, P13765CD247, CD3G, MAPK14, LCK, TBX21, HLA-DOBMore
Ethotoinhsa04659Th17 cell differentiation8.26E-0410P25963, Q16539, P06239, P13765, P14778, Q9UL17, P84022, Q13485, P09693, P20963NFKBIA, MAPK14, LCK, HLA-DOB, IL1R1, TBX21, SMAD3, SMAD4, CD3G, CD247More
Ethotoinhsa04660T cell receptor signaling pathway4.20E-027P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITKMore
Ethotoinhsa04666Fc gamma R-mediated phagocytosis9.96E-035P23528, P49006, P06396, P14598, P17252CFL1, MARCKSL1, GSN, NCF1, PRKCAMore
Ethotoinhsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Ethotoinhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Ethotoinhsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Ethotoinhsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Ethotoinhsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Ethotoinhsa04920Adipocytokine signaling pathway5.84E-036P25963, P33121, Q9Y478, Q04759, Q96RR4, P01375NFKBIA, ACSL1, PRKAB1, PRKCQ, CAMKK2, TNFMore
Ethotoinhsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Ethotoinhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Ethotoinhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Ethotoinhsa04970Salivary secretion4.49E-024P22694, Q14643, P17252, P49913PRKACB, ITPR1, PRKCA, CAMPMore
Ethotoinhsa04972Pancreatic secretion1.99E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Ethotoinhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Ethotoinhsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Ethotoinhsa05132Salmonella infection4.80E-0614P51617, P25963, P01375, Q9UJU2, P63261, Q13546, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, NFKBIA, TNF, LEF1, ACTG1, RIPK1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Ethotoinhsa05133Pertussis4.20E-021P0C0L4C4AMore
Ethotoinhsa05140Leishmaniasis1.43E-038P14598, P13765, O60603, P25963, P01375, P49006, P51617, Q15080NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, IRAK1, NCF4More
Ethotoinhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Ethotoinhsa05144Malaria1.44E-036P60033, P69905, P68871, O60603, P35443, P26718CD81, HBA2, HBB, TLR2, THBS4, KLRK1More
Ethotoinhsa05145Toxoplasmosis4.06E-037P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Ethotoinhsa05152Tuberculosis2.07E-029Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Ethotoinhsa05161Hepatitis B1.61E-0310P17252, P14780, P25963, Q13485, P01375, P10415, P84022, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, SMAD4, TNF, BCL2, SMAD3, IRAK1, TLR2, STAT4More
Ethotoinhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Ethotoinhsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Ethotoinhsa05170Human immunodeficiency virus 1 infection2.58E-0518Q02750, P62879, P16298, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333MAP2K1, GNB2, PPP3CB, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Ethotoinhsa05202Transcriptional misregulation in cancer3.51E-0617Q12778, Q15532, Q13315, P41732, P14780, P14923, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, JUP, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Ethotoinhsa05205Proteoglycans in cancer2.66E-028Q14643, P63261, P04637, P14780, P17252, O60603, Q13635, P08962ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63More
Ethotoinhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Ethotoinhsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Ethotoinhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Ethotoinhsa05216Thyroid cancer3.59E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Ethotoinhsa05217Basal cell carcinoma1.75E-035Q13635, P04628, Q9UJU2, P04637, P24522PTCH1, WNT1, LEF1, TP53, GADD45AMore
Ethotoinhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Ethotoinhsa05222Small cell lung cancer2.38E-036Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Ethotoinhsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Ethotoinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.03E-025P20963, P09693, P06239, O60603, Q16539CD247, CD3G, LCK, TLR2, MAPK14More
Ethotoinhsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Ethotoinhsa05321Inflammatory bowel disease1.28E-025O60603, P01375, P13765, Q14765, P23771TLR2, TNF, HLA-DOB, STAT4, GATA3More
Ethotoinhsa05322Systemic lupus erythematosus4.20E-027P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Ethotoinhsa05323Rheumatoid arthritis3.53E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Ethotoinhsa05332Graft-versus-host disease9.30E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Ethotoinhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Ethotoinhsa05418Fluid shear stress and atherosclerosis4.26E-026P14598, P14780, P63261, P04637, P10415, Q92974NCF1, MMP9, ACTG1, TP53, BCL2, ARHGEF2More

Community members of Ethotoin (SDC: 3.98)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Reported10.03150.949301.9143
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)