PharmaCoNets of Etacrynic-acid (SPCN: 7.92 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Etacrynic-acidhsa00040Pentose and glucuronate interconversions2.33E-042P15121, P14550AKR1B1, AKR1A1More
Etacrynic-acidhsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate3.56E-021Q9Y2C2USTMore
Etacrynic-acidhsa00561Glycerolipid metabolism2.62E-022P15121, P14550AKR1B1, AKR1A1More
Etacrynic-acidhsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Etacrynic-acidhsa00980Metabolism of xenobiotics by cytochrome P4502.97E-033P78417, P09211, P11712GSTO1, GSTP1, CYP2C9More
Etacrynic-acidhsa00982Drug metabolism - cytochrome P4503.10E-022P11712, P78417CYP2C9, GSTO1More
Etacrynic-acidhsa00983Drug metabolism - other enzymes1.63E-022P20839, Q16772IMPDH1, GSTA3More
Etacrynic-acidhsa01100Metabolic pathways2.59E-0211P35790, Q16772, P30041, P20839, O94777, P15121, O95861, P14550, Q9UHK6, Q86VZ5, Q9NVH6CHKA, GSTA3, PRDX6, IMPDH1, DPM2, AKR1B1, BPNT1, AKR1A1, AMACR, SGMS1, TMLHEMore
Etacrynic-acidhsa03010Ribosome2.25E-045P40429, Q07020, P27635, P05386, P62249RPL13A, RPL18, RPL10, RPLP1, RPS16More
Etacrynic-acidhsa03013RNA transport3.63E-027P52298, Q09161, O14893, Q7Z3B4, Q14152, O75822, P78345NCBP2, NCBP1, GEMIN2, NUP54, EIF3A, EIF3J, RPP38More
Etacrynic-acidhsa03040Spliceosome1.27E-026O43143, P08579, Q13595, Q07955, P84103, P11142DHX15, SNRPB2, TRA2A, SFRS1, SFRS3, HSPA8More
Etacrynic-acidhsa04014Ras signaling pathway4.12E-025P20827, P49767, Q14644, P0DP23, P63218EFNA1, VEGFC, RASA3, CALM1, GNG5More
Etacrynic-acidhsa04020Calcium signaling pathway3.36E-036Q16566, P30679, O15399, P0DP23, P23634, P49767CAMK4, GNA15, GRIN2D, CALM1, ATP2B4, VEGFCMore
Etacrynic-acidhsa04064NF-kappa B signaling pathway1.25E-039P10415, Q13489, P51617, O00463, Q13546, Q9UDY8, Q13077, Q16548, Q8WV28BCL2, BIRC3, IRAK1, TRAF5, RIPK1, MALT1, TRAF1, BCL2A1, BLNKMore
Etacrynic-acidhsa04110Cell cycle4.67E-035Q09472, P24522, P49918, P42773, P01106EP300, GADD45A, CDKN1C, CDKN2C, MYCMore
Etacrynic-acidhsa04142Lysosome1.96E-023Q9UBR2, P34059, P17900CTSZ, GALNS, GM2AMore
Etacrynic-acidhsa04210Apoptosis4.30E-027P10415, Q13489, Q13546, Q16548, Q13077, Q9UBR2, Q14643BCL2, BIRC3, RIPK1, BCL2A1, TRAF1, CTSZ, ITPR1More
Etacrynic-acidhsa04371Apelin signaling pathway4.16E-024P63218, Q13485, Q16566, P0DP23GNG5, SMAD4, CAMK4, CALM1More
Etacrynic-acidhsa04610Complement and coagulation cascades4.48E-023P01042, P09871, P11215KNG1, C1S, ITGAMMore
Etacrynic-acidhsa04630JAK-STAT signaling pathway4.43E-023P01106, Q09472, P16871MYC, EP300, IL7RMore
Etacrynic-acidhsa04640Hematopoietic cell lineage8.35E-034P20023, P09693, P01730, P16871CR2, CD3G, CD4, IL7RMore
Etacrynic-acidhsa04660T cell receptor signaling pathway4.41E-026Q9UDY8, P10747, O95267, Q08881, P09693, P10966MALT1, CD28, RASGRP1, ITK, CD3G, CD8BMore
Etacrynic-acidhsa04720Long-term potentiation1.79E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Etacrynic-acidhsa04724Glutamatergic synapse4.48E-023O15399, P63218, Q9NSB8GRIN2D, GNG5, HOMER2More
Etacrynic-acidhsa04922Glucagon signaling pathway4.91E-024P06737, Q12778, Q14643, P07195PYGL, FOXO1, ITPR1, LDHBMore
Etacrynic-acidhsa04925Aldosterone synthesis and secretion3.44E-023P0DP23, Q16566, P23634CALM1, CAMK4, ATP2B4More
Etacrynic-acidhsa05034Alcoholism4.05E-049O15399, P07101, Q16566, P0DP23, P63218, P62807, P33778, O60814, P68431GRIN2D, TH, CAMK4, CALM1, GNG5, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Etacrynic-acidhsa05132Salmonella infection6.27E-039P51617, Q9UJU2, Q13546, Q13489, P10415, O60603, Q9BQS8, Q13561, P68371IRAK1, LEF1, RIPK1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB2CMore
Etacrynic-acidhsa05133Pertussis1.70E-034P11215, P0DP23, P23528, P09871ITGAM, CALM1, CFL1, C1SMore
Etacrynic-acidhsa05152Tuberculosis2.95E-026P48382, O60603, P10415, P13765, Q9UDY8, P51617RFX5, TLR2, BCL2, HLA-DOB, MALT1, IRAK1More
Etacrynic-acidhsa05166Human T-cell leukemia virus 1 infection2.13E-025P01106, P09693, Q09472, P42773, P01730MYC, CD3G, EP300, CDKN2C, CD4More
Etacrynic-acidhsa05169Epstein-Barr virus infection1.36E-0312P20023, P13765, P01106, Q13546, O00463, P10415, P24522, Q8WV28, O60603, P51617, Q14790, P09693CR2, HLA-DOB, MYC, RIPK1, TRAF5, BCL2, GADD45A, BLNK, TLR2, IRAK1, CASP8, CD3GMore
Etacrynic-acidhsa05170Human immunodeficiency virus 1 infection9.66E-039P17252, Q13546, O00463, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5PRKCA, RIPK1, TRAF5, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2More
Etacrynic-acidhsa05171Coronavirus disease - COVID-193.87E-045P62249, P40429, P27635, Q07020, P05386RPS16, RPL13A, RPL10, RPL18, RPLP1More
Etacrynic-acidhsa05203Viral carcinogenesis6.08E-034Q14790, Q09472, P62807, P33778CASP8, EP300, HIST1H2BC, H2BC3More
Etacrynic-acidhsa05204Chemical carcinogenesis5.00E-033P09211, P78417, P11712GSTP1, GSTO1, CYP2C9More
Etacrynic-acidhsa05213Endometrial cancer3.77E-022P01106, P24522MYC, GADD45AMore
Etacrynic-acidhsa05216Thyroid cancer1.68E-022P01106, P24522MYC, GADD45AMore
Etacrynic-acidhsa05322Systemic lupus erythematosus3.95E-022P62807, P33778HIST1H2BC, H2BC3More
Etacrynic-acidhsa05332Graft-versus-host disease3.49E-023P13765, P10747, P26715HLA-DOB, CD28, KLRC1More
Etacrynic-acidhsa05340Primary immunodeficiency4.61E-022P01730, P16871CD4, IL7RMore

Community members of Etacrynic-acid (SDC: 1.44)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
GSTP1P09211IC503400
GSTP1P09211IC504000
GSTP1P09211IC502.60E+04