PharmaCoNets of Estrone-sulfate (SPCN: 39.58 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Estrone-sulfatehsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Estrone-sulfatehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Estrone-sulfatehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Estrone-sulfatehsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Estrone-sulfatehsa00500Starch and sucrose metabolism1.33E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Estrone-sulfatehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Estrone-sulfatehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Estrone-sulfatehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Estrone-sulfatehsa00970Aminoacyl-tRNA biosynthesis1.17E-023O95363, P14868, Q15046FARS2, DARS, KARSMore
Estrone-sulfatehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Estrone-sulfatehsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Estrone-sulfatehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Estrone-sulfatehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Estrone-sulfatehsa03013RNA transport2.48E-0512O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3More
Estrone-sulfatehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Estrone-sulfatehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Estrone-sulfatehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Estrone-sulfatehsa04071Sphingolipid signaling pathway1.53E-037Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Estrone-sulfatehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Estrone-sulfatehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Estrone-sulfatehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Estrone-sulfatehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Estrone-sulfatehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Estrone-sulfatehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Estrone-sulfatehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Estrone-sulfatehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Estrone-sulfatehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Estrone-sulfatehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Estrone-sulfatehsa04612Antigen processing and presentation1.51E-027P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Estrone-sulfatehsa04613Neutrophil extracellular trap formation7.32E-0313O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Estrone-sulfatehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Estrone-sulfatehsa04650Natural killer cell mediated cytotoxicity6.76E-0615P16298, P50591, P19174, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, PLCG1, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Estrone-sulfatehsa04657IL-17 signaling pathway6.64E-037O00463, Q16539, P49841, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, MMP9, ANAPC5, LCN2, TNFMore
Estrone-sulfatehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Estrone-sulfatehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Estrone-sulfatehsa04660T cell receptor signaling pathway2.24E-0413Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Estrone-sulfatehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Estrone-sulfatehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Estrone-sulfatehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Estrone-sulfatehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Estrone-sulfatehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Estrone-sulfatehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Estrone-sulfatehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Estrone-sulfatehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Estrone-sulfatehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Estrone-sulfatehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Estrone-sulfatehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Estrone-sulfatehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Estrone-sulfatehsa05133Pertussis4.20E-021P0C0L4C4AMore
Estrone-sulfatehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Estrone-sulfatehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Estrone-sulfatehsa05144Malaria4.04E-036P60033, P69905, P68871, O60603, P35443, P26718CD81, HBA2, HBB, TLR2, THBS4, KLRK1More
Estrone-sulfatehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Estrone-sulfatehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Estrone-sulfatehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Estrone-sulfatehsa05202Transcriptional misregulation in cancer1.45E-0212Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, GADD45AMore
Estrone-sulfatehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Estrone-sulfatehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Estrone-sulfatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Estrone-sulfatehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Estrone-sulfate (SDC: 5.22)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)