PharmaCoNets

PharmaCoNets of Estradiol-valerate (S_PCN: 202.43 )

Estradiol-valerate regulated-network (S_DN: 24.42)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Estradiol-valerate

hsa00030

Pentose phosphate pathway

5.10E-05

P52209, P11413, P37837

PGD, G6PD, TALDO1

Estradiol-valerate

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Estradiol-valerate

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Estradiol-valerate

hsa00190

Oxidative phosphorylation

8.71E-03

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Estradiol-valerate

hsa00220

Arginine biosynthesis

1.39E-04

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Estradiol-valerate

hsa00250

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Estradiol-valerate

hsa00310

Lysine degradation

3.15E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Estradiol-valerate

hsa00480

Glutathione metabolism

2.60E-05

Q9UJ14, P11413, Q16772, P09211, P30041

GGTL3, G6PD, GSTA3, GSTP1, PRDX6

Estradiol-valerate

hsa00500

Starch and sucrose metabolism

4.14E-09

O43451, P46976, P35573, P06737

MGAM, GYG1, AGL, PYGL

Estradiol-valerate

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Estradiol-valerate

hsa00520

Amino sugar and nucleotide sugar metabolism

7.87E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Estradiol-valerate

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

6.96E-04

Q9NY97

B3GNT2

Estradiol-valerate

hsa00563

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

3.01E-02

Q14442

PIGH

Estradiol-valerate

hsa00590

Arachidonic acid metabolism

2.97E-02

P09917

ALOX5

Estradiol-valerate

hsa00591

Linoleic acid metabolism

3.18E-02

P11712

CYP2C9

Estradiol-valerate

hsa00600

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Estradiol-valerate

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Estradiol-valerate

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

4.30E-03

P06865, O75752

HEXA, B3GALNT1

Estradiol-valerate

hsa00630

Glyoxylate and dicarboxylate metabolism

1.13E-02

P40925, P15104

MDH1, GLUL

Estradiol-valerate

hsa00730

Thiamine metabolism

1.07E-05

P05186, P24666

ALPL, ACP1

Estradiol-valerate

hsa00770

Pantothenate and CoA biosynthesis

7.90E-03

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Estradiol-valerate

hsa00830

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Estradiol-valerate

hsa00910

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Estradiol-valerate

hsa00970

Aminoacyl-tRNA biosynthesis

9.22E-06

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Estradiol-valerate

hsa00980

Metabolism of xenobiotics by cytochrome P450

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Estradiol-valerate

hsa00982

Drug metabolism - cytochrome P450

1.06E-02

Q16772, P09211

GSTA3, GSTP1

Estradiol-valerate

hsa00983

Drug metabolism - other enzymes

1.72E-02

Q16772, P09211

GSTA3, GSTP1

Estradiol-valerate

hsa01100

Metabolic pathways

3.55E-03

Q9NR34, P35790, P05089, Q16772, P09211, Q9UJ14, P30041, P32320, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, P05186, P24666, P15121, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9BQB6

MAN1C1, CHKA, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, CDA, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, ALPL, ACP1, AKR1B1, MCCC2, ACSL1, AMACR, SGMS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Estradiol-valerate

hsa01200

Carbon metabolism

2.00E-03

P11413, P52209, P37837

G6PD, PGD, TALDO1

Estradiol-valerate

hsa01210

2-Oxocarboxylic acid metabolism

6.96E-04

P50213

IDH3A

Estradiol-valerate

hsa01240

Biosynthesis of cofactors

2.95E-02

P13716, P14618

ALAD, PKM2

Estradiol-valerate

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Estradiol-valerate

hsa01522

Endocrine resistance

2.16E-02

P08069

IGF1R

Estradiol-valerate

hsa01524

Platinum drug resistance

3.80E-03

O15392, Q16772, P09211, P11388

BIRC5, GSTA3, GSTP1, TOP2A

Estradiol-valerate

hsa02010

ABC transporters

2.10E-03

P45844, Q8IZY2

ABCG1, ABCA7

Estradiol-valerate

hsa03013

RNA transport

2.99E-02

P38919, P37198, P35658, P55884

EIF4A3, NUP62, NUP214, EIF3B

Estradiol-valerate

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Estradiol-valerate

hsa03020

RNA polymerase

3.00E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Estradiol-valerate

hsa03040

Spliceosome

9.86E-09

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Estradiol-valerate

hsa03060

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Estradiol-valerate

hsa03320

PPAR signaling pathway

3.19E-03

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Estradiol-valerate

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Estradiol-valerate

hsa03460

Fanconi anemia pathway

1.85E-02

P40692, Q9UNA4

MLH1, POLI

Estradiol-valerate

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Estradiol-valerate

hsa04014

Ras signaling pathway

1.13E-02

P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Estradiol-valerate

hsa04015

Rap1 signaling pathway

7.59E-04

P20827, P49767, P08069, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P19174

EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, PLCG1

Estradiol-valerate

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Estradiol-valerate

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.32E-02

P09341, P25024, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB

Estradiol-valerate

hsa04062

Chemokine signaling pathway

4.65E-07

P25024, P25025, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P49841, Q8WYR1

CXCR1, CXCR2, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, GSK3B, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Estradiol-valerate

hsa04064

NF-kappa B signaling pathway

1.63E-07

P10415, Q13489, O00463, P14778, P01584, P29965, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7

BCL2, BIRC3, TRAF5, IL1R1, IL1B, CD40LG, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Estradiol-valerate

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Estradiol-valerate

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Estradiol-valerate

hsa04070

Phosphatidylinositol signaling system

2.81E-03

P19174, P0DP23, Q14643, P23743, P49619, P27987, P17252

PLCG1, CALM1, ITPR1, DGKA, DGKG, ITPKB, PRKCA

Estradiol-valerate

hsa04071

Sphingolipid signaling pathway

1.46E-03

P17252, P21453, Q9H228, Q13362, Q9BX95, P10415

PRKCA, S1PR1, EDG8, PPP2R5C, SGPP1, BCL2

Estradiol-valerate

hsa04080

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Estradiol-valerate

hsa04110

Cell cycle

2.90E-02

P06493, P30304, P33981, P01106, Q13547

CDK1, CDC25A, TTK, MYC, HDAC1

Estradiol-valerate

hsa04114

Oocyte meiosis

9.28E-07

Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1R

Estradiol-valerate

hsa04140

Autophagy - animal

2.95E-02

P08069, P22694, Q14643, P10415, Q04759

IGF1R, PRKACB, ITPR1, BCL2, PRKCQ

Estradiol-valerate

hsa04141

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Estradiol-valerate

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Estradiol-valerate

hsa04144

Endocytosis

1.13E-03

Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3

CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5

Estradiol-valerate

hsa04145

Phagosome

2.82E-04

Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Estradiol-valerate

hsa04150

mTOR signaling pathway

2.74E-03

P08069, P42338, Q02750, Q9NQL2, P51812, Q13322, P49841

IGF1R, PIK3CB, MAP2K1, RRAGD, RPS6KA3, GRB10, GSK3B

Estradiol-valerate

hsa04151

PI3K-Akt signaling pathway

5.33E-03

P42338, P43657, P25116, P20827, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252, P30281

PIK3CB, P2RY5, F2R, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Estradiol-valerate

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Estradiol-valerate

hsa04210

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Estradiol-valerate

hsa04211

Longevity regulating pathway

2.16E-02

P08069

IGF1R

Estradiol-valerate

hsa04213

Longevity regulating pathway - multiple species

8.54E-03

P08069, Q08828, P51828, P0DMV8

IGF1R, ADCY1, ADCY7, HSPA1A

Estradiol-valerate

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Estradiol-valerate

hsa04217

Necroptosis

9.14E-03

P01568, Q13489, P42224, Q6FI13, P10415, O43633, Q08752

IFNA21, BIRC3, STAT1, H2AC18; H2AC19, BCL2, CHMP2A, PPID

Estradiol-valerate

hsa04261

Adrenergic signaling in cardiomyocytes

2.84E-02

P09493, Q13362, P0DP23, P17252, P10415

TPM1, PPP2R5C, CALM1, PRKCA, BCL2

Estradiol-valerate

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Estradiol-valerate

hsa04310

Wnt signaling pathway

1.79E-02

P17612, P67870

PRKACA, CSNK2B

Estradiol-valerate

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Estradiol-valerate

hsa04340

Hedgehog signaling pathway

1.17E-04

P17612, P22694, Q13635, Q9Y496, P10415

PRKACA, PRKACB, PTCH1, KIF3A, BCL2

Estradiol-valerate

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Estradiol-valerate

hsa04360

Axon guidance

2.74E-03

P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124

NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11

Estradiol-valerate

hsa04370

VEGF signaling pathway

1.02E-07

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Estradiol-valerate

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Estradiol-valerate

hsa04380

Osteoclast differentiation

1.63E-03

Q9UQC2, Q16539, P06239, P42338, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, LCK, PIK3CB, IL1R1, FCGR3B, TNF, LILRA2

Estradiol-valerate

hsa04390

Hippo signaling pathway

2.17E-03

P63261, P84022, Q13485, O15105, Q13489

ACTG1, SMAD3, SMAD4, SMAD7, BIRC3

Estradiol-valerate

hsa04392

Hippo signaling pathway - multiple species

3.01E-02

Q6V0I7

FAT4

Estradiol-valerate

hsa04510

Focal adhesion

3.48E-02

P08069

IGF1R

Estradiol-valerate

hsa04512

ECM-receptor interaction

1.90E-02

P26012, P16070

ITGB8, CD44

Estradiol-valerate

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Estradiol-valerate

hsa04530

Tight junction

2.17E-03

P63261, Q9Y478, Q92974

ACTG1, PRKAB1, ARHGEF2

Estradiol-valerate

hsa04540

Gap junction

1.29E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Estradiol-valerate

hsa04550

Signaling pathways regulating pluripotency of stem cells

9.61E-03

Q13873, Q02750, P08069, Q86SE9

BMPR2, MAP2K1, IGF1R, PCGF5

Estradiol-valerate

hsa04610

Complement and coagulation cascades

1.91E-03

P0C0L4

C4A

Estradiol-valerate

hsa04611

Platelet activation

2.12E-02

Q9Y490, P17612

TLN1, PRKACA

Estradiol-valerate

hsa04612

Antigen processing and presentation

1.10E-04

P13765, P48382, P01730, P26715, P26717, Q13241, O43908, P01732

HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, KLRC4, CD8A

Estradiol-valerate

hsa04613

Neutrophil extracellular trap formation

5.05E-05

P19174, P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P21730, P21462

PLCG1, PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, C5AR1, FPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731

Estradiol-valerate

hsa04614

Renin-angiotensin system

1.52E-02

P50052

AGTR2

Estradiol-valerate

hsa04623

Cytosolic DNA-sensing pathway

1.65E-02

P01584, Q8NHW4

IL1B, CCL4L2

Estradiol-valerate

hsa04625

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Estradiol-valerate

hsa04630

JAK-STAT signaling pathway

3.20E-02

P01106, P42224, P14784, Q13651

MYC, STAT1, IL2RB, IL10RA

Estradiol-valerate

hsa04640

Hematopoietic cell lineage

1.60E-04

P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P09564, P13765

ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB

Estradiol-valerate

hsa04650

Natural killer cell mediated cytotoxicity

2.94E-11

P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721

Estradiol-valerate

hsa04657

IL-17 signaling pathway

1.88E-03

O00463, Q16539, P49841, P09341, P14780, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNF

Estradiol-valerate

hsa04658

Th1 and Th2 cell differentiation

6.61E-15

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725

Estradiol-valerate

hsa04659

Th17 cell differentiation

1.87E-13

P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Estradiol-valerate

hsa04660

T cell receptor signaling pathway

2.44E-08

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Estradiol-valerate

hsa04662

B cell receptor signaling pathway

1.86E-05

P49841, P42338, P60033, P07948, P21854, Q8N149

GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2

Estradiol-valerate

hsa04664

Fc epsilon RI signaling pathway

1.21E-04

P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Estradiol-valerate

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Estradiol-valerate

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Estradiol-valerate

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Estradiol-valerate

hsa04713

Circadian entrainment

2.60E-02

P0DP23, P17252, P62873, Q14643

CALM1, PRKCA, GNB1, ITPR1

Estradiol-valerate

hsa04714

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Estradiol-valerate

hsa04720

Long-term potentiation

1.09E-05

P17252, P16298, P0DP23, P51812, Q02750, Q14643

PRKCA, PPP3CB, CALM1, RPS6KA3, MAP2K1, ITPR1

Estradiol-valerate

hsa04723

Retrograde endocannabinoid signaling

1.88E-03

Q14643, P17252, P62873, P63218, P50151, P48058, Q16539, Q16718

ITPR1, PRKCA, GNB1, GNG5, GNG10, GRIA4, MAPK14, NDUFA5

Estradiol-valerate

hsa04724

Glutamatergic synapse

4.13E-04

P48058, O15399, P43003, P63218, P50151, P15104

GRIA4, GRIN2D, SLC1A3, GNG5, GNG10, GLUL

Estradiol-valerate

hsa04725

Cholinergic synapse

1.88E-02

Q14643, P17252, P62873, P10415

ITPR1, PRKCA, GNB1, BCL2

Estradiol-valerate

hsa04727

GABAergic synapse

4.42E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Estradiol-valerate

hsa04728

Dopaminergic synapse

2.03E-04

Q14643, P17252, P14416, P62873, P63218, P50151, P49841, Q16539, P49407, Q13362, P0DP23, P48058

ITPR1, PRKCA, DRD2, GNB1, GNG5, GNG10, GSK3B, MAPK14, ARRB1, PPP2R5C, CALM1, GRIA4

Estradiol-valerate

hsa04730

Long-term depression

1.16E-02

P08069

IGF1R

Estradiol-valerate

hsa04742

Taste transduction

3.91E-02

P17612

PRKACA

Estradiol-valerate

hsa04744

Phototransduction

1.02E-02

P62873, P0DP23

GNB1, CALM1

Estradiol-valerate

hsa04750

Inflammatory mediator regulation of TRP channels

4.01E-02

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Estradiol-valerate

hsa04912

GnRH signaling pathway

3.89E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Estradiol-valerate

hsa04913

Ovarian steroidogenesis

8.40E-04

P06213, P08069

INSR, IGF1R

Estradiol-valerate

hsa04914

Progesterone-mediated oocyte maturation

3.98E-06

P08069, Q17RY0, Q9Y6D9, P51812, Q02750

IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1

Estradiol-valerate

hsa04915

Estrogen signaling pathway

3.17E-02

Q08828, P51828, P0DMV8, P0DP23, Q15788

ADCY1, ADCY7, HSPA1A, CALM1, NCOA1

Estradiol-valerate

hsa04919

Thyroid hormone signaling pathway

1.64E-02

P19174, P42224, Q13547, P01106

PLCG1, STAT1, HDAC1, MYC

Estradiol-valerate

hsa04920

Adipocytokine signaling pathway

2.62E-03

Q06124, Q9Y478, Q96RR4

PTPN11, PRKAB1, CAMKK2

Estradiol-valerate

hsa04922

Glucagon signaling pathway

7.76E-04

P14618, P22694, P06737, Q12778, Q13370, P0DP23, Q14643

PKM2, PRKACB, PYGL, FOXO1, PDE3B, CALM1, ITPR1

Estradiol-valerate

hsa04923

Regulation of lipolysis in adipocytes

3.76E-02

P06213

INSR

Estradiol-valerate

hsa04924

Renin secretion

1.79E-04

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Estradiol-valerate

hsa04928

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Estradiol-valerate

hsa04930

Type II diabetes mellitus

3.14E-02

P06213

INSR

Estradiol-valerate

hsa04932

Non-alcoholic fatty liver disease

1.39E-02

O43521, O75460, P01584, P13073, P12074, O95298

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2

Estradiol-valerate

hsa04933

AGE-RAGE signaling pathway in diabetic complications

8.03E-05

P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174

SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1

Estradiol-valerate

hsa04960

Aldosterone-regulated sodium reabsorption

3.14E-02

P06213

INSR

Estradiol-valerate

hsa04964

Proximal tubule bicarbonate reclamation

4.48E-02

P00918

CA2

Estradiol-valerate

hsa04966

Collecting duct acid secretion

1.95E-03

Q13488, P00918, Q9Y666

TCIRG1, CA2, SLC12A7

Estradiol-valerate

hsa04970

Salivary secretion

4.78E-02

Q08828, P51828, P0DP23

ADCY1, ADCY7, CALM1

Estradiol-valerate

hsa04973

Carbohydrate digestion and absorption

1.57E-02

O43451, P42338

MGAM, PIK3CB

Estradiol-valerate

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Estradiol-valerate

hsa04976

Bile secretion

4.78E-02

Q08828, P51828, Q14032

ADCY1, ADCY7, BAAT

Estradiol-valerate

hsa05010

Alzheimer disease

3.55E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPID

Estradiol-valerate

hsa05012

Parkinson disease

2.25E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C

Estradiol-valerate

hsa05016

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Estradiol-valerate

hsa05017

Spinocerebellar ataxia

2.22E-02

Q92915, O15399, P42338, P21796

FGF14, GRIN2D, PIK3CB, VDAC1

Estradiol-valerate

hsa05020

Prion disease

1.15E-02

Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080

NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4

Estradiol-valerate

hsa05022

Pathways of neurodegeneration - multiple diseases

4.00E-03

Q14643, Q13509, P68371, P10415, Q16718, O14521, Q06055, Q13561, P17252, Q08752, O15020, P0DP23

ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, ATP5G2, DCTN2, PRKCA, PPID, SPTBN2, CALM1

Estradiol-valerate

hsa05034

Alcoholism

5.83E-03

Q13547, P62807, Q16778, O60814

HDAC1, HIST1H2BC, HIST2H2BE, H2BC12

Estradiol-valerate

hsa05100

Bacterial invasion of epithelial cells

2.85E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Estradiol-valerate

hsa05110

Vibrio cholerae infection

2.11E-03

Q99437, P17612

ATP6V0B, PRKACA

Estradiol-valerate

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.37E-04

Q16539, P09341, P25024, P25025, P07948

MAPK14, CXCL1, CXCR1, CXCR2, LYN

Estradiol-valerate

hsa05130

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Estradiol-valerate

hsa05131

Shigellosis

2.27E-02

P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752

H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID

Estradiol-valerate

hsa05132

Salmonella infection

8.60E-04

P25963, Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371

NFKBIA, LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Estradiol-valerate

hsa05133

Pertussis

3.51E-02

P0C0L4

C4A

Estradiol-valerate

hsa05134

Legionellosis

2.82E-02

P01584, Q9NR31, P0DMV8

IL1B, SAR1A, HSPA1A

Estradiol-valerate

hsa05135

Yersinia infection

2.79E-05

Q05397, P51812, P13612, P06239, Q16539, Q02750, P01375, P42338, P49841, Q96JJ3, P01730

PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, TNF, PIK3CB, GSK3B, ELMO2, CD4

Estradiol-valerate

hsa05140

Leishmaniasis

2.04E-04

O75015, P14598, P42224, P13765, O60603, P29350, P49006, Q16539, Q15080

FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, PTPN6, MARCKSL1, MAPK14, NCF4

Estradiol-valerate

hsa05144

Malaria

1.64E-03

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Estradiol-valerate

hsa05145

Toxoplasmosis

1.02E-03

P25963, P10415, Q13489, P42224, P13765, O60603, P29965

NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Estradiol-valerate

hsa05146

Amoebiasis

1.32E-03

P09341, P14778, P27930, O60603, P05089, P12814, P08311

CXCL1, IL1R1, IL1R2, TLR2, ARG1, ACTN1, CTSG

Estradiol-valerate

hsa05150

Staphylococcus aureus infection

1.31E-02

P0C0L4, P13646

C4A, KRT13

Estradiol-valerate

hsa05152

Tuberculosis

7.93E-04

Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8

TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1

Estradiol-valerate

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Estradiol-valerate

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Estradiol-valerate

hsa05163

Human cytomegalovirus infection

3.36E-07

P42338, P01375, P63218, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463

PIK3CB, TNF, GNG5, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788

Estradiol-valerate

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Estradiol-valerate

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.04E-03

P01568, P42224, P62873, P62879, P16298, Q14643, Q02750, P0DP23, P0CG47, Q9UJU2

IFNA21, STAT1, GNB1, GNB2, PPP3CB, ITPR1, MAP2K1, CALM1, UBB, LEF1

Estradiol-valerate

hsa05169

Epstein-Barr virus infection

5.41E-05

P13765, P01106, Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P42224, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, STAT1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Estradiol-valerate

hsa05170

Human immunodeficiency virus 1 infection

1.09E-05

Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5, P20333

MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2, TNFRSF1B

Estradiol-valerate

hsa05200

Pathways in cancer

1.55E-03

Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784

LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Estradiol-valerate

hsa05202

Transcriptional misregulation in cancer

2.48E-03

Q12778, Q13315, P14780, Q16548, O15550, P08069, P05164, P08246, Q9C0K0, P24522

FOXO1, ATM, MMP9, BCL2A1, UTX, IGF1R, MPO, ELA2, BCL11B, GADD45A

Estradiol-valerate

hsa05203

Viral carcinogenesis

7.95E-05

Q12933, P42229, Q13547, Q15283, P12814, P06493, P62807, Q16778, O60814

TRAF2, STAT5A, HDAC1, RASA2, ACTN1, CDK1, HIST1H2BC, HIST2H2BE, H2BC12

Estradiol-valerate

hsa05204

Chemical carcinogenesis

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Estradiol-valerate

hsa05205

Proteoglycans in cancer

3.48E-02

P08069

IGF1R

Estradiol-valerate

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Estradiol-valerate

hsa05211

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Estradiol-valerate

hsa05212

Pancreatic cancer

9.87E-04

P42338, P37173, P84022, Q13485, O75293

PIK3CB, TGFBR2, SMAD3, SMAD4, GADD45B

Estradiol-valerate

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Estradiol-valerate

hsa05214

Glioma

9.95E-03

P08069

IGF1R

Estradiol-valerate

hsa05215

Prostate cancer

1.33E-02

P08069

IGF1R

Estradiol-valerate

hsa05218

Melanoma

6.63E-03

P08069

IGF1R

Estradiol-valerate

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Estradiol-valerate

hsa05220

Chronic myeloid leukemia

1.44E-03

Q13547, Q13485, P25963, P84022, P42338, O75293

HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Estradiol-valerate

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Estradiol-valerate

hsa05224

Breast cancer

1.24E-02

P08069, P49841, Q92837, P04637, P24522

IGF1R, GSK3B, FRAT1, TP53, GADD45A

Estradiol-valerate

hsa05225

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Estradiol-valerate

hsa05226

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Estradiol-valerate

hsa05230

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Estradiol-valerate

hsa05231

Choline metabolism in cancer

1.39E-02

Q9Y259, P19174, P49619

CHKB, PLCG1, DGKG

Estradiol-valerate

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

6.45E-08

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84