PharmaCoNets of Estradiol-cypionate (SPCN: 75.31 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Estradiol-cypionatehsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Estradiol-cypionatehsa00040Pentose and glucuronate interconversions9.59E-032P15121, P14550AKR1B1, AKR1A1More
Estradiol-cypionatehsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Estradiol-cypionatehsa00220Arginine biosynthesis1.94E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Estradiol-cypionatehsa00230Purine metabolism2.11E-023Q7LG56, P31350, P21589RRM2B, RRM2, NT5EMore
Estradiol-cypionatehsa00240Pyrimidine metabolism1.86E-065Q7LG56, P31350, P21589, P04183, P04818RRM2B, RRM2, NT5E, TK1, TYMSMore
Estradiol-cypionatehsa00250Alanine, aspartate and glutamate metabolism4.32E-022P49448, P15104GLUD2, GLULMore
Estradiol-cypionatehsa00480Glutathione metabolism3.85E-022Q7LG56, P31350RRM2B, RRM2More
Estradiol-cypionatehsa00500Starch and sucrose metabolism3.28E-053O43451, P46976, P06737MGAM, GYG1, PYGLMore
Estradiol-cypionatehsa00520Amino sugar and nucleotide sugar metabolism7.87E-033Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Estradiol-cypionatehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Estradiol-cypionatehsa00561Glycerolipid metabolism7.94E-033P15121, P14550, Q86XP1AKR1B1, AKR1A1, DGKHMore
Estradiol-cypionatehsa00591Linoleic acid metabolism3.18E-021P11712CYP2C9More
Estradiol-cypionatehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.30E-032P06865, O75752HEXA, B3GALNT1More
Estradiol-cypionatehsa00630Glyoxylate and dicarboxylate metabolism1.32E-022P40925, P15104MDH1, GLULMore
Estradiol-cypionatehsa00730Thiamine metabolism3.21E-032P05186, P24666ALPL, ACP1More
Estradiol-cypionatehsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Estradiol-cypionatehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Estradiol-cypionatehsa00910Nitrogen metabolism4.32E-022P15104, P49448GLUL, GLUD2More
Estradiol-cypionatehsa00970Aminoacyl-tRNA biosynthesis1.58E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Estradiol-cypionatehsa00983Drug metabolism - other enzymes6.98E-054P04183, Q7LG56, P31350, P05164TK1, RRM2B, RRM2, MPOMore
Estradiol-cypionatehsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Estradiol-cypionatehsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Estradiol-cypionatehsa03008Ribosome biogenesis in eukaryotes5.07E-046Q9NYH9, O14980, O60832, P78345, Q9BVP2, Q9GZY0UTP6, XPO1, DKC1, RPP38, GNL3, NXF2; NXF2BMore
Estradiol-cypionatehsa03010Ribosome1.60E-029P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3More
Estradiol-cypionatehsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Estradiol-cypionatehsa03015mRNA surveillance pathway3.37E-023O43148, Q9GZY0, P52298RNMT, NXF2; NXF2B, NCBP2More
Estradiol-cypionatehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Estradiol-cypionatehsa03030DNA replication1.48E-023P49005, P33993, P15927POLD2, MCM7, RPA2More
Estradiol-cypionatehsa03040Spliceosome4.19E-0410Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, P11142, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8, PPIH, ASCC3L1More
Estradiol-cypionatehsa03060Protein export4.22E-022P37108, Q15005SRP14, SPCS2More
Estradiol-cypionatehsa03320PPAR signaling pathway3.78E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Estradiol-cypionatehsa04012ErbB signaling pathway1.34E-024P16333, P19174, P42338, P01106NCK1, PLCG1, PIK3CB, MYCMore
Estradiol-cypionatehsa04014Ras signaling pathway2.92E-0410P42338, P20827, Q9NRA1, P49767, Q13009, P0DP23, P62873, P63218, P50151, P19174PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Estradiol-cypionatehsa04015Rap1 signaling pathway4.83E-038P20827, Q9NRA1, P49767, P11215, Q13009, P42338, P0DP23, P19174EFNA1, PDGFC, VEGFC, ITGAM, TIAM1, PIK3CB, CALM1, PLCG1More
Estradiol-cypionatehsa04020Calcium signaling pathway8.05E-0513P27987, Q96DU7, P21796, Q13557, P21860, P19174, P0DP23, P05141, P12236, P26678, P63092, Q9NRA1, P49767ITPKB, ITPKC, VDAC1, CAMK2D, ERBB3, PLCG1, CALM1, SLC25A5, SLC25A6, PLN, GNAS, PDGFC, VEGFCMore
Estradiol-cypionatehsa04022cGMP-PKG signaling pathway9.36E-036P61586, P26678, Q99941, P18848, P05141, P12236RHOA, PLN, CREBL1, ATF4, SLC25A5, SLC25A6More
Estradiol-cypionatehsa04061Viral protein interaction with cytokine and cytokine receptor3.57E-038Q8NHW4, P09341, P19875, P25024, P25025, P61073, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, CXCR4, IL10RA, IL2RBMore
Estradiol-cypionatehsa04062Chemokine signaling pathway6.40E-0820P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P25963, P49841CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, NFKBIA, GSK3BMore
Estradiol-cypionatehsa04064NF-kappa B signaling pathway6.33E-0618P10415, O00463, P14778, P01584, P19174, Q04759, Q9UDY8, P67870, Q16548, P06239, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, TRAF5, IL1R1, IL1B, PLCG1, PRKCQ, MALT1, CSNK2B, BCL2A1, LCK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Estradiol-cypionatehsa04070Phosphatidylinositol signaling system1.12E-025P19174, P0DP23, P42338, P23743, P27987PLCG1, CALM1, PIK3CB, DGKA, ITPKBMore
Estradiol-cypionatehsa04071Sphingolipid signaling pathway1.19E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Estradiol-cypionatehsa04072Phospholipase D signaling pathway5.49E-038P42338, P43657, P25024, P25025, P19174, Q14344, P23743, Q9NRA1PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, DGKA, PDGFCMore
Estradiol-cypionatehsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Estradiol-cypionatehsa04114Oocyte meiosis1.62E-045Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Estradiol-cypionatehsa04115p53 signaling pathway1.74E-034Q7LG56, P31350, Q9HA38, P04637RRM2B, RRM2, ZMAT3, TP53More
Estradiol-cypionatehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Estradiol-cypionatehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Estradiol-cypionatehsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Estradiol-cypionatehsa04150mTOR signaling pathway4.72E-036P42338, Q02750, Q9NQL2, P51812, Q13322, P49841PIK3CB, MAP2K1, RRAGD, RPS6KA3, GRB10, GSK3BMore
Estradiol-cypionatehsa04151PI3K-Akt signaling pathway2.62E-0421P42338, P21860, P01106, P27348, P20827, O14944, Q9NRA1, P49767, P07900, P08238, Q15831, P62873, P63218, P50151, O15335, P22105, P14784, P01568, Q99941, P18848, O95988PIK3CB, ERBB3, MYC, YWHAQ, EFNA1, EREG, PDGFC, VEGFC, HSP90AA1, HSP90AB1, STK11, GNB1, GNG5, GNG10, CHAD, TNXB, IL2RB, IFNA21, CREBL1, ATF4, TCL1BMore
Estradiol-cypionatehsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Estradiol-cypionatehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Estradiol-cypionatehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Estradiol-cypionatehsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Estradiol-cypionatehsa04261Adrenergic signaling in cardiomyocytes3.12E-025P63092, Q99941, P18848, P26678, Q13557GNAS, CREBL1, ATF4, PLN, CAMK2DMore
Estradiol-cypionatehsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Estradiol-cypionatehsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Estradiol-cypionatehsa04360Axon guidance2.87E-025P16333, P20827, O95631, P42338, P19174NCK1, EFNA1, NTN1, PIK3CB, PLCG1More
Estradiol-cypionatehsa04370VEGF signaling pathway1.43E-053P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Estradiol-cypionatehsa04371Apelin signaling pathway2.41E-037P62873, P63218, P50151, Q13370, Q14814, Q14344, P0DP23GNB1, GNG5, GNG10, PDE3B, MEF2D, GNA13, CALM1More
Estradiol-cypionatehsa04380Osteoclast differentiation4.71E-026Q16539, P06239, P42338, P14778, O75015, Q8N149MAPK14, LCK, PIK3CB, IL1R1, FCGR3B, LILRA2More
Estradiol-cypionatehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Estradiol-cypionatehsa04612Antigen processing and presentation1.93E-037P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Estradiol-cypionatehsa04613Neutrophil extracellular trap formation6.09E-0417P42338, P19174, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P62807, Q93079, O60814, P21796, P14598, Q15080, P20160, P08311, P21730PIK3CB, PLCG1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HIST1H2BC, H2BC9, H2BC12, VDAC1, NCF1, NCF4, AZU1, CTSG, C5AR1More
Estradiol-cypionatehsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Estradiol-cypionatehsa04620Toll-like receptor signaling pathway4.00E-024P01568, P42224, P25963, P42338IFNA21, STAT1, NFKBIA, PIK3CBMore
Estradiol-cypionatehsa04623Cytosolic DNA-sensing pathway9.60E-044P01584, P01568, P25963, Q8NHW4IL1B, IFNA21, NFKBIA, CCL4L2More
Estradiol-cypionatehsa04625C-type lectin receptor signaling pathway2.17E-025Q9ULY5, P42224, P25963, P42338, P0DP23CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1More
Estradiol-cypionatehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Estradiol-cypionatehsa04650Natural killer cell mediated cytotoxicity2.84E-1016P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Estradiol-cypionatehsa04658Th1 and Th2 cell differentiation2.95E-1016P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Estradiol-cypionatehsa04659Th17 cell differentiation4.40E-0818P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Estradiol-cypionatehsa04660T cell receptor signaling pathway7.02E-0817P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Estradiol-cypionatehsa04662B cell receptor signaling pathway8.98E-057P25963, P49841, P42338, P60033, P07948, P21854, Q8N149NFKBIA, GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Estradiol-cypionatehsa04664Fc epsilon RI signaling pathway5.84E-045Q16539, P42338, P07948, P19174, P09917MAPK14, PIK3CB, LYN, PLCG1, ALOX5More
Estradiol-cypionatehsa04666Fc gamma R-mediated phagocytosis2.92E-024P07948, P42338, P19174, P14598LYN, PIK3CB, PLCG1, NCF1More
Estradiol-cypionatehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Estradiol-cypionatehsa04713Circadian entrainment4.00E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Estradiol-cypionatehsa04720Long-term potentiation7.72E-043P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Estradiol-cypionatehsa04723Retrograde endocannabinoid signaling3.86E-024P63218, P50151, P48058, Q16539GNG5, GNG10, GRIA4, MAPK14More
Estradiol-cypionatehsa04724Glutamatergic synapse5.51E-046P48058, P43003, P62873, P63218, P50151, P15104GRIA4, SLC1A3, GNB1, GNG5, GNG10, GLULMore
Estradiol-cypionatehsa04725Cholinergic synapse2.92E-024P62873, P63218, P50151, P42338GNB1, GNG5, GNG10, PIK3CBMore
Estradiol-cypionatehsa04727GABAergic synapse8.14E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Estradiol-cypionatehsa04728Dopaminergic synapse1.85E-037P14416, P63218, P50151, P49841, Q16539, P49407, P48058DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1, GRIA4More
Estradiol-cypionatehsa04744Phototransduction1.32E-022P62873, P0DP23GNB1, CALM1More
Estradiol-cypionatehsa04750Inflammatory mediator regulation of TRP channels8.12E-046P14778, P19174, P42338, P24723, Q04759, P0DP23IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Estradiol-cypionatehsa04810Regulation of actin cytoskeleton2.61E-026P12814, Q13009, P42338, P11215, Q14344, Q9NRA1ACTN1, TIAM1, PIK3CB, ITGAM, GNA13, PDGFCMore
Estradiol-cypionatehsa04911Insulin secretion4.47E-034P63092, Q99941, P18848, Q13557GNAS, CREBL1, ATF4, CAMK2DMore
Estradiol-cypionatehsa04914Progesterone-mediated oocyte maturation1.31E-048Q17RY0, P42338, Q13370, Q9Y6D9, P30304, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1More
Estradiol-cypionatehsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Estradiol-cypionatehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Estradiol-cypionatehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Estradiol-cypionatehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Estradiol-cypionatehsa04925Aldosterone synthesis and secretion1.68E-024Q99941, P18848, P63092, Q13557CREBL1, ATF4, GNAS, CAMK2DMore
Estradiol-cypionatehsa04926Relaxin signaling pathway8.74E-036P25963, P42338, P62873, P63218, P50151, P49767NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFCMore
Estradiol-cypionatehsa04927Cortisol synthesis and secretion2.40E-023Q99941, P18848, P63092CREBL1, ATF4, GNASMore
Estradiol-cypionatehsa04928Parathyroid hormone synthesis, secretion and action2.59E-038Q14643, P63092, P22694, P23771, P61586, Q99941, P18848, P10415ITPR1, GNAS, PRKACB, GATA3, RHOA, CREBL1, ATF4, BCL2More
Estradiol-cypionatehsa04932Non-alcoholic fatty liver disease1.24E-026O43521, O75460, P01584, P13073, P12074, O15239BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA1More
Estradiol-cypionatehsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Estradiol-cypionatehsa04934Cushing syndrome1.37E-035Q99941, P18848, P63092, O15169, Q13557CREBL1, ATF4, GNAS, AXIN1, CAMK2DMore
Estradiol-cypionatehsa04973Carbohydrate digestion and absorption2.02E-042O43451, P42338MGAM, PIK3CBMore
Estradiol-cypionatehsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Estradiol-cypionatehsa05010Alzheimer disease9.99E-0418Q92542, O15239, P05496, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P18848, O15169, P67870, P05141, P12236, P28070, P43686, P62195NCSTN, NDUFA1, ATP5G1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4, PSMC4, PSMC5More
Estradiol-cypionatehsa05012Parkinson disease5.04E-0415O15239, P05496, P05141, P12236, P21796, P60604, P63092, P18848, P43686, P62195, P19174, P0DP23, Q13557, Q71U36, Q13509NDUFA1, ATP5G1, SLC25A5, SLC25A6, VDAC1, UBE2G2, GNAS, ATF4, PSMC4, PSMC5, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3More
Estradiol-cypionatehsa05014Amyotrophic lateral sclerosis3.92E-028P20333, O15239, P05496, P18848, P43686, P62195, P51991, P35658TNFRSF1B, NDUFA1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, NUP214More
Estradiol-cypionatehsa05020Prion disease1.15E-029P46531, O15239, P05496, P18848, P05141, P12236, P43686, P62195, Q99941NOTCH1, NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, PSMC4, PSMC5, CREBL1More
Estradiol-cypionatehsa05022Pathways of neurodegeneration - multiple diseases1.57E-0210O15239, P05496, P18848, P05141, P12236, P20333, O15169, Q13557, P43686, P62195NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, TNFRSF1B, AXIN1, CAMK2D, PSMC4, PSMC5More
Estradiol-cypionatehsa05030Cocaine addiction2.40E-023P63092, Q99941, P18848GNAS, CREBL1, ATF4More
Estradiol-cypionatehsa05031Amphetamine addiction4.47E-034Q13557, P63092, Q99941, P18848CAMK2D, GNAS, CREBL1, ATF4More
Estradiol-cypionatehsa05032Morphine addiction7.60E-035P62873, P63218, P50151, Q13370, P43250GNB1, GNG5, GNG10, PDE3B, GRK6More
Estradiol-cypionatehsa05034Alcoholism9.84E-048Q13547, P0DP23, P62873, P63218, P50151, P62807, Q93079, O60814HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2BC, H2BC9, H2BC12More
Estradiol-cypionatehsa05120Epithelial cell signaling in Helicobacter pylori infection2.06E-057Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Estradiol-cypionatehsa05132Salmonella infection2.07E-0311P25963, P08238, P01106, P42338, Q13489, P10415, O75369, Q9BQS8, Q71U36, Q13509, P49754NFKBIA, HSP90AB1, MYC, PIK3CB, BIRC3, BCL2, FLNB, FYCO1, TUBA1A, TUBB3, VPS41More
Estradiol-cypionatehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Estradiol-cypionatehsa05135Yersinia infection1.98E-0411Q05397, P51812, P13612, P06239, Q16539, Q02750, P01375, P42338, P49841, Q96JJ3, P01730PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, TNF, PIK3CB, GSK3B, ELMO2, CD4More
Estradiol-cypionatehsa05144Malaria1.64E-035P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Estradiol-cypionatehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Estradiol-cypionatehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Estradiol-cypionatehsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Estradiol-cypionatehsa05162Measles1.84E-027P01568, P25963, P42224, P14784, P07766, P42338, P11142IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8More
Estradiol-cypionatehsa05163Human cytomegalovirus infection6.71E-0822P42338, P01375, P25963, P62873, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P23458, P49841, P01106, P14778, P01584, P61073, Q13651, P25025, Q16539, O00463, P30101, P01568PIK3CB, TNF, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, JAK1, GSK3B, MYC, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21More
Estradiol-cypionatehsa05167Kaposi sarcoma-associated herpesvirus infection4.21E-0615P01568, P42224, P25963, P42338, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P01106, P0DP23, P0CG47IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, MYC, CALM1, UBBMore
Estradiol-cypionatehsa05168Herpes simplex virus 1 infection4.57E-0210P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF189More
Estradiol-cypionatehsa05169Epstein-Barr virus infection1.10E-0415P01106, Q13547, O00463, P25963, Q16539, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, P07766, P20963MYC, HDAC1, TRAF5, NFKBIA, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, CD3E, CD247More
Estradiol-cypionatehsa05170Human immunodeficiency virus 1 infection7.25E-0615P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, P19174, P07766, P20333PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, PLCG1, CD3E, TNFRSF1BMore
Estradiol-cypionatehsa05200Pathways in cancer1.82E-0317P42338, P08238, P42224, P25963, P19174, P01106, P43246, Q13547, P49767, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, HDAC1, VEGFC, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Estradiol-cypionatehsa05202Transcriptional misregulation in cancer1.09E-0312Q12778, Q15532, Q13315, P14780, P14923, Q16548, O15550, P04637, P05164, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, JUP, BCL2A1, UTX, TP53, MPO, ELA2, BCL11B, GADD45AMore
Estradiol-cypionatehsa05203Viral carcinogenesis1.47E-0516Q99941, P18848, P42338, P06746, P07948, P27348, P29083, Q13547, Q15283, P61586, P12814, P25963, P61978, P62807, Q93079, O60814CREBL1, ATF4, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, HDAC1, RASA2, RHOA, ACTN1, NFKBIA, HNRPK, HIST1H2BC, H2BC9, H2BC12More
Estradiol-cypionatehsa05206MicroRNAs in cancer1.34E-0313P30304, P09493, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P61586, P20827, P19174CDC25A, TPM1, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, RHOA, EFNA1, PLCG1More
Estradiol-cypionatehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Estradiol-cypionatehsa05212Pancreatic cancer4.21E-033P37173, P84022, Q13485TGFBR2, SMAD3, SMAD4More
Estradiol-cypionatehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Estradiol-cypionatehsa05214Glioma1.34E-024P0DP23, P42338, P19174, O75293CALM1, PIK3CB, PLCG1, GADD45BMore
Estradiol-cypionatehsa05218Melanoma2.31E-023Q9NRA1, P42338, O75293PDGFC, PIK3CB, GADD45BMore
Estradiol-cypionatehsa05220Chronic myeloid leukemia1.14E-037Q13547, P01106, Q13485, P25963, P84022, P42338, O75293HDAC1, MYC, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45BMore
Estradiol-cypionatehsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Estradiol-cypionatehsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Estradiol-cypionatehsa05231Choline metabolism in cancer2.92E-035P42338, Q9NRA1, Q9Y259, P19174, P23743PIK3CB, PDGFC, CHKB, PLCG1, DGKAMore
Estradiol-cypionatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.56E-0613P25963, P42338, P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q16539, P01730NFKBIA, PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, MAPK14, CD4More
Estradiol-cypionatehsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Estradiol-cypionatehsa05322Systemic lupus erythematosus2.93E-022P62807, O60814HIST1H2BC, H2BC12More
Estradiol-cypionatehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Estradiol-cypionatehsa05332Graft-versus-host disease3.45E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Estradiol-cypionatehsa05415Diabetic cardiomyopathy1.92E-026P05141, P12236, O15239, P05496, Q13557, P26678SLC25A5, SLC25A6, NDUFA1, ATP5G1, CAMK2D, PLNMore
Estradiol-cypionatehsa05418Fluid shear stress and atherosclerosis3.61E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Estradiol-cypionate (SDC: 4.11)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)