PharmaCoNets

Pentose phosphate pathway

3.67E-03

P60891, P11413, P37837

PRPS1, G6PD, TALDO1

Estradiol-acetate

Fatty acid degradation

3.43E-04

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874

Estradiol-acetate

hsa00190

Oxidative phosphorylation

2.11E-04

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Estradiol-acetate

Arginine biosynthesis

1.94E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Estradiol-acetate

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Estradiol-acetate

Glutathione metabolism

2.60E-05

Q9UJ14, P11413, Q16772, P09211, P30041

GGTL3, G6PD, GSTA3, GSTP1, PRDX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P21589	NT5E	5'-nucleotidase	Q7LG56	RRM2B	Ribonucleoside-diphosphate reductase subunit M2 B	0.7
P21589	NT5E	5'-nucleotidase	P31350	RRM2	Ribonucleoside-diphosphate reductase subunit M2	-0.732
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Estradiol-acetate

Starch and sucrose metabolism

1.59E-06

O43451, P46976, P06737

MGAM, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P49841	GSK3B	Glycogen synthase kinase-3 beta	O43451	MGAM	Maltase-glucoamylase	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P49841	GSK3B	Glycogen synthase kinase-3 beta	P46976	GYG1	Glycogenin-1	0.813
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P49841	GSK3B	Glycogen synthase kinase-3 beta	P06737	PYGL	Glycogen phosphorylase, liver form	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71

Estradiol-acetate

Amino sugar and nucleotide sugar metabolism

7.87E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Estradiol-acetate

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Estradiol-acetate

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Estradiol-acetate

Linoleic acid metabolism

1.29E-03

P11712

CYP2C9

Estradiol-acetate

Glycosphingolipid biosynthesis - globo and isoglobo series

4.30E-03

P06865, O75752

HEXA, B3GALNT1

Estradiol-acetate

Thiamine metabolism

3.21E-03

P05186, P24666

ALPL, ACP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
P49841	GSK3B	Glycogen synthase kinase-3 beta	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P49841	GSK3B	Glycogen synthase kinase-3 beta	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76

Estradiol-acetate

Pantothenate and CoA biosynthesis

7.90E-03

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Estradiol-acetate

Retinol metabolism

2.20E-02

P00325, P11766, Q9BPW9, O75911

ADH1B, ADH5, DHRS9, DHRS3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P06239	LCK	Tyrosine-protein kinase Lck	P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	0.771
P06239	LCK	Tyrosine-protein kinase Lck	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	-0.825
P06239	LCK	Tyrosine-protein kinase Lck	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745

Estradiol-acetate

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Estradiol-acetate

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Estradiol-acetate

Aminoacyl-tRNA biosynthesis

2.75E-06

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
O43451	MGAM	Maltase-glucoamylase	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
O43451	MGAM	Maltase-glucoamylase	Q15046	KARS	Lysine--tRNA ligase	-0.71
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
O43451	MGAM	Maltase-glucoamylase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
O43451	MGAM	Maltase-glucoamylase	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
O43451	MGAM	Maltase-glucoamylase	Q15046	KARS	Lysine--tRNA ligase	-0.71
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.799
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q15046	KARS	Lysine--tRNA ligase	-0.818
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704

Estradiol-acetate

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Estradiol-acetate

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Estradiol-acetate

Drug metabolism - other enzymes

1.72E-02

Q16772, P09211

GSTA3, GSTP1

Estradiol-acetate

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Estradiol-acetate

Carbon metabolism

2.91E-02

P11413

G6PD

Estradiol-acetate

2-Oxocarboxylic acid metabolism

3.43E-02

P50213

IDH3A

Estradiol-acetate

Biosynthesis of amino acids

3.27E-03

P51854, P60891, Q99707, P50213, P37837

TKTL1, PRPS1, MTR, IDH3A, TALDO1

Estradiol-acetate

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Estradiol-acetate

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Estradiol-acetate

Ribosome biogenesis in eukaryotes

2.40E-03

P19784, P67870, O14980, O60832, Q9BVP2

CSNK2A2, CSNK2B, XPO1, DKC1, GNL3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P19784	CSNK2A2	Casein kinase II subunit alpha'	-0.701
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P67870	CSNK2B	Casein kinase II subunit beta	-0.752
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
P21589	NT5E	5'-nucleotidase	Q9NYH9	UTP6	U3 small nucleolar RNA-associated protein 6 homolog	0.836
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
P21589	NT5E	5'-nucleotidase	P78345	RPP38	Ribonuclease P protein subunit p38	0.82
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
P21589	NT5E	5'-nucleotidase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.749
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838

Estradiol-acetate

RNA transport

2.35E-05

O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5

XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758

Estradiol-acetate

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Estradiol-acetate

PPAR signaling pathway

3.78E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Estradiol-acetate

hsa04024

cAMP signaling pathway

3.37E-02

P63092, P26678, P61586

GNAS, PLN, RHOA

Estradiol-acetate

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816

Estradiol-acetate

Chemokine signaling pathway

2.83E-05

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, ARRB1, ITK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716

Estradiol-acetate

NF-kappa B signaling pathway

1.16E-06

P10415, Q13489, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9UNE0, Q9NQC7

BCL2, BIRC3, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799

Estradiol-acetate

Sphingolipid signaling pathway

1.19E-02

P21453, Q9H228, Q13362, Q9BX95, P10415

S1PR1, EDG8, PPP2R5C, SGPP1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol-acetate

Phospholipase D signaling pathway

5.37E-03

P42338, P61586, P43657, P25024, P25025, P19174, O14986, P63092

PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNAS

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	-0.736
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P23743	DGKA	Diacylglycerol kinase alpha	0.843
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7

Estradiol-acetate

Neuroactive ligand-receptor interaction

1.23E-03

P08311, P48058, Q15722, P21453, Q9H228, P43657, O00398, P21730, P07550, P35318

CTSG, GRIA4, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, C5AR1, ADRB2, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735

Estradiol-acetate

Oocyte meiosis

1.62E-04

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776

Estradiol-acetate

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Estradiol-acetate

hsa04137

Mitophagy - animal

2.52E-02

P19784, P67870

CSNK2A2, CSNK2B

Estradiol-acetate

Autophagy - animal

3.19E-02

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Estradiol-acetate

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q86TM6	SYVN1	E3 ubiquitin-protein ligase synoviolin	0.711
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51668	UBE2D1	Ubiquitin-conjugating enzyme E2 D1	0.726
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q86TM6	SYVN1	E3 ubiquitin-protein ligase synoviolin	0.711
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51668	UBE2D1	Ubiquitin-conjugating enzyme E2 D1	0.726
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836

Estradiol-acetate

Phagosome

4.48E-02

Q15080, P05164, O60603, P35443, P13765

NCF4, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Estradiol-acetate

mTOR signaling pathway

4.72E-03

P42338, Q02750, Q9NQL2, P51812, Q13322, P49841

PIK3CB, MAP2K1, RRAGD, RPS6KA3, GRB10, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762

Estradiol-acetate

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol-acetate

hsa04211

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Estradiol-acetate

Longevity regulating pathway - multiple species

4.41E-03

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1

Estradiol-acetate

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Estradiol-acetate

hsa04217

Necroptosis

2.93E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P15104	GLUL	Glutamine synthetase	0.772
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P15104	GLUL	Glutamine synthetase	0.772
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797

Estradiol-acetate

hsa04310

Wnt signaling pathway

4.17E-03

P61586, P19784, P67870

RHOA, CSNK2A2, CSNK2B

Estradiol-acetate

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P00441	SOD1	Superoxide dismutase [Cu-Zn]	Q9Y496	KIF3A	Kinesin-like protein KIF3A	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol-acetate

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Estradiol-acetate

Axon guidance

1.50E-02

P20827, P23528, Q06124

EFNA1, CFL1, PTPN11

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P16333	NCK1	Cytoplasmic protein NCK1	0.876
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O95631	NTN1	Netrin-1	0.807
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1

Estradiol-acetate

VEGF signaling pathway

1.43E-05

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-acetate

Osteoclast differentiation

3.40E-04

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P49841	GSK3B	Glycogen synthase kinase-3 beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715

Estradiol-acetate

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O14684	PTGES	Prostaglandin E synthase	O15105	SMAD7	Mothers against decapentaplegic homolog 7	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O14684	PTGES	Prostaglandin E synthase	O15105	SMAD7	Mothers against decapentaplegic homolog 7	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708

Estradiol-acetate

hsa04510

Focal adhesion

4.07E-02

O14986, P61586, Q16363

PIP5K1B, RHOA, LAMA4

Estradiol-acetate

hsa04520

Adherens junction

1.38E-04

P19784, P67870, P61586

CSNK2A2, CSNK2B, RHOA

Estradiol-acetate

Tight junction

1.74E-03

P63261, P16989, P56750, Q9Y478, Q92974, Q14247

ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742

Estradiol-acetate

Antigen processing and presentation

1.93E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92

Estradiol-acetate

Neutrophil extracellular trap formation

1.31E-06

P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q93077, P62807, P58876, Q16778, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol-acetate

Renin-angiotensin system

7.48E-03

P50052, P15144, P08311, O75787

AGTR2, ANPEP, CTSG, ATP6AP2

Estradiol-acetate

hsa04620

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Estradiol-acetate

hsa04621

NOD-like receptor signaling pathway

4.72E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Estradiol-acetate

hsa04622

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Estradiol-acetate

Cytosolic DNA-sensing pathway

2.20E-03

P01568, Q13546

IFNA21, RIPK1

Estradiol-acetate

C-type lectin receptor signaling pathway

8.11E-03

Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539

CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P49841	GSK3B	Glycogen synthase kinase-3 beta	P20749	BCL3	B-cell lymphoma 3 protein	0.745
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol-acetate

Hematopoietic cell lineage

1.16E-04

P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P01584

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Estradiol-acetate

Natural killer cell mediated cytotoxicity

8.54E-13

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Estradiol-acetate

IL-17 signaling pathway

1.56E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Estradiol-acetate

Th1 and Th2 cell differentiation

1.22E-12

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Estradiol-acetate

Th17 cell differentiation

6.65E-11

P25963, Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P07766, P09693, P20963, P23458

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Estradiol-acetate

T cell receptor signaling pathway

1.91E-11

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Estradiol-acetate

B cell receptor signaling pathway

2.80E-03

P49841, P42338, P60033, P07948, P21854, Q8N149

GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21854	CD72	B-cell differentiation antigen CD72	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P07948	LYN	Tyrosine-protein kinase Lyn	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P07948	LYN	Tyrosine-protein kinase Lyn	P60033	CD81	CD81 antigen	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P07948	LYN	Tyrosine-protein kinase Lyn	P07948	LYN	Tyrosine-protein kinase Lyn	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P07948	LYN	Tyrosine-protein kinase Lyn	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.843
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Estradiol-acetate

Fc epsilon RI signaling pathway

1.80E-02

Q16539, P42338, P07948, P09917

MAPK14, PIK3CB, LYN, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.904
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796

Estradiol-acetate

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Estradiol-acetate

hsa04713

Circadian entrainment

4.94E-02

P62873, P63092

GNB1, GNAS

Estradiol-acetate

Thermogenesis

1.73E-04

Q16539, P15336, P63261, P33121, Q9Y478, Q16718, O14521

MAPK14, ATF2, ACTG1, ACSL1, PRKAB1, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Estradiol-acetate

Long-term potentiation

7.72E-04

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-acetate

hsa04721

Synaptic vesicle cycle

1.80E-02

Q13488, P31645

TCIRG1, SLC6A4

Estradiol-acetate

Retrograde endocannabinoid signaling

5.93E-03

P48169, P62873, P63218, P50151, P48058, Q16539

GABRA4, GNB1, GNG5, GNG10, GRIA4, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	1
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811

Estradiol-acetate

Glutamatergic synapse

6.91E-04

P48058, P43003, P63092, P62873, P63218, P50151, P15104

GRIA4, SLC1A3, GNAS, GNB1, GNG5, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P15104	GLUL	Glutamine synthetase	-0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P07948	LYN	Tyrosine-protein kinase Lyn	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P07948	LYN	Tyrosine-protein kinase Lyn	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P07948	LYN	Tyrosine-protein kinase Lyn	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.94
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P07948	LYN	Tyrosine-protein kinase Lyn	P15104	GLUL	Glutamine synthetase	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84

Estradiol-acetate

hsa04726

Serotonergic synapse

2.52E-02

P63092, P62873

GNAS, GNB1

Estradiol-acetate

Dopaminergic synapse

1.85E-03

P14416, P63218, P50151, P49841, Q16539, P49407, P48058

DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1, GRIA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701

Estradiol-acetate

Inflammatory mediator regulation of TRP channels

3.14E-04

P14778, P01584, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24

IL1R1, IL1B, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P24723	PRKCH	Protein kinase C eta type	0.752
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828

Estradiol-acetate

GnRH signaling pathway

4.33E-02

P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694

ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828

Estradiol-acetate

Progesterone-mediated oocyte maturation

5.67E-04

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.767
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30304	CDC25A	M-phase inducer phosphatase 1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-acetate

Adipocytokine signaling pathway

2.62E-03

Q06124, Q9Y478, Q96RR4

PTPN11, PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Estradiol-acetate

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P07947	YES1	Tyrosine-protein kinase Yes	P14618	PKM2	Pyruvate kinase PKM	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P07947	YES1	Tyrosine-protein kinase Yes	P06737	PYGL	Glycogen phosphorylase, liver form	0.808
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol-acetate

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Estradiol-acetate

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol-acetate

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol-acetate

Non-alcoholic fatty liver disease

3.62E-02

P49841, Q16718, O14521

GSK3B, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Estradiol-acetate

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742

Estradiol-acetate

hsa04972

Pancreatic secretion

3.65E-02

P63092, P61586

GNAS, RHOA

Estradiol-acetate

Carbohydrate digestion and absorption

2.02E-04

O43451, P42338

MGAM, PIK3CB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774

Estradiol-acetate

Fat digestion and absorption

9.50E-04

O14494

PLPP1

Estradiol-acetate

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Estradiol-acetate

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P40926	MDH2	Malate dehydrogenase, mitochondrial	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Estradiol-acetate

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.772
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15169	AXIN1	Axin-1	0.795
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P30530	AXL	Tyrosine-protein kinase receptor UFO	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.735
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P30530	AXL	Tyrosine-protein kinase receptor UFO	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	0.738
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859

Estradiol-acetate

hsa05032

Morphine addiction

2.47E-03

P62873, P48169, P63092

GNB1, GABRA4, GNAS

Estradiol-acetate

Alcoholism

3.52E-06

Q13547, Q93077, P62807, P58876, Q16778, O60814, P68431

HDAC1, HIST1H2AC, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761

Estradiol-acetate

Epithelial cell signaling in Helicobacter pylori infection

2.38E-06

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719

Estradiol-acetate

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754

Estradiol-acetate

Salmonella infection

5.76E-04

P25963, Q13546, Q13489, P10415, Q9BQS8, O60282, P68371

NFKBIA, RIPK1, BIRC3, BCL2, FYCO1, KIF5C, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75369	FLNB	Filamin-B	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.807
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722

Estradiol-acetate

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707

Estradiol-acetate

Yersinia infection

1.11E-05

Q05397, P51812, P13612, P06239, Q16539, Q02750, P01375, P42338, P49841, Q96JJ3, P01730, P01732

PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, TNF, PIK3CB, GSK3B, ELMO2, CD4, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q05397	PTK2	Focal adhesion kinase 1	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.898
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84

Estradiol-acetate

Leishmaniasis

5.95E-04

P13612, O75015, P14598, P23458, P13765, O60603, P25963, P01375, P01584, P29350, Q16539, Q15080

ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762

Estradiol-acetate

Malaria

1.35E-04

P60033, O60603, P01375, P35443, P01584, P26718

CD81, TLR2, TNF, THBS4, IL1B, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91

Estradiol-acetate

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708

Estradiol-acetate

Amoebiasis

1.06E-05

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744

Estradiol-acetate

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769

Estradiol-acetate

Human cytomegalovirus infection

3.52E-05

P42338, P01375, P62873, P63218, P50151, P61586, P49841, P14778, Q13651, P25025, Q16539, P63092, O00463, P61769

PIK3CB, TNF, GNB1, GNG5, GNG10, RHOA, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, GNAS, TRAF5, B2M

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61769	B2M	Beta-2-microglobulin	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61769	B2M	Beta-2-microglobulin	0.764

Estradiol-acetate

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Estradiol-acetate

Epstein-Barr virus infection

2.32E-02

Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P07766, P20963

HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P07195	LDHB	L-lactate dehydrogenase B chain	Q92769	HDAC2	Histone deacetylase 2	0.759
P07195	LDHB	L-lactate dehydrogenase B chain	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Estradiol-acetate

Human immunodeficiency virus 1 infection

8.23E-04

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Estradiol-acetate

Transcriptional misregulation in cancer

2.04E-04

Q12778, Q13315, P17844, P14780, P27930, Q16548, P11215, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, ATM, DDX5, MMP9, IL1R2, BCL2A1, ITGAM, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P21589	NT5E	5'-nucleotidase	Q15532	SS18	Protein SSXT	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P21589	NT5E	5'-nucleotidase	P14923	JUP	Junction plakoglobin	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P21589	NT5E	5'-nucleotidase	O15550	UTX	Lysine-specific demethylase 6A	-0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P21589	NT5E	5'-nucleotidase	P04637	TP53	Cellular tumor antigen p53	0.701
P21589	NT5E	5'-nucleotidase	P05164	MPO	Myeloperoxidase	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Estradiol-acetate

Viral carcinogenesis

1.46E-05

Q12933, P42229, Q13547, Q15283, P62807, P58876, Q16778, O60814

TRAF2, STAT5A, HDAC1, RASA2, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P06746	POLB	DNA polymerase beta	0.837
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P29083	GTF2E1	General transcription factor IIE subunit 1	0.786
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15283	RASA2	Ras GTPase-activating protein 2	-0.815
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P12814	ACTN1	Alpha-actinin-1	-0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.878
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Estradiol-acetate

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Estradiol-acetate

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742

Estradiol-acetate

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Estradiol-acetate

Pancreatic cancer

4.21E-03

P37173, P84022, Q13485

TGFBR2, SMAD3, SMAD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721

Estradiol-acetate

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Estradiol-acetate

Basal cell carcinoma

3.50E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P07195	LDHB	L-lactate dehydrogenase B chain	Q13635	PTCH1	Protein patched homolog 1	0.75
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.753
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819

Estradiol-acetate

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769

Estradiol-acetate

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728

Estradiol-acetate

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736

Estradiol-acetate

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Estradiol-acetate

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.49E-07

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, P10747, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, CD28, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol-acetate

Inflammatory bowel disease

8.20E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718

Estradiol-acetate

Systemic lupus erythematosus

5.41E-07

P09871, Q93077, P62807, P58876, Q16778, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Estradiol-acetate

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717

Estradiol-acetate

Graft-versus-host disease

3.45E-03

P13765, P10747, P26715, Q13241

HLA-DOB, CD28, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Estradiol-acetate

Primary immunodeficiency

3.76E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Estradiol-acetate

Diabetic cardiomyopathy

4.92E-03

Q16718, O14521, Q16539, P49841, P11413

NDUFA5, SDHD, MAPK14, GSK3B, G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P40926	MDH2	Malate dehydrogenase, mitochondrial	P26678	PLN	Cardiac phospholamban	-0.71
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Estradiol-acetate

Fluid shear stress and atherosclerosis

3.61E-02

Q16539, P10599, P14780, P01375, P14778, P27930

MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q14145	KEAP1	Kelch-like ECH-associated protein 1	-0.733
Q16539	MAPK14	Mitogen-activated protein kinase 14	P10599	TXN	Thioredoxin	0.749
P49841	GSK3B	Glycogen synthase kinase-3 beta	P10599	TXN	Thioredoxin	0.836
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P49841	GSK3B	Glycogen synthase kinase-3 beta	P27930	IL1R2	Interleukin-1 receptor type 2	0.848
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955

Estradiol-benzoate

Pentose phosphate pathway

1.69E-02

P60891, P37837

PRPS1, TALDO1

Estradiol-benzoate

Fatty acid degradation

3.65E-03

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874

Estradiol-benzoate

Arginine biosynthesis

1.94E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Estradiol-benzoate

hsa00240

Pyrimidine metabolism

4.29E-02

P21589, P04183

NT5E, TK1

Estradiol-benzoate

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Estradiol-benzoate

Starch and sucrose metabolism

3.28E-05

O43451, P46976, P06737

MGAM, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P49841	GSK3B	Glycogen synthase kinase-3 beta	O43451	MGAM	Maltase-glucoamylase	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P49841	GSK3B	Glycogen synthase kinase-3 beta	P46976	GYG1	Glycogenin-1	0.813
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P49841	GSK3B	Glycogen synthase kinase-3 beta	P06737	PYGL	Glycogen phosphorylase, liver form	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71

Estradiol-benzoate

hsa00513

Various types of N-glycan biosynthesis

4.96E-02

Q9NR34

MAN1C1

Estradiol-benzoate

Amino sugar and nucleotide sugar metabolism

7.87E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Estradiol-benzoate

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Estradiol-benzoate

hsa00564

Glycerophospholipid metabolism

4.29E-02

Q6P1A2, P23743

MBOAT5, DGKA

Estradiol-benzoate

Linoleic acid metabolism

3.18E-02

P11712

CYP2C9

Estradiol-benzoate

Glycosphingolipid biosynthesis - globo and isoglobo series

4.30E-03

P06865, O75752

HEXA, B3GALNT1

Estradiol-benzoate

Thiamine metabolism

3.21E-03

P05186, P24666

ALPL, ACP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
P49841	GSK3B	Glycogen synthase kinase-3 beta	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P49841	GSK3B	Glycogen synthase kinase-3 beta	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76

Estradiol-benzoate

Pantothenate and CoA biosynthesis

7.90E-03

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Estradiol-benzoate

Retinol metabolism

2.20E-02

P00325, P11766, Q9BPW9, O75911

ADH1B, ADH5, DHRS9, DHRS3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P06239	LCK	Tyrosine-protein kinase Lck	P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	0.771
P06239	LCK	Tyrosine-protein kinase Lck	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	-0.825
P06239	LCK	Tyrosine-protein kinase Lck	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745

Estradiol-benzoate

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Estradiol-benzoate

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Estradiol-benzoate

Aminoacyl-tRNA biosynthesis

1.58E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
O43451	MGAM	Maltase-glucoamylase	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
O43451	MGAM	Maltase-glucoamylase	Q15046	KARS	Lysine--tRNA ligase	-0.71
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
O43451	MGAM	Maltase-glucoamylase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
O43451	MGAM	Maltase-glucoamylase	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
O43451	MGAM	Maltase-glucoamylase	Q15046	KARS	Lysine--tRNA ligase	-0.71
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.799
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q15046	KARS	Lysine--tRNA ligase	-0.818
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704

Estradiol-benzoate

Biosynthesis of amino acids

3.59E-02

P60891, Q99707, P37837

PRPS1, MTR, TALDO1

Estradiol-benzoate

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P19784	CSNK2A2	Casein kinase II subunit alpha'	-0.701
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P67870	CSNK2B	Casein kinase II subunit beta	-0.752
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
P21589	NT5E	5'-nucleotidase	Q9NYH9	UTP6	U3 small nucleolar RNA-associated protein 6 homolog	0.836
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
P21589	NT5E	5'-nucleotidase	P78345	RPP38	Ribonuclease P protein subunit p38	0.82
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
P21589	NT5E	5'-nucleotidase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.749
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838

Estradiol-benzoate

RNA transport

2.35E-05

O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5

XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758

Estradiol-benzoate

PPAR signaling pathway

3.78E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Estradiol-benzoate

hsa04015

Rap1 signaling pathway

3.07E-02

P25116, Q8TEU7, P08514, P17252

F2R, RAPGEF6, ITGA2B, PRKCA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25116	F2R	Proteinase-activated receptor 1	P25116	F2R	Proteinase-activated receptor 1	1
P25116	F2R	Proteinase-activated receptor 1	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.811
P25116	F2R	Proteinase-activated receptor 1	P08514	ITGA2B	Integrin alpha-IIb	0.813
P25116	F2R	Proteinase-activated receptor 1	P17252	PRKCA	Protein kinase C alpha type	0.857
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Estradiol-benzoate

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816

Estradiol-benzoate

Chemokine signaling pathway

2.83E-05

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, ARRB1, ITK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716

Estradiol-benzoate

NF-kappa B signaling pathway

1.68E-05

P10415, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9NQC7

BCL2, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799

Estradiol-benzoate

Sphingolipid signaling pathway

1.19E-02

P21453, Q9H228, Q13362, Q9BX95, P10415

S1PR1, EDG8, PPP2R5C, SGPP1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol-benzoate

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	-0.736
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P23743	DGKA	Diacylglycerol kinase alpha	0.843
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7

Estradiol-benzoate

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735

Estradiol-benzoate

Oocyte meiosis

1.62E-04

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776

Estradiol-benzoate

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Estradiol-benzoate

Autophagy - animal

3.19E-02

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Estradiol-benzoate

Phagosome

4.48E-02

Q15080, P05164, O60603, P35443, P13765

NCF4, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Estradiol-benzoate

mTOR signaling pathway

4.72E-03

P42338, Q02750, Q9NQL2, P51812, Q13322, P49841

PIK3CB, MAP2K1, RRAGD, RPS6KA3, GRB10, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762

Estradiol-benzoate

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol-benzoate

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1

Estradiol-benzoate

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Estradiol-benzoate

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P00441	SOD1	Superoxide dismutase [Cu-Zn]	Q9Y496	KIF3A	Kinesin-like protein KIF3A	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol-benzoate

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Estradiol-benzoate

VEGF signaling pathway

1.43E-05

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-benzoate

Osteoclast differentiation

3.40E-04

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P49841	GSK3B	Glycogen synthase kinase-3 beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715

Estradiol-benzoate

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O14684	PTGES	Prostaglandin E synthase	O15105	SMAD7	Mothers against decapentaplegic homolog 7	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O14684	PTGES	Prostaglandin E synthase	O15105	SMAD7	Mothers against decapentaplegic homolog 7	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708

Estradiol-benzoate

hsa04611

Platelet activation

3.39E-02

P25116, P08514, P07359

F2R, ITGA2B, GP1BA

Estradiol-benzoate

Antigen processing and presentation

1.93E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92

Estradiol-benzoate

Neutrophil extracellular trap formation

1.09E-03

P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, P62807, O60814, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, HIST1H2BC, H2BC12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol-benzoate

Renin-angiotensin system

7.48E-03

P50052, P15144, P08311, O75787

AGTR2, ANPEP, CTSG, ATP6AP2

Estradiol-benzoate

C-type lectin receptor signaling pathway

8.11E-03

Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539

CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P49841	GSK3B	Glycogen synthase kinase-3 beta	P20749	BCL3	B-cell lymphoma 3 protein	0.745
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol-benzoate

Hematopoietic cell lineage

2.62E-03

P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P01584

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Estradiol-benzoate

Natural killer cell mediated cytotoxicity

9.96E-11

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Estradiol-benzoate

IL-17 signaling pathway

1.56E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Estradiol-benzoate

Th1 and Th2 cell differentiation

1.57E-09

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Estradiol-benzoate

Th17 cell differentiation

4.79E-08

P25963, Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P07766, P09693, P20963, P23458

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Estradiol-benzoate

T cell receptor signaling pathway

4.54E-09

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Estradiol-benzoate

B cell receptor signaling pathway

2.80E-03

P49841, P42338, P60033, P07948, P21854, Q8N149

GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21854	CD72	B-cell differentiation antigen CD72	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P07948	LYN	Tyrosine-protein kinase Lyn	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P07948	LYN	Tyrosine-protein kinase Lyn	P60033	CD81	CD81 antigen	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P07948	LYN	Tyrosine-protein kinase Lyn	P07948	LYN	Tyrosine-protein kinase Lyn	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P07948	LYN	Tyrosine-protein kinase Lyn	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.843
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Estradiol-benzoate

Fc epsilon RI signaling pathway

1.80E-02

Q16539, P42338, P07948, P09917

MAPK14, PIK3CB, LYN, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.904
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796

Estradiol-benzoate

hsa04672

Intestinal immune network for IgA production

1.35E-02

P29965, P13765

CD40LG, HLA-DOB

Estradiol-benzoate

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Estradiol-benzoate

Long-term potentiation

7.72E-04

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-benzoate

Retrograde endocannabinoid signaling

3.86E-02

P63218, P50151, P48058, Q16539

GNG5, GNG10, GRIA4, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	1
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811

Estradiol-benzoate

Glutamatergic synapse

7.09E-03

P48058, P43003, P63218, P50151, P15104

GRIA4, SLC1A3, GNG5, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P15104	GLUL	Glutamine synthetase	-0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P07948	LYN	Tyrosine-protein kinase Lyn	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P07948	LYN	Tyrosine-protein kinase Lyn	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P07948	LYN	Tyrosine-protein kinase Lyn	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.94
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P07948	LYN	Tyrosine-protein kinase Lyn	P15104	GLUL	Glutamine synthetase	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84

Estradiol-benzoate

Dopaminergic synapse

1.85E-03

P14416, P63218, P50151, P49841, Q16539, P49407, P48058

DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1, GRIA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701

Estradiol-benzoate

Inflammatory mediator regulation of TRP channels

3.14E-04

P14778, P01584, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24

IL1R1, IL1B, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P24723	PRKCH	Protein kinase C eta type	0.752
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828

Estradiol-benzoate

GnRH signaling pathway

4.33E-02

P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694

ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828

Estradiol-benzoate

Progesterone-mediated oocyte maturation

5.67E-04

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.767
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30304	CDC25A	M-phase inducer phosphatase 1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-benzoate

hsa04918

Thyroid hormone synthesis

3.16E-02

P17252, P27824

PRKCA, CANX

Estradiol-benzoate

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Estradiol-benzoate

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P07947	YES1	Tyrosine-protein kinase Yes	P14618	PKM2	Pyruvate kinase PKM	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P07947	YES1	Tyrosine-protein kinase Yes	P06737	PYGL	Glycogen phosphorylase, liver form	0.808
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol-benzoate

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Estradiol-benzoate

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol-benzoate

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol-benzoate

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742

Estradiol-benzoate

Carbohydrate digestion and absorption

2.02E-04

O43451, P42338

MGAM, PIK3CB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774

Estradiol-benzoate

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Estradiol-benzoate

Alcoholism

4.54E-02

P62807, O60814

HIST1H2BC, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761

Estradiol-benzoate

Epithelial cell signaling in Helicobacter pylori infection

2.06E-05

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719

Estradiol-benzoate

Salmonella infection

2.04E-02

P25963, Q13489, P10415, Q9BQS8

NFKBIA, BIRC3, BCL2, FYCO1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75369	FLNB	Filamin-B	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.807
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722

Estradiol-benzoate

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707

Estradiol-benzoate

Yersinia infection

1.98E-04

Q05397, P51812, P13612, P06239, Q16539, Q02750, P01375, P42338, P49841, Q96JJ3, P01730

PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, TNF, PIK3CB, GSK3B, ELMO2, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q05397	PTK2	Focal adhesion kinase 1	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.898
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84

Estradiol-benzoate

Leishmaniasis

2.29E-02

P13612, O75015, P23458, P13765, O60603, P01375, P01584, Q16539, Q15080

ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762

Estradiol-benzoate

Malaria

1.35E-04

P60033, O60603, P01375, P35443, P01584, P26718

CD81, TLR2, TNF, THBS4, IL1B, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91

Estradiol-benzoate

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708

Estradiol-benzoate

Amoebiasis

1.54E-04

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744

Estradiol-benzoate

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769

Estradiol-benzoate

Human cytomegalovirus infection

2.16E-04

P42338, P01375, P63218, P50151, P49841, P14778, Q13651, P25025, Q16539, O00463

PIK3CB, TNF, GNG5, GNG10, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61769	B2M	Beta-2-microglobulin	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61769	B2M	Beta-2-microglobulin	0.764

Estradiol-benzoate

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Estradiol-benzoate

Epstein-Barr virus infection

2.32E-02

Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P07766, P20963

HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P07195	LDHB	L-lactate dehydrogenase B chain	Q92769	HDAC2	Histone deacetylase 2	0.759
P07195	LDHB	L-lactate dehydrogenase B chain	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Estradiol-benzoate

Human immunodeficiency virus 1 infection

8.23E-04

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Estradiol-benzoate

Transcriptional misregulation in cancer

8.91E-04

Q12778, Q13315, P17844, P14780, P27930, Q16548, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, ATM, DDX5, MMP9, IL1R2, BCL2A1, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P21589	NT5E	5'-nucleotidase	Q15532	SS18	Protein SSXT	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P21589	NT5E	5'-nucleotidase	P14923	JUP	Junction plakoglobin	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P21589	NT5E	5'-nucleotidase	O15550	UTX	Lysine-specific demethylase 6A	-0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P21589	NT5E	5'-nucleotidase	P04637	TP53	Cellular tumor antigen p53	0.701
P21589	NT5E	5'-nucleotidase	P05164	MPO	Myeloperoxidase	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Estradiol-benzoate

Viral carcinogenesis

2.13E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P06746	POLB	DNA polymerase beta	0.837
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P29083	GTF2E1	General transcription factor IIE subunit 1	0.786
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15283	RASA2	Ras GTPase-activating protein 2	-0.815
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P12814	ACTN1	Alpha-actinin-1	-0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.878
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Estradiol-benzoate

hsa05205

Proteoglycans in cancer

4.46E-02

Q12955, Q14247, P17252, P08962

ANK3, CTTN, PRKCA, CD63

Estradiol-benzoate

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742

Estradiol-benzoate

Pancreatic cancer

4.21E-03

P37173, P84022, Q13485

TGFBR2, SMAD3, SMAD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721

Estradiol-benzoate

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Estradiol-benzoate

Basal cell carcinoma

3.50E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P07195	LDHB	L-lactate dehydrogenase B chain	Q13635	PTCH1	Protein patched homolog 1	0.75
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.753
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819

Estradiol-benzoate

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769

Estradiol-benzoate

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728

Estradiol-benzoate

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736

Estradiol-benzoate

PD-L1 expression and PD-1 checkpoint pathway in cancer

7.33E-06

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, P10747, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, CD28, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol-benzoate

hsa05310

Asthma

1.35E-02

P13765, P29965

HLA-DOB, CD40LG

Estradiol-benzoate

hsa05320

Autoimmune thyroid disease

3.16E-02

P13765, P29965

HLA-DOB, CD40LG

Estradiol-benzoate

Inflammatory bowel disease

8.20E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718

Estradiol-benzoate

Systemic lupus erythematosus

2.93E-02

P62807, O60814

HIST1H2BC, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Estradiol-benzoate

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717

Estradiol-benzoate

hsa05330

Allograft rejection

3.16E-02

P13765, P29965

HLA-DOB, CD40LG

Estradiol-benzoate

Graft-versus-host disease

3.45E-03

P13765, P10747, P26715, Q13241

HLA-DOB, CD28, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Estradiol-benzoate

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

1.82E-02

P14923, P08514, Q9UJU2

JUP, ITGA2B, LEF1

Estradiol-benzoate

hsa05416

Viral myocarditis

4.29E-02

P13765, P29965

HLA-DOB, CD40LG

Estradiol-benzoate

Fluid shear stress and atherosclerosis

3.61E-02

Q16539, P10599, P14780, P01375, P14778, P27930

MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q14145	KEAP1	Kelch-like ECH-associated protein 1	-0.733
Q16539	MAPK14	Mitogen-activated protein kinase 14	P10599	TXN	Thioredoxin	0.749
P49841	GSK3B	Glycogen synthase kinase-3 beta	P10599	TXN	Thioredoxin	0.836
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P49841	GSK3B	Glycogen synthase kinase-3 beta	P27930	IL1R2	Interleukin-1 receptor type 2	0.848
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955

Estradiol-cypionate

Pentose phosphate pathway

1.69E-02

P60891, P37837

PRPS1, TALDO1

Estradiol-cypionate

hsa00040

Pentose and glucuronate interconversions

9.59E-03

P15121, P14550

AKR1B1, AKR1A1

Estradiol-cypionate

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874

Estradiol-cypionate

Arginine biosynthesis

1.94E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Estradiol-cypionate

hsa00230

Purine metabolism

2.11E-02

Q7LG56, P31350, P21589

RRM2B, RRM2, NT5E

Estradiol-cypionate

hsa00240

Pyrimidine metabolism

1.86E-06

Q7LG56, P31350, P21589, P04183, P04818

RRM2B, RRM2, NT5E, TK1, TYMS

Estradiol-cypionate

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Estradiol-cypionate

Glutathione metabolism

3.85E-02

Q7LG56, P31350

RRM2B, RRM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P21589	NT5E	5'-nucleotidase	Q7LG56	RRM2B	Ribonucleoside-diphosphate reductase subunit M2 B	0.7
P21589	NT5E	5'-nucleotidase	P31350	RRM2	Ribonucleoside-diphosphate reductase subunit M2	-0.732
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Estradiol-cypionate

Starch and sucrose metabolism

3.28E-05

O43451, P46976, P06737

MGAM, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P49841	GSK3B	Glycogen synthase kinase-3 beta	O43451	MGAM	Maltase-glucoamylase	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P49841	GSK3B	Glycogen synthase kinase-3 beta	P46976	GYG1	Glycogenin-1	0.813
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P49841	GSK3B	Glycogen synthase kinase-3 beta	P06737	PYGL	Glycogen phosphorylase, liver form	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71

Estradiol-cypionate

Amino sugar and nucleotide sugar metabolism

7.87E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Estradiol-cypionate

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Estradiol-cypionate

hsa00561

Glycerolipid metabolism

7.94E-03

P15121, P14550, Q86XP1

AKR1B1, AKR1A1, DGKH

Estradiol-cypionate

Linoleic acid metabolism

3.18E-02

P11712

CYP2C9

Estradiol-cypionate

Glycosphingolipid biosynthesis - globo and isoglobo series

4.30E-03

P06865, O75752

HEXA, B3GALNT1

Estradiol-cypionate

hsa00630

Glyoxylate and dicarboxylate metabolism

1.32E-02

P40925, P15104

MDH1, GLUL

Estradiol-cypionate

Thiamine metabolism

3.21E-03

P05186, P24666

ALPL, ACP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
P49841	GSK3B	Glycogen synthase kinase-3 beta	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P49841	GSK3B	Glycogen synthase kinase-3 beta	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76

Estradiol-cypionate

Pantothenate and CoA biosynthesis

7.90E-03

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Estradiol-cypionate

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Estradiol-cypionate

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Estradiol-cypionate

Aminoacyl-tRNA biosynthesis

1.58E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
O43451	MGAM	Maltase-glucoamylase	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
O43451	MGAM	Maltase-glucoamylase	Q15046	KARS	Lysine--tRNA ligase	-0.71
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
O43451	MGAM	Maltase-glucoamylase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
O43451	MGAM	Maltase-glucoamylase	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
O43451	MGAM	Maltase-glucoamylase	Q15046	KARS	Lysine--tRNA ligase	-0.71
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.799
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q15046	KARS	Lysine--tRNA ligase	-0.818
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704

Estradiol-cypionate

Drug metabolism - other enzymes

6.98E-05

P04183, Q7LG56, P31350, P05164

TK1, RRM2B, RRM2, MPO

Estradiol-cypionate

Biosynthesis of amino acids

3.59E-02

P60891, Q99707, P37837

PRPS1, MTR, TALDO1

Estradiol-cypionate

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Estradiol-cypionate

Ribosome biogenesis in eukaryotes

5.07E-04

Q9NYH9, O14980, O60832, P78345, Q9BVP2, Q9GZY0

UTP6, XPO1, DKC1, RPP38, GNL3, NXF2; NXF2B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P19784	CSNK2A2	Casein kinase II subunit alpha'	-0.701
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P67870	CSNK2B	Casein kinase II subunit beta	-0.752
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
P21589	NT5E	5'-nucleotidase	Q9NYH9	UTP6	U3 small nucleolar RNA-associated protein 6 homolog	0.836
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
P21589	NT5E	5'-nucleotidase	P78345	RPP38	Ribonuclease P protein subunit p38	0.82
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
P21589	NT5E	5'-nucleotidase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.749
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838

Estradiol-cypionate

hsa03010

Ribosome

1.60E-02

P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396

RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3

Estradiol-cypionate

RNA transport

2.35E-05

O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5

XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758

Estradiol-cypionate

hsa03015

mRNA surveillance pathway

3.37E-02

O43148, Q9GZY0, P52298

RNMT, NXF2; NXF2B, NCBP2

Estradiol-cypionate

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Estradiol-cypionate

hsa03030

DNA replication

1.48E-02

P49005, P33993, P15927

POLD2, MCM7, RPA2

Estradiol-cypionate

hsa03040

Spliceosome

4.19E-04

Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, P11142, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.803
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.869
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O60508	CDC40	Pre-mRNA-processing factor 17	0.827
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.866
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.835
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.908
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.928
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.786
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	0.78
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Estradiol-cypionate

hsa03060

Protein export

4.22E-02

P37108, Q15005

SRP14, SPCS2

Estradiol-cypionate

PPAR signaling pathway

3.78E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Estradiol-cypionate

hsa04012

ErbB signaling pathway

1.34E-02

P16333, P19174, P42338, P01106

NCK1, PLCG1, PIK3CB, MYC

Estradiol-cypionate

hsa04014

Ras signaling pathway

2.92E-04

P42338, P20827, Q9NRA1, P49767, Q13009, P0DP23, P62873, P63218, P50151, P19174

PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Estradiol-cypionate

hsa04015

Rap1 signaling pathway

4.83E-03

P20827, Q9NRA1, P49767, P11215, Q13009, P42338, P0DP23, P19174

EFNA1, PDGFC, VEGFC, ITGAM, TIAM1, PIK3CB, CALM1, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25116	F2R	Proteinase-activated receptor 1	P25116	F2R	Proteinase-activated receptor 1	1
P25116	F2R	Proteinase-activated receptor 1	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.811
P25116	F2R	Proteinase-activated receptor 1	P08514	ITGA2B	Integrin alpha-IIb	0.813
P25116	F2R	Proteinase-activated receptor 1	P17252	PRKCA	Protein kinase C alpha type	0.857
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Estradiol-cypionate

hsa04020

Calcium signaling pathway

8.05E-05

P27987, Q96DU7, P21796, Q13557, P21860, P19174, P0DP23, P05141, P12236, P26678, P63092, Q9NRA1, P49767

ITPKB, ITPKC, VDAC1, CAMK2D, ERBB3, PLCG1, CALM1, SLC25A5, SLC25A6, PLN, GNAS, PDGFC, VEGFC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.891
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.766
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P40926	MDH2	Malate dehydrogenase, mitochondrial	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	P26678	PLN	Cardiac phospholamban	-0.71
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802

Estradiol-cypionate

hsa04022

cGMP-PKG signaling pathway

9.36E-03

P61586, P26678, Q99941, P18848, P05141, P12236

RHOA, PLN, CREBL1, ATF4, SLC25A5, SLC25A6

Estradiol-cypionate

Viral protein interaction with cytokine and cytokine receptor

3.57E-03

Q8NHW4, P09341, P19875, P25024, P25025, P61073, Q13651, P14784

CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, CXCR4, IL10RA, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816

Estradiol-cypionate

Chemokine signaling pathway

6.40E-08

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P25963, P49841

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, NFKBIA, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716

Estradiol-cypionate

NF-kappa B signaling pathway

6.33E-06

P10415, O00463, P14778, P01584, P19174, Q04759, Q9UDY8, P67870, Q16548, P06239, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

BCL2, TRAF5, IL1R1, IL1B, PLCG1, PRKCQ, MALT1, CSNK2B, BCL2A1, LCK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799

Estradiol-cypionate

hsa04070

Phosphatidylinositol signaling system

1.12E-02

P19174, P0DP23, P42338, P23743, P27987

PLCG1, CALM1, PIK3CB, DGKA, ITPKB

Estradiol-cypionate

Sphingolipid signaling pathway

1.19E-02

P21453, Q9H228, Q13362, Q9BX95, P10415

S1PR1, EDG8, PPP2R5C, SGPP1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol-cypionate

Phospholipase D signaling pathway

5.49E-03

P42338, P43657, P25024, P25025, P19174, Q14344, P23743, Q9NRA1

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, DGKA, PDGFC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	-0.736
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P23743	DGKA	Diacylglycerol kinase alpha	0.843
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7

Estradiol-cypionate

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735

Estradiol-cypionate

Oocyte meiosis

1.62E-04

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776

Estradiol-cypionate

hsa04115

p53 signaling pathway

1.74E-03

Q7LG56, P31350, Q9HA38, P04637

RRM2B, RRM2, ZMAT3, TP53

Estradiol-cypionate

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Estradiol-cypionate

Autophagy - animal

3.19E-02

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Estradiol-cypionate

Phagosome

4.48E-02

Q15080, P05164, O60603, P35443, P13765

NCF4, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Estradiol-cypionate

mTOR signaling pathway

4.72E-03

P42338, Q02750, Q9NQL2, P51812, Q13322, P49841

PIK3CB, MAP2K1, RRAGD, RPS6KA3, GRB10, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762

Estradiol-cypionate

hsa04151

PI3K-Akt signaling pathway

2.62E-04

P42338, P21860, P01106, P27348, P20827, O14944, Q9NRA1, P49767, P07900, P08238, Q15831, P62873, P63218, P50151, O15335, P22105, P14784, P01568, Q99941, P18848, O95988

PIK3CB, ERBB3, MYC, YWHAQ, EFNA1, EREG, PDGFC, VEGFC, HSP90AA1, HSP90AB1, STK11, GNB1, GNG5, GNG10, CHAD, TNXB, IL2RB, IFNA21, CREBL1, ATF4, TCL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40926	MDH2	Malate dehydrogenase, mitochondrial	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40926	MDH2	Malate dehydrogenase, mitochondrial	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P40926	MDH2	Malate dehydrogenase, mitochondrial	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.718
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15831	STK11	Serine/threonine-protein kinase STK11	0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O15335	CHAD	Chondroadherin	-0.704
P40926	MDH2	Malate dehydrogenase, mitochondrial	P22105	TNXB	Tenascin-X	0.802
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	O95988	TCL1B	T-cell leukemia/lymphoma protein 1B	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Estradiol-cypionate

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol-cypionate

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1

Estradiol-cypionate

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Estradiol-cypionate

hsa04260

Cardiac muscle contraction

4.49E-02

P67936, P13073, P12074

TPM4, COX4I1, COX6A1

Estradiol-cypionate

hsa04261

Adrenergic signaling in cardiomyocytes

3.12E-02

P63092, Q99941, P18848, P26678, Q13557

GNAS, CREBL1, ATF4, PLN, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P26678	PLN	Cardiac phospholamban	-0.71
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797

Estradiol-cypionate

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P00441	SOD1	Superoxide dismutase [Cu-Zn]	Q9Y496	KIF3A	Kinesin-like protein KIF3A	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol-cypionate

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Estradiol-cypionate

Axon guidance

2.87E-02

P16333, P20827, O95631, P42338, P19174

NCK1, EFNA1, NTN1, PIK3CB, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P16333	NCK1	Cytoplasmic protein NCK1	0.876
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O95631	NTN1	Netrin-1	0.807
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1

Estradiol-cypionate

VEGF signaling pathway

1.43E-05

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-cypionate

hsa04371

Apelin signaling pathway

2.41E-03

P62873, P63218, P50151, Q13370, Q14814, Q14344, P0DP23

GNB1, GNG5, GNG10, PDE3B, MEF2D, GNA13, CALM1

Estradiol-cypionate

Osteoclast differentiation

4.71E-02

Q16539, P06239, P42338, P14778, O75015, Q8N149

MAPK14, LCK, PIK3CB, IL1R1, FCGR3B, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P49841	GSK3B	Glycogen synthase kinase-3 beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715

Estradiol-cypionate

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O14684	PTGES	Prostaglandin E synthase	O15105	SMAD7	Mothers against decapentaplegic homolog 7	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O14684	PTGES	Prostaglandin E synthase	O15105	SMAD7	Mothers against decapentaplegic homolog 7	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708

Estradiol-cypionate

Antigen processing and presentation

1.93E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92

Estradiol-cypionate

Neutrophil extracellular trap formation

6.09E-04

P42338, P19174, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P62807, Q93079, O60814, P21796, P14598, Q15080, P20160, P08311, P21730

PIK3CB, PLCG1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HIST1H2BC, H2BC9, H2BC12, VDAC1, NCF1, NCF4, AZU1, CTSG, C5AR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol-cypionate

Renin-angiotensin system

1.52E-02

P50052

AGTR2

Estradiol-cypionate

hsa04620

Toll-like receptor signaling pathway

4.00E-02

P01568, P42224, P25963, P42338

IFNA21, STAT1, NFKBIA, PIK3CB

Estradiol-cypionate

Cytosolic DNA-sensing pathway

9.60E-04

P01584, P01568, P25963, Q8NHW4

IL1B, IFNA21, NFKBIA, CCL4L2

Estradiol-cypionate

C-type lectin receptor signaling pathway

2.17E-02

Q9ULY5, P42224, P25963, P42338, P0DP23

CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P49841	GSK3B	Glycogen synthase kinase-3 beta	P20749	BCL3	B-cell lymphoma 3 protein	0.745
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol-cypionate

Hematopoietic cell lineage

1.37E-02

P14778, P27930, P11215, P25063, P07766, P01732, P09564

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Estradiol-cypionate

Natural killer cell mediated cytotoxicity

2.84E-10

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Estradiol-cypionate

Th1 and Th2 cell differentiation

2.95E-10

P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Estradiol-cypionate

Th17 cell differentiation

4.40E-08

P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Estradiol-cypionate

T cell receptor signaling pathway

7.02E-08

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Estradiol-cypionate

B cell receptor signaling pathway

8.98E-05

P25963, P49841, P42338, P60033, P07948, P21854, Q8N149

NFKBIA, GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21854	CD72	B-cell differentiation antigen CD72	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P07948	LYN	Tyrosine-protein kinase Lyn	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P07948	LYN	Tyrosine-protein kinase Lyn	P60033	CD81	CD81 antigen	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P07948	LYN	Tyrosine-protein kinase Lyn	P07948	LYN	Tyrosine-protein kinase Lyn	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P07948	LYN	Tyrosine-protein kinase Lyn	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.843
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Estradiol-cypionate

Fc epsilon RI signaling pathway

5.84E-04

Q16539, P42338, P07948, P19174, P09917

MAPK14, PIK3CB, LYN, PLCG1, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.904
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796

Estradiol-cypionate

hsa04666

Fc gamma R-mediated phagocytosis

2.92E-02

P07948, P42338, P19174, P14598

LYN, PIK3CB, PLCG1, NCF1

Estradiol-cypionate

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Estradiol-cypionate

hsa04713

Circadian entrainment

4.00E-02

P0DP23, P62873, P63218, P50151

CALM1, GNB1, GNG5, GNG10

Estradiol-cypionate

Long-term potentiation

7.72E-04

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-cypionate

Retrograde endocannabinoid signaling

3.86E-02

P63218, P50151, P48058, Q16539

GNG5, GNG10, GRIA4, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	1
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811

Estradiol-cypionate

Glutamatergic synapse

5.51E-04

P48058, P43003, P62873, P63218, P50151, P15104

GRIA4, SLC1A3, GNB1, GNG5, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P15104	GLUL	Glutamine synthetase	-0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P07948	LYN	Tyrosine-protein kinase Lyn	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P07948	LYN	Tyrosine-protein kinase Lyn	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P07948	LYN	Tyrosine-protein kinase Lyn	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.94
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P07948	LYN	Tyrosine-protein kinase Lyn	P15104	GLUL	Glutamine synthetase	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84

Estradiol-cypionate

Cholinergic synapse

2.92E-02

P62873, P63218, P50151, P42338

GNB1, GNG5, GNG10, PIK3CB

Estradiol-cypionate

hsa04727

GABAergic synapse

8.14E-03

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Estradiol-cypionate

Dopaminergic synapse

1.85E-03

P14416, P63218, P50151, P49841, Q16539, P49407, P48058

DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1, GRIA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701

Estradiol-cypionate

hsa04744

Phototransduction

1.32E-02

P62873, P0DP23

GNB1, CALM1

Estradiol-cypionate

Inflammatory mediator regulation of TRP channels

8.12E-04

P14778, P19174, P42338, P24723, Q04759, P0DP23

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P24723	PRKCH	Protein kinase C eta type	0.752
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828

Estradiol-cypionate

hsa04810

Regulation of actin cytoskeleton

2.61E-02

P12814, Q13009, P42338, P11215, Q14344, Q9NRA1

ACTN1, TIAM1, PIK3CB, ITGAM, GNA13, PDGFC

Estradiol-cypionate

hsa04911

Insulin secretion

4.47E-03

P63092, Q99941, P18848, Q13557

GNAS, CREBL1, ATF4, CAMK2D

Estradiol-cypionate

Progesterone-mediated oocyte maturation

1.31E-04

Q17RY0, P42338, Q13370, Q9Y6D9, P30304, P08238, P51812, Q02750

CPEB4, PIK3CB, PDE3B, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.767
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30304	CDC25A	M-phase inducer phosphatase 1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-cypionate

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Estradiol-cypionate

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P07947	YES1	Tyrosine-protein kinase Yes	P14618	PKM2	Pyruvate kinase PKM	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P07947	YES1	Tyrosine-protein kinase Yes	P06737	PYGL	Glycogen phosphorylase, liver form	0.808
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol-cypionate

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Estradiol-cypionate

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol-cypionate

hsa04925

Aldosterone synthesis and secretion

1.68E-02

Q99941, P18848, P63092, Q13557

CREBL1, ATF4, GNAS, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797

Estradiol-cypionate

hsa04926

Relaxin signaling pathway

8.74E-03

P25963, P42338, P62873, P63218, P50151, P49767

NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFC

Estradiol-cypionate

hsa04927

Cortisol synthesis and secretion

2.40E-02

Q99941, P18848, P63092

CREBL1, ATF4, GNAS

Estradiol-cypionate

Parathyroid hormone synthesis, secretion and action

2.59E-03

Q14643, P63092, P22694, P23771, P61586, Q99941, P18848, P10415

ITPR1, GNAS, PRKACB, GATA3, RHOA, CREBL1, ATF4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol-cypionate

Non-alcoholic fatty liver disease

1.24E-02

O43521, O75460, P01584, P13073, P12074, O15239

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Estradiol-cypionate

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742

Estradiol-cypionate

hsa04934

Cushing syndrome

1.37E-03

Q99941, P18848, P63092, O15169, Q13557

CREBL1, ATF4, GNAS, AXIN1, CAMK2D

Estradiol-cypionate

Carbohydrate digestion and absorption

2.02E-04

O43451, P42338

MGAM, PIK3CB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774

Estradiol-cypionate

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Estradiol-cypionate

hsa05010

Alzheimer disease

9.99E-04

Q92542, O15239, P05496, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P18848, O15169, P67870, P05141, P12236, P28070, P43686, P62195

NCSTN, NDUFA1, ATP5G1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4, PSMC4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q92542	NCSTN	Nicastrin	0.751
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.783
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O95197	RTN3	Reticulon-3	0.702
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15169	AXIN1	Axin-1	0.795
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P28070	PSMB4	Proteasome subunit beta type-4	0.778
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O95197	RTN3	Reticulon-3	0.702
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P28070	PSMB4	Proteasome subunit beta type-4	0.778
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725

Estradiol-cypionate

hsa05012

Parkinson disease

5.04E-04

O15239, P05496, P05141, P12236, P21796, P60604, P63092, P18848, P43686, P62195, P19174, P0DP23, Q13557, Q71U36, Q13509

NDUFA1, ATP5G1, SLC25A5, SLC25A6, VDAC1, UBE2G2, GNAS, ATF4, PSMC4, PSMC5, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P60604	UBE2G2	Ubiquitin-conjugating enzyme E2 G2	0.82
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842

Estradiol-cypionate

hsa05014

Amyotrophic lateral sclerosis

3.92E-02

P20333, O15239, P05496, P18848, P43686, P62195, P51991, P35658

TNFRSF1B, NDUFA1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, NUP214

Estradiol-cypionate

Prion disease

1.15E-02

P46531, O15239, P05496, P18848, P05141, P12236, P43686, P62195, Q99941

NOTCH1, NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, PSMC4, PSMC5, CREBL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P40926	MDH2	Malate dehydrogenase, mitochondrial	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Estradiol-cypionate

Pathways of neurodegeneration - multiple diseases

1.57E-02

O15239, P05496, P18848, P05141, P12236, P20333, O15169, Q13557, P43686, P62195

NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, TNFRSF1B, AXIN1, CAMK2D, PSMC4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.772
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15169	AXIN1	Axin-1	0.795
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P30530	AXL	Tyrosine-protein kinase receptor UFO	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.735
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P30530	AXL	Tyrosine-protein kinase receptor UFO	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	0.738
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859

Estradiol-cypionate

hsa05030

Cocaine addiction

2.40E-02

P63092, Q99941, P18848

GNAS, CREBL1, ATF4

Estradiol-cypionate

hsa05031

Amphetamine addiction

4.47E-03

Q13557, P63092, Q99941, P18848

CAMK2D, GNAS, CREBL1, ATF4

Estradiol-cypionate

hsa05032

Morphine addiction

7.60E-03

P62873, P63218, P50151, Q13370, P43250

GNB1, GNG5, GNG10, PDE3B, GRK6

Estradiol-cypionate

Alcoholism

9.84E-04

Q13547, P0DP23, P62873, P63218, P50151, P62807, Q93079, O60814

HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2BC, H2BC9, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761

Estradiol-cypionate

Epithelial cell signaling in Helicobacter pylori infection

2.06E-05

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719

Estradiol-cypionate

Salmonella infection

2.07E-03

P25963, P08238, P01106, P42338, Q13489, P10415, O75369, Q9BQS8, Q71U36, Q13509, P49754

NFKBIA, HSP90AB1, MYC, PIK3CB, BIRC3, BCL2, FLNB, FYCO1, TUBA1A, TUBB3, VPS41

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75369	FLNB	Filamin-B	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.807
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722

Estradiol-cypionate

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707

Estradiol-cypionate

Yersinia infection

1.98E-04

Q05397, P51812, P13612, P06239, Q16539, Q02750, P01375, P42338, P49841, Q96JJ3, P01730

PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, TNF, PIK3CB, GSK3B, ELMO2, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q05397	PTK2	Focal adhesion kinase 1	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.898
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84

Estradiol-cypionate

Malaria

1.64E-03

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91

Estradiol-cypionate

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708

Estradiol-cypionate

Amoebiasis

2.21E-04

P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814

CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744

Estradiol-cypionate

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769

Estradiol-cypionate

hsa05162

Measles

1.84E-02

P01568, P25963, P42224, P14784, P07766, P42338, P11142

IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.928
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.738
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P30281	CCND3	G1/S-specific cyclin-D3	0.716
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.738
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P30281	CCND3	G1/S-specific cyclin-D3	0.716

Estradiol-cypionate

Human cytomegalovirus infection

6.71E-08

P42338, P01375, P25963, P62873, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P23458, P49841, P01106, P14778, P01584, P61073, Q13651, P25025, Q16539, O00463, P30101, P01568

PIK3CB, TNF, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, JAK1, GSK3B, MYC, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61769	B2M	Beta-2-microglobulin	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61769	B2M	Beta-2-microglobulin	0.764

Estradiol-cypionate

Kaposi sarcoma-associated herpesvirus infection

4.21E-06

P01568, P42224, P25963, P42338, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P01106, P0DP23, P0CG47

IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, MYC, CALM1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Estradiol-cypionate

hsa05168

Herpes simplex virus 1 infection

4.57E-02

P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, O75820

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF189

Estradiol-cypionate

Epstein-Barr virus infection

1.10E-04

P01106, Q13547, O00463, P25963, Q16539, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, P07766, P20963

MYC, HDAC1, TRAF5, NFKBIA, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P07195	LDHB	L-lactate dehydrogenase B chain	Q92769	HDAC2	Histone deacetylase 2	0.759
P07195	LDHB	L-lactate dehydrogenase B chain	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Estradiol-cypionate

Human immunodeficiency virus 1 infection

7.25E-06

P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, P19174, P07766, P20333

PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, PLCG1, CD3E, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Estradiol-cypionate

hsa05200

Pathways in cancer

1.82E-03

P42338, P08238, P42224, P25963, P19174, P01106, P43246, Q13547, P49767, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784

PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, HDAC1, VEGFC, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43246	MSH2	DNA mismatch repair protein Msh2	0.887
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Estradiol-cypionate

Transcriptional misregulation in cancer

1.09E-03

Q12778, Q15532, Q13315, P14780, P14923, Q16548, O15550, P04637, P05164, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, MMP9, JUP, BCL2A1, UTX, TP53, MPO, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P21589	NT5E	5'-nucleotidase	Q15532	SS18	Protein SSXT	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P21589	NT5E	5'-nucleotidase	P14923	JUP	Junction plakoglobin	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P21589	NT5E	5'-nucleotidase	O15550	UTX	Lysine-specific demethylase 6A	-0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P21589	NT5E	5'-nucleotidase	P04637	TP53	Cellular tumor antigen p53	0.701
P21589	NT5E	5'-nucleotidase	P05164	MPO	Myeloperoxidase	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Estradiol-cypionate

Viral carcinogenesis

1.47E-05

Q99941, P18848, P42338, P06746, P07948, P27348, P29083, Q13547, Q15283, P61586, P12814, P25963, P61978, P62807, Q93079, O60814

CREBL1, ATF4, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, HDAC1, RASA2, RHOA, ACTN1, NFKBIA, HNRPK, HIST1H2BC, H2BC9, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P06746	POLB	DNA polymerase beta	0.837
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P29083	GTF2E1	General transcription factor IIE subunit 1	0.786
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15283	RASA2	Ras GTPase-activating protein 2	-0.815
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P12814	ACTN1	Alpha-actinin-1	-0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.878
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Estradiol-cypionate

hsa05206

MicroRNAs in cancer

1.34E-03

P30304, P09493, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P61586, P20827, P19174

CDC25A, TPM1, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, RHOA, EFNA1, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30304	CDC25A	M-phase inducer phosphatase 1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P09493	TPM1	Tropomyosin alpha-1 chain	-0.78
P40926	MDH2	Malate dehydrogenase, mitochondrial	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.878
P40926	MDH2	Malate dehydrogenase, mitochondrial	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.747
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.731
P40926	MDH2	Malate dehydrogenase, mitochondrial	P22105	TNXB	Tenascin-X	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769

Estradiol-cypionate

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742

Estradiol-cypionate

Pancreatic cancer

4.21E-03

P37173, P84022, Q13485

TGFBR2, SMAD3, SMAD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721

Estradiol-cypionate

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Estradiol-cypionate

hsa05214

Glioma

1.34E-02

P0DP23, P42338, P19174, O75293

CALM1, PIK3CB, PLCG1, GADD45B

Estradiol-cypionate

hsa05218

Melanoma

2.31E-02

Q9NRA1, P42338, O75293

PDGFC, PIK3CB, GADD45B

Estradiol-cypionate

Chronic myeloid leukemia

1.14E-03

Q13547, P01106, Q13485, P25963, P84022, P42338, O75293

HDAC1, MYC, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769

Estradiol-cypionate

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728

Estradiol-cypionate

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736

Estradiol-cypionate

hsa05231

Choline metabolism in cancer

2.92E-03

P42338, Q9NRA1, Q9Y259, P19174, P23743

PIK3CB, PDGFC, CHKB, PLCG1, DGKA

Estradiol-cypionate

PD-L1 expression and PD-1 checkpoint pathway in cancer

3.56E-06

P25963, P42338, P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q16539, P01730

NFKBIA, PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol-cypionate

Inflammatory bowel disease

1.17E-03

O60603, P13765, Q14765, Q9UL17, P23771

TLR2, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718

Estradiol-cypionate

Systemic lupus erythematosus

2.93E-02

P62807, O60814

HIST1H2BC, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Estradiol-cypionate

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717

Estradiol-cypionate

Graft-versus-host disease

3.45E-03

P13765, P10747, P26715, Q13241

HLA-DOB, CD28, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Estradiol-cypionate

Diabetic cardiomyopathy

1.92E-02

P05141, P12236, O15239, P05496, Q13557, P26678

SLC25A5, SLC25A6, NDUFA1, ATP5G1, CAMK2D, PLN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P40926	MDH2	Malate dehydrogenase, mitochondrial	P26678	PLN	Cardiac phospholamban	-0.71
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Estradiol-cypionate

Fluid shear stress and atherosclerosis

3.61E-02

Q16539, P10599, P14780, P01375, P14778, P27930

MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q14145	KEAP1	Kelch-like ECH-associated protein 1	-0.733
Q16539	MAPK14	Mitogen-activated protein kinase 14	P10599	TXN	Thioredoxin	0.749
P49841	GSK3B	Glycogen synthase kinase-3 beta	P10599	TXN	Thioredoxin	0.836
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P49841	GSK3B	Glycogen synthase kinase-3 beta	P27930	IL1R2	Interleukin-1 receptor type 2	0.848
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955

Estradiol-dienanthate

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874

Estradiol-dienanthate

Arginine biosynthesis

1.94E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Estradiol-dienanthate

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Estradiol-dienanthate

hsa00340

Histidine metabolism

4.52E-02

O95954

FTCD

Estradiol-dienanthate

Starch and sucrose metabolism

3.28E-05

O43451, P46976, P06737

MGAM, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P49841	GSK3B	Glycogen synthase kinase-3 beta	O43451	MGAM	Maltase-glucoamylase	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P49841	GSK3B	Glycogen synthase kinase-3 beta	P46976	GYG1	Glycogenin-1	0.813
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P49841	GSK3B	Glycogen synthase kinase-3 beta	P06737	PYGL	Glycogen phosphorylase, liver form	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71

Estradiol-dienanthate

Amino sugar and nucleotide sugar metabolism

7.87E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Estradiol-dienanthate

Glycosaminoglycan biosynthesis - keratan sulfate

6.96E-04

Q9NY97

B3GNT2

Estradiol-dienanthate

hsa00564

Glycerophospholipid metabolism

9.70E-03

Q9Y259, P49619

CHKB, DGKG

Estradiol-dienanthate

Linoleic acid metabolism

3.18E-02

P11712

CYP2C9

Estradiol-dienanthate

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Estradiol-dienanthate

Glycosphingolipid biosynthesis - globo and isoglobo series

4.30E-03

P06865, O75752

HEXA, B3GALNT1

Estradiol-dienanthate

Thiamine metabolism

3.21E-03

P05186, P24666

ALPL, ACP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
P49841	GSK3B	Glycogen synthase kinase-3 beta	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P49841	GSK3B	Glycogen synthase kinase-3 beta	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76

Estradiol-dienanthate

Pantothenate and CoA biosynthesis

7.90E-03

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Estradiol-dienanthate

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Estradiol-dienanthate

Aminoacyl-tRNA biosynthesis

1.58E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
O43451	MGAM	Maltase-glucoamylase	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
O43451	MGAM	Maltase-glucoamylase	Q15046	KARS	Lysine--tRNA ligase	-0.71
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
O43451	MGAM	Maltase-glucoamylase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
O43451	MGAM	Maltase-glucoamylase	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
O43451	MGAM	Maltase-glucoamylase	Q15046	KARS	Lysine--tRNA ligase	-0.71
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.799
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q15046	KARS	Lysine--tRNA ligase	-0.818
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704

Estradiol-dienanthate

Metabolic pathways

2.25E-02

Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573

CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Estradiol-dienanthate

2-Oxocarboxylic acid metabolism

1.91E-02

P50213

IDH3A

Estradiol-dienanthate

RNA transport

8.19E-04

Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042

RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758

Estradiol-dienanthate

hsa03040

Spliceosome

3.98E-02

Q15427, P38159, P61978, P11142

SF3B4, RBMX, HNRPK, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.803
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.869
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O60508	CDC40	Pre-mRNA-processing factor 17	0.827
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.866
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.835
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.908
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.928
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.786
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	0.78
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Estradiol-dienanthate

hsa03060

Protein export

1.13E-03

P37108, Q15005

SRP14, SPCS2

Estradiol-dienanthate

PPAR signaling pathway

2.00E-03

Q6PCB7, Q9UNU6, Q13133, Q02318

SLC27A1, CYP8B1, NR1H3, CYP27A1

Estradiol-dienanthate

hsa04012

ErbB signaling pathway

2.98E-03

P21860, P16333, Q13557, P19174, O14944, P01106

ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYC

Estradiol-dienanthate

hsa04020

Calcium signaling pathway

6.50E-04

Q96DU7, P45880, Q13557, P21860, P51828, P23634

ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.891
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.766
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P40926	MDH2	Malate dehydrogenase, mitochondrial	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	P26678	PLN	Cardiac phospholamban	-0.71
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802

Estradiol-dienanthate

hsa04022

cGMP-PKG signaling pathway

4.72E-02

Q99941, P23634, P51828, P45880

CREBL1, ATP2B4, ADCY7, VDAC2

Estradiol-dienanthate

Viral protein interaction with cytokine and cytokine receptor

2.60E-02

Q8NHW4, P61073, Q13651

CCL4L2, CXCR4, IL10RA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816

Estradiol-dienanthate

Chemokine signaling pathway

4.38E-04

P25024, P25025, P47992, Q9UBD3, P07948, P42338, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, XCL1, XCL2, LYN, PIK3CB, GNG5, GNG10, ARRB1, ITK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716

Estradiol-dienanthate

NF-kappa B signaling pathway

4.09E-03

P01584, P67870, P63279, Q8NHW4, Q9NQC7

IL1B, CSNK2B, UBE2I, CCL4L2, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799

Estradiol-dienanthate

hsa04110

Cell cycle

1.79E-03

Q9UBD5, P06493, O75293, P30304, P33981, P42773, P01106, Q13547

ORC3, CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1

Estradiol-dienanthate

Oocyte meiosis

4.51E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776

Estradiol-dienanthate

Protein processing in endoplasmic reticulum

3.64E-02

Q99941, O75460, P11142, Q9H3Z4, P07900

CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q86TM6	SYVN1	E3 ubiquitin-protein ligase synoviolin	0.711
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51668	UBE2D1	Ubiquitin-conjugating enzyme E2 D1	0.726
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q86TM6	SYVN1	E3 ubiquitin-protein ligase synoviolin	0.711
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51668	UBE2D1	Ubiquitin-conjugating enzyme E2 D1	0.726
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836

Estradiol-dienanthate

mTOR signaling pathway

2.72E-02

P42338, Q9NQL2, Q13322, P49841

PIK3CB, RRAGD, GRB10, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762

Estradiol-dienanthate

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Estradiol-dienanthate

hsa04260

Cardiac muscle contraction

4.49E-02

P67936, P13073, P12074

TPM4, COX4I1, COX6A1

Estradiol-dienanthate

hsa04261

Adrenergic signaling in cardiomyocytes

3.98E-02

P51828, Q99941, Q13557, P23634

ADCY7, CREBL1, CAMK2D, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P26678	PLN	Cardiac phospholamban	-0.71
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797

Estradiol-dienanthate

hsa04330

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Estradiol-dienanthate

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Estradiol-dienanthate

VEGF signaling pathway

2.47E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-dienanthate

Osteoclast differentiation

4.71E-02

Q16539, P06239, P42338, P14778, O75015, Q8N149

MAPK14, LCK, PIK3CB, IL1R1, FCGR3B, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P49841	GSK3B	Glycogen synthase kinase-3 beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715

Estradiol-dienanthate

Hippo signaling pathway

2.17E-03

P63261, P84022, Q13485, O15105, Q13489

ACTG1, SMAD3, SMAD4, SMAD7, BIRC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O14684	PTGES	Prostaglandin E synthase	O15105	SMAD7	Mothers against decapentaplegic homolog 7	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O14684	PTGES	Prostaglandin E synthase	O15105	SMAD7	Mothers against decapentaplegic homolog 7	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708

Estradiol-dienanthate

Tight junction

4.35E-02

P63261, Q92974

ACTG1, ARHGEF2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742

Estradiol-dienanthate

Antigen processing and presentation

1.51E-02

P13765, P48382, P26715, P26717, Q13241, O43908, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92

Estradiol-dienanthate

Neutrophil extracellular trap formation

3.07E-02

P11215, P62807, O60814

ITGAM, HIST1H2BC, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol-dienanthate

Renin-angiotensin system

1.52E-02

P50052

AGTR2

Estradiol-dienanthate

Cytosolic DNA-sensing pathway

1.54E-02

P01584, Q8NHW4

IL1B, CCL4L2

Estradiol-dienanthate

Natural killer cell mediated cytotoxicity

3.63E-06

P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, P26715

PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Estradiol-dienanthate

Th1 and Th2 cell differentiation

2.25E-06

P07766, P20963, Q16539, P19174, P01730, P06239, P42224, Q9UL17, P14784, Q13761

CD3E, CD247, MAPK14, PLCG1, CD4, LCK, STAT1, TBX21, IL2RB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Estradiol-dienanthate

Th17 cell differentiation

2.20E-05

P25963, Q16539, P19174, P01730, P06239, P42224, P14784, P14778, Q9UL17, P84022, Q13485, P07766, P20963

NFKBIA, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Estradiol-dienanthate

T cell receptor signaling pathway

1.60E-05

P01375, P42338, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, PIK3CB, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Estradiol-dienanthate

B cell receptor signaling pathway

2.80E-03

P49841, P42338, P60033, P07948, P21854, Q8N149

GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21854	CD72	B-cell differentiation antigen CD72	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P07948	LYN	Tyrosine-protein kinase Lyn	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P07948	LYN	Tyrosine-protein kinase Lyn	P60033	CD81	CD81 antigen	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P07948	LYN	Tyrosine-protein kinase Lyn	P07948	LYN	Tyrosine-protein kinase Lyn	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P07948	LYN	Tyrosine-protein kinase Lyn	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.843
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Estradiol-dienanthate

Fc epsilon RI signaling pathway

1.80E-02

Q16539, P42338, P07948, P09917

MAPK14, PIK3CB, LYN, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.904
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796

Estradiol-dienanthate

hsa04668

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Estradiol-dienanthate

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Estradiol-dienanthate

Long-term potentiation

2.35E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-dienanthate

Retrograde endocannabinoid signaling

3.86E-02

P63218, P50151, P48058, Q16539

GNG5, GNG10, GRIA4, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	1
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811

Estradiol-dienanthate

Glutamatergic synapse

7.09E-03

P48058, P43003, P63218, P50151, P15104

GRIA4, SLC1A3, GNG5, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P15104	GLUL	Glutamine synthetase	-0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P07948	LYN	Tyrosine-protein kinase Lyn	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P07948	LYN	Tyrosine-protein kinase Lyn	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P07948	LYN	Tyrosine-protein kinase Lyn	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.94
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P07948	LYN	Tyrosine-protein kinase Lyn	P15104	GLUL	Glutamine synthetase	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84

Estradiol-dienanthate

Dopaminergic synapse

1.85E-03

P14416, P63218, P50151, P49841, Q16539, P49407, P48058

DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1, GRIA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701

Estradiol-dienanthate

Inflammatory mediator regulation of TRP channels

3.74E-02

P01584, P51828, Q13557

IL1B, ADCY7, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P24723	PRKCH	Protein kinase C eta type	0.752
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828

Estradiol-dienanthate

hsa04911

Insulin secretion

1.48E-02

P51828, Q99941, Q13557

ADCY7, CREBL1, CAMK2D

Estradiol-dienanthate

Progesterone-mediated oocyte maturation

7.70E-03

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.767
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30304	CDC25A	M-phase inducer phosphatase 1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-dienanthate

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q15788	NCOA1	Nuclear receptor coactivator 1	0.843
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q15788	NCOA1	Nuclear receptor coactivator 1	0.843

Estradiol-dienanthate

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Estradiol-dienanthate

hsa04925

Aldosterone synthesis and secretion

5.19E-03

Q99941, P51828, Q13557, P23634

CREBL1, ADCY7, CAMK2D, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797

Estradiol-dienanthate

Non-alcoholic fatty liver disease

1.24E-02

O43521, O75460, P01584, P13073, P12074, O15239

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Estradiol-dienanthate

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742

Estradiol-dienanthate

hsa04934

Cushing syndrome

3.48E-03

Q99941, P51828, O15169, Q13557

CREBL1, ADCY7, AXIN1, CAMK2D

Estradiol-dienanthate

hsa04971

Gastric acid secretion

1.48E-02

P51828, P15311, Q13557

ADCY7, VIL2, CAMK2D

Estradiol-dienanthate

Carbohydrate digestion and absorption

1.57E-02

O43451, P42338

MGAM, PIK3CB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774

Estradiol-dienanthate

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Estradiol-dienanthate

hsa05010

Alzheimer disease

1.56E-03

Q92542, O15239, P05496, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, O15169, P67870, P45880, P28070

NCSTN, NDUFA1, ATP5G1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, AXIN1, CSNK2B, VDAC2, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q92542	NCSTN	Nicastrin	0.751
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.783
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O95197	RTN3	Reticulon-3	0.702
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15169	AXIN1	Axin-1	0.795
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P28070	PSMB4	Proteasome subunit beta type-4	0.778
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O95197	RTN3	Reticulon-3	0.702
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P28070	PSMB4	Proteasome subunit beta type-4	0.778
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725

Estradiol-dienanthate

Prion disease

1.81E-02

P01584, P46531, P11142, P05496, P12074, P45880, Q99941

IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P40926	MDH2	Malate dehydrogenase, mitochondrial	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Estradiol-dienanthate

Alcoholism

4.54E-02

P62807, O60814

HIST1H2BC, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761

Estradiol-dienanthate

Epithelial cell signaling in Helicobacter pylori infection

2.04E-03

Q16539, P25024, P25025, P07948

MAPK14, CXCR1, CXCR2, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719

Estradiol-dienanthate

Salmonella infection

2.04E-02

P25963, Q13489, P10415, Q9BQS8

NFKBIA, BIRC3, BCL2, FYCO1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75369	FLNB	Filamin-B	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.807
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722

Estradiol-dienanthate

Yersinia infection

1.98E-04

Q05397, P51812, P13612, P06239, Q16539, Q02750, P01375, P42338, P49841, Q96JJ3, P01730

PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, TNF, PIK3CB, GSK3B, ELMO2, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q05397	PTK2	Focal adhesion kinase 1	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.898
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84

Estradiol-dienanthate

Malaria

1.64E-03

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91

Estradiol-dienanthate

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708

Estradiol-dienanthate

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769

Estradiol-dienanthate

Human cytomegalovirus infection

2.50E-05

P42338, P01375, P63218, P50151, P0DP23, Q8NHW4, Q08828, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, O00463

PIK3CB, TNF, GNG5, GNG10, CALM1, CCL4L2, ADCY1, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61769	B2M	Beta-2-microglobulin	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61769	B2M	Beta-2-microglobulin	0.764

Estradiol-dienanthate

Epstein-Barr virus infection

2.32E-02

Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P07766, P20963

HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P07195	LDHB	L-lactate dehydrogenase B chain	Q92769	HDAC2	Histone deacetylase 2	0.759
P07195	LDHB	L-lactate dehydrogenase B chain	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Estradiol-dienanthate

Human immunodeficiency virus 1 infection

4.37E-02

Q02750, P62879, P16298, Q05397

MAP2K1, GNB2, PPP3CB, PTK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Estradiol-dienanthate

Viral carcinogenesis

2.13E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P06746	POLB	DNA polymerase beta	0.837
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P29083	GTF2E1	General transcription factor IIE subunit 1	0.786
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15283	RASA2	Ras GTPase-activating protein 2	-0.815
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P12814	ACTN1	Alpha-actinin-1	-0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.878
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Estradiol-dienanthate

hsa05206

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30304	CDC25A	M-phase inducer phosphatase 1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P09493	TPM1	Tropomyosin alpha-1 chain	-0.78
P40926	MDH2	Malate dehydrogenase, mitochondrial	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.878
P40926	MDH2	Malate dehydrogenase, mitochondrial	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.747
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.731
P40926	MDH2	Malate dehydrogenase, mitochondrial	P22105	TNXB	Tenascin-X	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769

Estradiol-dienanthate

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742

Estradiol-dienanthate

Pancreatic cancer

4.21E-03

P37173, P84022, Q13485

TGFBR2, SMAD3, SMAD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721

Estradiol-dienanthate

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769

Estradiol-dienanthate

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728

Estradiol-dienanthate

hsa05223

Non-small cell lung cancer

4.24E-02

P19174, Q9HC35, O75293

PLCG1, EML4, GADD45B

Estradiol-dienanthate

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736

Estradiol-dienanthate

hsa05231

Choline metabolism in cancer

2.99E-03

Q9Y259, P19174, P49619

CHKB, PLCG1, DGKG

Estradiol-dienanthate

PD-L1 expression and PD-1 checkpoint pathway in cancer

7.83E-05

P42338, P19174, P07766, P20963, P06239, P42224, Q16539, Q9HC35, P01730

PIK3CB, PLCG1, CD3E, CD247, LCK, STAT1, MAPK14, EML4, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol-dienanthate

Systemic lupus erythematosus

2.93E-02

P62807, O60814

HIST1H2BC, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Estradiol-dienanthate

Primary immunodeficiency

4.24E-02

P01730, P07766, P06239

CD4, CD3E, LCK

Estradiol-dienanthate

Fluid shear stress and atherosclerosis

3.61E-02

Q16539, P10599, P14780, P01375, P14778, P27930

MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q14145	KEAP1	Kelch-like ECH-associated protein 1	-0.733
Q16539	MAPK14	Mitogen-activated protein kinase 14	P10599	TXN	Thioredoxin	0.749
P49841	GSK3B	Glycogen synthase kinase-3 beta	P10599	TXN	Thioredoxin	0.836
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P49841	GSK3B	Glycogen synthase kinase-3 beta	P27930	IL1R2	Interleukin-1 receptor type 2	0.848
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955

Estradiol

Pentose phosphate pathway

2.21E-04

P60891, P11413, P37837

PRPS1, G6PD, TALDO1

Estradiol

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Estradiol

Fatty acid degradation

3.43E-04

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874

Estradiol

Glutathione metabolism

2.60E-05

Q9UJ14, P11413, Q16772, P09211, P30041

GGTL3, G6PD, GSTA3, GSTP1, PRDX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P21589	NT5E	5'-nucleotidase	Q7LG56	RRM2B	Ribonucleoside-diphosphate reductase subunit M2 B	0.7
P21589	NT5E	5'-nucleotidase	P31350	RRM2	Ribonucleoside-diphosphate reductase subunit M2	-0.732
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Estradiol

Starch and sucrose metabolism

9.09E-06

O43451, P46976, P35573, P06737

MGAM, GYG1, AGL, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P49841	GSK3B	Glycogen synthase kinase-3 beta	O43451	MGAM	Maltase-glucoamylase	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P49841	GSK3B	Glycogen synthase kinase-3 beta	P46976	GYG1	Glycogenin-1	0.813
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P49841	GSK3B	Glycogen synthase kinase-3 beta	P06737	PYGL	Glycogen phosphorylase, liver form	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71

Estradiol

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Estradiol

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Estradiol

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Estradiol

Linoleic acid metabolism

1.29E-03

P11712

CYP2C9

Estradiol

Thiamine metabolism

4.66E-02

P05186, P24666

ALPL, ACP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
P49841	GSK3B	Glycogen synthase kinase-3 beta	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P49841	GSK3B	Glycogen synthase kinase-3 beta	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76

Estradiol

Pantothenate and CoA biosynthesis

7.90E-03

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Estradiol

Retinol metabolism

2.20E-02

P00325, P11766, Q9BPW9, O75911

ADH1B, ADH5, DHRS9, DHRS3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P06239	LCK	Tyrosine-protein kinase Lck	P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	0.771
P06239	LCK	Tyrosine-protein kinase Lck	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	-0.825
P06239	LCK	Tyrosine-protein kinase Lck	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745

Estradiol

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Estradiol

Aminoacyl-tRNA biosynthesis

2.75E-06

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
O43451	MGAM	Maltase-glucoamylase	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
O43451	MGAM	Maltase-glucoamylase	Q15046	KARS	Lysine--tRNA ligase	-0.71
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
O43451	MGAM	Maltase-glucoamylase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
O43451	MGAM	Maltase-glucoamylase	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
O43451	MGAM	Maltase-glucoamylase	Q15046	KARS	Lysine--tRNA ligase	-0.71
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.799
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q15046	KARS	Lysine--tRNA ligase	-0.818
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704

Estradiol

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Estradiol

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Estradiol

Drug metabolism - other enzymes

1.92E-03

P04183, P32320, P05164, Q16772, P09211

TK1, CDA, MPO, GSTA3, GSTP1

Estradiol

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Estradiol

Carbon metabolism

2.91E-02

P11413

G6PD

Estradiol

2-Oxocarboxylic acid metabolism

3.43E-02

P50213

IDH3A

Estradiol

Biosynthesis of amino acids

3.59E-02

P60891, Q99707, P37837

PRPS1, MTR, TALDO1

Estradiol

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Estradiol

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Estradiol

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P19784	CSNK2A2	Casein kinase II subunit alpha'	-0.701
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P67870	CSNK2B	Casein kinase II subunit beta	-0.752
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
P21589	NT5E	5'-nucleotidase	Q9NYH9	UTP6	U3 small nucleolar RNA-associated protein 6 homolog	0.836
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
P21589	NT5E	5'-nucleotidase	P78345	RPP38	Ribonuclease P protein subunit p38	0.82
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
P21589	NT5E	5'-nucleotidase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.749
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838

Estradiol

RNA transport

2.35E-05

O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5

XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758

Estradiol

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816

Estradiol

Chemokine signaling pathway

2.43E-04

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, ARRB1, ITK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716

Estradiol

NF-kappa B signaling pathway

6.84E-08

P10415, Q13489, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9UNE0, Q9NQC7

BCL2, BIRC3, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799

Estradiol

Sphingolipid signaling pathway

1.00E-03

P21453, Q9H228, Q13362, Q9BX95, P10415

S1PR1, EDG8, PPP2R5C, SGPP1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	-0.736
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P23743	DGKA	Diacylglycerol kinase alpha	0.843
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7

Estradiol

Neuroactive ligand-receptor interaction

1.31E-04

P08311, P48058, Q15722, P21453, Q9H228, P43657, O00398, P21730, Q16581, P07550, P35318

CTSG, GRIA4, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, C5AR1, C3AR1, ADRB2, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735

Estradiol

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776

Estradiol

hsa04115

p53 signaling pathway

3.98E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Estradiol

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Estradiol

Autophagy - animal

3.19E-02

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Estradiol

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q86TM6	SYVN1	E3 ubiquitin-protein ligase synoviolin	0.711
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51668	UBE2D1	Ubiquitin-conjugating enzyme E2 D1	0.726
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q86TM6	SYVN1	E3 ubiquitin-protein ligase synoviolin	0.711
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51668	UBE2D1	Ubiquitin-conjugating enzyme E2 D1	0.726
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836

Estradiol

Phagosome

4.48E-02

Q15080, P05164, O60603, P35443, P13765

NCF4, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Estradiol

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762

Estradiol

Apoptosis

3.83E-03

Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol

hsa04211

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Estradiol

Longevity regulating pathway - multiple species

4.41E-03

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1

Estradiol

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Estradiol

hsa04217

Necroptosis

2.93E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P15104	GLUL	Glutamine synthetase	0.772
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P15104	GLUL	Glutamine synthetase	0.772
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797

Estradiol

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P00441	SOD1	Superoxide dismutase [Cu-Zn]	Q9Y496	KIF3A	Kinesin-like protein KIF3A	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Estradiol

Axon guidance

1.50E-02

P20827, P23528, Q06124

EFNA1, CFL1, PTPN11

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P16333	NCK1	Cytoplasmic protein NCK1	0.876
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O95631	NTN1	Netrin-1	0.807
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1

Estradiol

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol

Osteoclast differentiation

2.05E-03

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P49841	GSK3B	Glycogen synthase kinase-3 beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715

Estradiol

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O14684	PTGES	Prostaglandin E synthase	O15105	SMAD7	Mothers against decapentaplegic homolog 7	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O14684	PTGES	Prostaglandin E synthase	O15105	SMAD7	Mothers against decapentaplegic homolog 7	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708

Estradiol

Tight junction

1.74E-03

P63261, P16989, P56750, Q9Y478, Q92974, Q14247

ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742

Estradiol

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Estradiol

Antigen processing and presentation

1.51E-05

P13765, P48382, P26715, P26717, Q13241, O43908, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92

Estradiol

Neutrophil extracellular trap formation

7.70E-06

P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q93077, P62807, P58876, Q16778, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol

Renin-angiotensin system

7.48E-03

P50052, P15144, P08311, O75787

AGTR2, ANPEP, CTSG, ATP6AP2

Estradiol

hsa04620

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Estradiol

hsa04621

NOD-like receptor signaling pathway

4.72E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Estradiol

hsa04622

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Estradiol

Cytosolic DNA-sensing pathway

2.20E-03

P01568, Q13546

IFNA21, RIPK1

Estradiol

C-type lectin receptor signaling pathway

8.11E-03

Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539

CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P49841	GSK3B	Glycogen synthase kinase-3 beta	P20749	BCL3	B-cell lymphoma 3 protein	0.745
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol

Hematopoietic cell lineage

8.19E-06

P13612, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P01584

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Estradiol

Natural killer cell mediated cytotoxicity

6.86E-13

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Estradiol

IL-17 signaling pathway

1.56E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Estradiol

Th1 and Th2 cell differentiation

6.04E-12

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Estradiol

Th17 cell differentiation

2.02E-10

P25963, Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P07766, P09693, P20963, P23458

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Estradiol

T cell receptor signaling pathway

1.48E-11

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Estradiol

hsa04672

Intestinal immune network for IgA production

4.27E-02

P13765, P13612

HLA-DOB, ITGA4

Estradiol

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Estradiol

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Estradiol

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol

Cholinergic synapse

4.83E-02

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Estradiol

Dopaminergic synapse

2.82E-02

P14416, P63218, P50151, P49841, Q16539, P49407

DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701

Estradiol

Inflammatory mediator regulation of TRP channels

3.14E-04

P14778, P01584, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24

IL1R1, IL1B, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P24723	PRKCH	Protein kinase C eta type	0.752
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828

Estradiol

GnRH signaling pathway

4.33E-02

P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694

ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828

Estradiol

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.767
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30304	CDC25A	M-phase inducer phosphatase 1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol

Estrogen signaling pathway

2.96E-02

P14780, P22694, P18848, Q14643, P10415

MMP9, PRKACB, ATF4, ITPR1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q15788	NCOA1	Nuclear receptor coactivator 1	0.843
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q15788	NCOA1	Nuclear receptor coactivator 1	0.843

Estradiol

hsa04918

Thyroid hormone synthesis

3.50E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Estradiol

Adipocytokine signaling pathway

2.62E-03

Q06124, Q9Y478, Q96RR4

PTPN11, PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Estradiol

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P07947	YES1	Tyrosine-protein kinase Yes	P14618	PKM2	Pyruvate kinase PKM	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P07947	YES1	Tyrosine-protein kinase Yes	P06737	PYGL	Glycogen phosphorylase, liver form	0.808
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Estradiol

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol

hsa04927

Cortisol synthesis and secretion

8.60E-03

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Estradiol

Parathyroid hormone synthesis, secretion and action

2.33E-03

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742

Estradiol

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Estradiol

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Estradiol

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774

Estradiol

Fat digestion and absorption

9.50E-04

O14494

PLPP1

Estradiol

Alcoholism

3.52E-06

Q13547, Q93077, P62807, P58876, Q16778, O60814, P68431

HDAC1, HIST1H2AC, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761

Estradiol

Epithelial cell signaling in Helicobacter pylori infection

2.99E-05

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719

Estradiol

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754

Estradiol

Salmonella infection

5.76E-04

P25963, Q13546, Q13489, P10415, Q9BQS8, O60282, P68371

NFKBIA, RIPK1, BIRC3, BCL2, FYCO1, KIF5C, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75369	FLNB	Filamin-B	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.807
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722

Estradiol

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Estradiol

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707

Estradiol

Yersinia infection

1.98E-03

P13612, P06239, Q16539, P01375, P49841, P01730, P01732

ITGA4, LCK, MAPK14, TNF, GSK3B, CD4, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q05397	PTK2	Focal adhesion kinase 1	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.898
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84

Estradiol

Leishmaniasis

2.29E-02

P13612, O75015, P23458, P13765, O60603, P01375, P01584, Q16539, Q15080

ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762

Estradiol

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Estradiol

Malaria

2.17E-05

P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91

Estradiol

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708

Estradiol

Amoebiasis

1.06E-05

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744

Estradiol

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769

Estradiol

Human cytomegalovirus infection

1.72E-02

P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463

TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61769	B2M	Beta-2-microglobulin	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61769	B2M	Beta-2-microglobulin	0.764

Estradiol

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Estradiol

Epstein-Barr virus infection

3.10E-02

P20023, P13765, Q92769, O00463, P24522, P09693, P20963

CR2, HLA-DOB, HDAC2, TRAF5, GADD45A, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P07195	LDHB	L-lactate dehydrogenase B chain	Q92769	HDAC2	Histone deacetylase 2	0.759
P07195	LDHB	L-lactate dehydrogenase B chain	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Estradiol

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Estradiol

Transcriptional misregulation in cancer

1.24E-05

Q12778, Q15532, Q13315, P17844, P14780, P27930, Q15744, Q16548, P11215, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P21589	NT5E	5'-nucleotidase	Q15532	SS18	Protein SSXT	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P21589	NT5E	5'-nucleotidase	P14923	JUP	Junction plakoglobin	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P21589	NT5E	5'-nucleotidase	O15550	UTX	Lysine-specific demethylase 6A	-0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P21589	NT5E	5'-nucleotidase	P04637	TP53	Cellular tumor antigen p53	0.701
P21589	NT5E	5'-nucleotidase	P05164	MPO	Myeloperoxidase	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Estradiol

Viral carcinogenesis

1.46E-05

Q12933, P42229, Q13547, Q15283, P62807, P58876, Q16778, O60814

TRAF2, STAT5A, HDAC1, RASA2, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P06746	POLB	DNA polymerase beta	0.837
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P29083	GTF2E1	General transcription factor IIE subunit 1	0.786
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15283	RASA2	Ras GTPase-activating protein 2	-0.815
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P12814	ACTN1	Alpha-actinin-1	-0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.878
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Estradiol

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Estradiol

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742

Estradiol

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Estradiol

Pancreatic cancer

4.21E-03

P37173, P84022, Q13485

TGFBR2, SMAD3, SMAD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721

Estradiol

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Estradiol

Basal cell carcinoma

3.44E-03

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P07195	LDHB	L-lactate dehydrogenase B chain	Q13635	PTCH1	Protein patched homolog 1	0.75
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.753
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819

Estradiol

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769

Estradiol

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728

Estradiol

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736

Estradiol

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Estradiol

PD-L1 expression and PD-1 checkpoint pathway in cancer

3.11E-06

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, P10747, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, CD28, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol

Inflammatory bowel disease

5.85E-07

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718

Estradiol

Systemic lupus erythematosus

5.41E-07

P09871, Q93077, P62807, P58876, Q16778, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Estradiol

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717

Estradiol

Graft-versus-host disease

3.28E-06

P13765, P10747, P26715, Q13241

HLA-DOB, CD28, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Estradiol

Primary immunodeficiency

3.76E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Estradiol

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Estradiol

Diabetic cardiomyopathy

3.59E-02

P11413

G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P40926	MDH2	Malate dehydrogenase, mitochondrial	P26678	PLN	Cardiac phospholamban	-0.71
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Estradiol

Fluid shear stress and atherosclerosis

3.61E-02

Q16539, P10599, P14780, P01375, P14778, P27930

MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q14145	KEAP1	Kelch-like ECH-associated protein 1	-0.733
Q16539	MAPK14	Mitogen-activated protein kinase 14	P10599	TXN	Thioredoxin	0.749
P49841	GSK3B	Glycogen synthase kinase-3 beta	P10599	TXN	Thioredoxin	0.836
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P49841	GSK3B	Glycogen synthase kinase-3 beta	P27930	IL1R2	Interleukin-1 receptor type 2	0.848
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955

Estradiol-valerate

Pentose phosphate pathway

5.10E-05

P52209, P11413, P37837

PGD, G6PD, TALDO1

Estradiol-valerate

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Estradiol-valerate

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874

Estradiol-valerate

hsa00190

Oxidative phosphorylation

8.71E-03

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Estradiol-valerate

Arginine biosynthesis

1.39E-04

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Estradiol-valerate

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Estradiol-valerate

hsa00310

Lysine degradation

3.15E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Estradiol-valerate

Glutathione metabolism

2.60E-05

Q9UJ14, P11413, Q16772, P09211, P30041

GGTL3, G6PD, GSTA3, GSTP1, PRDX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P21589	NT5E	5'-nucleotidase	Q7LG56	RRM2B	Ribonucleoside-diphosphate reductase subunit M2 B	0.7
P21589	NT5E	5'-nucleotidase	P31350	RRM2	Ribonucleoside-diphosphate reductase subunit M2	-0.732
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Estradiol-valerate

Starch and sucrose metabolism

4.14E-09

O43451, P46976, P35573, P06737

MGAM, GYG1, AGL, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P49841	GSK3B	Glycogen synthase kinase-3 beta	O43451	MGAM	Maltase-glucoamylase	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P49841	GSK3B	Glycogen synthase kinase-3 beta	P46976	GYG1	Glycogenin-1	0.813
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P49841	GSK3B	Glycogen synthase kinase-3 beta	P06737	PYGL	Glycogen phosphorylase, liver form	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71

Estradiol-valerate

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Estradiol-valerate

Amino sugar and nucleotide sugar metabolism

7.87E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Estradiol-valerate

Glycosaminoglycan biosynthesis - keratan sulfate

6.96E-04

Q9NY97

B3GNT2

Estradiol-valerate

hsa00563

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

3.01E-02

Q14442

PIGH

Estradiol-valerate

Arachidonic acid metabolism

2.97E-02

P09917

ALOX5

Estradiol-valerate

Linoleic acid metabolism

3.18E-02

P11712

CYP2C9

Estradiol-valerate

hsa00600

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Estradiol-valerate

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Estradiol-valerate

Glycosphingolipid biosynthesis - globo and isoglobo series

4.30E-03

P06865, O75752

HEXA, B3GALNT1

Estradiol-valerate

hsa00630

Glyoxylate and dicarboxylate metabolism

1.13E-02

P40925, P15104

MDH1, GLUL

Estradiol-valerate

Thiamine metabolism

1.07E-05

P05186, P24666

ALPL, ACP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
P49841	GSK3B	Glycogen synthase kinase-3 beta	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P25024	CXCR1	C-X-C chemokine receptor type 1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.882
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P49841	GSK3B	Glycogen synthase kinase-3 beta	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.76

Estradiol-valerate

Pantothenate and CoA biosynthesis

7.90E-03

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Estradiol-valerate

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P06239	LCK	Tyrosine-protein kinase Lck	P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	0.771
P06239	LCK	Tyrosine-protein kinase Lck	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	-0.825
P06239	LCK	Tyrosine-protein kinase Lck	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745

Estradiol-valerate

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Estradiol-valerate

Aminoacyl-tRNA biosynthesis

9.22E-06

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
O43451	MGAM	Maltase-glucoamylase	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
O43451	MGAM	Maltase-glucoamylase	Q15046	KARS	Lysine--tRNA ligase	-0.71
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
O43451	MGAM	Maltase-glucoamylase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
O43451	MGAM	Maltase-glucoamylase	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
O43451	MGAM	Maltase-glucoamylase	Q15046	KARS	Lysine--tRNA ligase	-0.71
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.799
P25025	CXCR2	C-X-C chemokine receptor type 2	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.757
P25024	CXCR1	C-X-C chemokine receptor type 1	O95363	FARS2	Phenylalanine--tRNA ligase, mitochondrial	-0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	-0.77
P25025	CXCR2	C-X-C chemokine receptor type 2	P14868	DARS	Aspartate--tRNA ligase, cytoplasmic	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q15046	KARS	Lysine--tRNA ligase	-0.818
P25025	CXCR2	C-X-C chemokine receptor type 2	Q15046	KARS	Lysine--tRNA ligase	-0.741
P25024	CXCR1	C-X-C chemokine receptor type 1	Q15046	KARS	Lysine--tRNA ligase	-0.704

Estradiol-valerate

Metabolism of xenobiotics by cytochrome P450

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Estradiol-valerate

Drug metabolism - cytochrome P450

1.06E-02

Q16772, P09211

GSTA3, GSTP1

Estradiol-valerate

Drug metabolism - other enzymes

1.72E-02

Q16772, P09211

GSTA3, GSTP1

Estradiol-valerate

Metabolic pathways

3.55E-03

Q9NR34, P35790, P05089, Q16772, P09211, Q9UJ14, P30041, P32320, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, P05186, P24666, P15121, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9BQB6

MAN1C1, CHKA, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, CDA, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, ALPL, ACP1, AKR1B1, MCCC2, ACSL1, AMACR, SGMS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Estradiol-valerate

Carbon metabolism

2.00E-03

P11413, P52209, P37837

G6PD, PGD, TALDO1

Estradiol-valerate

2-Oxocarboxylic acid metabolism

6.96E-04

P50213

IDH3A

Estradiol-valerate

hsa01240

Biosynthesis of cofactors

2.95E-02

P13716, P14618

ALAD, PKM2

Estradiol-valerate

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Estradiol-valerate

hsa01522

Endocrine resistance

2.16E-02

P08069

IGF1R

Estradiol-valerate

Platinum drug resistance

3.80E-03

O15392, Q16772, P09211, P11388

BIRC5, GSTA3, GSTP1, TOP2A

Estradiol-valerate

ABC transporters

2.10E-03

P45844, Q8IZY2

ABCG1, ABCA7

Estradiol-valerate

RNA transport

2.99E-02

P38919, P37198, P35658, P55884

EIF4A3, NUP62, NUP214, EIF3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758

Estradiol-valerate

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Estradiol-valerate

hsa03020

RNA polymerase

3.00E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Estradiol-valerate

hsa03040

Spliceosome

9.86E-09

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.803
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.869
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O60508	CDC40	Pre-mRNA-processing factor 17	0.827
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.866
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.835
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.908
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.928
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.786
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	0.78
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Estradiol-valerate

hsa03060

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Estradiol-valerate

PPAR signaling pathway

3.19E-03

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Estradiol-valerate

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Estradiol-valerate

hsa03460

Fanconi anemia pathway

1.85E-02

P40692, Q9UNA4

MLH1, POLI

Estradiol-valerate

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Estradiol-valerate

hsa04014

Ras signaling pathway

1.13E-02

P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Estradiol-valerate

hsa04015

Rap1 signaling pathway

7.59E-04

P20827, P49767, P08069, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P19174

EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25116	F2R	Proteinase-activated receptor 1	P25116	F2R	Proteinase-activated receptor 1	1
P25116	F2R	Proteinase-activated receptor 1	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.811
P25116	F2R	Proteinase-activated receptor 1	P08514	ITGA2B	Integrin alpha-IIb	0.813
P25116	F2R	Proteinase-activated receptor 1	P17252	PRKCA	Protein kinase C alpha type	0.857
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Estradiol-valerate

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Estradiol-valerate

Viral protein interaction with cytokine and cytokine receptor

1.32E-02

P09341, P25024, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816

Estradiol-valerate

Chemokine signaling pathway

4.65E-07

P25024, P25025, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P49841, Q8WYR1

CXCR1, CXCR2, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, GSK3B, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716

Estradiol-valerate

NF-kappa B signaling pathway

1.63E-07

P10415, Q13489, O00463, P14778, P01584, P29965, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7

BCL2, BIRC3, TRAF5, IL1R1, IL1B, CD40LG, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799

Estradiol-valerate

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Estradiol-valerate

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Estradiol-valerate

hsa04070

Phosphatidylinositol signaling system

2.81E-03

P19174, P0DP23, Q14643, P23743, P49619, P27987, P17252

PLCG1, CALM1, ITPR1, DGKA, DGKG, ITPKB, PRKCA

Estradiol-valerate

Sphingolipid signaling pathway

1.46E-03

P17252, P21453, Q9H228, Q13362, Q9BX95, P10415

PRKCA, S1PR1, EDG8, PPP2R5C, SGPP1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol-valerate

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735

Estradiol-valerate

hsa04110

Cell cycle

2.90E-02

P06493, P30304, P33981, P01106, Q13547

CDK1, CDC25A, TTK, MYC, HDAC1

Estradiol-valerate

Oocyte meiosis

9.28E-07

Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776

Estradiol-valerate

Autophagy - animal

2.95E-02

P08069, P22694, Q14643, P10415, Q04759

IGF1R, PRKACB, ITPR1, BCL2, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Estradiol-valerate

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q86TM6	SYVN1	E3 ubiquitin-protein ligase synoviolin	0.711
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51668	UBE2D1	Ubiquitin-conjugating enzyme E2 D1	0.726
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q86TM6	SYVN1	E3 ubiquitin-protein ligase synoviolin	0.711
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51668	UBE2D1	Ubiquitin-conjugating enzyme E2 D1	0.726
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836

Estradiol-valerate

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Estradiol-valerate

hsa04144

Endocytosis

1.13E-03

Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3

CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5

Estradiol-valerate

Phagosome

2.82E-04

Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Estradiol-valerate

mTOR signaling pathway

2.74E-03

P08069, P42338, Q02750, Q9NQL2, P51812, Q13322, P49841

IGF1R, PIK3CB, MAP2K1, RRAGD, RPS6KA3, GRB10, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762

Estradiol-valerate

hsa04151

PI3K-Akt signaling pathway

5.33E-03

P42338, P43657, P25116, P20827, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252, P30281

PIK3CB, P2RY5, F2R, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40926	MDH2	Malate dehydrogenase, mitochondrial	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40926	MDH2	Malate dehydrogenase, mitochondrial	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P40926	MDH2	Malate dehydrogenase, mitochondrial	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.718
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15831	STK11	Serine/threonine-protein kinase STK11	0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O15335	CHAD	Chondroadherin	-0.704
P40926	MDH2	Malate dehydrogenase, mitochondrial	P22105	TNXB	Tenascin-X	0.802
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	O95988	TCL1B	T-cell leukemia/lymphoma protein 1B	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Estradiol-valerate

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Estradiol-valerate

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol-valerate

hsa04211

Longevity regulating pathway

2.16E-02

P08069

IGF1R

Estradiol-valerate

Longevity regulating pathway - multiple species

8.54E-03

P08069, Q08828, P51828, P0DMV8

IGF1R, ADCY1, ADCY7, HSPA1A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1

Estradiol-valerate

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Estradiol-valerate

hsa04217

Necroptosis

9.14E-03

P01568, Q13489, P42224, Q6FI13, P10415, O43633, Q08752

IFNA21, BIRC3, STAT1, H2AC18; H2AC19, BCL2, CHMP2A, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P15104	GLUL	Glutamine synthetase	0.772
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P15104	GLUL	Glutamine synthetase	0.772
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797

Estradiol-valerate

hsa04261

Adrenergic signaling in cardiomyocytes

2.84E-02

P09493, Q13362, P0DP23, P17252, P10415

TPM1, PPP2R5C, CALM1, PRKCA, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P26678	PLN	Cardiac phospholamban	-0.71
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797

Estradiol-valerate

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Estradiol-valerate

hsa04310

Wnt signaling pathway

1.79E-02

P17612, P67870

PRKACA, CSNK2B

Estradiol-valerate

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Estradiol-valerate

Hedgehog signaling pathway

1.17E-04

P17612, P22694, Q13635, Q9Y496, P10415

PRKACA, PRKACB, PTCH1, KIF3A, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P00441	SOD1	Superoxide dismutase [Cu-Zn]	Q9Y496	KIF3A	Kinesin-like protein KIF3A	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol-valerate

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Estradiol-valerate

Axon guidance

2.74E-03

P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124

NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P16333	NCK1	Cytoplasmic protein NCK1	0.876
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O95631	NTN1	Netrin-1	0.807
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1

Estradiol-valerate

VEGF signaling pathway

1.02E-07

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-valerate

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Estradiol-valerate

Osteoclast differentiation

1.63E-03

Q9UQC2, Q16539, P06239, P42338, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, LCK, PIK3CB, IL1R1, FCGR3B, TNF, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P49841	GSK3B	Glycogen synthase kinase-3 beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715

Estradiol-valerate

Hippo signaling pathway

2.17E-03

P63261, P84022, Q13485, O15105, Q13489

ACTG1, SMAD3, SMAD4, SMAD7, BIRC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O14684	PTGES	Prostaglandin E synthase	O15105	SMAD7	Mothers against decapentaplegic homolog 7	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O14684	PTGES	Prostaglandin E synthase	O15105	SMAD7	Mothers against decapentaplegic homolog 7	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708

Estradiol-valerate

hsa04392

Hippo signaling pathway - multiple species

3.01E-02

Q6V0I7

FAT4

Estradiol-valerate

hsa04510

Focal adhesion

3.48E-02

P08069

IGF1R

Estradiol-valerate

hsa04512

ECM-receptor interaction

1.90E-02

P26012, P16070

ITGB8, CD44

Estradiol-valerate

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Estradiol-valerate

Tight junction

2.17E-03

P63261, Q9Y478, Q92974

ACTG1, PRKAB1, ARHGEF2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742

Estradiol-valerate

hsa04540

Gap junction

1.29E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Estradiol-valerate

hsa04550

Signaling pathways regulating pluripotency of stem cells

9.61E-03

Q13873, Q02750, P08069, Q86SE9

BMPR2, MAP2K1, IGF1R, PCGF5

Estradiol-valerate

hsa04610

Complement and coagulation cascades

1.91E-03

P0C0L4

C4A

Estradiol-valerate

hsa04611

Platelet activation

2.12E-02

Q9Y490, P17612

TLN1, PRKACA

Estradiol-valerate

Antigen processing and presentation

1.10E-04

P13765, P48382, P01730, P26715, P26717, Q13241, O43908, P01732

HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, KLRC4, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92

Estradiol-valerate

Neutrophil extracellular trap formation

5.05E-05

P19174, P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P21730, P21462

PLCG1, PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, C5AR1, FPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol-valerate

Renin-angiotensin system

1.52E-02

P50052

AGTR2

Estradiol-valerate

Cytosolic DNA-sensing pathway

1.65E-02

P01584, Q8NHW4

IL1B, CCL4L2

Estradiol-valerate

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P49841	GSK3B	Glycogen synthase kinase-3 beta	P20749	BCL3	B-cell lymphoma 3 protein	0.745
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol-valerate

hsa04630

JAK-STAT signaling pathway

3.20E-02

P01106, P42224, P14784, Q13651

MYC, STAT1, IL2RB, IL10RA

Estradiol-valerate

Hematopoietic cell lineage

1.60E-04

P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P09564, P13765

ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Estradiol-valerate

Natural killer cell mediated cytotoxicity

2.94E-11

P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Estradiol-valerate

IL-17 signaling pathway

1.88E-03

O00463, Q16539, P49841, P09341, P14780, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Estradiol-valerate

Th1 and Th2 cell differentiation

6.61E-15

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Estradiol-valerate

Th17 cell differentiation

1.87E-13

P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Estradiol-valerate

T cell receptor signaling pathway

2.44E-08

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Estradiol-valerate

B cell receptor signaling pathway

1.86E-05

P49841, P42338, P60033, P07948, P21854, Q8N149

GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21854	CD72	B-cell differentiation antigen CD72	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P07948	LYN	Tyrosine-protein kinase Lyn	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P07948	LYN	Tyrosine-protein kinase Lyn	P60033	CD81	CD81 antigen	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P07948	LYN	Tyrosine-protein kinase Lyn	P07948	LYN	Tyrosine-protein kinase Lyn	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P07948	LYN	Tyrosine-protein kinase Lyn	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.843
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Estradiol-valerate

Fc epsilon RI signaling pathway

1.21E-04

P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.904
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796

Estradiol-valerate

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Estradiol-valerate

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Estradiol-valerate

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Estradiol-valerate

hsa04713

Circadian entrainment

2.60E-02

P0DP23, P17252, P62873, Q14643

CALM1, PRKCA, GNB1, ITPR1

Estradiol-valerate

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Estradiol-valerate

Long-term potentiation

1.09E-05

P17252, P16298, P0DP23, P51812, Q02750, Q14643

PRKCA, PPP3CB, CALM1, RPS6KA3, MAP2K1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-valerate

Retrograde endocannabinoid signaling

1.88E-03

Q14643, P17252, P62873, P63218, P50151, P48058, Q16539, Q16718

ITPR1, PRKCA, GNB1, GNG5, GNG10, GRIA4, MAPK14, NDUFA5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	1
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811

Estradiol-valerate

Glutamatergic synapse

4.13E-04

P48058, O15399, P43003, P63218, P50151, P15104

GRIA4, GRIN2D, SLC1A3, GNG5, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P15104	GLUL	Glutamine synthetase	-0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P07948	LYN	Tyrosine-protein kinase Lyn	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
P07948	LYN	Tyrosine-protein kinase Lyn	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P07948	LYN	Tyrosine-protein kinase Lyn	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.94
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P07948	LYN	Tyrosine-protein kinase Lyn	P15104	GLUL	Glutamine synthetase	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84

Estradiol-valerate

Cholinergic synapse

1.88E-02

Q14643, P17252, P62873, P10415

ITPR1, PRKCA, GNB1, BCL2

Estradiol-valerate

hsa04727

GABAergic synapse

4.42E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Estradiol-valerate

Dopaminergic synapse

2.03E-04

Q14643, P17252, P14416, P62873, P63218, P50151, P49841, Q16539, P49407, Q13362, P0DP23, P48058

ITPR1, PRKCA, DRD2, GNB1, GNG5, GNG10, GSK3B, MAPK14, ARRB1, PPP2R5C, CALM1, GRIA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P14416	DRD2	D(2) dopamine receptor	-0.772
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701

Estradiol-valerate

hsa04730

Long-term depression

1.16E-02

P08069

IGF1R

Estradiol-valerate

hsa04742

Taste transduction

3.91E-02

P17612

PRKACA

Estradiol-valerate

hsa04744

Phototransduction

1.02E-02

P62873, P0DP23

GNB1, CALM1

Estradiol-valerate

Inflammatory mediator regulation of TRP channels

4.01E-02

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P24723	PRKCH	Protein kinase C eta type	0.752
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828

Estradiol-valerate

GnRH signaling pathway

3.89E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828

Estradiol-valerate

hsa04913

Ovarian steroidogenesis

8.40E-04

P06213, P08069

INSR, IGF1R

Estradiol-valerate

Progesterone-mediated oocyte maturation

3.98E-06

P08069, Q17RY0, Q9Y6D9, P51812, Q02750

IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.767
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30304	CDC25A	M-phase inducer phosphatase 1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Estradiol-valerate

Estrogen signaling pathway

3.17E-02

Q08828, P51828, P0DMV8, P0DP23, Q15788

ADCY1, ADCY7, HSPA1A, CALM1, NCOA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q15788	NCOA1	Nuclear receptor coactivator 1	0.843
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q15788	NCOA1	Nuclear receptor coactivator 1	0.843

Estradiol-valerate

hsa04919

Thyroid hormone signaling pathway

1.64E-02

P19174, P42224, Q13547, P01106

PLCG1, STAT1, HDAC1, MYC

Estradiol-valerate

Adipocytokine signaling pathway

2.62E-03

Q06124, Q9Y478, Q96RR4

PTPN11, PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Estradiol-valerate

Glucagon signaling pathway

7.76E-04

P14618, P22694, P06737, Q12778, Q13370, P0DP23, Q14643

PKM2, PRKACB, PYGL, FOXO1, PDE3B, CALM1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P07947	YES1	Tyrosine-protein kinase Yes	P14618	PKM2	Pyruvate kinase PKM	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P07947	YES1	Tyrosine-protein kinase Yes	P06737	PYGL	Glycogen phosphorylase, liver form	0.808
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol-valerate

Regulation of lipolysis in adipocytes

3.76E-02

P06213

INSR

Estradiol-valerate

Renin secretion

1.79E-04

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Estradiol-valerate

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Estradiol-valerate

hsa04930

Type II diabetes mellitus

3.14E-02

P06213

INSR

Estradiol-valerate

Non-alcoholic fatty liver disease

1.39E-02

O43521, O75460, P01584, P13073, P12074, O95298

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Estradiol-valerate

AGE-RAGE signaling pathway in diabetic complications

8.03E-05

P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174

SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742

Estradiol-valerate

hsa04960

Aldosterone-regulated sodium reabsorption

3.14E-02

P06213

INSR

Estradiol-valerate

hsa04964

Proximal tubule bicarbonate reclamation

4.48E-02

P00918

CA2

Estradiol-valerate

hsa04966

Collecting duct acid secretion

1.95E-03

Q13488, P00918, Q9Y666

TCIRG1, CA2, SLC12A7

Estradiol-valerate

hsa04970

Salivary secretion

4.78E-02

Q08828, P51828, P0DP23

ADCY1, ADCY7, CALM1

Estradiol-valerate

Carbohydrate digestion and absorption

1.57E-02

O43451, P42338

MGAM, PIK3CB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774

Estradiol-valerate

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Estradiol-valerate

hsa04976

Bile secretion

4.78E-02

Q08828, P51828, Q14032

ADCY1, ADCY7, BAAT

Estradiol-valerate

hsa05010

Alzheimer disease

3.55E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q92542	NCSTN	Nicastrin	0.751
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.783
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O95197	RTN3	Reticulon-3	0.702
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15169	AXIN1	Axin-1	0.795
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P28070	PSMB4	Proteasome subunit beta type-4	0.778
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O95197	RTN3	Reticulon-3	0.702
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P28070	PSMB4	Proteasome subunit beta type-4	0.778
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725

Estradiol-valerate

hsa05012

Parkinson disease

2.25E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P60604	UBE2G2	Ubiquitin-conjugating enzyme E2 G2	0.82
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842

Estradiol-valerate

hsa05016

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Estradiol-valerate

hsa05017

Spinocerebellar ataxia

2.22E-02

Q92915, O15399, P42338, P21796

FGF14, GRIN2D, PIK3CB, VDAC1

Estradiol-valerate

Prion disease

1.15E-02

Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080

NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P40926	MDH2	Malate dehydrogenase, mitochondrial	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Estradiol-valerate

Pathways of neurodegeneration - multiple diseases

4.00E-03

Q14643, Q13509, P68371, P10415, Q16718, O14521, Q06055, Q13561, P17252, Q08752, O15020, P0DP23

ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, ATP5G2, DCTN2, PRKCA, PPID, SPTBN2, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.772
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15169	AXIN1	Axin-1	0.795
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P30530	AXL	Tyrosine-protein kinase receptor UFO	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.735
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P30530	AXL	Tyrosine-protein kinase receptor UFO	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	0.738
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859

Estradiol-valerate

Alcoholism

5.83E-03

Q13547, P62807, Q16778, O60814

HDAC1, HIST1H2BC, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761

Estradiol-valerate

hsa05100

Bacterial invasion of epithelial cells

2.85E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Estradiol-valerate

hsa05110

Vibrio cholerae infection

2.11E-03

Q99437, P17612

ATP6V0B, PRKACA

Estradiol-valerate

Epithelial cell signaling in Helicobacter pylori infection

1.37E-04

Q16539, P09341, P25024, P25025, P07948

MAPK14, CXCL1, CXCR1, CXCR2, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719

Estradiol-valerate

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754

Estradiol-valerate

hsa05131

Shigellosis

2.27E-02

P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752

H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID

Estradiol-valerate

Salmonella infection

8.60E-04

P25963, Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371

NFKBIA, LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75369	FLNB	Filamin-B	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.807
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722

Estradiol-valerate

hsa05133

Pertussis

3.51E-02

P0C0L4

C4A

Estradiol-valerate

Legionellosis

2.82E-02

P01584, Q9NR31, P0DMV8

IL1B, SAR1A, HSPA1A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707

Estradiol-valerate

Yersinia infection

2.79E-05

Q05397, P51812, P13612, P06239, Q16539, Q02750, P01375, P42338, P49841, Q96JJ3, P01730

PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, TNF, PIK3CB, GSK3B, ELMO2, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P25024	CXCR1	C-X-C chemokine receptor type 1	P13612	ITGA4	Integrin alpha-4	-0.713
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q05397	PTK2	Focal adhesion kinase 1	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.898
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.819
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84

Estradiol-valerate

Leishmaniasis

2.04E-04

O75015, P14598, P42224, P13765, O60603, P29350, P49006, Q16539, Q15080

FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, PTPN6, MARCKSL1, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762

Estradiol-valerate

Malaria

1.64E-03

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91

Estradiol-valerate

Toxoplasmosis

1.02E-03

P25963, P10415, Q13489, P42224, P13765, O60603, P29965

NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708

Estradiol-valerate

Amoebiasis

1.32E-03

P09341, P14778, P27930, O60603, P05089, P12814, P08311

CXCL1, IL1R1, IL1R2, TLR2, ARG1, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744

Estradiol-valerate

hsa05150

Staphylococcus aureus infection

1.31E-02

P0C0L4, P13646

C4A, KRT13

Estradiol-valerate

hsa05152

Tuberculosis

7.93E-04

Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8

TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1

Estradiol-valerate

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769

Estradiol-valerate

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.928
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.759
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.738
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P30281	CCND3	G1/S-specific cyclin-D3	0.716
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.738
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P30281	CCND3	G1/S-specific cyclin-D3	0.716

Estradiol-valerate

Human cytomegalovirus infection

3.36E-07

P42338, P01375, P63218, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463

PIK3CB, TNF, GNG5, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61769	B2M	Beta-2-microglobulin	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61073	CXCR4	C-X-C chemokine receptor type 4	0.744
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P61769	B2M	Beta-2-microglobulin	0.764

Estradiol-valerate

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Estradiol-valerate

Kaposi sarcoma-associated herpesvirus infection

3.04E-03

P01568, P42224, P62873, P62879, P16298, Q14643, Q02750, P0DP23, P0CG47, Q9UJU2

IFNA21, STAT1, GNB1, GNB2, PPP3CB, ITPR1, MAP2K1, CALM1, UBB, LEF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Estradiol-valerate

Epstein-Barr virus infection

5.41E-05

P13765, P01106, Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P42224, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, STAT1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P07195	LDHB	L-lactate dehydrogenase B chain	Q92769	HDAC2	Histone deacetylase 2	0.759
P07195	LDHB	L-lactate dehydrogenase B chain	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Estradiol-valerate

Human immunodeficiency virus 1 infection

1.09E-05

Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5, P20333

MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Estradiol-valerate

hsa05200

Pathways in cancer

1.55E-03

Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784

LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43246	MSH2	DNA mismatch repair protein Msh2	0.887
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Estradiol-valerate

Transcriptional misregulation in cancer

2.48E-03

Q12778, Q13315, P14780, Q16548, O15550, P08069, P05164, P08246, Q9C0K0, P24522

FOXO1, ATM, MMP9, BCL2A1, UTX, IGF1R, MPO, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P21589	NT5E	5'-nucleotidase	Q15532	SS18	Protein SSXT	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P21589	NT5E	5'-nucleotidase	P14923	JUP	Junction plakoglobin	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P21589	NT5E	5'-nucleotidase	O15550	UTX	Lysine-specific demethylase 6A	-0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P21589	NT5E	5'-nucleotidase	P04637	TP53	Cellular tumor antigen p53	0.701
P21589	NT5E	5'-nucleotidase	P05164	MPO	Myeloperoxidase	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Estradiol-valerate

Viral carcinogenesis

7.95E-05

Q12933, P42229, Q13547, Q15283, P12814, P06493, P62807, Q16778, O60814

TRAF2, STAT5A, HDAC1, RASA2, ACTN1, CDK1, HIST1H2BC, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P06746	POLB	DNA polymerase beta	0.837
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P29083	GTF2E1	General transcription factor IIE subunit 1	0.786
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15283	RASA2	Ras GTPase-activating protein 2	-0.815
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P12814	ACTN1	Alpha-actinin-1	-0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.878
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Estradiol-valerate

Chemical carcinogenesis

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Estradiol-valerate

hsa05205

Proteoglycans in cancer

3.48E-02

P08069

IGF1R

Estradiol-valerate

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742

Estradiol-valerate

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Estradiol-valerate

Pancreatic cancer

9.87E-04

P42338, P37173, P84022, Q13485, O75293

PIK3CB, TGFBR2, SMAD3, SMAD4, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721

Estradiol-valerate

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Estradiol-valerate

hsa05214

Glioma

9.95E-03

P08069

IGF1R

Estradiol-valerate

hsa05215

Prostate cancer

1.33E-02

P08069

IGF1R

Estradiol-valerate

hsa05218

Melanoma

6.63E-03

P08069

IGF1R

Estradiol-valerate

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Estradiol-valerate

Chronic myeloid leukemia

1.44E-03

Q13547, Q13485, P25963, P84022, P42338, O75293

HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769

Estradiol-valerate

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728

Estradiol-valerate

hsa05224

Breast cancer

1.24E-02

P08069, P49841, Q92837, P04637, P24522

IGF1R, GSK3B, FRAT1, TP53, GADD45A

Estradiol-valerate

hsa05225

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Estradiol-valerate

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736

Estradiol-valerate

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Estradiol-valerate

hsa05231

Choline metabolism in cancer

1.39E-02

Q9Y259, P19174, P49619

CHKB, PLCG1, DGKG

Estradiol-valerate

PD-L1 expression and PD-1 checkpoint pathway in cancer

6.45E-08

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Estradiol-valerate

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Estradiol-valerate

Inflammatory bowel disease

1.17E-03

O60603, P13765, Q14765, Q9UL17, P23771

TLR2, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718

Estradiol-valerate

Systemic lupus erythematosus

3.55E-05

P08246, P09871, P10747, P13765, P29965, Q6FI13, P62807, Q16778, O60814, P68431, P12814

ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Estradiol-valerate

Rheumatoid arthritis

5.16E-04

P13765, Q13488, P10747, P09341, O60603

HLA-DOB, TCIRG1, CD28, CXCL1, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717

Estradiol-valerate

hsa05330

Allograft rejection

1.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Estradiol-valerate

Graft-versus-host disease

3.63E-04

P13765, P10747, P26715, Q13241

HLA-DOB, CD28, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Estradiol-valerate

Primary immunodeficiency

2.19E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Estradiol-valerate

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.48E-02

P54284

CACNB3

Estradiol-valerate

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Estradiol-valerate

Diabetic cardiomyopathy

2.33E-02

P17252, P14598, Q15080, Q16718, O14521, P11413

PRKCA, NCF1, NCF4, NDUFA5, SDHD, G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P40926	MDH2	Malate dehydrogenase, mitochondrial	P26678	PLN	Cardiac phospholamban	-0.71
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Estradiol-valerate

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Estradiol-valerate

Fluid shear stress and atherosclerosis

1.79E-05

Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q14145	KEAP1	Kelch-like ECH-associated protein 1	-0.733
Q16539	MAPK14	Mitogen-activated protein kinase 14	P10599	TXN	Thioredoxin	0.749
P49841	GSK3B	Glycogen synthase kinase-3 beta	P10599	TXN	Thioredoxin	0.836
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P49841	GSK3B	Glycogen synthase kinase-3 beta	P27930	IL1R2	Interleukin-1 receptor type 2	0.848
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955

Ethinylestradiol

Pentose phosphate pathway

1.69E-02

P60891, P37837

PRPS1, TALDO1

Ethinylestradiol

Fatty acid degradation

3.50E-02

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874

Ethinylestradiol

Starch and sucrose metabolism

2.67E-02

P35573

AGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P49841	GSK3B	Glycogen synthase kinase-3 beta	O43451	MGAM	Maltase-glucoamylase	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P25025	CXCR2	C-X-C chemokine receptor type 2	O43451	MGAM	Maltase-glucoamylase	0.942
P25024	CXCR1	C-X-C chemokine receptor type 1	O43451	MGAM	Maltase-glucoamylase	0.895
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P49841	GSK3B	Glycogen synthase kinase-3 beta	P46976	GYG1	Glycogenin-1	0.813
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P25025	CXCR2	C-X-C chemokine receptor type 2	P46976	GYG1	Glycogenin-1	0.827
P25024	CXCR1	C-X-C chemokine receptor type 1	P46976	GYG1	Glycogenin-1	0.859
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P49841	GSK3B	Glycogen synthase kinase-3 beta	P06737	PYGL	Glycogen phosphorylase, liver form	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	P06737	PYGL	Glycogen phosphorylase, liver form	0.901
P25024	CXCR1	C-X-C chemokine receptor type 1	P06737	PYGL	Glycogen phosphorylase, liver form	0.801
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71

Ethinylestradiol

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Ethinylestradiol

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Ethinylestradiol

Linoleic acid metabolism

1.29E-03

P11712

CYP2C9

Ethinylestradiol

Retinol metabolism

2.20E-02

P00325, P11766, Q9BPW9, O75911

ADH1B, ADH5, DHRS9, DHRS3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P06239	LCK	Tyrosine-protein kinase Lck	P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	0.771
P06239	LCK	Tyrosine-protein kinase Lck	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	-0.825
P06239	LCK	Tyrosine-protein kinase Lck	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745

Ethinylestradiol

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Ethinylestradiol

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Ethinylestradiol

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Ethinylestradiol

2-Oxocarboxylic acid metabolism

3.43E-02

P50213

IDH3A

Ethinylestradiol

Biosynthesis of amino acids

3.59E-02

P60891, Q99707, P37837

PRPS1, MTR, TALDO1

Ethinylestradiol

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P19784	CSNK2A2	Casein kinase II subunit alpha'	-0.701
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P67870	CSNK2B	Casein kinase II subunit beta	-0.752
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
P21589	NT5E	5'-nucleotidase	Q9NYH9	UTP6	U3 small nucleolar RNA-associated protein 6 homolog	0.836
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
P21589	NT5E	5'-nucleotidase	P78345	RPP38	Ribonuclease P protein subunit p38	0.82
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
P21589	NT5E	5'-nucleotidase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.749
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838

Ethinylestradiol

RNA transport

2.35E-05

O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5

XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758

Ethinylestradiol

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816

Ethinylestradiol

Chemokine signaling pathway

1.83E-02

P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151

CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716

Ethinylestradiol

NF-kappa B signaling pathway

7.84E-04

O00463, P14778, P01584, P01375, P19174, Q04759, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, P19875, Q06643, Q9NQC7

TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799

Ethinylestradiol

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	-0.736
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P23743	DGKA	Diacylglycerol kinase alpha	0.843
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7

Ethinylestradiol

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776

Ethinylestradiol

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Ethinylestradiol

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q86TM6	SYVN1	E3 ubiquitin-protein ligase synoviolin	0.711
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51668	UBE2D1	Ubiquitin-conjugating enzyme E2 D1	0.726
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q86TM6	SYVN1	E3 ubiquitin-protein ligase synoviolin	0.711
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51668	UBE2D1	Ubiquitin-conjugating enzyme E2 D1	0.726
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836

Ethinylestradiol

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762

Ethinylestradiol

Longevity regulating pathway - multiple species

4.41E-03

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1

Ethinylestradiol

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Ethinylestradiol

Axon guidance

1.50E-02

P20827, P23528, Q06124

EFNA1, CFL1, PTPN11

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P16333	NCK1	Cytoplasmic protein NCK1	0.876
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O95631	NTN1	Netrin-1	0.807
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1

Ethinylestradiol

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Ethinylestradiol

Osteoclast differentiation

2.05E-03

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P49841	GSK3B	Glycogen synthase kinase-3 beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715

Ethinylestradiol

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O14684	PTGES	Prostaglandin E synthase	O15105	SMAD7	Mothers against decapentaplegic homolog 7	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O14684	PTGES	Prostaglandin E synthase	O15105	SMAD7	Mothers against decapentaplegic homolog 7	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708

Ethinylestradiol

Tight junction

1.74E-03

P63261, P16989, P56750, Q9Y478, Q92974, Q14247

ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742

Ethinylestradiol

Neutrophil extracellular trap formation

4.64E-05

P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539

ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Ethinylestradiol

Renin-angiotensin system

2.74E-02

P15144, P08311, O75787

ANPEP, CTSG, ATP6AP2

Ethinylestradiol

C-type lectin receptor signaling pathway

8.11E-03

Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539

CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P49841	GSK3B	Glycogen synthase kinase-3 beta	P20749	BCL3	B-cell lymphoma 3 protein	0.745
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Ethinylestradiol

Hematopoietic cell lineage

2.62E-03

P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P01584

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Ethinylestradiol

Natural killer cell mediated cytotoxicity

3.85E-05

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Ethinylestradiol

IL-17 signaling pathway

1.56E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Ethinylestradiol

Th1 and Th2 cell differentiation

2.95E-05

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Ethinylestradiol

Th17 cell differentiation

1.82E-05

P25963, Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P07766, P09693, P20963, P23458

NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Ethinylestradiol

T cell receptor signaling pathway

1.96E-04

P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Ethinylestradiol

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Ethinylestradiol

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Ethinylestradiol

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Ethinylestradiol

Inflammatory mediator regulation of TRP channels

3.14E-04

P14778, P01584, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24

IL1R1, IL1B, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P24723	PRKCH	Protein kinase C eta type	0.752
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828

Ethinylestradiol

GnRH signaling pathway

4.33E-02

P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694

ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828

Ethinylestradiol

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.767
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30304	CDC25A	M-phase inducer phosphatase 1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Ethinylestradiol

Adipocytokine signaling pathway

2.62E-03

Q06124, Q9Y478, Q96RR4

PTPN11, PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Ethinylestradiol

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Ethinylestradiol

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742

Ethinylestradiol

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774

Ethinylestradiol

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Ethinylestradiol

Alcoholism

3.52E-06

Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761

Ethinylestradiol

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P25025

CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719

Ethinylestradiol

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754

Ethinylestradiol

Salmonella infection

2.04E-02

P25963, Q13489, P10415, Q9BQS8

NFKBIA, BIRC3, BCL2, FYCO1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75369	FLNB	Filamin-B	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.807
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722

Ethinylestradiol

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707

Ethinylestradiol

Leishmaniasis

2.29E-02

P13612, O75015, P23458, P13765, O60603, P01375, P01584, Q16539, Q15080

ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762

Ethinylestradiol

Malaria

2.43E-02

P60033, O60603, P01375, P35443, P01584, P26718

CD81, TLR2, TNF, THBS4, IL1B, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91

Ethinylestradiol

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708

Ethinylestradiol

Amoebiasis

1.54E-04

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744

Ethinylestradiol

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769

Ethinylestradiol

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Ethinylestradiol

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Ethinylestradiol

Transcriptional misregulation in cancer

2.04E-03

P17844, P14780, P27930, Q16548, P11215, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

DDX5, MMP9, IL1R2, BCL2A1, ITGAM, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P21589	NT5E	5'-nucleotidase	Q15532	SS18	Protein SSXT	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P21589	NT5E	5'-nucleotidase	P14923	JUP	Junction plakoglobin	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P21589	NT5E	5'-nucleotidase	O15550	UTX	Lysine-specific demethylase 6A	-0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P21589	NT5E	5'-nucleotidase	P04637	TP53	Cellular tumor antigen p53	0.701
P21589	NT5E	5'-nucleotidase	P05164	MPO	Myeloperoxidase	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Ethinylestradiol

Viral carcinogenesis

7.94E-05

Q13547, Q15283, P58876, P62807, Q16778, O60814

HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P06746	POLB	DNA polymerase beta	0.837
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P29083	GTF2E1	General transcription factor IIE subunit 1	0.786
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15283	RASA2	Ras GTPase-activating protein 2	-0.815
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P12814	ACTN1	Alpha-actinin-1	-0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.878
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Ethinylestradiol

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Ethinylestradiol

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742

Ethinylestradiol

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Ethinylestradiol

Pancreatic cancer

3.52E-02

P84022, Q13485

SMAD3, SMAD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P50052	AGTR2	Type-2 angiotensin II receptor	P37173	TGFBR2	TGF-beta receptor type-2	0.835
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721

Ethinylestradiol

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Ethinylestradiol

Basal cell carcinoma

3.50E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P07195	LDHB	L-lactate dehydrogenase B chain	Q13635	PTCH1	Protein patched homolog 1	0.75
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.753
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819

Ethinylestradiol

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769

Ethinylestradiol

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728

Ethinylestradiol

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736

Ethinylestradiol

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.58E-03

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Ethinylestradiol

Inflammatory bowel disease

1.21E-02

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718

Ethinylestradiol

Systemic lupus erythematosus

5.41E-07

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Fluoroestradiol-F-18

Pentose phosphate pathway

3.67E-03

P60891, P11413, P37837

PRPS1, G6PD, TALDO1

Fluoroestradiol-F-18

Fatty acid degradation

3.50E-02

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
O43451	MGAM	Maltase-glucoamylase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.736
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
O43451	MGAM	Maltase-glucoamylase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
O43451	MGAM	Maltase-glucoamylase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.822
P25025	CXCR2	C-X-C chemokine receptor type 2	P11766	ADH5	Alcohol dehydrogenase class-3	-0.747
P25025	CXCR2	C-X-C chemokine receptor type 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75521	ECI2	Enoyl-CoA delta isomerase 2	-0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.874

Fluoroestradiol-F-18

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Fluoroestradiol-F-18

Glutathione metabolism

2.60E-05

Q9UJ14, P11413, Q16772, P09211, P30041

GGTL3, G6PD, GSTA3, GSTP1, PRDX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P21589	NT5E	5'-nucleotidase	Q7LG56	RRM2B	Ribonucleoside-diphosphate reductase subunit M2 B	0.7
P21589	NT5E	5'-nucleotidase	P31350	RRM2	Ribonucleoside-diphosphate reductase subunit M2	-0.732
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Fluoroestradiol-F-18

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Fluoroestradiol-F-18

Linoleic acid metabolism

1.29E-03

P11712

CYP2C9

Fluoroestradiol-F-18

Retinol metabolism

2.20E-02

P00325, P11766, Q9BPW9, O75911

ADH1B, ADH5, DHRS9, DHRS3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P06239	LCK	Tyrosine-protein kinase Lck	P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	0.771
P06239	LCK	Tyrosine-protein kinase Lck	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	-0.825
P06239	LCK	Tyrosine-protein kinase Lck	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11766	ADH5	Alcohol dehydrogenase class-3	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.745

Fluoroestradiol-F-18

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Fluoroestradiol-F-18

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Fluoroestradiol-F-18

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Fluoroestradiol-F-18

Drug metabolism - other enzymes

1.92E-03

P04183, P32320, P05164, Q16772, P09211

TK1, CDA, MPO, GSTA3, GSTP1

Fluoroestradiol-F-18

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Fluoroestradiol-F-18

Carbon metabolism

2.91E-02

P11413

G6PD

Fluoroestradiol-F-18

2-Oxocarboxylic acid metabolism

3.43E-02

P50213

IDH3A

Fluoroestradiol-F-18

Biosynthesis of amino acids

3.59E-02

P60891, Q99707, P37837

PRPS1, MTR, TALDO1

Fluoroestradiol-F-18

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Fluoroestradiol-F-18

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Fluoroestradiol-F-18

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P19784	CSNK2A2	Casein kinase II subunit alpha'	-0.701
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P67870	CSNK2B	Casein kinase II subunit beta	-0.752
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
P21589	NT5E	5'-nucleotidase	Q9NYH9	UTP6	U3 small nucleolar RNA-associated protein 6 homolog	0.836
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
P21589	NT5E	5'-nucleotidase	P78345	RPP38	Ribonuclease P protein subunit p38	0.82
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
P21589	NT5E	5'-nucleotidase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.749
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.718
Q92769	HDAC2	Histone deacetylase 2	Q9BVP2	GNL3	Guanine nucleotide-binding protein-like 3	0.838

Fluoroestradiol-F-18

RNA transport

2.35E-05

O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5

XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758

Fluoroestradiol-F-18

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Fluoroestradiol-F-18

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816

Fluoroestradiol-F-18

Chemokine signaling pathway

1.83E-02

P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151

CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716

Fluoroestradiol-F-18

NF-kappa B signaling pathway

9.80E-07

P10415, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9NQC7

BCL2, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799

Fluoroestradiol-F-18

Sphingolipid signaling pathway

1.00E-03

P21453, Q9H228, Q13362, Q9BX95, P10415

S1PR1, EDG8, PPP2R5C, SGPP1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Fluoroestradiol-F-18

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	-0.736
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P23743	DGKA	Diacylglycerol kinase alpha	0.843
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7

Fluoroestradiol-F-18

Neuroactive ligand-receptor interaction

1.05E-03

P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735

Fluoroestradiol-F-18

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P27348	YWHAQ	14-3-3 protein theta	0.769
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.776

Fluoroestradiol-F-18

hsa04115

p53 signaling pathway

3.98E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Fluoroestradiol-F-18

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Fluoroestradiol-F-18

Autophagy - animal

3.19E-02

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Fluoroestradiol-F-18

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q86TM6	SYVN1	E3 ubiquitin-protein ligase synoviolin	0.711
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51668	UBE2D1	Ubiquitin-conjugating enzyme E2 D1	0.726
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q86TM6	SYVN1	E3 ubiquitin-protein ligase synoviolin	0.711
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51668	UBE2D1	Ubiquitin-conjugating enzyme E2 D1	0.726
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836

Fluoroestradiol-F-18

Phagosome

4.48E-02

Q15080, P05164, O60603, P35443, P13765

NCF4, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Fluoroestradiol-F-18

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762

Fluoroestradiol-F-18

Apoptosis

3.83E-03

Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Fluoroestradiol-F-18

Longevity regulating pathway - multiple species

4.41E-03

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1

Fluoroestradiol-F-18

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P00441	SOD1	Superoxide dismutase [Cu-Zn]	Q9Y496	KIF3A	Kinesin-like protein KIF3A	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Fluoroestradiol-F-18

Axon guidance

1.50E-02

P20827, P23528, Q06124

EFNA1, CFL1, PTPN11

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P16333	NCK1	Cytoplasmic protein NCK1	0.876
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O95631	NTN1	Netrin-1	0.807
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1

Fluoroestradiol-F-18

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Fluoroestradiol-F-18

Osteoclast differentiation

2.05E-03

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P49841	GSK3B	Glycogen synthase kinase-3 beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.747
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.745
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P23458	JAK1	Tyrosine-protein kinase JAK1	0.777
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715

Fluoroestradiol-F-18

Tight junction

1.74E-03

P63261, P16989, P56750, Q9Y478, Q92974, Q14247

ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742

Fluoroestradiol-F-18

Antigen processing and presentation

3.90E-03

P13765, P48382, P26715, P26717, Q13241, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92

Fluoroestradiol-F-18

Neutrophil extracellular trap formation

1.31E-06

P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Fluoroestradiol-F-18

Renin-angiotensin system

2.74E-02

P15144, P08311, O75787

ANPEP, CTSG, ATP6AP2

Fluoroestradiol-F-18

C-type lectin receptor signaling pathway

8.11E-03

Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539

CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	-0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P49841	GSK3B	Glycogen synthase kinase-3 beta	P20749	BCL3	B-cell lymphoma 3 protein	0.745
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9ULY5	CLEC4E	C-type lectin domain family 4 member E	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20749	BCL3	B-cell lymphoma 3 protein	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Fluoroestradiol-F-18

Hematopoietic cell lineage

2.62E-03

P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P01584

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Fluoroestradiol-F-18

Natural killer cell mediated cytotoxicity

4.09E-06

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Fluoroestradiol-F-18

IL-17 signaling pathway

1.56E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Fluoroestradiol-F-18

Th1 and Th2 cell differentiation

1.52E-07

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Fluoroestradiol-F-18

Th17 cell differentiation

7.74E-06

Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458

PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Fluoroestradiol-F-18

T cell receptor signaling pathway

8.13E-06

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Fluoroestradiol-F-18

Thermogenesis

1.73E-04

Q16539, P15336, P63261, P33121, Q9Y478, Q16718, O14521

MAPK14, ATF2, ACTG1, ACSL1, PRKAB1, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Fluoroestradiol-F-18

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Fluoroestradiol-F-18

Cholinergic synapse

4.83E-02

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Fluoroestradiol-F-18

Inflammatory mediator regulation of TRP channels

3.14E-04

P14778, P01584, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24

IL1R1, IL1B, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P24723	PRKCH	Protein kinase C eta type	0.752
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828

Fluoroestradiol-F-18

GnRH signaling pathway

4.33E-02

P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694

ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9Y6R4	MAP3K4	Mitogen-activated protein kinase kinase kinase 4	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.797
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828

Fluoroestradiol-F-18

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.767
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30304	CDC25A	M-phase inducer phosphatase 1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Fluoroestradiol-F-18

Estrogen signaling pathway

2.96E-02

P14780, P22694, P18848, Q14643, P10415

MMP9, PRKACB, ATF4, ITPR1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q15788	NCOA1	Nuclear receptor coactivator 1	0.843
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P51828	ADCY7	Adenylate cyclase type 7	0.802
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q15788	NCOA1	Nuclear receptor coactivator 1	0.843

Fluoroestradiol-F-18

hsa04918

Thyroid hormone synthesis

3.50E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Fluoroestradiol-F-18

Adipocytokine signaling pathway

2.80E-02

Q06124, Q9Y478

PTPN11, PRKAB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Fluoroestradiol-F-18

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P07947	YES1	Tyrosine-protein kinase Yes	P14618	PKM2	Pyruvate kinase PKM	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P07947	YES1	Tyrosine-protein kinase Yes	P06737	PYGL	Glycogen phosphorylase, liver form	0.808
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Fluoroestradiol-F-18

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Fluoroestradiol-F-18

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Fluoroestradiol-F-18

hsa04927

Cortisol synthesis and secretion

8.60E-03

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Fluoroestradiol-F-18

Parathyroid hormone synthesis, secretion and action

2.33E-03

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P40926	MDH2	Malate dehydrogenase, mitochondrial	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Fluoroestradiol-F-18

Non-alcoholic fatty liver disease

3.62E-02

P49841, Q16718, O14521

GSK3B, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Fluoroestradiol-F-18

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	O43451	MGAM	Maltase-glucoamylase	-0.838
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774

Fluoroestradiol-F-18

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Fluoroestradiol-F-18

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P40926	MDH2	Malate dehydrogenase, mitochondrial	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Fluoroestradiol-F-18

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05141	SLC25A5	ADP/ATP translocase 2	0.725
P40926	MDH2	Malate dehydrogenase, mitochondrial	P12236	SLC25A6	ADP/ATP translocase 3	0.722
P40926	MDH2	Malate dehydrogenase, mitochondrial	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.772
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15169	AXIN1	Axin-1	0.795
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.749
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P30530	AXL	Tyrosine-protein kinase receptor UFO	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.735
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P30530	AXL	Tyrosine-protein kinase receptor UFO	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	0.738
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859

Fluoroestradiol-F-18

Alcoholism

3.52E-06

Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.72
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DP24	CALM2	Calmodulin-2	0.828
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.724
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0C0S5	H2AFZ	Histone H2A.Z	0.764
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P84243	H3F3A	Histone H3.3	0.761

Fluoroestradiol-F-18

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P25025

CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719

Fluoroestradiol-F-18

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754

Fluoroestradiol-F-18

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.716
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P01584	IL1B	Interleukin-1 beta	0.715
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.836
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707
Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.707

Fluoroestradiol-F-18

Leishmaniasis

2.29E-02

P13612, O75015, P23458, P13765, O60603, P01375, P01584, Q16539, Q15080

ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762

Fluoroestradiol-F-18

Malaria

2.43E-02

P60033, O60603, P01375, P35443, P01584, P26718

CD81, TLR2, TNF, THBS4, IL1B, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P25025	CXCR2	C-X-C chemokine receptor type 2	P60033	CD81	CD81 antigen	-0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P60033	CD81	CD81 antigen	-0.873
P25025	CXCR2	C-X-C chemokine receptor type 2	O60603	TLR2	Toll-like receptor 2	0.795
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P35443	THBS4	Thrombospondin-4	0.767
P25024	CXCR1	C-X-C chemokine receptor type 1	P35443	THBS4	Thrombospondin-4	0.743
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P60033	CD81	CD81 antigen	-0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35443	THBS4	Thrombospondin-4	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91

Fluoroestradiol-F-18

Amoebiasis

1.54E-04

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744

Fluoroestradiol-F-18

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Fluoroestradiol-F-18

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Fluoroestradiol-F-18

Transcriptional misregulation in cancer

1.24E-05

Q12778, Q15532, Q13315, P17844, P14780, P27930, Q15744, Q16548, P11215, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P21589	NT5E	5'-nucleotidase	Q15532	SS18	Protein SSXT	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P21589	NT5E	5'-nucleotidase	P14923	JUP	Junction plakoglobin	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P21589	NT5E	5'-nucleotidase	O15550	UTX	Lysine-specific demethylase 6A	-0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P21589	NT5E	5'-nucleotidase	P04637	TP53	Cellular tumor antigen p53	0.701
P21589	NT5E	5'-nucleotidase	P05164	MPO	Myeloperoxidase	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Fluoroestradiol-F-18

Viral carcinogenesis

1.46E-05

Q12933, P42229, Q13547, Q15283, P58876, P62807, Q16778, O60814

TRAF2, STAT5A, HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P06746	POLB	DNA polymerase beta	0.837
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P29083	GTF2E1	General transcription factor IIE subunit 1	0.786
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15283	RASA2	Ras GTPase-activating protein 2	-0.815
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61586	RHOA	Transforming protein RhoA	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P12814	ACTN1	Alpha-actinin-1	-0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40926	MDH2	Malate dehydrogenase, mitochondrial	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.878
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q99527	GPER1	G-protein coupled estrogen receptor 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.81
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Fluoroestradiol-F-18

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Fluoroestradiol-F-18

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Fluoroestradiol-F-18

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Fluoroestradiol-F-18

Basal cell carcinoma

3.50E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P07195	LDHB	L-lactate dehydrogenase B chain	Q13635	PTCH1	Protein patched homolog 1	0.75
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.753
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13635	PTCH1	Protein patched homolog 1	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819

Fluoroestradiol-F-18

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	O15169	AXIN1	Axin-1	-0.736

Fluoroestradiol-F-18

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Fluoroestradiol-F-18

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.51E-04

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, P10747, Q04759, Q16539

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, CD28, PRKCQ, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Fluoroestradiol-F-18

Inflammatory bowel disease

5.29E-06

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718

Fluoroestradiol-F-18

Systemic lupus erythematosus

5.41E-07

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Fluoroestradiol-F-18

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717

Fluoroestradiol-F-18

Graft-versus-host disease

6.43E-05

P13765, P10747, P26715, Q13241

HLA-DOB, CD28, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Fluoroestradiol-F-18